Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 07:11, 9 October 2007 (UTC)
[edit]Proteins without matches (3)
[edit]Proteins with a High Potential Match (6)
[edit]Redirected Proteins (41)
[edit]Manual Inspection (Page not found) (9)
[edit]
Protein Status Grid - Date: 07:11, 9 October 2007 (UTC)
[edit]Vebose Log - Date: 07:11, 9 October 2007 (UTC)
[edit]- INFO: Beginning work on ACE... {October 8, 2007 11:46:23 PM PDT}
- SEARCH REDIRECT: Control Box Found: Angiotensin-converting enzyme {October 8, 2007 11:46:50 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:46:51 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:46:51 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:46:51 PM PDT}
- UPDATED: Updated protein page: Angiotensin-converting enzyme {October 8, 2007 11:46:57 PM PDT}
- INFO: Beginning work on ARNTL... {October 8, 2007 11:41:29 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:42:13 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Aryl hydrocarbon receptor nuclear translocator-like
| HGNCid = 701
| Symbol = ARNTL
| AltSymbols =; BMAL1; BMAL1c; JAP3; MGC47515; MOP3; PASD3; TIC
| OMIM = 602550
| ECnumber =
| Homologene = 910
| MGIid = 1096381
| GeneAtlas_image1 = PBB_GE_ARNTL_210971_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARNTL_209824_s_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 406
| Hs_Ensembl = ENSG00000133794
| Hs_RefseqProtein = NP_001025443
| Hs_RefseqmRNA = NM_001030272
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 13255921
| Hs_GenLoc_end = 13365345
| Hs_Uniprot = O00327
| Mm_EntrezGene = 11865
| Mm_Ensembl = ENSMUSG00000055116
| Mm_RefseqmRNA = NM_007489
| Mm_RefseqProtein = NP_031515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 112998646
| Mm_GenLoc_end = 113105303
| Mm_Uniprot = Q3UHZ2
}}
}}
'''Aryl hydrocarbon receptor nuclear translocator-like''', also known as '''ARNTL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ARNTL aryl hydrocarbon receptor nuclear translocator-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=406| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ARNTL2... {October 9, 2007 12:02:31 AM PDT}
- SEARCH REDIRECT: Control Box Found: ARNTL2 {October 9, 2007 12:03:02 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:03:04 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:03:04 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:03:04 AM PDT}
- UPDATED: Updated protein page: ARNTL2 {October 9, 2007 12:03:09 AM PDT}
- INFO: Beginning work on CDH1... {October 8, 2007 11:42:13 PM PDT}
- SEARCH REDIRECT: Control Box Found: Cadherin {October 8, 2007 11:42:50 PM PDT}
- UPLOAD: Added new Image to wikiCreated new protein page: <a href=http://en.wikipedia.org/w/index.php?title=Cadherin>Cadherin</a> {October 8, 2007 11:42:58 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:43:06 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:43:06 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:43:06 PM PDT}
- UPDATED: Updated protein page: Cadherin {October 8, 2007 11:43:11 PM PDT}
- INFO: Beginning work on CFTR... {October 8, 2007 11:43:11 PM PDT}
- SEARCH REDIRECT: Control Box Found: cystic fibrosis transmembrane conductance regulator {October 8, 2007 11:43:42 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:43:44 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:43:44 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:43:44 PM PDT}
- UPDATED: Updated protein page: cystic fibrosis transmembrane conductance regulator {October 8, 2007 11:43:52 PM PDT}
- INFO: Beginning work on CLOCK... {October 8, 2007 11:57:40 PM PDT}
- SEARCH REDIRECT: Control Box Found: CLOCK {October 8, 2007 11:58:00 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:58:02 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:58:02 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:58:02 PM PDT}
- UPDATED: Updated protein page: CLOCK {October 8, 2007 11:58:08 PM PDT}
- INFO: Beginning work on CRY1... {October 8, 2007 11:43:52 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:44:04 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cryptochrome 1 (photolyase-like)
| HGNCid = 2384
| Symbol = CRY1
| AltSymbols =; PHLL1
| OMIM = 601933
| ECnumber =
| Homologene = 7042
| MGIid = 1270841
