Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 18:50, 17 November 2007 (UTC)
[edit]Proteins without matches (11)
[edit]Proteins with a High Potential Match (9)
[edit]Redirected Proteins (5)
[edit]Manual Inspection (Page not found) (20)
[edit]
Protein Status Grid - Date: 18:50, 17 November 2007 (UTC)
[edit]Vebose Log - Date: 18:50, 17 November 2007 (UTC)
[edit]- INFO: Beginning work on ACVRL1... {November 17, 2007 10:13:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:14:17 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Activin A receptor type II-like 1
| HGNCid = 175
| Symbol = ACVRL1
| AltSymbols =; ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I
| OMIM = 601284
| ECnumber =
| Homologene = 20058
| MGIid = 1338946
| GeneAtlas_image1 = PBB_GE_ACVRL1_210838_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016361 |text = activin receptor activity, type I}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}} {{GNF_GO|id=GO:0048185 |text = activin binding}} {{GNF_GO|id=GO:0050431 |text = transforming growth factor beta binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007162 |text = negative regulation of cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007179 |text = transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0035313 |text = wound healing, spreading of epidermal cells}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0051895 |text = negative regulation of focal adhesion formation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 94
| Hs_Ensembl = ENSG00000139567
| Hs_RefseqProtein = NP_000011
| Hs_RefseqmRNA = NM_000020
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 50587469
| Hs_GenLoc_end = 50601120
| Hs_Uniprot = P37023
| Mm_EntrezGene = 11482
| Mm_Ensembl = ENSMUSG00000000530
| Mm_RefseqmRNA = NM_009612
| Mm_RefseqProtein = NP_033742
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 100956556
| Mm_GenLoc_end = 100971674
| Mm_Uniprot = Q91YR0
}}
}}
'''Activin A receptor type II-like 1''', also known as '''ACVRL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ACVRL1 activin A receptor type II-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.<ref name="entrez">{{cite web | title = Entrez Gene: ACVRL1 activin A receptor type II-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Attisano L, Cárcamo J, Ventura F, ''et al.'' |title=Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. |journal=Cell |volume=75 |issue= 4 |pages= 671-80 |year= 1993 |pmid= 8242742 |doi= }}
*{{cite journal | author=ten Dijke P, Ichijo H, Franzén P, ''et al.'' |title=Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. |journal=Oncogene |volume=8 |issue= 10 |pages= 2879-87 |year= 1993 |pmid= 8397373 |doi= }}
*{{cite journal | author=Johnson DW, Berg JN, Baldwin MA, ''et al.'' |title=Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. |journal=Nat. Genet. |volume=13 |issue= 2 |pages= 189-95 |year= 1996 |pmid= 8640225 |doi= 10.1038/ng0696-189 }}
*{{cite journal | author=Johnson DW, Berg JN, Gallione CJ, ''et al.'' |title=A second locus for hereditary hemorrhagic telangiectasia maps to chromosome 12. |journal=Genome Res. |volume=5 |issue= 1 |pages= 21-8 |year= 1996 |pmid= 8717052 |doi= }}
*{{cite journal | author=Panchenko MP, Williams MC, Brody JS, Yu Q |title=Type I receptor serine-threonine kinase preferentially expressed in pulmonary blood vessels. |journal=Am. J. Physiol. |volume=270 |issue= 4 Pt 1 |pages= L547-58 |year= 1996 |pmid= 8928814 |doi= }}
*{{cite journal | author=Berg JN, Gallione CJ, Stenzel TT, ''et al.'' |title=The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. |journal=Am. J. Hum. Genet. |volume=61 |issue= 1 |pages= 60-7 |year= 1997 |pmid= 9245985 |doi= }}
*{{cite journal | author=Stockwell BR, Schreiber SL |title=Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= 761-70 |year= 1998 |pmid= 9651680 |doi= }}
*{{cite journal | author=Lux A, Attisano L, Marchuk DA |title=Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9984-92 |year= 1999 |pmid= 10187774 |doi= }}
*{{cite journal | author=Klaus DJ, Gallione CJ, Anthony K, ''et al.'' |title=Novel missense and frameshift mutations in the activin receptor-like kinase-1 gene in hereditary hemorrhagic telangiectasia. Mutations in brief no. 164. Online. |journal=Hum. Mutat. |volume=12 |issue= 2 |pages= 137 |year= 2000 |pmid= 10694922 |doi= 10.1002/(SICI)1098-1004(1998)12:2<137::AID-HUMU16>3.0.CO;2-J }}
*{{cite journal | author=Oh SP, Seki T, Goss KA, ''et al.'' |title=Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2626-31 |year= 2000 |pmid= 10716993 |doi= }}
*{{cite journal | author=Abdalla SA, Pece-Barbara N, Vera S, ''et al.'' |title=Analysis of ALK-1 and endoglin in newborns from families with hereditary hemorrhagic telangiectasia type 2. |journal=Hum. Mol. Genet. |volume=9 |issue= 8 |pages= 1227-37 |year= 2000 |pmid= 10767348 |doi= }}
*{{cite journal | author=Kjeldsen AD, Brusgaard K, Poulsen L, ''et al.'' |title=Mutations in the ALK-1 gene and the phenotype of hereditary hemorrhagic telangiectasia in two large Danish families. |journal=Am. J. Med. Genet. |volume=98 |issue= 4 |pages= 298-302 |year= 2001 |pmid= 11170071 |doi= }}
*{{cite journal | author=Wurthner JU, Frank DB, Felici A, ''et al.'' |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495-502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200 }}
*{{cite journal | author=Parks WT, Frank DB, Huff C, ''et al.'' |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332-9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200 }}
*{{cite journal | author=Birkey Reffey S, Wurthner JU, Parks WT, ''et al.'' |title=X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26542-9 |year= 2001 |pmid= 11356828 |doi= 10.1074/jbc.M100331200 }}
*{{cite journal | author=Trembath RC, Thomson JR, Machado RD, ''et al.'' |title=Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. |journal=N. Engl. J. Med. |volume=345 |issue= 5 |pages= 325-34 |year= 2001 |pmid= 11484689 |doi= }}
*{{cite journal | author=Inman GJ, Nicolás FJ, Callahan JF, ''et al.'' |title=SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. |journal=Mol. Pharmacol. |volume=62 |issue= 1 |pages= 65-74 |year= 2002 |pmid= 12065756 |doi= }}
*{{cite journal | author=Olivieri C, Mira E, Delù G, ''et al.'' |title=Identification of 13 new mutations in the ACVRL1 gene in a group of 52 unselected Italian patients affected by hereditary haemorrhagic telangiectasia. |journal=J. Med. Genet. |volume=39 |issue= 7 |pages= E39 |year= 2002 |pmid= 12114496 |doi= }}
*{{cite journal | author=Mo J, Fang SJ, Chen W, Blobe GC |title=Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50788-94 |year= 2003 |pmid= 12393874 |doi= 10.1074/jbc.M210376200 }}
*{{cite journal | author=Lamouille S, Mallet C, Feige JJ, Bailly S |title=Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. |journal=Blood |volume=100 |issue= 13 |pages= 4495-501 |year= 2003 |pmid= 12453878 |doi= 10.1182/blood.V100.13.4495 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCK... {November 17, 2007 10:14:17 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:14:40 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholecystokinin
| HGNCid = 1569
| Symbol = CCK
| AltSymbols =; MGC117187
| OMIM = 118440
| ECnumber =
| Homologene = 583
| MGIid = 88297
| GeneAtlas_image1 = PBB_GE_CCK_205827_at_tn.png
| Function = {{GNF_GO|id=GO:0005184 |text = neuropeptide hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0030424 |text = axon}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0042755 |text = eating behavior}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 885
| Hs_Ensembl = ENSG00000187094
| Hs_RefseqProtein = NP_000720
| Hs_RefseqmRNA = NM_000729
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 42274322
| Hs_GenLoc_end = 42281399
| Hs_Uniprot = P06307
| Mm_EntrezGene = 12424
| Mm_Ensembl = ENSMUSG00000032532
| Mm_RefseqmRNA = NM_031161
| Mm_RefseqProtein = NP_112438
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 121338523
| Mm_GenLoc_end = 121344360
