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User:Richarnj/sandbox

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Welcome to my main sandbox page.

The Five Pillar Summary[1]

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Wikipedia is an encyclopedia

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Wikipedia is NOT a dictionary, newspaper, list of sources, or publisher of personal research, but it IS a combination of many informative sources to provide general information on a topic backed up by sources which can be consulted for further information beyond that of the encyclopedia.

Wikipedia is written from a neutral point of view

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Wikipedia strives to present ALL points of view without giving preference to any particular view. Articles are NOT a forum for debate and should only be present impartial, verifiable facts.

Wikipedia is free content that anyone can edit, use, modify, and distribute

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ALL content is freely licensed to the public and therefore not owned by any individual. ALL content can be edited by any individual.

Editors should treat each other with respect and civility

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There will often be disagreements between fellow editors; however, consensus should be sought through good faith and calm conversation.

Wikipedia does not have firm rules

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Wikipedia only has general policies and guidelines allowing for evolution in interpretation. Mistakes can always be corrected, and edits should be made often and in good spirit.

Summary of characteristics of target article[2]

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Stub Class Articles

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A stub class article is with what we will begin our project. These articles are extremely basic likely without any references. In many cases these pages are similar to a dictionary definition. In other cases they contain incomprehensible information that does not add to the value of the article despite the added length.

B Class and Good Articles

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Our target end class for our project article is somewhere between a B-class and a good article. There are six criteria an article must meet to be considered B-class as outlined by the Wikipedia guidelines. Articles of this class must be reasonably well written in terms of style and grammar. The article must be well-structured covering all aspects of the topic and be verifiable with ample reliable references and inline citations. Figures, diagrams, charts, and other supporting information should be included as appropriate to improve understanding of the topic.

In order to improve an article from B-class to a good article, the article needs to approach a professional level. Good articles have very well written broad coverage of the topic that requires little to no prior knowledge of the subject. These articles contain plenty of references and inline citations to verify the articles content without any original research on the part of the reader. Images are used to enhance the content, but are included only with suitable captions, copyright status, and rationale as necessary. Good articles are approved as such by an official review.

RefTools Citation Practice

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Demo cite from course page [3]

Caffeine and Parkinson disease

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Parkinson disease is a condition that generally manifests itself later in life showing symptoms including tremors, loss of motor control, loss of posture control, sleep disorders and depression. This symptoms are caused by the death of dopaminergic neurons resulting in emotional, memory, and motor control degradation [4]. Early studies suggest that caffeine may provide protection for the dopaminergic neurons and improve motor control in patients [4] allowing them to maintain their quality of life for a longer period of time.

Management of esophageal cancer

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Esophageal cancer is one of the most deadly cancers in the US with 15210 deaths in 17990 cases in 2013 [5]. There are two types of esophageal cancer, one that begins in the squamous of flat cells lining the esophagus and adenocarcinoma which releases mucus from the esophageal cells [5]. Integration of PET and CT scanning in the early stages may increase the success of treatment when combined with the traditional chemotherapy, radiation therapy, and esophagectomy. [6] PET/CT may be able to detect metastatic disease that would otherwise go unnoticed in early stages therefore improving the chances that treatment will be successful.

Viral transformation outline

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The following is an initial outline for proposed edits to the Viral transformation article.

Lead section

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Simple overview answering the question, What is viral transformation? Basic information regarding applications of viral transformation.

Introduction

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Slightly more in depth description of what viral transformation is and why it is important.

Process

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How do viruses prepare to transform other cells

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Discussion of methods both in vitro and in vivo

How is a cell transformed once the vector enters the cell

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Changes in the cell

  • Physiological
  • Biochemical
  • Genomic

Assays

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Applications

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Each application could have its own section given there is enough information to support it, such as personalized medicine, tumor reduction, and drug delivery.

Images

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Not sure how useful some of these images will be but they are at least a start. Many of them are how viruses infect and kill cells.

