CFAP97D2

Cilia- and flagella-associated protein 97 domain-containing 2 (CFAP97D2) also known as KIAA1430 ^[1] (previous name) is a domain of CFAP97 gene located at position 34 on the long arm of human chromosome 13^[2].

Identification

CFAP97D2 has an identifier accession number of XP_016876399^[3].

Function

CFAP97D2 is found to be highly expressed in human testes, pancreases, lungs, white blood cells, and ovaries, also highly expressed in stomachs during human fetal development^[4]. It is illustrated to be highly expressed in the organs with densely packed fibers.

In 2006, an expressed sequence tags analysis in human Parkinson's disease tissues and MPTP treated mice model^[5] indicated that the expression of CFAP97D2 is affected by Parkinson’s disease. It shows that both protein levels and RNA levels of CFAP97D2 and other tubulin genes undergo a decrease, supporting that CFAP97D2 may be highly related to tubulin in human tissue compositions.

Another domain of CFAP97 protein: CFAP97D1 is proved to function in both structural components of mammalian sperm flagella and sufficient motility of sperm and affect subsequent fertilization^[6]. Since CFAP97D1 and CFAP97D2 are different protein domains with distinct particular functions but certain interactions with each other contributing to the overall function of CFAP97 protein, CFAP97D2 is initially determined to be related to sperm motility in mammals.

References

^ NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) isoform 2 protein [1]
^ NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) genomic context [2]
^ NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) protein [3]
^ NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) expression [4]
^ Kim, J. M., Lee, K. H., Jeon, Y. J., Oh, J. H., Jeong, S. Y., Song, I. S., Kim, J. M., Lee, D. S., & Kim, N. S. (2006). Identification of genes related to Parkinson's disease using expressed sequence tags. DNA research : an international journal for rapid publication of reports on genes and genomes, 13(6), 275–286. https://doi.org/10.1093/dnares/dsl016
^ Oura, S., Kazi, S., Savolainen, A., Nozawa, K., Castañeda, J., Yu, Z., Miyata, H., Matzuk, R. M., Hansen, J. N., Wachten, D., Matzuk, M. M., & Prunskaite-Hyyryläinen, R. (2020). Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. PLoS genetics, 16(8), e1008954. https://doi.org/10.1371/journal.pgen.1008954

[1] NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) isoform 2 protein [1]

[2] NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) genomic context [2]

[3] NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) protein [3]

[4] NCBI (National Center for Biotechnology Information) CFAP97D2 (Homo sapiens) expression [4]

[5] Kim, J. M., Lee, K. H., Jeon, Y. J., Oh, J. H., Jeong, S. Y., Song, I. S., Kim, J. M., Lee, D. S., & Kim, N. S. (2006). Identification of genes related to Parkinson's disease using expressed sequence tags. DNA research : an international journal for rapid publication of reports on genes and genomes, 13(6), 275–286. https://doi.org/10.1093/dnares/dsl016

[6] Oura, S., Kazi, S., Savolainen, A., Nozawa, K., Castañeda, J., Yu, Z., Miyata, H., Matzuk, R. M., Hansen, J. N., Wachten, D., Matzuk, M. M., & Prunskaite-Hyyryläinen, R. (2020). Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility. PLoS genetics, 16(8), e1008954. https://doi.org/10.1371/journal.pgen.1008954

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