| Mm_Uniprot = Q53WS9
}}
}}
'''Cholecystokinin''', also known as '''CCK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCK cholecystokinin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=885| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages.<ref name="entrez">{{cite web | title = Entrez Gene: CCK cholecystokinin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=885| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Beinfeld MC |title=CCK biosynthesis and processing: recent progress and future challenges. |journal=Life Sci. |volume=61 |issue= 24 |pages= 2359-66 |year= 1997 |pmid= 9399627 |doi= }}
*{{cite journal | author=Bradwejn J, Koszycki D |title=Cholecystokinin and panic disorder: past and future clinical research strategies. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 19-27 |year= 2002 |pmid= 11713976 |doi= }}
*{{cite journal | author=Hansen TV, Nielsen FC |title=Regulation of neuronal cholecystokinin gene transcription. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 61-7 |year= 2002 |pmid= 11713982 |doi= }}
*{{cite journal | author=Jønson L, Johnsen AH |title=Post-translational modifications of heterologously expressed cholecystokinin in Saccharomyces cerevisiae. |journal=Scand. J. Clin. Lab. Invest. Suppl. |volume=234 |issue= |pages= 87-92 |year= 2002 |pmid= 11713985 |doi= }}
*{{cite journal | author=Beinfeld MC |title=Biosynthesis and processing of pro CCK: recent progress and future challenges. |journal=Life Sci. |volume=72 |issue= 7 |pages= 747-57 |year= 2003 |pmid= 12479974 |doi= }}
*{{cite journal | author=Herranz R |title=Cholecystokinin antagonists: pharmacological and therapeutic potential. |journal=Med Res Rev |volume=23 |issue= 5 |pages= 559-605 |year= 2004 |pmid= 12789687 |doi= 10.1002/med.10042 }}
*{{cite journal | author=Varga G, Bálint A, Burghardt B, D'Amato M |title=Involvement of endogenous CCK and CCK1 receptors in colonic motor function. |journal=Br. J. Pharmacol. |volume=141 |issue= 8 |pages= 1275-84 |year= 2004 |pmid= 15100163 |doi= 10.1038/sj.bjp.0705769 }}
*{{cite journal | author=Rehfeld JF |title=Clinical endocrinology and metabolism. Cholecystokinin. |journal=Best Pract. Res. Clin. Endocrinol. Metab. |volume=18 |issue= 4 |pages= 569-86 |year= 2005 |pmid= 15533776 |doi= 10.1016/j.beem.2004.07.002 }}
*{{cite journal | author=Eberlein GA, Eysselein VE, Davis MT, ''et al.'' |title=Patterns of prohormone processing. Order revealed by a new procholecystokinin-derived peptide. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1517-21 |year= 1992 |pmid= 1370477 |doi= }}
*{{cite journal | author=Lund T, Geurts van Kessel AH, Haun S, Dixon JE |title=The genes for human gastrin and cholecystokinin are located on different chromosomes. |journal=Hum. Genet. |volume=73 |issue= 1 |pages= 77-80 |year= 1986 |pmid= 3011648 |doi= }}
*{{cite journal | author=Takahashi Y, Fukushige S, Murotsu T, Matsubara K |title=Structure of human cholecystokinin gene and its chromosomal location. |journal=Gene |volume=50 |issue= 1-3 |pages= 353-60 |year= 1987 |pmid= 3582983 |doi= }}
*{{cite journal | author=Takahashi Y, Kato K, Hayashizaki Y, ''et al.'' |title=Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 7 |pages= 1931-5 |year= 1985 |pmid= 3856870 |doi= }}
*{{cite journal | author=Studler JM, Javoy-Agid F, Cesselin F, ''et al.'' |title=CCK-8-Immunoreactivity distribution in human brain: selective decrease in the substantia nigra from parkinsonian patients. |journal=Brain Res. |volume=243 |issue= 1 |pages= 176-9 |year= 1982 |pmid= 6288173 |doi= }}
*{{cite journal | author=Bacarese-Hamilton AJ, Adrian TE, Bloom SR |title=Measurement and characterisation of human cholecystokinin-like immunoreactivity (CCK-LI) in tissues by radioimmunoassay. |journal=Clin. Chim. Acta |volume=144 |issue= 2-3 |pages= 213-24 |year= 1985 |pmid= 6529856 |doi= }}
*{{cite journal | author=Migaud M, Durieux C, Viereck J, ''et al.'' |title=The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A. |journal=Peptides |volume=17 |issue= 4 |pages= 601-7 |year= 1997 |pmid= 8804068 |doi= }}
*{{cite journal | author=Kennedy K, Gigoux V, Escrieut C, ''et al.'' |title=Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2920-6 |year= 1997 |pmid= 9006937 |doi= }}
*{{cite journal | author=Cain BM, Wang W, Beinfeld MC |title=Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing. |journal=Endocrinology |volume=138 |issue= 9 |pages= 4034-7 |year= 1997 |pmid= 9275097 |doi= }}
*{{cite journal | author=Gigoux V, Escrieut C, Silvente-Poirot S, ''et al.'' |title=Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14380-6 |year= 1998 |pmid= 9603948 |doi= }}
*{{cite journal | author=Anders J, Blüggel M, Meyer HE, ''et al.'' |title=Direct identification of the agonist binding site in the human brain cholecystokininB receptor. |journal=Biochemistry |volume=38 |issue= 19 |pages= 6043-55 |year= 1999 |pmid= 10320330 |doi= 10.1021/bi990269z }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCND2... {November 17, 2007 10:14:41 AM PST}
- SEARCH REDIRECT: Control Box Found: CCND2 {November 17, 2007 10:15:15 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 10:15:17 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 10:15:17 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 10:15:17 AM PST}
- UPDATED: Updated protein page: CCND2 {November 17, 2007 10:15:24 AM PST}
- INFO: Beginning work on CDK5R1... {November 17, 2007 10:41:44 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:42:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CDK5R1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h4l.
| PDB = {{PDB2|1h4l}}, {{PDB2|1ung}}, {{PDB2|1unh}}, {{PDB2|1unl}}
| Name = Cyclin-dependent kinase 5, regulatory subunit 1 (p35)
| HGNCid = 1775
| Symbol = CDK5R1
| AltSymbols =; CDK5P35; CDK5R; MGC33831; NCK5A; p23; p25; p35; p35nck5a
| OMIM = 603460
| ECnumber =
| Homologene = 31200
| MGIid = 101764
| GeneAtlas_image1 = PBB_GE_CDK5R1_204995_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDK5R1_204996_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016534 |text = cyclin-dependent protein kinase 5 activator activity}} {{GNF_GO|id=GO:0043539 |text = protein serine/threonine kinase activator activity}} {{GNF_GO|id=GO:0045296 |text = cadherin binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016533 |text = cyclin-dependent protein kinase 5 activator complex}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0030426 |text = growth cone}} {{GNF_GO|id=GO:0031594 |text = neuromuscular junction}} {{GNF_GO|id=GO:0043025 |text = cell soma}} {{GNF_GO|id=GO:0043197 |text = dendritic spine}} {{GNF_GO|id=GO:0043292 |text = contractile fiber}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0007158 |text = neuron adhesion}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007413 |text = axonal fasciculation}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009790 |text = embryonic development}} {{GNF_GO|id=GO:0031175 |text = neurite development}} {{GNF_GO|id=GO:0035235 |text = ionotropic glutamate receptor signaling pathway}} {{GNF_GO|id=GO:0043525 |text = positive regulation of neuron apoptosis}} {{GNF_GO|id=GO:0045664 |text = regulation of neuron differentiation}} {{GNF_GO|id=GO:0048675 |text = axon extension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8851
| Hs_Ensembl = ENSG00000176749
| Hs_RefseqProtein = NP_003876
| Hs_RefseqmRNA = NM_003885
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 27838214
| Hs_GenLoc_end = 27842383
| Hs_Uniprot = Q15078
| Mm_EntrezGene = 12569
| Mm_Ensembl = ENSMUSG00000048895
| Mm_RefseqmRNA = XM_001001743
| Mm_RefseqProtein = XP_001001743
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 80293218
| Mm_GenLoc_end = 80297379
| Mm_Uniprot = Q3V3I8
}}
}}