| GeneAtlas_image1 = PBB_GE_CRY1_209674_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003913 |text = DNA photolyase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008020 |text = G-protein coupled photoreceptor activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1407
| Hs_Ensembl = ENSG00000008405
| Hs_RefseqProtein = NP_004066
| Hs_RefseqmRNA = NM_004075
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 105909289
| Hs_GenLoc_end = 106011737
| Hs_Uniprot = Q16526
| Mm_EntrezGene = 12952
| Mm_Ensembl = ENSMUSG00000020038
| Mm_RefseqmRNA = NM_007771
| Mm_RefseqProtein = NP_031797
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 84561499
| Mm_GenLoc_end = 84614853
| Mm_Uniprot = P97784
}}
}}
'''Cryptochrome 1 (photolyase-like)''', also known as '''CRY1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRY2... {October 8, 2007 11:44:04 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:44:25 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cryptochrome 2 (photolyase-like)
| HGNCid = 2385
| Symbol = CRY2
| AltSymbols =; FLJ10332; HCRY2; KIAA0658; PHLL2
| OMIM = 603732
| ECnumber =
| Homologene = 56466
| MGIid = 1270859
| GeneAtlas_image1 = PBB_GE_CRY2_212695_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003913 |text = DNA photolyase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0048511 |text = rhythmic process}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1408
| Hs_Ensembl = ENSG00000121671
| Hs_RefseqProtein = NP_066940
| Hs_RefseqmRNA = NM_021117
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 45825605
| Hs_GenLoc_end = 45861372
| Hs_Uniprot = Q49AN0
| Mm_EntrezGene = 12953
| Mm_Ensembl = ENSMUSG00000068742
| Mm_RefseqmRNA = XM_994658
| Mm_RefseqProtein = XP_999752
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 92204485
| Mm_GenLoc_end = 92234867
| Mm_Uniprot = Q99JJ1
}}
}}
'''Cryptochrome 2 (photolyase-like)''', also known as '''CRY2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CSNK1D... {October 8, 2007 11:45:23 PM PDT}
- SEARCH REDIRECT: Control Box Found: CSNK1D {October 8, 2007 11:45:43 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:45:45 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:45:45 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:45:45 PM PDT}
- UPDATED: Updated protein page: CSNK1D {October 8, 2007 11:45:58 PM PDT}
- INFO: Beginning work on CSNK1E... {October 8, 2007 11:45:58 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:46:23 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1cki}}, {{PDB2|1ckj}}
| Name = Casein kinase 1, epsilon
| HGNCid = 2453
| Symbol = CSNK1E
| AltSymbols =; HCKIE; MGC10398
| OMIM = 600863
| ECnumber =
| Homologene = 37548
| MGIid = 1351660
| GeneAtlas_image1 = PBB_GE_CSNK1E_202332_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004681 |text = casein kinase I activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1454
| Hs_Ensembl = ENSG00000100181
| Hs_RefseqProtein = NP_001885
| Hs_RefseqmRNA = NM_001894
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 37017870
| Hs_GenLoc_end = 37124473
| Hs_Uniprot = P49674
| Mm_EntrezGene = 27373
| Mm_Ensembl = ENSMUSG00000022433
| Mm_RefseqmRNA = NM_013767
| Mm_RefseqProtein = NP_038795
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 79245107
| Mm_GenLoc_end = 79266120
| Mm_Uniprot = Q8CBH9
}}
}}
'''Casein kinase 1, epsilon''', also known as '''CSNK1E''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: CSNK1E casein kinase 1, epsilon| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1454| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FAS... {October 8, 2007 11:40:42 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:41:29 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1ddf}}
| Name = Fas (TNF receptor superfamily, member 6)
| HGNCid = 11920
| Symbol = FAS
| AltSymbols =; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
| OMIM = 134637
| ECnumber =
| Homologene = 27
| MGIid = 95484
| GeneAtlas_image1 = PBB_GE_FAS_204780_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FAS_204781_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_FAS_215719_x_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 355
| Hs_Ensembl = ENSG00000026103
| Hs_RefseqProtein = NP_000034
| Hs_RefseqmRNA = NM_000043
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 90739206
