The 2018–19 CONCACAF SuperLiga knockout phase is scheduled to begin on 14 February and end on 29 May 2019 with the final at the Estadio Olímpico Félix Sánchez in Santo Domingo, Dominican Republican, to decide the champions of the 2018–19 CONCACAF SuperLiga. A total of 32 teams compete in the knockout phase.
For the first time, the video assistant referee (VAR) system will be used in the competition, where it will be implemented in the final.
The knockout phase involves 32 teams: the 24 teams which qualify as winners and runners-up of each of the twelve groups in the group stage, and the eight third-placed teams from the Champions League group stage.
Each tie in the knockout phase, apart from the final, is played over two legs, with each team playing one leg at home. The team that scores more goals on aggregate over the two legs advance to the next round. If the aggregate score is level, the away goals rule is applied, i.e. the team that scores more goals away from home over the two legs advances. If away goals are also equal, then extra time is played. The away goals rule is again applied after extra time, i.e. if there are goals scored during extra time and the aggregate score is still level, the visiting team advances by virtue of more away goals scored. If no goals are scored during extra time, the tie is decided by penalty shoot-out. In the final, which is played as a single match, if the score is level at the end of normal time, extra time is played, followed by penalty shoot-out if the score remains tied.
The mechanism of the draws for each round is as follows:
In the draw for the round of 32, the twelve group winners and the four third-placed teams from the Champions League group stage with the better group records are seeded, and the twelve group runners-up and the other four third-placed teams from the Champions League group stage are unseeded. The seeded teams are drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same group or the same association cannot be drawn against each other.
In the draws for the round of 16, quarter-finals and semi-finals, there are no seedings, and teams from the same group or the same association can be drawn against each other. As the draws for the quarter-finals and semi-finals are held together before the quarter-finals are played, the identity of the quarter-final winners is not known at the time of the semi-final draw. A draw is also held to determine which semi-final winner is designated as the "home" team for the final (for administrative purposes as it is played at a neutral venue).