'''Cyclin-dependent kinase 5, regulatory subunit 1 (p35)''', also known as '''CDK5R1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.<ref name="entrez">{{cite web | title = Entrez Gene: CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8851| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Peruzzi F, Gordon J, Darbinian N, Amini S |title=Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway. |journal=J. Neurovirol. |volume=8 Suppl 2 |issue= |pages= 91-6 |year= 2003 |pmid= 12491158 |doi= 10.1080/13550280290167885 }}
*{{cite journal | author=Studzinski GP, Harrison JS |title=The neuronal cyclin-dependent kinase 5 activator p35Nck5a and Cdk5 activity in monocytic cells. |journal=Leuk. Lymphoma |volume=44 |issue= 2 |pages= 235-40 |year= 2003 |pmid= 12688339 |doi= }}
*{{cite journal | author=Takahashi M, Tomizawa K, Sato K, ''et al.'' |title=A novel tau-tubulin kinase from bovine brain. |journal=FEBS Lett. |volume=372 |issue= 1 |pages= 59-64 |year= 1995 |pmid= 7556643 |doi= }}
*{{cite journal | author=Tang D, Yeung J, Lee KY, ''et al.'' |title=An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator. |journal=J. Biol. Chem. |volume=270 |issue= 45 |pages= 26897-903 |year= 1995 |pmid= 7592934 |doi= }}
*{{cite journal | author=Tsai LH, Delalle I, Caviness VS, ''et al.'' |title=p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. |journal=Nature |volume=371 |issue= 6496 |pages= 419-23 |year= 1994 |pmid= 8090221 |doi= 10.1038/371419a0 }}
*{{cite journal | author=Chae T, Kwon YT, Bronson R, ''et al.'' |title=Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. |journal=Neuron |volume=18 |issue= 1 |pages= 29-42 |year= 1997 |pmid= 9010203 |doi= }}
*{{cite journal | author=Poon RY, Lew J, Hunter T |title=Identification of functional domains in the neuronal Cdk5 activator protein. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 5703-8 |year= 1997 |pmid= 9038181 |doi= }}
*{{cite journal | author=Fletcher AI, Shuang R, Giovannucci DR, ''et al.'' |title=Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4027-35 |year= 1999 |pmid= 9933594 |doi= }}
*{{cite journal | author=Patrick GN, Zukerberg L, Nikolic M, ''et al.'' |title=Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. |journal=Nature |volume=402 |issue= 6762 |pages= 615-22 |year= 2000 |pmid= 10604467 |doi= 10.1038/45159 }}
*{{cite journal | author=Ching YP, Qi Z, Wang JH |title=Cloning of three novel neuronal Cdk5 activator binding proteins. |journal=Gene |volume=242 |issue= 1-2 |pages= 285-94 |year= 2000 |pmid= 10721722 |doi= }}
*{{cite journal | author=Kwon YT, Gupta A, Zhou Y, ''et al.'' |title=Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. |journal=Curr. Biol. |volume=10 |issue= 7 |pages= 363-72 |year= 2000 |pmid= 10753743 |doi= }}
*{{cite journal | author=Lee MS, Kwon YT, Li M, ''et al.'' |title=Neurotoxicity induces cleavage of p35 to p25 by calpain. |journal=Nature |volume=405 |issue= 6784 |pages= 360-4 |year= 2000 |pmid= 10830966 |doi= 10.1038/35012636 }}
*{{cite journal | author=Wang X, Ching YP, Lam WH, ''et al.'' |title=Identification of a common protein association region in the neuronal Cdk5 activator. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763-9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200 }}
*{{cite journal | author=Floyd SR, Porro EB, Slepnev VI, ''et al.'' |title=Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 8104-10 |year= 2001 |pmid= 11113134 |doi= 10.1074/jbc.M008932200 }}
*{{cite journal | author=Kesavapany S, Lau KF, McLoughlin DM, ''et al.'' |title=p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction. |journal=Eur. J. Neurosci. |volume=13 |issue= 2 |pages= 241-7 |year= 2001 |pmid= 11168528 |doi= }}
*{{cite journal | author=Chen F, Studzinski GP |title=Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. |journal=Blood |volume=97 |issue= 12 |pages= 3763-7 |year= 2001 |pmid= 11389014 |doi= }}
*{{cite journal | author=Tarricone C, Dhavan R, Peng J, ''et al.'' |title=Structure and regulation of the CDK5-p25(nck5a) complex. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 657-69 |year= 2001 |pmid= 11583627 |doi= }}
*{{cite journal | author=Rashid T, Banerjee M, Nikolic M |title=Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology. |journal=J. Biol. Chem. |volume=276 |issue= 52 |pages= 49043-52 |year= 2002 |pmid= 11604394 |doi= 10.1074/jbc.M105599200 }}
*{{cite journal | author=Qu D, Li Q, Lim HY, ''et al.'' |title=The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7324-32 |year= 2002 |pmid= 11741927 |doi= 10.1074/jbc.M107270200 }}
*{{cite journal | author=Patzke H, Tsai LH |title=Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8054-60 |year= 2002 |pmid= 11784720 |doi= 10.1074/jbc.M109645200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CGB... {November 17, 2007 10:15:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:15:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CGB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hcn.
| PDB = {{PDB2|1hcn}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}
| Name = Chorionic gonadotropin, beta polypeptide
| HGNCid = 1886
| Symbol = CGB
| AltSymbols =; CGB3; hCGB; HCG; MGC119822
| OMIM = 118860
| ECnumber =
| Homologene = 37338
| MGIid =
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1082
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000728
| Hs_RefseqmRNA = NM_000737
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chorionic gonadotropin, beta polypeptide''', also known as '''CGB''', is a human [[gene]].<ref name="entrez">cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = </ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.<ref name="entrez">{{cite web | title = Entrez Gene: CGB chorionic gonadotropin, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1082| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*cite journal | author=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179-84 |year= 1992 |pmid= 1371113 |doi=
*cite journal | author=Maruo T, Ladines-Llave CA, Matsuo H, ''et al.'' |title=A novel change in cytologic localization of human chorionic gonadotropin and human placental lactogen in first-trimester placenta in the course of gestation. |journal=Am. J. Obstet. Gynecol. |volume=167 |issue= 1 |pages= 217-22 |year= 1992 |pmid= 1442929 |doi=
*cite journal | author=Rothman PA, Chao VA, Taylor MR, ''et al.'' |title=Extraplacental human fetal tissues express mRNA transcripts encoding the human chorionic gonadotropin-beta subunit protein. |journal=Mol. Reprod. Dev. |volume=33 |issue= 1 |pages= 1-6 |year= 1992 |pmid= 1510839 |doi= 10.1002/mrd.1080330102
*cite journal | author=Weisshaar G, Hiyama J, Renwick AG |title=Site-specific N-glycosylation of human chorionic gonadotrophin--structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. |journal=Glycobiology |volume=1 |issue= 4 |pages= 393-404 |year= 1992 |pmid= 1820200 |doi=
*cite journal | author=Xie YB, Wang H, Segaloff DL |title=Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. |journal=J. Biol. Chem. |volume=265 |issue= 35 |pages= 21411-4 |year= 1991 |pmid= 2254302 |doi=
*{{cite journal | author=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster. |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907-16 |year= 1986 |pmid= 2422163 |doi= }}
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. |journal=DNA |volume=5 |issue= 3 |pages= 227-34 |year= 1986 |pmid= 2424697 |doi=
*cite journal | author=Morrish DW, Marusyk H, Bhardwaj D |title=Ultrastructural localization of human placental lactogen in distinctive granules in human term placenta: comparison with granules containing human chorionic gonadotropin. |journal=J. Histochem. Cytochem. |volume=36 |issue= 2 |pages= 193-7 |year= 1988 |pmid= 2447154 |doi=
*{{cite journal | author=Otani T, Otani F, Krych M, ''et al.'' |title=Identification of a promoter region in the CG beta gene cluster. |journal=J. Biol. Chem. |volume=263 |issue= 15 |pages= 7322-9 |year= 1988 |pmid= 2452822 |doi= }}
*cite journal | author=Jameson JL, Lindell CM |title=Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP. |journal=Mol. Cell. Biol. |volume=8 |issue= 12 |pages= 5100-7 |year= 1989 |pmid= 2468994 |doi=