| Hs_GenLoc_end = 90765521
| Hs_Uniprot = P25445
| Mm_EntrezGene = 14102
| Mm_Ensembl = ENSMUSG00000024778
| Mm_RefseqmRNA = NM_007987
| Mm_RefseqProtein = NP_032013
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 34356663
| Mm_GenLoc_end = 34393767
| Mm_Uniprot = Q6GT31
}}
}}
'''Fas (TNF receptor superfamily, member 6)''', also known as '''FAS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.<ref>{{cite web | title = Entrez Gene: FAS Fas (TNF receptor superfamily, member 6)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=355| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nagata S |title=Apoptosis by death factor. |journal=Cell |volume=88 |issue= 3 |pages= 355-65 |year= 1997 |pmid= 9039262 |doi= }}
*{{cite journal | author=Cascino I, Papoff G, Eramo A, Ruberti G |title=Soluble Fas/Apo-1 splicing variants and apoptosis. |journal=Front. Biosci. |volume=1 |issue= |pages= d12-8 |year= 2004 |pmid= 9159204 |doi= }}
*{{cite journal | author=Uckun FM |title=Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. |journal=Biochem. Pharmacol. |volume=56 |issue= 6 |pages= 683-91 |year= 1998 |pmid= 9751072 |doi= }}
*{{cite journal | author=Krammer PH |title=CD95's deadly mission in the immune system. |journal=Nature |volume=407 |issue= 6805 |pages= 789-95 |year= 2000 |pmid= 11048730 |doi= 10.1038/35037728 }}
*{{cite journal | author=Siegel RM, Chan FK, Chun HJ, Lenardo MJ |title=The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity. |journal=Nat. Immunol. |volume=1 |issue= 6 |pages= 469-74 |year= 2001 |pmid= 11101867 |doi= 10.1038/82712 }}
*{{cite journal | author=Wajant H |title=The Fas signaling pathway: more than a paradigm. |journal=Science |volume=296 |issue= 5573 |pages= 1635-6 |year= 2002 |pmid= 12040174 |doi= 10.1126/science.1071553 }}
*{{cite journal | author=Yonehara S |title=Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 393-402 |year= 2003 |pmid= 12220552 |doi= }}
*{{cite journal | author=Choi C, Benveniste EN |title=Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses. |journal=Brain Res. Brain Res. Rev. |volume=44 |issue= 1 |pages= 65-81 |year= 2004 |pmid= 14739003 |doi= }}
*{{cite journal | author=Poppema S, Maggio E, van den Berg A |title=Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. |journal=Leuk. Lymphoma |volume=45 |issue= 3 |pages= 423-31 |year= 2004 |pmid= 15160902 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FBXL3... {October 8, 2007 11:59:01 PM PDT}
- SEARCH REDIRECT: Control Box Found: FBXL3 {October 8, 2007 11:59:25 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:59:29 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:59:29 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:59:29 PM PDT}
- UPDATED: Updated protein page: FBXL3 {October 8, 2007 11:59:34 PM PDT}
- INFO: Beginning work on GSK3A... {October 8, 2007 11:46:57 PM PDT}
- SEARCH REDIRECT: Control Box Found: GSK3A {October 8, 2007 11:47:09 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:47:12 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:47:12 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:47:12 PM PDT}
- UPDATED: Updated protein page: GSK3A {October 8, 2007 11:47:17 PM PDT}
- INFO: Beginning work on MAPK14... {October 8, 2007 11:44:25 PM PDT}
- SEARCH REDIRECT: Control Box Found: MAPK14 {October 8, 2007 11:45:15 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:45:18 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:45:18 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:45:18 PM PDT}
- UPDATED: Updated protein page: MAPK14 {October 8, 2007 11:45:23 PM PDT}
- INFO: Beginning work on MAPT... {October 8, 2007 11:47:17 PM PDT}
- SEARCH REDIRECT: Control Box Found: Tau protein {October 8, 2007 11:48:13 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:48:15 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:48:15 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:48:15 PM PDT}
- UPDATED: Updated protein page: Tau protein {October 8, 2007 11:48:23 PM PDT}
- INFO: Beginning work on MTHFR... {October 8, 2007 11:48:51 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:49:15 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = 5,10-methylenetetrahydrofolate reductase (NADPH)
| HGNCid = 7436
| Symbol = MTHFR
| AltSymbols =;
| OMIM = 607093
| ECnumber =
