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User:Rwintle

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Richard F. Wintle
Born1967
NationalityCanadian
CitizenshipCanadian, British
Alma materUniversity of Toronto
Scientific career
FieldsGenomics
InstitutionsThe Centre for Applied Genomics, The Hospital for Sick Children

I am a human geneticist and molecular biologist by training and have a PhD from the University of Toronto's Department of Molecular and Medical Genetics. Over the years I have studied the organization of immunoglobulin heavy chain genes[1][2][3], the neurobiology of dopamine signaling in the nematode C. elegans,[4][5] and the genetics of inflammatory diseases (Crohn's Disease[6][7][8] and Rheumatoid Arthritis[9]). Currently I work at The Centre for Applied Genomics and am interested in structural variation of the human genome.[10][11][12]

Personal interests include electronic musical instruments, photography, motorsports, and writing. I have a theoretical interest in Ferrari sports cars, but unfortunately no practical experience.

Wikipedia Work

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Pages I've Primarily Authored

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Subpages for Project Workspaces

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Places

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Credit where credit is due: I stole the idea of listing these by flag from George Church's user page.

Places I've Been

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Antigua Australia Canada China England France The Netherlands Scotland Thailand United Kingdom USA Wales

I've also been through Belgium on a train, and airports in Seoul, Tokyo, and Hong Kong.

Places I've Lived

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Canada Wales

Userboxes

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More credit where credit is due: I've stolen this layout idea from Wikipedian Kisholi.

Wikipedia Editing Foibles

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???
?!?
!!!
This user terminates excessive use of exclamation points and question marks on sight. Grow up!
This editor is a WikiGnome.
its
it's
It's really not that hard to use each word in its proper manner.
’sThi's user know's that not every word that end's with s need's an apostrophe and will remove misused apostrophe's from Wikipedia with extreme prejudice.
. TheThis user does not put two spaces after a full stop.
less & fewerThis user understands the difference between less & fewer.
en-5This user can contribute with a professional level of English.

Other Things

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It is approximately 4:10 PM where this user lives.
This user loves to read.
This user loves to write.
<html>This user can write HTML.
This user is a scientist.
This user is interested in
DNA and genetics.
This user is interested in
Molecular Biology.
UTThis user attends or attended the University of Toronto.
Driver's
license
This user has a driver's license.
This user pumps his own gas.
This user is a Canadaphile
This user is British by ethnicity
This user is interested in the
British Isles.
This user enjoys electronic music.
This user is a MIDI author.
This user enjoys photography.
Logo of the "G" rating in the Motion Picture Association film rating systemThis user is rated 'G' by the Motion Picture Association.

References

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  1. ^ Wintle RF, Nygaard TG, Herbrick JS, et al. (1997). Genetic polymorphism and recombination in the subtelomeric region of chromosome 14q. Genomics 40:409-414
  2. ^ Wintle RF, Costa T, Haslam RHA, et al. (1995). Molecular analysis redefines three human chromosome 14 deletions. Hum. Genet. 95:495-500
  3. ^ Wintle RF and Cox DW (1994). Mapping of human immunoglobulin heavy chain variable gene segments outside the major IGH locus. Genomics 23:151-157
  4. ^ Sanyal S, Wintle RF (co-first authors), Kindt KS, et al. (2004). Dopamine modulates the plasticity of mechanosensory responses in C. elegans. EMBO J. 23(2):473-82
  5. ^ Wintle RF and Van Tol HHM (2001). Dopamine signaling in C. elegans – potential for parkinsonism research. Parkinsonism Rel. Disord. 7(3):177-183
  6. ^ Newman WG, Gu X, Wintle R.F., et al. (2006). DLG5 variants contribute to Crohn disease risk in a Canadian population. Hum. Mutat. 27(4):353-358
  7. ^ Newman B, Gu X, Wintle R, et al. (2005). A risk haplotype in the SLC22A4/SLC22A5 gene cluster influences phenotypic expression of Crohn’s Disease. Gastroenterology 128(2):260-9
  8. ^ Peltekova VD, Wintle RF, Rubin LA, et al. (2004). Functional variants of OCTN transporter genes are associated with Crohn’s Disease. Nature Genet. 36(5):471-75
  9. ^ Newman B, Wintle RF, Van Oene M., et al. (2005). SLC22A4 polymorphisms implicated in Rheumatoid Arthritis and Crohn’s Disease are not associated with Rheumatoid Arthritis in a Canadian caucasian population. Arthritis Rheum. 52(2):425-9
  10. ^ Feuk L, Marshall CR, Wintle RF, et al. (2006). Structural variants: changing the landscape of chromosomes and design of disease studies. Hum. Mol. Genet. 15:R57-R66
  11. ^ Goobie S, Knijnenburg J, FitzPatrick D, et al. (2008). Molecular and clinical characterization of de novo and familial cases with microduplication 3q29: guidelines for copy number variation case reporting. Cytogenet. Genome Res. 123:65-78
  12. ^ Uddin M, Thiruvahindrapuram B, Walker S, et al. (2014). A high-resolution copy-number variation resource for clinical and population genetics.Genet Med 2014 Dec 11. doi: 10.1038/gim.2014.178