*cite journal | author=Matzuk MM, Keene JL, Boime I |title=Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction. |journal=J. Biol. Chem. |volume=264 |issue= 5 |pages= 2409-14 |year= 1989 |pmid= 2536708 |doi=
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Gonadotropin and thyrotropin alpha- and beta-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes. |journal=J. Clin. Endocrinol. Metab. |volume=64 |issue= 2 |pages= 319-27 |year= 1987 |pmid= 3098775 |doi=
*{{cite journal | author=Gaspard UJ, Hustin J, Reuter AM, ''et al.'' |title=Immunofluorescent localization of placental lactogen, chorionic gonadotrophin and its alpha and beta subunits in organ cultures of human placenta. |journal=Placenta |volume=1 |issue= 2 |pages= 135-44 |year= 1981 |pmid= 6160572 |doi= }}
*cite journal | author=Policastro P, Ovitt CE, Hoshina M, ''et al.'' |title=The beta subunit of human chorionic gonadotropin is encoded by multiple genes. |journal=J. Biol. Chem. |volume=258 |issue= 19 |pages= 11492-9 |year= 1983 |pmid= 6194155 |doi=
*cite journal | author=Keutmann HT, Ratanabanangkoon K, Pierce MW, ''et al.'' |title=Phosphorylation of human choriogonadotropin. Stoichiometry and sites of phosphate incorporation. |journal=J. Biol. Chem. |volume=258 |issue= 23 |pages= 14521-6 |year= 1984 |pmid= 6196363 |doi=
*cite journal | author=Julier C, Weil D, Couillin P, ''et al.'' |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174-7 |year= 1984 |pmid= 6204923 |doi=
*cite journal | author=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. |journal=DNA |volume=2 |issue= 4 |pages= 281-9 |year= 1984 |pmid= 6319099 |doi=
*cite journal | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37-40 |year= 1984 |pmid= 6690982 |doi=
*cite journal | author=Fiddes JC, Goodman HM |title=The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. |journal=Nature |volume=286 |issue= 5774 |pages= 684-7 |year= 1980 |pmid= 6774259 |doi=
*cite journal | author=McGregor WG, Raymoure WJ, Kuhn RW, Jaffe RB |title=Fetal tissue can synthesize a placental hormone. Evidence for chorionic gonadotropin beta-subunit synthesis by human fetal kidney. |journal=J. Clin. Invest. |volume=68 |issue= 1 |pages= 306-9 |year= 1981 |pmid= 7251865 |doi=
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CHRM3... {November 17, 2007 10:15:51 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:16:12 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cholinergic receptor, muscarinic 3
| HGNCid = 1952
| Symbol = CHRM3
| AltSymbols =; HM3
| OMIM = 118494
| ECnumber =
| Homologene = 20191
| MGIid = 88398
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004981 |text = muscarinic acetylcholine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0045987 |text = positive regulation of smooth muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1131
| Hs_Ensembl =
| Hs_RefseqProtein = XP_001130695
| Hs_RefseqmRNA = XM_001130695
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12671
| Mm_Ensembl = ENSMUSG00000046159
| Mm_RefseqmRNA = NM_033269
| Mm_RefseqProtein = NP_150372
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 9876475
| Mm_GenLoc_end = 9878244
| Mm_Uniprot = Q542R4
}}
}}
'''Cholinergic receptor, muscarinic 3''', also known as '''CHRM3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHRM3 cholinergic receptor, muscarinic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1131| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.<ref name="entrez">{{cite web | title = Entrez Gene: CHRM3 cholinergic receptor, muscarinic 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1131| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Goyal RK |title=Muscarinic receptor subtypes. Physiology and clinical implications. |journal=N. Engl. J. Med. |volume=321 |issue= 15 |pages= 1022-9 |year= 1989 |pmid= 2674717 |doi= }}
*{{cite journal | author=Eglen RM, Reddy H, Watson N, Challiss RA |title=Muscarinic acetylcholine receptor subtypes in smooth muscle. |journal=Trends Pharmacol. Sci. |volume=15 |issue= 4 |pages= 114-9 |year= 1994 |pmid= 8016895 |doi= }}
*{{cite journal | author=Brann MR, Ellis J, Jørgensen H, ''et al.'' |title=Muscarinic acetylcholine receptor subtypes: localization and structure/function. |journal=Prog. Brain Res. |volume=98 |issue= |pages= 121-7 |year= 1994 |pmid= 8248499 |doi= }}
*{{cite journal | author=Gutkind JS, Novotny EA, Brann MR, Robbins KC |title=Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 11 |pages= 4703-7 |year= 1991 |pmid= 1905013 |doi= }}
*{{cite journal | author=Ashkenazi A, Ramachandran J, Capon DJ |title=Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes. |journal=Nature |volume=340 |issue= 6229 |pages= 146-50 |year= 1989 |pmid= 2739737 |doi= 10.1038/340146a0 }}
*{{cite journal | author=Bonner TI, Buckley NJ, Young AC, Brann MR |title=Identification of a family of muscarinic acetylcholine receptor genes. |journal=Science |volume=237 |issue= 4814 |pages= 527-32 |year= 1987 |pmid= 3037705 |doi= }}
*{{cite journal | author=Bonner TI, Young AC, Brann MR, Buckley NJ |title=Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. |journal=Neuron |volume=1 |issue= 5 |pages= 403-10 |year= 1990 |pmid= 3272174 |doi= }}
*{{cite journal | author=Peralta EG, Ashkenazi A, Winslow JW, ''et al.'' |title=Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. |journal=EMBO J. |volume=6 |issue= 13 |pages= 3923-9 |year= 1988 |pmid= 3443095 |doi= }}
*{{cite journal | author=Blin N, Yun J, Wess J |title=Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17741-8 |year= 1995 |pmid= 7629074 |doi= }}
*{{cite journal | author=Crespo P, Xu N, Daniotti JL, ''et al.'' |title=Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 21103-9 |year= 1994 |pmid= 8063729 |doi= }}
*{{cite journal | author=Haga K, Kameyama K, Haga T, ''et al.'' |title=Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2776-82 |year= 1996 |pmid= 8576254 |doi= }}
*{{cite journal | author=Szekeres PG, Koenig JA, Edwardson JM |title=The relationship between agonist intrinsic activity and the rate of endocytosis of muscarinic receptors in a human neuroblastoma cell line. |journal=Mol. Pharmacol. |volume=53 |issue= 4 |pages= 759-65 |year= 1998 |pmid= 9547368 |doi= }}
*{{cite journal | author=von der Kammer H, Mayhaus M, Albrecht C, ''et al.'' |title=Muscarinic acetylcholine receptors activate expression of the EGR gene family of transcription factors. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14538-44 |year= 1998 |pmid= 9603968 |doi= }}
*{{cite journal | author=Ndoye A, Buchli R, Greenberg B, ''et al.'' |title=Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. |journal=J. Invest. Dermatol. |volume=111 |issue= 3 |pages= 410-6 |year= 1998 |pmid= 9740233 |doi= 10.1046/j.1523-1747.1998.00299.x }}
*{{cite journal | author=Goodchild RE, Court JA, Hobson I, ''et al.'' |title=Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases. |journal=Eur. J. Neurosci. |volume=11 |issue= 2 |pages= 449-56 |year= 1999 |pmid= 10051746 |doi= }}
*{{cite journal | author=Sato KZ, Fujii T, Watanabe Y, ''et al.'' |title=Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. |journal=Neurosci. Lett. |volume=266 |issue= 1 |pages= 17-20 |year= 1999 |pmid= 10336173 |doi= }}
*{{cite journal | author=Budd DC, McDonald JE, Tobin AB |title=Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19667-75 |year= 2000 |pmid= 10777483 |doi= 10.1074/jbc.M000492200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CMA1... {November 17, 2007 10:16:12 AM PST}
- SEARCH REDIRECT: Control Box Found: CMA1 {November 17, 2007 10:32:30 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 10:32:31 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 10:32:31 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 10:32:31 AM PST}
- UPDATED: Updated protein page: CMA1 {November 17, 2007 10:32:37 AM PST}
- INFO: Beginning work on COL4A2... {November 17, 2007 10:32:37 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:33:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL4A2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1li1.