| Homologene = 4349
| MGIid = 106639
| GeneAtlas_image1 = PBB_GE_MTHFR_206800_at_tn.png
| GeneAtlas_image2 = PBB_GE_MTHFR_217071_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_MTHFR_217070_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004489 |text = methylenetetrahydrofolate reductase (NADPH) activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006520 |text = amino acid metabolic process}} {{GNF_GO|id=GO:0006555 |text = methionine metabolic process}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0009086 |text = methionine biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4524
| Hs_Ensembl = ENSG00000177000
| Hs_RefseqProtein = NP_005948
| Hs_RefseqmRNA = NM_005957
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 11768367
| Hs_GenLoc_end = 11788702
| Hs_Uniprot = P42898
| Mm_EntrezGene = 17769
| Mm_Ensembl = ENSMUSG00000029009
| Mm_RefseqmRNA = NM_010840
| Mm_RefseqProtein = NP_034970
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 146882883
| Mm_GenLoc_end = 146903353
| Mm_Uniprot = Q3V399
}}
}}
'''5,10-methylenetetrahydrofolate reductase (NADPH)''', also known as '''MTHFR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Methylenetetrahydrofolate reductase (EC 1.5.1.20) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: MTHFR 5,10-methylenetetrahydrofolate reductase (NADPH)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4524| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Matthews RG |title=Methylenetetrahydrofolate reductase: a common human polymorphism and its biochemical implications. |journal=Chemical record (New York, N.Y.) |volume=2 |issue= 1 |pages= 4-12 |year= 2003 |pmid= 11933257 |doi= }}
*{{cite journal | author=Schwahn B, Rozen R |title=Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences. |journal=American journal of pharmacogenomics : genomics-related research in drug development and clinical practice |volume=1 |issue= 3 |pages= 189-201 |year= 2002 |pmid= 12083967 |doi= }}
*{{cite journal | author=Iqbal MP, Frossard PM |title=Methylene tetrahydrofolate reductase gene and coronary artery disease. |journal=JPMA. The Journal of the Pakistan Medical Association |volume=53 |issue= 1 |pages= 33-6 |year= 2003 |pmid= 12666851 |doi= }}
*{{cite journal | author=Bailey LB |title=Folate, methyl-related nutrients, alcohol, and the MTHFR 677C-->T polymorphism affect cancer risk: intake recommendations. |journal=J. Nutr. |volume=133 |issue= 11 Suppl 1 |pages= 3748S-3753S |year= 2003 |pmid= 14608109 |doi= }}
*{{cite journal | author=Wiwanitkit V |title=Roles of methylenetetrahydrofolate reductase C677T polymorphism in repeated pregnancy loss. |journal=Clin. Appl. Thromb. Hemost. |volume=11 |issue= 3 |pages= 343-5 |year= 2005 |pmid= 16015422 |doi= }}
*{{cite journal | author=Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M |title=Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 143-9 |year= 2006 |pmid= 16172608 |doi= 10.1038/sj.mp.4001746 }}
*{{cite journal | author=Lewis SJ, Lawlor DA, Davey Smith G, ''et al.'' |title=The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. |journal=Mol. Psychiatry |volume=11 |issue= 4 |pages= 352-60 |year= 2006 |pmid= 16402130 |doi= 10.1038/sj.mp.4001790 }}
*{{cite journal | author=Pereira TV, Rudnicki M, Pereira AC, ''et al.'' |title=5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1956-63 |year= 2007 |pmid= 17035405 |doi= 10.1158/1055-9965.EPI-06-0334 }}
*{{cite journal | author=Leclerc D, Rozen R |title=[Molecular genetics of MTHFR: polymorphisms are not all benign] |journal=Med Sci (Paris) |volume=23 |issue= 3 |pages= 297-302 |year= 2007 |pmid= 17349292 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NPAS2... {October 8, 2007 11:49:15 PM PDT}
- SEARCH REDIRECT: Control Box Found: NPAS2 {October 8, 2007 11:49:38 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:49:41 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:49:41 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:49:41 PM PDT}
- UPDATED: Updated protein page: NPAS2 {October 8, 2007 11:49:45 PM PDT}
- INFO: Beginning work on NR1D1... {October 8, 2007 11:57:14 PM PDT}
- SEARCH REDIRECT: Control Box Found: NR1D1 {October 8, 2007 11:57:34 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:57:35 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:57:35 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:57:35 PM PDT}
