User:Rgudipudi/sandbox
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I am from the Wikipedia article U-M. This is the U-M website
Link to RNAse P
[edit]RNase P and RNAse MRP are ribonucleoprotein complexes that are important in RNA processing. Both subunits have a highly conserved P4 helical region RNAse P which is also the region that has catalytic function. RNAse P is found in both eukaryotes and prokaryotes and it cleaves a pre-tRNA to generate the mature 5’ end of the tRNA. RNase MRP is found only in eukaryotes, and is involved in rRNA processing. These two RNases are most likely evolutionarily related through a common ancestor, since they have common protein subunits and can be folded into very similar secondary structures. Sequences of the CR-I, CR-V, and CR-IV in domain 1 are conserved, with the consensus sequence in CR-IV being AGNNNNA for P RNA and AGNNA for MRP RNA. CR-II and CR-III are also conserved in domain 2 of P RNA. These conserved regions are evidence of the evolutionary relation between these two important ribonucleoprotein complexes.