| PDB = {{PDB2|1li1}}, {{PDB2|1m3d}}, {{PDB2|1t60}}, {{PDB2|1t61}}
| Name = Collagen, type IV, alpha 2
| HGNCid = 2203
| Symbol = COL4A2
| AltSymbols =; DKFZp686I14213; FLJ22259
| OMIM = 120090
| ECnumber =
| Homologene = 1390
| MGIid = 88455
| GeneAtlas_image1 = PBB_GE_COL4A2_211964_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL4A2_211966_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005587 |text = collagen type IV}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0030198 |text = extracellular matrix organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1284
| Hs_Ensembl = ENSG00000134871
| Hs_RefseqProtein = NP_001837
| Hs_RefseqmRNA = NM_001846
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 109757632
| Hs_GenLoc_end = 109963375
| Hs_Uniprot = P08572
| Mm_EntrezGene = 12827
| Mm_Ensembl = ENSMUSG00000031503
| Mm_RefseqmRNA = NM_009932
| Mm_RefseqProtein = NP_034062
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 11354249
| Mm_GenLoc_end = 11448288
| Mm_Uniprot = Q53WU4
}}
}}
'''Collagen, type IV, alpha 2''', also known as '''COL4A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COL4A2 collagen, type IV, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.<ref name="entrez">{{cite web | title = Entrez Gene: COL4A2 collagen, type IV, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1284| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hinek A |title=Nature and the multiple functions of the 67-kD elastin-/laminin binding protein. |journal=Cell Adhes. Commun. |volume=2 |issue= 3 |pages= 185-93 |year= 1995 |pmid= 7827955 |doi= }}
*{{cite journal | author=Ständer M, Naumann U, Wick W, Weller M |title=Transforming growth factor-beta and p-21: multiple molecular targets of decorin-mediated suppression of neoplastic growth. |journal=Cell Tissue Res. |volume=296 |issue= 2 |pages= 221-7 |year= 1999 |pmid= 10382266 |doi= }}
*{{cite journal | author=Kurpakus Wheater M, Kernacki KA, Hazlett LD |title=Corneal cell proteins and ocular surface pathology. |journal=Biotechnic & histochemistry : official publication of the Biological Stain Commission |volume=74 |issue= 3 |pages= 146-59 |year= 1999 |pmid= 10416788 |doi= }}
*{{cite journal | author=Kalluri R, Sukhatme VP |title=Fibrosis and angiogenesis. |journal=Curr. Opin. Nephrol. Hypertens. |volume=9 |issue= 4 |pages= 413-8 |year= 2000 |pmid= 10926178 |doi= }}
*{{cite journal | author=Ghebrehiwet B, Peerschke EI, Hong Y, ''et al.'' |title=Short amino acid sequences derived from C1q receptor (C1q-R) show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV. |journal=J. Leukoc. Biol. |volume=51 |issue= 6 |pages= 546-56 |year= 1992 |pmid= 1377218 |doi= }}
*{{cite journal | author=Gupta S, Batchu RB, Datta K |title=Purification, partial characterization of rat kidney hyaluronic acid binding protein and its localization on the cell surface. |journal=Eur. J. Cell Biol. |volume=56 |issue= 1 |pages= 58-67 |year= 1992 |pmid= 1724753 |doi= }}
*{{cite journal | author=Paralkar VM, Nandedkar AK, Pointer RH, ''et al.'' |title=Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17281-4 |year= 1990 |pmid= 2211625 |doi= }}
*{{cite journal | author=Hernandez MR, Igoe F, Neufeld AH |title=Extracellular matrix of the human optic nerve head. |journal=Am. J. Ophthalmol. |volume=102 |issue= 2 |pages= 139-48 |year= 1986 |pmid= 2426947 |doi= }}
*{{cite journal | author=Myers JC, Howard PS, Jelen AM, ''et al.'' |title=Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes. |journal=J. Biol. Chem. |volume=262 |issue= 19 |pages= 9231-8 |year= 1987 |pmid= 2439508 |doi= }}
*{{cite journal | author=Siebold B, Deutzmann R, Kühn K |title=The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen. |journal=Eur. J. Biochem. |volume=176 |issue= 3 |pages= 617-24 |year= 1988 |pmid= 2844531 |doi= }}
*{{cite journal | author=Pöschl E, Pollner R, Kühn K |title=The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure. |journal=EMBO J. |volume=7 |issue= 9 |pages= 2687-95 |year= 1988 |pmid= 2846280 |doi= }}
*{{cite journal | author=Griffin CA, Emanuel BS, Hansen JR, ''et al.'' |title=Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 2 |pages= 512-6 |year= 1987 |pmid= 3025878 |doi= }}
*{{cite journal | author=Murata K, Motayama T, Kotake C |title=Collagen types in various layers of the human aorta and their changes with the atherosclerotic process. |journal=Atherosclerosis |volume=60 |issue= 3 |pages= 251-62 |year= 1986 |pmid= 3089234 |doi= }}
*{{cite journal | author=Soininen R, Huotari M, Hostikka SL, ''et al.'' |title=The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. |journal=J. Biol. Chem. |volume=263 |issue= 33 |pages= 17217-20 |year= 1988 |pmid= 3182844 |doi= }}
*{{cite journal | author=Hostikka SL, Tryggvason K |title=The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain. |journal=J. Biol. Chem. |volume=263 |issue= 36 |pages= 19488-93 |year= 1989 |pmid= 3198637 |doi= }}
*{{cite journal | author=Brazel D, Pollner R, Oberbäumer I, Kühn K |title=Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain. |journal=Eur. J. Biochem. |volume=172 |issue= 1 |pages= 35-42 |year= 1988 |pmid= 3345760 |doi= }}
*{{cite journal | author=Hostikka SL, Kurkinen M, Tryggvason K |title=Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region. |journal=FEBS Lett. |volume=216 |issue= 2 |pages= 281-6 |year= 1987 |pmid= 3582677 |doi= }}
*{{cite journal | author=Killen PD, Francomano CA, Yamada Y, ''et al.'' |title=Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2). |journal=Hum. Genet. |volume=77 |issue= 4 |pages= 318-24 |year= 1988 |pmid= 3692475 |doi= }}
*{{cite journal | author=Glant TT, Hadházy C, Mikecz K, Sipos A |title=Appearance and persistence of fibronectin in cartilage. Specific interaction of fibronectin with collagen type II. |journal=Histochemistry |volume=82 |issue= 2 |pages= 149-58 |year= 1985 |pmid= 3997552 |doi= }}
*{{cite journal | author=Uscanga L, Kennedy RH, Stocker S, ''et al.'' |title=Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas. |journal=Digestion |volume=30 |issue= 3 |pages= 158-64 |year= 1984 |pmid= 6389236 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CUL1... {November 17, 2007 10:40:29 AM PST}
- SEARCH REDIRECT: Control Box Found: CUL1 {November 17, 2007 10:40:56 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 10:40:57 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 10:40:57 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 10:40:57 AM PST}
- UPDATED: Updated protein page: CUL1 {November 17, 2007 10:41:03 AM PST}
- INFO: Beginning work on CXADR... {November 17, 2007 10:33:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:33:39 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CXADR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1eaj.
| PDB = {{PDB2|1eaj}}, {{PDB2|1f5w}}, {{PDB2|1jew}}, {{PDB2|1kac}}, {{PDB2|1p69}}, {{PDB2|1p6a}}, {{PDB2|1rsf}}, {{PDB2|2j12}}, {{PDB2|2j1k}}, {{PDB2|2npl}}
| Name = Coxsackie virus and adenovirus receptor
| HGNCid = 2559
| Symbol = CXADR
| AltSymbols =; CAR; HCAR
| OMIM = 602621
| ECnumber =
| Homologene = 1024
| MGIid = 1201679
| GeneAtlas_image1 = PBB_GE_CXADR_203917_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005923 |text = tight junction}}
| Process = {{GNF_GO|id=GO:0007005 |text = mitochondrion organization and biogenesis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0048739 |text = cardiac muscle fiber development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1525
| Hs_Ensembl = ENSG00000154639
| Hs_RefseqProtein = NP_001329
| Hs_RefseqmRNA = NM_001338
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 21
| Hs_GenLoc_start = 17807201
| Hs_GenLoc_end = 17861135
| Hs_Uniprot = P78310
| Mm_EntrezGene = 13052
| Mm_Ensembl = ENSMUSG00000022865
| Mm_RefseqmRNA = NM_001025192
| Mm_RefseqProtein = NP_001020363
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 78184283
| Mm_GenLoc_end = 78222167
| Mm_Uniprot = Q3TV22
}}
}}
'''Coxsackie virus and adenovirus receptor''', also known as '''CXADR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CXADR coxsackie virus and adenovirus receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1525| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.<ref name="entrez">{{cite web | title = Entrez Gene: CXADR coxsackie virus and adenovirus receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1525| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Carson SD |title=Receptor for the group B coxsackieviruses and adenoviruses: CAR. |journal=Rev. Med. Virol. |volume=11 |issue= 4 |pages= 219-26 |year= 2002 |pmid= 11479928 |doi= }}
*{{cite journal | author=Selinka HC, Wolde A, Sauter M, ''et al.'' |title=Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism. |journal=Med. Microbiol. Immunol. |volume=193 |issue= 2-3 |pages= 127-31 |year= 2004 |pmid= 12920584 |doi= 10.1007/s00430-003-0193-y }}
*{{cite journal | author=Bergelson JM, Cunningham JA, Droguett G, ''et al.'' |title=Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. |journal=Science |volume=275 |issue= 5304 |pages= 1320-3 |year= 1997 |pmid= 9036860 |doi= }}