- UPDATED: Updated protein page: NR1D1 {October 8, 2007 11:57:40 PM PDT}
- INFO: Beginning work on NR1D2... {October 8, 2007 11:58:08 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:58:34 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1a6y}}, {{PDB2|1ga5}}, {{PDB2|1hlz}}
| Name = Nuclear receptor subfamily 1, group D, member 2
| HGNCid = 7963
| Symbol = NR1D2
| AltSymbols =; HZF2; BD73; EAR-1r; Hs.37288; RVR
| OMIM = 602304
| ECnumber =
| Homologene = 3763
| MGIid = 2449205
| GeneAtlas_image1 = PBB_GE_NR1D2_209750_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9975
| Hs_Ensembl = ENSG00000174738
| Hs_RefseqProtein = XP_001130839
| Hs_RefseqmRNA = XM_001130839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 23961810
| Hs_GenLoc_end = 23996240
| Hs_Uniprot = Q14995
| Mm_EntrezGene = 353187
| Mm_Ensembl = ENSMUSG00000021775
| Mm_RefseqmRNA = NM_011584
| Mm_RefseqProtein = NP_035714
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 16997124
| Mm_GenLoc_end = 17032066
| Mm_Uniprot = Q4VAB7
}}
}}
'''Nuclear receptor subfamily 1, group D, member 2''', also known as '''NR1D2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PER1... {October 8, 2007 11:49:45 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:50:05 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Period homolog 1 (Drosophila)
| HGNCid = 8845
| Symbol = PER1
| AltSymbols =; MGC88021; PER; RIGUI; hPER
| OMIM = 602260
| ECnumber =
| Homologene = 1966
| MGIid = 1098283
| GeneAtlas_image1 = PBB_GE_PER1_36829_at_tn.png
| GeneAtlas_image2 = PBB_GE_PER1_202861_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0009649 |text = entrainment of circadian clock}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5187
| Hs_Ensembl = ENSG00000179094
| Hs_RefseqProtein = NP_002607
| Hs_RefseqmRNA = NM_002616
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 7984534
| Hs_GenLoc_end = 7996427
| Hs_Uniprot = O15534
| Mm_EntrezGene = 18626
| Mm_Ensembl = ENSMUSG00000020893
| Mm_RefseqmRNA = NM_011065
| Mm_RefseqProtein = NP_035195
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 68915129
| Mm_GenLoc_end = 68926158
| Mm_Uniprot = Q3U378
}}
}}
'''Period homolog 1 (Drosophila)''', also known as '''PER1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.<ref>{{cite web | title = Entrez Gene: PER1 period homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5187| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PER2... {October 8, 2007 11:56:25 PM PDT}
- SEARCH REDIRECT: Control Box Found: PER2 {October 8, 2007 11:56:44 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:56:47 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:56:47 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:56:47 PM PDT}
- UPDATED: Updated protein page: PER2 {October 8, 2007 11:56:51 PM PDT}
- INFO: Beginning work on PER3... {October 8, 2007 11:55:53 PM PDT}
- SEARCH REDIRECT: Control Box Found: PER3 {October 8, 2007 11:56:13 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:56:16 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:56:16 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:56:16 PM PDT}
- UPDATED: Updated protein page: PER3 {October 8, 2007 11:56:25 PM PDT}
- INFO: Beginning work on RORA... {October 8, 2007 11:50:05 PM PDT}
- SEARCH REDIRECT: Control Box Found: RORA {October 8, 2007 11:50:38 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:50:41 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:50:41 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:50:41 PM PDT}
- UPDATED: Updated protein page: RORA {October 8, 2007 11:50:46 PM PDT}
- INFO: Beginning work on RORB... {October 8, 2007 11:50:46 PM PDT}
- SEARCH REDIRECT: Control Box Found: RORB {October 8, 2007 11:51:10 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:51:11 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:51:11 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:51:11 PM PDT}
- UPDATED: Updated protein page: RORB {October 8, 2007 11:51:15 PM PDT}
- INFO: Beginning work on STAT3... {October 8, 2007 11:51:15 PM PDT}
- AMBIGUITY: Did not locate an acceptable page to update. {October 8, 2007 11:52:02 PM PDT}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB = {{PDB2|1bg1}}
