Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 19:58, 20 December 2007 (UTC)
[edit]Proteins with a High Potential Match (1)
[edit]Redirected Proteins (12)
[edit]Manual Inspection (Page not found) (1)
[edit]
Protein Status Grid - Date: 19:58, 20 December 2007 (UTC)
[edit]Vebose Log - Date: 19:58, 20 December 2007 (UTC)
[edit]- INFO: Beginning work on DIAPH1... {December 20, 2007 11:46:05 AM PST}
- REDIRECT: Protein Redirected to: DIAPH1 {December 20, 2007 11:46:49 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:46:51 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:46:51 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:46:51 AM PST}
- UPDATED: Updated protein page: DIAPH1 {December 20, 2007 11:46:57 AM PST}
- INFO: Beginning work on DNMT3B... {December 20, 2007 11:46:57 AM PST}
- REDIRECT: Page directory gave bad page (DNMT3B). Continuing with search.. Please correct entry: <1789,DNMT3B>. {December 20, 2007 11:47:33 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {December 20, 2007 11:47:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DNMT3B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1khc.
| PDB = {{PDB2|1khc}}
| Name = DNA (cytosine-5-)-methyltransferase 3 beta
| HGNCid = 2979
| Symbol = DNMT3B
| AltSymbols =; ICF; M.HsaIIIB
| OMIM = 602900
| ECnumber =
| Homologene = 56000
| MGIid = 1261819
| GeneAtlas_image1 = PBB_GE_DNMT3B_220668_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003886 |text = DNA (cytosine-5-)-methyltransferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008326 |text = site-specific DNA-methyltransferase (cytosine-specific) activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}}
| Process = {{GNF_GO|id=GO:0006306 |text = DNA methylation}} {{GNF_GO|id=GO:0006349 |text = imprinting}} {{GNF_GO|id=GO:0031503 |text = protein complex localization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1789
| Hs_Ensembl = ENSG00000088305
| Hs_RefseqProtein = NP_008823
| Hs_RefseqmRNA = NM_006892
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 30813852
| Hs_GenLoc_end = 30860823
| Hs_Uniprot = Q9UBC3
| Mm_EntrezGene = 13436
| Mm_Ensembl = ENSMUSG00000027478
| Mm_RefseqmRNA = XM_001003158
| Mm_RefseqProtein = XP_001003158
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 153340894
| Mm_GenLoc_end = 153379171
| Mm_Uniprot = O88509
}}
}}
'''DNA (cytosine-5-)-methyltransferase 3 beta''', also known as '''DNMT3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1789| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1789| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wijmenga C, Hansen RS, Gimelli G, ''et al.'' |title=Genetic variation in ICF syndrome: evidence for genetic heterogeneity. |journal=Hum. Mutat. |volume=16 |issue= 6 |pages= 509-17 |year= 2001 |pmid= 11102980 |doi= 10.1002/1098-1004(200012)16:6<509::AID-HUMU8>3.0.CO;2-V }}
*{{cite journal | author=Okano M, Xie S, Li E |title=Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. |journal=Nat. Genet. |volume=19 |issue= 3 |pages= 219-20 |year= 1998 |pmid= 9662389 |doi= 10.1038/890 }}
*{{cite journal | author=Robertson KD, Uzvolgyi E, Liang G, ''et al.'' |title=The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. |journal=Nucleic Acids Res. |volume=27 |issue= 11 |pages= 2291-8 |year= 1999 |pmid= 10325416 |doi= }}
*{{cite journal | author=Xie S, Wang Z, Okano M, ''et al.'' |title=Cloning, expression and chromosome locations of the human DNMT3 gene family. |journal=Gene |volume=236 |issue= 1 |pages= 87-95 |year= 1999 |pmid= 10433969 |doi= }}
*{{cite journal | author=Okano M, Bell DW, Haber DA, Li E |title=DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. |journal=Cell |volume=99 |issue= 3 |pages= 247-57 |year= 1999 |pmid= 10555141 |doi= }}
*{{cite journal | author=Hansen RS, Wijmenga C, Luo P, ''et al.'' |title=The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 25 |pages= 14412-7 |year= 2000 |pmid= 10588719 |doi= }}
*{{cite journal | author=Xu GL, Bestor TH, Bourc'his D, ''et al.'' |title=Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. |journal=Nature |volume=402 |issue= 6758 |pages= 187-91 |year= 2000 |pmid= 10647011 |doi= 10.1038/46052 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Fuks F, Burgers WA, Godin N, ''et al.'' |title=Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. |journal=EMBO J. |volume=20 |issue= 10 |pages= 2536-44 |year= 2001 |pmid= 11350943 |doi= 10.1093/emboj/20.10.2536 }}
*{{cite journal | author=Kang ES, Park CW, Chung JH |title=Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 4 |pages= 862-8 |year= 2002 |pmid= 11735126 |doi= 10.1006/bbrc.2001.6057 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Rhee I, Bachman KE, Park BH, ''et al.'' |title=DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. |journal=Nature |volume=416 |issue= 6880 |pages= 552-6 |year= 2002 |pmid= 11932749 |doi= 10.1038/416552a }}
*{{cite journal | author=Hata K, Okano M, Lei H, Li E |title=Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. |journal=Development |volume=129 |issue= 8 |pages= 1983-93 |year= 2002 |pmid= 11934864 |doi= }}