*{{cite journal | author=Tomko RP, Xu R, Philipson L |title=HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 3352-6 |year= 1997 |pmid= 9096397 |doi= }}
*{{cite journal | author=Carson SD, Chapman NN, Tracy SM |title=Purification of the putative coxsackievirus B receptor from HeLa cells. |journal=Biochem. Biophys. Res. Commun. |volume=233 |issue= 2 |pages= 325-8 |year= 1997 |pmid= 9144533 |doi= 10.1006/bbrc.1997.6449 }}
*{{cite journal | author=Bergelson JM, Krithivas A, Celi L, ''et al.'' |title=The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. |journal=J. Virol. |volume=72 |issue= 1 |pages= 415-9 |year= 1998 |pmid= 9420240 |doi= }}
*{{cite journal | author=Fechner H, Haack A, Wang H, ''et al.'' |title=Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. |journal=Gene Ther. |volume=6 |issue= 9 |pages= 1520-35 |year= 2000 |pmid= 10490761 |doi= 10.1038/sj.gt.3301030 }}
*{{cite journal | author=Bowles KR, Gibson J, Wu J, ''et al.'' |title=Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene. |journal=Hum. Genet. |volume=105 |issue= 4 |pages= 354-9 |year= 1999 |pmid= 10543405 |doi= }}
*{{cite journal | author=Bewley MC, Springer K, Zhang YB, ''et al.'' |title=Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. |journal=Science |volume=286 |issue= 5444 |pages= 1579-83 |year= 1999 |pmid= 10567268 |doi= }}
*{{cite journal | author=Tomko RP, Johansson CB, Totrov M, ''et al.'' |title=Expression of the adenovirus receptor and its interaction with the fiber knob. |journal=Exp. Cell Res. |volume=255 |issue= 1 |pages= 47-55 |year= 2000 |pmid= 10666333 |doi= 10.1006/excr.1999.4761 }}
*{{cite journal | author=van Raaij MJ, Chouin E, van der Zandt H, ''et al.'' |title=Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. |journal=Structure |volume=8 |issue= 11 |pages= 1147-55 |year= 2001 |pmid= 11080637 |doi= }}
*{{cite journal | author=Cohen CJ, Gaetz J, Ohman T, Bergelson JM |title=Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25392-8 |year= 2001 |pmid= 11316797 |doi= 10.1074/jbc.M009531200 }}
*{{cite journal | author=Noutsias M, Fechner H, de Jonge H, ''et al.'' |title=Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. |journal=Circulation |volume=104 |issue= 3 |pages= 275-80 |year= 2001 |pmid= 11457744 |doi= }}
*{{cite journal | author=Thoelen I, Magnusson C, Tågerud S, ''et al.'' |title=Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 1 |pages= 216-22 |year= 2001 |pmid= 11549277 |doi= 10.1006/bbrc.2001.5535 }}
*{{cite journal | author=He Y, Chipman PR, Howitt J, ''et al.'' |title=Interaction of coxsackievirus B3 with the full length coxsackievirus-adenovirus receptor. |journal=Nat. Struct. Biol. |volume=8 |issue= 10 |pages= 874-8 |year= 2001 |pmid= 11573093 |doi= 10.1038/nsb1001-874 }}
*{{cite journal | author=Cohen CJ, Shieh JT, Pickles RJ, ''et al.'' |title=The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15191-6 |year= 2002 |pmid= 11734628 |doi= 10.1073/pnas.261452898 }}
*{{cite journal | author=Law LK, Davidson BL |title=Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor. |journal=J. Virol. |volume=76 |issue= 2 |pages= 656-61 |year= 2002 |pmid= 11752156 |doi= }}
*{{cite journal | author=van't Hof W, Crystal RG |title=Fatty acid modification of the coxsackievirus and adenovirus receptor. |journal=J. Virol. |volume=76 |issue= 12 |pages= 6382-6 |year= 2002 |pmid= 12021372 |doi= }}
*{{cite journal | author=Walters RW, Freimuth P, Moninger TO, ''et al.'' |title=Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. |journal=Cell |volume=110 |issue= 6 |pages= 789-99 |year= 2002 |pmid= 12297051 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MTTP... {November 17, 2007 10:33:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:34:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Microsomal triglyceride transfer protein
| HGNCid = 7467
| Symbol = MTTP
| AltSymbols =; ABL; MTP; MGC149819; MGC149820
| OMIM = 157147
| ECnumber =
| Homologene = 212
| MGIid = 106926
| GeneAtlas_image1 = PBB_GE_MTTP_205675_at_tn.png
| Function = {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4547
| Hs_Ensembl = ENSG00000138823
| Hs_RefseqProtein = NP_000244
| Hs_RefseqmRNA = NM_000253
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 100715004
| Hs_GenLoc_end = 100763649
| Hs_Uniprot = P55157
| Mm_EntrezGene = 17777
| Mm_Ensembl = ENSMUSG00000028158
| Mm_RefseqmRNA = NM_008642
| Mm_RefseqProtein = NP_032668
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 138028273
| Mm_GenLoc_end = 138071492
| Mm_Uniprot = Q3TVF2
}}
}}
'''Microsomal triglyceride transfer protein''', also known as '''MTTP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTTP microsomal triglyceride transfer protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4547| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.<ref name="entrez">{{cite web | title = Entrez Gene: MTTP microsomal triglyceride transfer protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4547| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Luz JM, Lennarz WJ |title=Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum. |journal=EXS |volume=77 |issue= |pages= 97-117 |year= 1996 |pmid= 8856971 |doi= }}
*{{cite journal | author=Wetterau JR, Lin MC, Jamil H |title=Microsomal triglyceride transfer protein. |journal=Biochim. Biophys. Acta |volume=1345 |issue= 2 |pages= 136-50 |year= 1997 |pmid= 9106493 |doi= }}
*{{cite journal | author=Gordon DA |title=Recent advances in elucidating the role of the microsomal triglyceride transfer protein in apolipoprotein B lipoprotein assembly. |journal=Curr. Opin. Lipidol. |volume=8 |issue= 3 |pages= 131-7 |year= 1997 |pmid= 9211060 |doi= }}
*{{cite journal | author=Ye J |title=Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus. |journal=PLoS Pathog. |volume=3 |issue= 8 |pages= e108 |year= 2007 |pmid= 17784784 |doi= 10.1371/journal.ppat.0030108 }}
*{{cite journal | author=Wetterau JR, Aggerbeck LP, Bouma ME, ''et al.'' |title=Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. |journal=Science |volume=258 |issue= 5084 |pages= 999-1001 |year= 1992 |pmid= 1439810 |doi= }}
*{{cite journal | author=Sharp D, Ricci B, Kienzle B, ''et al.'' |title=Human microsomal triglyceride transfer protein large subunit gene structure. |journal=Biochemistry |volume=33 |issue= 31 |pages= 9057-61 |year= 1994 |pmid= 7545943 |doi= }}
*{{cite journal | author=Shoulders CC, Narcisi TM, Read J, ''et al.'' |title=The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain. |journal=Nat. Struct. Biol. |volume=1 |issue= 5 |pages= 285-6 |year= 1995 |pmid= 7664034 |doi= }}
*{{cite journal | author=Hagan DL, Kienzle B, Jamil H, Hariharan N |title=Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 28737-44 |year= 1994 |pmid= 7961826 |doi= }}
*{{cite journal | author=Shoulders CC, Brett DJ, Bayliss JD, ''et al.'' |title=Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein. |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2109-16 |year= 1994 |pmid= 8111381 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Sharp D, Blinderman L, Combs KA, ''et al.'' |title=Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. |journal=Nature |volume=365 |issue= 6441 |pages= 65-9 |year= 1993 |pmid= 8361539 |doi= 10.1038/365065a0 }}
*{{cite journal | author=Narcisi TM, Shoulders CC, Chester SA, ''et al.'' |title=Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia. |journal=Am. J. Hum. Genet. |volume=57 |issue= 6 |pages= 1298-310 |year= 1996 |pmid= 8533758 |doi= }}
*{{cite journal | author=Rehberg EF, Samson-Bouma ME, Kienzle B, ''et al.'' |title=A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 29945-52 |year= 1997 |pmid= 8939939 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Linnik KM, Herscovitz H |title=Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 21368-73 |year= 1998 |pmid= 9694898 |doi= }}
*{{cite journal | author=Bradbury P, Mann CJ, Köchl S, ''et al.'' |title=A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 3159-64 |year= 1999 |pmid= 9915855 |doi= }}
*{{cite journal | author=Wang J, Hegele RA |title=Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia. |journal=Hum. Mutat. |volume=15 |issue= 3 |pages= 294-5 |year= 2000 |pmid= 10679949 |doi= 10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYBL2... {November 17, 2007 10:34:04 AM PST}
- SEARCH REDIRECT: Control Box Found: MYBL2 {November 17, 2007 10:34:30 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 10:34:31 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 10:34:31 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 10:34:31 AM PST}
- UPDATED: Updated protein page: MYBL2 {November 17, 2007 10:34:37 AM PST}
- INFO: Beginning work on NR1H4... {November 17, 2007 10:42:36 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:43:14 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1H4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1osh.