| Name = Signal transducer and activator of transcription 3 (acute-phase response factor)
| HGNCid = 11364
| Symbol = STAT3
| AltSymbols =; APRF; FLJ20882; MGC16063
| OMIM = 102582
| ECnumber =
| Homologene = 7960
| MGIid = 103038
| GeneAtlas_image1 = PBB_GE_STAT3_208991_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAT3_208992_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STAT3_gnf1h01250_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = ~~~~~
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005062 |text = hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6774
| Hs_Ensembl = ENSG00000168610
| Hs_RefseqProtein = NP_003141
| Hs_RefseqmRNA = NM_003150
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 37718869
| Hs_GenLoc_end = 37794039
| Hs_Uniprot = P40763
| Mm_EntrezGene = 20848
| Mm_Ensembl = ENSMUSG00000004040
| Mm_RefseqmRNA = XM_001005155
| Mm_RefseqProtein = XP_001005155
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 100701188
| Mm_GenLoc_end = 100755630
| Mm_Uniprot = Q8CFJ6
}}
}}
'''Signal transducer and activator of transcription 3 (acute-phase response factor)''', also known as '''STAT3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.<ref>{{cite web | title = Entrez Gene: STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6774| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoey T, Grusby MJ |title=STATs as mediators of cytokine-induced responses. |journal=Adv. Immunol. |volume=71 |issue= |pages= 145-62 |year= 1999 |pmid= 9917912 |doi= }}
*{{cite journal | author=Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW |title=Signaling through the JAK/STAT pathway, recent advances and future challenges. |journal=Gene |volume=285 |issue= 1-2 |pages= 1-24 |year= 2002 |pmid= 12039028 |doi= }}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87-94 |year= 2005 |pmid= 15638726 |doi= }}
*{{cite journal | author=Inghirami G, Chiarle R, Simmons WJ, ''et al.'' |title=New and old functions of STAT3: a pivotal target for individualized treatment of cancer. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1131-3 |year= 2006 |pmid= 16082218 |doi= }}
*{{cite journal | author=Leeman RJ, Lui VW, Grandis JR |title=STAT3 as a therapeutic target in head and neck cancer. |journal=Expert opinion on biological therapy |volume=6 |issue= 3 |pages= 231-41 |year= 2006 |pmid= 16503733 |doi= 10.1517/14712598.6.3.231 }}
*{{cite journal | author=Aggarwal BB, Sethi G, Ahn KS, ''et al.'' |title=Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. |journal=Ann. N. Y. Acad. Sci. |volume=1091 |issue= |pages= 151-69 |year= 2007 |pmid= 17341611 |doi= 10.1196/annals.1378.063 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRPA1... {October 8, 2007 11:56:52 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPA1 {October 8, 2007 11:57:05 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:57:09 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:57:09 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:57:09 PM PDT}
- UPDATED: Updated protein page: TRPA1 {October 8, 2007 11:57:14 PM PDT}
- INFO: Beginning work on TRPC1... {October 8, 2007 11:52:02 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC1 {October 8, 2007 11:52:26 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:52:29 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:52:29 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:52:29 PM PDT}
- UPDATED: Updated protein page: TRPC1 {October 8, 2007 11:52:34 PM PDT}
- INFO: Beginning work on TRPC2... {October 8, 2007 11:52:34 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC2 {October 8, 2007 11:52:43 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:52:45 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:52:45 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:52:45 PM PDT}
- UPDATED: Updated protein page: TRPC2 {October 8, 2007 11:52:50 PM PDT}
- INFO: Beginning work on TRPC3... {October 8, 2007 11:52:51 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC3 {October 8, 2007 11:53:05 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:53:08 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:53:08 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:53:08 PM PDT}
- UPDATED: Updated protein page: TRPC3 {October 8, 2007 11:53:12 PM PDT}