Article refs

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  1. Effect of transforming viruses on molecular mechanisms associated with cancer.[7]
  2. Viral transformation for production of personalized type I interferons.[8]
  3. Cell Transformation by RNA Viruses: An Overview[9]
  4. Alteration of cell-surface proteins by viral transformation[10] (Cell-surface proteins are altered during viral transformation, and ultimately it affects the rate of cell growth.)
  5. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism of generating the transforming virus.[11] (summary of the recombination techniques associated with the c-src gene to insert genes into the transforming virus)
  6. The DNA damage response in viral induced cellular transformation.[12] (DNA damage response (genomic changes) that take place when a viral induced transformation occurs in oncogenesis)
  7. Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis. [13] (how EB virus induced transformation induced changes in the cell cycle (genomic changes))

References

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  1. ^ Five Pillar Summary. Wikipedia, The Free Encyclopedia. Accessed 2014-01-31.
  2. ^ Article Quality Grading. Wikipedia, The Free Encyclopedia. Accessed 2014-02-07.
  3. ^ Maloney, C (2011). "JATSPack and JATSPAN, a packaging format and infrastructure for the NLM/NISO Journal Archiving Tag Suite (JATS)". Balisage Series on Markup Technologies. Proceedings of Balisage: The Markup Conference 2011. 7. doi:10.4242/BalisageVol7.Maloney01. ISBN 978-1-935958-03-1. PMC 3159421. PMID 21866248.
  4. ^ a b Prediger, RD (2010). "Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms". Journal of Alzheimer's Disease : JAD. 20 (Suppl 1): S205-20. doi:10.3233/JAD-2010-091459. PMID 20182024.
  5. ^ a b "Esophageal Cancer". National Cancer Institute. Retrieved 22 February 2014.
  6. ^ Bruzzi, J. F.; Munden, R. F.; Truong, M. T.; Marom, E. M.; Sabloff, B. S.; Gladish, G. W.; Iyer, R. B.; Pan, T. S.; MacApinlac, H. A.; Erasmus, J. J. (2007 Nov-Dec). "PET/CT of esophageal cancer: its role in clinical management". Radiographics : A Review Publication of the Radiological Society of North America, Inc. 27 (6): 1635–52. doi:10.1148/rg.276065742. PMID 18025508. {{cite journal}}: Check date values in: |date= (help)
  7. ^ Dayaram, T.; Marriott, S. J. (2008 Aug). "Effect of transforming viruses on molecular mechanisms associated with cancer". Journal of Cellular Physiology. 216 (2): 309–14. doi:10.1002/jcp.21439. PMC 4160108. PMID 18366075. {{cite journal}}: Check date values in: |date= (help)
  8. ^ Xu, D.; Zhang, L. (2010 Jun). "Viral transformation for production of personalized type I interferons". Biotechnology Journal. 5 (6): 578–81. doi:10.1002/biot.201000038. PMC 3023146. PMID 20518060. {{cite journal}}: Check date values in: |date= (help)
  9. ^ Fan, Hung (2011 June 15). "Cell Transformation by RNA Viruses: An Overview". Viruses. 3 (6): 858–860. doi:10.3390/v3060858. PMC 3185770. PMID 21994757. {{cite journal}}: Check date values in: |date= (help)
  10. ^ Hynes, RO (1973 Nov). "Alteration of cell-surface proteins by viral transformation and by proteolysis". Proceedings of the National Academy of Sciences of the United States of America. 70 (11): 3170–4. doi:10.1073/pnas.70.11.3170. PMC 427194. PMID 4361679. {{cite journal}}: Check date values in: |date= (help)
  11. ^ Takeya, T (1983 Mar). "Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus". Cell. 32 (3): 881–90. doi:10.1016/0092-8674(83)90073-9. PMID 6299580. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)
  12. ^ Nikitin, P. A.; Luftig, M. A. (2012 Jan 31). "The DNA damage response in viral-induced cellular transformation". British Journal of Cancer. 106 (3): 429–35. doi:10.1038/bjc.2011.612. PMC 3273341. PMID 22240795. {{cite journal}}: Check date values in: |date= (help)
  13. ^ Parker, G. A.; Touitou, R.; Allday, M. J. (2000 Feb 3). "Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis". Oncogene. 19 (5): 700–9. doi:10.1038/sj.onc.1203327. PMID 10698515. {{cite journal}}: Check date values in: |date= (help)
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