| PDB = {{PDB2|1osh}}, {{PDB2|1osv}}, {{PDB2|1ot7}}
| Name = Nuclear receptor subfamily 1, group H, member 4
| HGNCid = 7967
| Symbol = NR1H4
| AltSymbols =; BAR; FXR; HRR-1; HRR1; MGC163445; RIP14
| OMIM = 603826
| ECnumber =
| Homologene = 3760
| MGIid = 1352464
| GeneAtlas_image1 = PBB_GE_NR1H4_206340_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9971
| Hs_Ensembl = ENSG00000012504
| Hs_RefseqProtein = NP_005114
| Hs_RefseqmRNA = NM_005123
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 99391810
| Hs_GenLoc_end = 99481772
| Hs_Uniprot = Q96RI1
| Mm_EntrezGene = 20186
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009108
| Mm_RefseqProtein = NP_033134
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nuclear receptor subfamily 1, group H, member 4''', also known as '''NR1H4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1H4 nuclear receptor subfamily 1, group H, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9971| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kalaany NY, Mangelsdorf DJ |title=LXRS and FXR: the yin and yang of cholesterol and fat metabolism. |journal=Annu. Rev. Physiol. |volume=68 |issue= |pages= 159-91 |year= 2006 |pmid= 16460270 |doi= 10.1146/annurev.physiol.68.033104.152158 }}
*{{cite journal | author=Kuipers F, Stroeve JH, Caron S, Staels B |title=Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 289-97 |year= 2007 |pmid= 17495603 |doi= 10.1097/MOL.0b013e3281338d08 }}
*{{cite journal | author=Seol W, Choi HS, Moore DD |title=Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 72-85 |year= 1995 |pmid= 7760852 |doi= }}
*{{cite journal | author=Forman BM, Goode E, Chen J, ''et al.'' |title=Identification of a nuclear receptor that is activated by farnesol metabolites. |journal=Cell |volume=81 |issue= 5 |pages= 687-93 |year= 1995 |pmid= 7774010 |doi= }}
*{{cite journal | author=Zavacki AM, Lehmann JM, Seol W, ''et al.'' |title=Activation of the orphan receptor RIP14 by retinoids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 15 |pages= 7909-14 |year= 1997 |pmid= 9223286 |doi= }}
*{{cite journal | author=Makishima M, Okamoto AY, Repa JJ, ''et al.'' |title=Identification of a nuclear receptor for bile acids. |journal=Science |volume=284 |issue= 5418 |pages= 1362-5 |year= 1999 |pmid= 10334992 |doi= }}
*{{cite journal | author=Parks DJ, Blanchard SG, Bledsoe RK, ''et al.'' |title=Bile acids: natural ligands for an orphan nuclear receptor. |journal=Science |volume=284 |issue= 5418 |pages= 1365-8 |year= 1999 |pmid= 10334993 |doi= }}
*{{cite journal | author=Bramlett KS, Yao S, Burris TP |title=Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids. |journal=Mol. Genet. Metab. |volume=71 |issue= 4 |pages= 609-15 |year= 2001 |pmid= 11136553 |doi= 10.1006/mgme.2000.3106 }}
*{{cite journal | author=Stegh AH, Barnhart BC, Volkland J, ''et al.'' |title=Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4351-60 |year= 2002 |pmid= 11733517 |doi= 10.1074/jbc.M108947200 }}
*{{cite journal | author=Cui J, Heard TS, Yu J, ''et al.'' |title=The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 25963-9 |year= 2002 |pmid= 12004058 |doi= 10.1074/jbc.M200824200 }}
*{{cite journal | author=Huber RM, Murphy K, Miao B, ''et al.'' |title=Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. |journal=Gene |volume=290 |issue= 1-2 |pages= 35-43 |year= 2002 |pmid= 12062799 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Pineda Torra I, Claudel T, Duval C, ''et al.'' |title=Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. |journal=Mol. Endocrinol. |volume=17 |issue= 2 |pages= 259-72 |year= 2003 |pmid= 12554753 |doi= }}
*{{cite journal | author=Anisfeld AM, Kast-Woelbern HR, Meyer ME, ''et al.'' |title=Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20420-8 |year= 2003 |pmid= 12660231 |doi= 10.1074/jbc.M302505200 }}
*{{cite journal | author=Pircher PC, Kitto JL, Petrowski ML, ''et al.'' |title=Farnesoid X receptor regulates bile acid-amino acid conjugation. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27703-11 |year= 2003 |pmid= 12754200 |doi= 10.1074/jbc.M302128200 }}
*{{cite journal | author=Zhao A, Lew JL, Huang L, ''et al.'' |title=Human kininogen gene is transactivated by the farnesoid X receptor. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28765-70 |year= 2003 |pmid= 12761213 |doi= 10.1074/jbc.M304568200 }}
*{{cite journal | author=Barbier O, Torra IP, Sirvent A, ''et al.'' |title=FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. |journal=Gastroenterology |volume=124 |issue= 7 |pages= 1926-40 |year= 2003 |pmid= 12806625 |doi= }}
*{{cite journal | author=Holt JA, Luo G, Billin AN, ''et al.'' |title=Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1581-91 |year= 2003 |pmid= 12815072 |doi= 10.1101/gad.1083503 }}
*{{cite journal | author=Claudel T, Inoue Y, Barbier O, ''et al.'' |title=Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. |journal=Gastroenterology |volume=125 |issue= 2 |pages= 544-55 |year= 2003 |pmid= 12891557 |doi= }}
*{{cite journal | author=Hsiao PW, Fryer CJ, Trotter KW, ''et al.'' |title=BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6210-20 |year= 2003 |pmid= 12917342 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OSM... {November 17, 2007 10:34:37 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:35:00 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_OSM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1evs.
| PDB = {{PDB2|1evs}}
| Name = Oncostatin M
| HGNCid = 8506
| Symbol = OSM
| AltSymbols =; MGC20461
| OMIM = 165095
| ECnumber =
| Homologene = 10741
| MGIid = 104749
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005147 |text = oncostatin-M receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009408 |text = response to heat}} {{GNF_GO|id=GO:0042503 |text = tyrosine phosphorylation of Stat3 protein}} {{GNF_GO|id=GO:0042506 |text = tyrosine phosphorylation of Stat5 protein}} {{GNF_GO|id=GO:0042508 |text = tyrosine phosphorylation of Stat1 protein}} {{GNF_GO|id=GO:0048266 |text = behavioral response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5008
| Hs_Ensembl = ENSG00000099985
| Hs_RefseqProtein = NP_065391
| Hs_RefseqmRNA = NM_020530
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 28988821
| Hs_GenLoc_end = 28992840
| Hs_Uniprot = P13725
| Mm_EntrezGene = 18413
| Mm_Ensembl = ENSMUSG00000058755
| Mm_RefseqmRNA = NM_001013365
| Mm_RefseqProtein = NP_001013383
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 4136423
| Mm_GenLoc_end = 4141029
| Mm_Uniprot = Q3U1Y5
}}
}}
'''Oncostatin M''', also known as '''OSM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OSM oncostatin M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5008| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.<ref name="entrez">{{cite web | title = Entrez Gene: OSM oncostatin M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5008| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gearing DP, Bruce AG |title=Oncostatin M binds the high-affinity leukemia inhibitory factor receptor. |journal=New Biol. |volume=4 |issue= 1 |pages= 61-5 |year= 1992 |pmid= 1536831 |doi= }}
*{{cite journal | author=Miles SA, Martínez-Maza O, Rezai A, ''et al.'' |title=Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. |journal=Science |volume=255 |issue= 5050 |pages= 1432-4 |year= 1992 |pmid= 1542793 |doi= }}
*{{cite journal | author=Gearing DP, Comeau MR, Friend DJ, ''et al.'' |title=The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. |journal=Science |volume=255 |issue= 5050 |pages= 1434-7 |year= 1992 |pmid= 1542794 |doi= }}
*{{cite journal | author=Rose TM, Bruce AG |title=Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 19 |pages= 8641-5 |year= 1991 |pmid= 1717982 |doi= }}
*{{cite journal | author=Kallestad JC, Shoyab M, Linsley PS |title=Disulfide bond assignment and identification of regions required for functional activity of oncostatin M. |journal=J. Biol. Chem. |volume=266 |issue= 14 |pages= 8940-5 |year= 1991 |pmid= 2026606 |doi= }}
*{{cite journal | author=Linsley PS, Kallestad J, Ochs V, Neubauer M |title=Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M. |journal=Mol. Cell. Biol. |volume=10 |issue= 5 |pages= 1882-90 |year= 1990 |pmid= 2325640 |doi= }}
*{{cite journal | author=Malik N, Kallestad JC, Gunderson NL, ''et al.'' |title=Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M. |journal=Mol. Cell. Biol. |volume=9 |issue= 7 |pages= 2847-53 |year= 1989 |pmid= 2779549 |doi= }}
*{{cite journal | author=Zarling JM, Shoyab M, Marquardt H, ''et al.'' |title=Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 24 |pages= 9739-43 |year= 1987 |pmid= 3540948 |doi= }}
*{{cite journal | author=Yamaguchi M, Miki N, Ono M, ''et al.'' |title=Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. |journal=Endocrinology |volume=136 |issue= 3 |pages= 1072-8 |year= 1995 |pmid= 7867561 |doi= }}
*{{cite journal | author=Rose TM, Lagrou MJ, Fransson I, ''et al.'' |title=The genes for oncostatin M (OSM) and leukemia inhibitory factor (LIF) are tightly linked on human chromosome 22. |journal=Genomics |volume=17 |issue= 1 |pages= 136-40 |year= 1993 |pmid= 8406444 |doi= 10.1006/geno.1993.1294 }}
*{{cite journal | author=Giovannini M, Selleri L, Hermanson GG, Evans GA |title=Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint. |journal=Cytogenet. Cell Genet. |volume=62 |issue= 1 |pages= 32-4 |year= 1993 |pmid= 8422753 |doi= }}
*{{cite journal | author=Mosley B, De Imus C, Friend D, ''et al.'' |title=Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. |journal=J. Biol. Chem. |volume=271 |issue= 51 |pages= 32635-43 |year= 1997 |pmid= 8999038 |doi= }}
*{{cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi= }}
*{{cite journal | author=Tanaka M, Hara T, Copeland NG, ''et al.'' |title=Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit. |journal=Blood |volume=93 |issue= 3 |pages= 804-15 |year= 1999 |pmid= 9920829 |doi= }}
*{{cite journal | author=Ma Y, Streiff RJ, Liu J, ''et al.'' |title=Cloning and characterization of human oncostatin M promoter. |journal=Nucleic Acids Res. |volume=27 |issue= 23 |pages= 4649-57 |year= 2000 |pmid= 10556323 |doi= }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | author=Deller MC, Hudson KR, Ikemizu S, ''et al.'' |title=Crystal structure and functional dissection of the cytostatic cytokine oncostatin M. |journal=Structure |volume=8 |issue= 8 |pages= 863-74 |year= 2001 |pmid= 10997905 |doi= }}
*{{cite journal | author=Somasundaram R, Ruehl M, Schaefer B, ''et al.'' |title=Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3242-6 |year= 2002 |pmid= 11711546 |doi= 10.1074/jbc.M110011200 }}
*{{cite journal | author=Mahboubi K, Pober JS |title=Activation of signal transducer and activator of transcription 1 (STAT1) is not sufficient for the induction of STAT1-dependent genes in endothelial cells. Comparison of interferon-gamma and oncostatin M. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8012-21 |year= 2002 |pmid= 11777927 |doi= 10.1074/jbc.M107542200 }}
*{{cite journal | author=Grant SL, Douglas AM, Goss GA, Begley CG |title=Oncostatin M and leukemia inhibitory factor regulate the growth of normal human breast epithelial cells. |journal=Growth Factors |volume=19 |issue= 3 |pages= 153-62 |year= 2002 |pmid= 11811789 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PAFAH1B1... {November 17, 2007 10:35:00 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:35:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PAFAH1B1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uuj.