- INFO: Beginning work on TRPC4... {October 8, 2007 11:53:12 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC4 {October 8, 2007 11:53:43 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:53:46 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:53:46 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:53:46 PM PDT}
- UPDATED: Updated protein page: TRPC4 {October 8, 2007 11:53:51 PM PDT}
- INFO: Beginning work on TRPC4AP... {October 8, 2007 11:58:34 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC4AP {October 8, 2007 11:58:51 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:58:53 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:58:53 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:58:53 PM PDT}
- UPDATED: Updated protein page: TRPC4AP {October 8, 2007 11:59:01 PM PDT}
- INFO: Beginning work on TRPC5... {October 8, 2007 11:53:51 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC5 {October 8, 2007 11:54:09 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:54:11 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:54:11 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:54:11 PM PDT}
- UPDATED: Updated protein page: TRPC5 {October 8, 2007 11:54:16 PM PDT}
- INFO: Beginning work on TRPC6... {October 8, 2007 11:54:16 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC6 {October 8, 2007 11:54:33 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:54:36 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:54:36 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:54:36 PM PDT}
- UPDATED: Updated protein page: TRPC6 {October 8, 2007 11:54:42 PM PDT}
- INFO: Beginning work on TRPC7... {October 9, 2007 12:03:09 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPC7 {October 9, 2007 12:03:24 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:03:26 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:03:26 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:03:26 AM PDT}
- UPDATED: Updated protein page: TRPC7 {October 9, 2007 12:03:34 AM PDT}
- INFO: Beginning work on TRPM1... {October 8, 2007 11:48:23 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM1 {October 8, 2007 11:48:41 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:48:45 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:48:45 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:48:45 PM PDT}
- UPDATED: Updated protein page: TRPM1 {October 8, 2007 11:48:51 PM PDT}
- INFO: Beginning work on TRPM2... {October 8, 2007 11:54:42 PM PDT}
- REDIRECT: Protein Redirected to: TRPM2 {October 8, 2007 11:54:51 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:54:53 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:54:53 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:54:53 PM PDT}
- UPDATED: Updated protein page: TRPM2 {October 8, 2007 11:54:58 PM PDT}
- INFO: Beginning work on TRPM3... {October 9, 2007 12:04:37 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM3 {October 9, 2007 12:05:01 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:05:03 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:05:03 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:05:03 AM PDT}
- UPDATED: Updated protein page: TRPM3 {October 9, 2007 12:06:55 AM PDT}
- INFO: Beginning work on TRPM4... {October 9, 2007 12:00:27 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM4 {October 9, 2007 12:00:41 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:00:44 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:00:44 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:00:44 AM PDT}
- UPDATED: Updated protein page: TRPM4 {October 9, 2007 12:00:49 AM PDT}
- INFO: Beginning work on TRPM5... {October 8, 2007 11:59:34 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM5 {October 8, 2007 11:59:47 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:59:51 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:59:51 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:59:51 PM PDT}
- UPDATED: Updated protein page: TRPM5 {October 8, 2007 11:59:55 PM PDT}
- INFO: Beginning work on TRPM6... {October 9, 2007 12:07:20 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM6 {October 9, 2007 12:07:44 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:07:47 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:07:47 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:07:47 AM PDT}