*{{cite journal | author=Beaulieu N, Morin S, Chute IC, ''et al.'' |title=An essential role for DNA methyltransferase DNMT3B in cancer cell survival. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28176-81 |year= 2002 |pmid= 12015329 |doi= 10.1074/jbc.M204734200 }}
*{{cite journal | author=Saito Y, Kanai Y, Sakamoto M, ''et al.'' |title=Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 15 |pages= 10060-5 |year= 2002 |pmid= 12110732 |doi= 10.1073/pnas.152121799 }}
*{{cite journal | author=Kim GD, Ni J, Kelesoglu N, ''et al.'' |title=Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. |journal=EMBO J. |volume=21 |issue= 15 |pages= 4183-95 |year= 2002 |pmid= 12145218 |doi= }}
*{{cite journal | author=Deplus R, Brenner C, Burgers WA, ''et al.'' |title=Dnmt3L is a transcriptional repressor that recruits histone deacetylase. |journal=Nucleic Acids Res. |volume=30 |issue= 17 |pages= 3831-8 |year= 2002 |pmid= 12202768 |doi= }}
*{{cite journal | author=Shen H, Wang L, Spitz MR, ''et al.'' |title=A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. |journal=Cancer Res. |volume=62 |issue= 17 |pages= 4992-5 |year= 2002 |pmid= 12208751 |doi= }}
*{{cite journal | author=Shirohzu H, Kubota T, Kumazawa A, ''et al.'' |title=Three novel DNMT3B mutations in Japanese patients with ICF syndrome. |journal=Am. J. Med. Genet. |volume=112 |issue= 1 |pages= 31-7 |year= 2003 |pmid= 12239717 |doi= 10.1002/ajmg.10658 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ERBB3... {December 20, 2007 11:48:31 AM PST}
- REDIRECT: Protein Redirected to: ERBB3 {December 20, 2007 11:49:36 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:49:37 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:49:37 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:49:37 AM PST}
- UPDATED: Updated protein page: ERBB3 {December 20, 2007 11:49:44 AM PST}
- INFO: Beginning work on ERCC5... {December 20, 2007 11:49:44 AM PST}
- REDIRECT: Protein Redirected to: ERCC5 {December 20, 2007 11:50:31 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:50:34 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:50:34 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:50:34 AM PST}
- UPDATED: Updated protein page: ERCC5 {December 20, 2007 11:50:40 AM PST}
- INFO: Beginning work on EWSR1... {December 20, 2007 11:52:06 AM PST}
- REDIRECT: Protein Redirected to: Ewing sarcoma breakpoint region 1 {December 20, 2007 11:52:42 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:52:43 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:52:43 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:52:43 AM PST}
- UPDATED: Updated protein page: Ewing sarcoma breakpoint region 1 {December 20, 2007 11:52:49 AM PST}
- INFO: Beginning work on EXOSC7... {December 20, 2007 11:58:02 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein EXOSC7 image.jpg {December 20, 2007 11:59:17 AM PST}
- REDIRECT: Protein Redirected to: EXOSC7 {December 20, 2007 11:59:41 AM PST}
- CREATED: Created new protein page: EXOSC7 {December 20, 2007 11:59:53 AM PST}
- INFO: Beginning work on FBL... {December 20, 2007 11:50:40 AM PST}
- REDIRECT: Protein Redirected to: FBL (gene) {December 20, 2007 11:51:59 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:52:00 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:52:00 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:52:00 AM PST}
- UPDATED: Updated protein page: FBL (gene) {December 20, 2007 11:52:06 AM PST}
- INFO: Beginning work on FEN1... {December 20, 2007 11:53:55 AM PST}
- REDIRECT: Protein Redirected to: Flap structure-specific endonuclease 1 {December 20, 2007 11:54:44 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:54:46 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:54:46 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:54:46 AM PST}
- UPDATED: Updated protein page: Flap structure-specific endonuclease 1 {December 20, 2007 11:54:52 AM PST}
- INFO: Beginning work on FKBP3... {December 20, 2007 11:54:52 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FKBP3 image.jpg {December 20, 2007 11:55:35 AM PST}
- REDIRECT: Protein Redirected to: FKBP3 {December 20, 2007 11:55:42 AM PST}
- CREATED: Created new protein page: FKBP3 {December 20, 2007 11:55:50 AM PST}
- INFO: Beginning work on PHC1... {December 20, 2007 11:47:40 AM PST}
- REDIRECT: Protein Redirected to: PHC1 {December 20, 2007 11:48:23 AM PST}
- CREATED: Created new protein page: PHC1 {December 20, 2007 11:48:31 AM PST}
- INFO: Beginning work on SEPHS1... {December 20, 2007 11:55:50 AM PST}
- REDIRECT: Protein Redirected to: SEPHS1 {December 20, 2007 11:57:05 AM PST}
- CREATED: Created new protein page: SEPHS1 {December 20, 2007 11:57:13 AM PST}
- INFO: Beginning work on TPX2... {December 20, 2007 11:57:13 AM PST}
- REDIRECT: Protein Redirected to: TPX2 {December 20, 2007 11:57:54 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {December 20, 2007 11:57:56 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {December 20, 2007 11:57:56 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {December 20, 2007 11:57:56 AM PST}
- UPDATED: Updated protein page: TPX2 {December 20, 2007 11:58:02 AM PST}
end log.