- UPDATED: Updated protein page: TRPM6 {October 9, 2007 12:07:55 AM PDT}
- INFO: Beginning work on TRPM7... {October 9, 2007 12:00:49 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM7 {October 9, 2007 12:01:20 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:01:22 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:01:22 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:01:22 AM PDT}
- UPDATED: Updated protein page: TRPM7 {October 9, 2007 12:01:27 AM PDT}
- INFO: Beginning work on TRPM8... {October 9, 2007 12:04:09 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPM8 {October 9, 2007 12:04:28 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:04:31 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:04:31 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:04:31 AM PDT}
- UPDATED: Updated protein page: TRPM8 {October 9, 2007 12:04:37 AM PDT}
- INFO: Beginning work on TRPS1... {October 8, 2007 11:54:58 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPS1 {October 8, 2007 11:55:18 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:55:20 PM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 8, 2007 11:55:20 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:55:20 PM PDT}
- UPDATED: Updated protein page: TRPS1 {October 8, 2007 11:55:26 PM PDT}
- INFO: Beginning work on TRPT1... {October 9, 2007 12:06:55 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPT1 {October 9, 2007 12:07:13 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:07:16 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:07:16 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:07:16 AM PDT}
- UPDATED: Updated protein page: TRPT1 {October 9, 2007 12:07:20 AM PDT}
- INFO: Beginning work on TRPV1... {October 8, 2007 11:55:26 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV1 {October 8, 2007 11:55:44 PM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 8, 2007 11:55:47 PM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 8, 2007 11:55:47 PM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 8, 2007 11:55:47 PM PDT}
- UPDATED: Updated protein page: TRPV1 {October 8, 2007 11:55:53 PM PDT}
- INFO: Beginning work on TRPV2... {October 8, 2007 11:59:55 PM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV2 {October 9, 2007 12:00:20 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:00:22 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:00:22 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:00:22 AM PDT}
- UPDATED: Updated protein page: TRPV2 {October 9, 2007 12:00:27 AM PDT}
- INFO: Beginning work on TRPV3... {October 9, 2007 12:07:55 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV3 {October 9, 2007 12:08:08 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:08:10 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:08:10 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:08:10 AM PDT}
- UPDATED: Updated protein page: TRPV3 {October 9, 2007 12:08:15 AM PDT}
- INFO: Beginning work on TRPV4... {October 9, 2007 12:03:34 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV4 {October 9, 2007 12:04:01 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:04:04 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:04:04 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:04:04 AM PDT}
- UPDATED: Updated protein page: TRPV4 {October 9, 2007 12:04:09 AM PDT}
- INFO: Beginning work on TRPV5... {October 9, 2007 12:02:05 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV5 {October 9, 2007 12:02:22 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:02:26 AM PDT}
- UPDATE SUMMARY: Updating Summary, No Errors. {October 9, 2007 12:02:26 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:02:26 AM PDT}
- UPDATED: Updated protein page: TRPV5 {October 9, 2007 12:02:31 AM PDT}
- INFO: Beginning work on TRPV6... {October 9, 2007 12:01:28 AM PDT}
- SEARCH REDIRECT: Control Box Found: TRPV6 {October 9, 2007 12:01:54 AM PDT}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {October 9, 2007 12:01:56 AM PDT}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {October 9, 2007 12:01:56 AM PDT}
- UPDATE CITATIONS: Updating Citations, No Errors. {October 9, 2007 12:01:56 AM PDT}
- UPDATED: Updated protein page: TRPV6 {October 9, 2007 12:02:05 AM PDT}
end log.