| PDB = {{PDB2|1uuj}}, {{PDB2|1vyh}}
| Name = Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa
| HGNCid = 8574
| Symbol = PAFAH1B1
| AltSymbols =; MDCR; LIS1; LIS2; PAFAH
| OMIM = 601545
| ECnumber =
| Homologene = 371
| MGIid = 109520
| GeneAtlas_image1 = PBB_GE_PAFAH1B1_211547_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008017 |text = microtubule binding}} {{GNF_GO|id=GO:0045502 |text = dynein binding}}
| Component = {{GNF_GO|id=GO:0000235 |text = astral microtubule}} {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005874 |text = microtubule}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0005938 |text = cell cortex}}
| Process = {{GNF_GO|id=GO:0000132 |text = establishment of mitotic spindle orientation}} {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0001675 |text = acrosome formation}} {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007405 |text = neuroblast proliferation}} {{GNF_GO|id=GO:0008090 |text = retrograde axon cargo transport}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0047496 |text = vesicle transport along microtubule}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5048
| Hs_Ensembl = ENSG00000007168
| Hs_RefseqProtein = NP_000421
| Hs_RefseqmRNA = NM_000430
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 2443686
| Hs_GenLoc_end = 2535638
| Hs_Uniprot = P43034
| Mm_EntrezGene = 18472
| Mm_Ensembl = ENSMUSG00000020745
| Mm_RefseqmRNA = XM_982651
| Mm_RefseqProtein = XP_987745
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 74490144
| Mm_GenLoc_end = 74540865
| Mm_Uniprot = Q3TUH5
}}
}}
'''Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa''', also known as '''PAFAH1B1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5048| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.<ref name="entrez">{{cite web | title = Entrez Gene: PAFAH1B1 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5048| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tjoelker LW, Eberhardt C, Wilder C, ''et al.'' |title=Functional and structural features of plasma platelet-activating factor acetylhydrolase. |journal=Adv. Exp. Med. Biol. |volume=416 |issue= |pages= 107-11 |year= 1997 |pmid= 9131135 |doi= }}
*{{cite journal | author=Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM |title=Platelet-activating factor acetylhydrolases. |journal=J. Biol. Chem. |volume=272 |issue= 29 |pages= 17895-8 |year= 1997 |pmid= 9218411 |doi= }}
*{{cite journal | author=Yamada Y, Yokota M |title=Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases. |journal=Jpn. Circ. J. |volume=62 |issue= 5 |pages= 328-35 |year= 1998 |pmid= 9626899 |doi= }}
*{{cite journal | author=Reiner O, Cahana A, Escamez T, Martinez S |title=LIS1-no more no less. |journal=Mol. Psychiatry |volume=7 |issue= 1 |pages= 12-6 |year= 2002 |pmid= 11803439 |doi= 10.1038/sj/mp/4000975 }}
*{{cite journal | author=Guerrini R, Carrozzo R |title=Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing. |journal=Seizure : the journal of the British Epilepsy Association |volume=11 Suppl A |issue= |pages= 532-43; quiz 544-7 |year= 2002 |pmid= 12185771 |doi= }}
*{{cite journal | author=Wynshaw-Boris A |title=Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development. |journal=Clin. Genet. |volume=72 |issue= 4 |pages= 296-304 |year= 2007 |pmid= 17850624 |doi= 10.1111/j.1399-0004.2007.00888.x }}
*{{cite journal | author=Mizuguchi M, Takashima S, Kakita A, ''et al.'' |title=Lissencephaly gene product. Localization in the central nervous system and loss of immunoreactivity in Miller-Dieker syndrome. |journal=Am. J. Pathol. |volume=147 |issue= 4 |pages= 1142-51 |year= 1995 |pmid= 7573359 |doi= }}
*{{cite journal | author=Hattori M, Adachi H, Tsujimoto M, ''et al.'' |title=Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected] |journal=Nature |volume=370 |issue= 6486 |pages= 216-8 |year= 1994 |pmid= 8028668 |doi= 10.1038/370216a0 }}
*{{cite journal | author=Reiner O, Carrozzo R, Shen Y, ''et al.'' |title=Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats. |journal=Nature |volume=364 |issue= 6439 |pages= 717-21 |year= 1993 |pmid= 8355785 |doi= 10.1038/364717a0 }}
*{{cite journal | author=Reiner O, Bar-Am I, Sapir T, ''et al.'' |title=LIS2, gene and pseudogene, homologous to LIS1 (lissencephaly 1), located on the short and long arms of chromosome 2. |journal=Genomics |volume=30 |issue= 2 |pages= 251-6 |year= 1996 |pmid= 8586424 |doi= 10.1006/geno.1995.9880 }}
*{{cite journal | author=Isumi H, Takashima S, Kakita A, ''et al.'' |title=Expression of the LIS-1 gene product in brain anomalies with a migration disorder. |journal=Pediatr. Neurol. |volume=16 |issue= 1 |pages= 42-4 |year= 1997 |pmid= 9044400 |doi= }}
*{{cite journal | author=Lo Nigro C, Chong CS, Smith AC, ''et al.'' |title=Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome. |journal=Hum. Mol. Genet. |volume=6 |issue= 2 |pages= 157-64 |year= 1997 |pmid= 9063735 |doi= }}
*{{cite journal | author=Sapir T, Elbaum M, Reiner O |title=Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. |journal=EMBO J. |volume=16 |issue= 23 |pages= 6977-84 |year= 1998 |pmid= 9384577 |doi= 10.1093/emboj/16.23.6977 }}
*{{cite journal | author=Morris SM, Albrecht U, Reiner O, ''et al.'' |title=The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC. |journal=Curr. Biol. |volume=8 |issue= 10 |pages= 603-6 |year= 1998 |pmid= 9601647 |doi= }}
*{{cite journal | author=Pilz DT, Kuc J, Matsumoto N, ''et al.'' |title=Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1757-60 |year= 2000 |pmid= 10441340 |doi= }}
*{{cite journal | author=Sapir T, Cahana A, Seger R, ''et al.'' |title=LIS1 is a microtubule-associated phosphoprotein. |journal=Eur. J. Biochem. |volume=265 |issue= 1 |pages= 181-8 |year= 1999 |pmid= 10491172 |doi= }}
*{{cite journal | author=Sweeney KJ, Clark GD, Prokscha A, ''et al.'' |title=Lissencephaly associated mutations suggest a requirement for the PAFAH1B heterotrimeric complex in brain development. |journal=Mech. Dev. |volume=92 |issue= 2 |pages= 263-71 |year= 2000 |pmid= 10727864 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on POLH... {November 17, 2007 10:35:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:36:09 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POLH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i5o.
| PDB = {{PDB2|2i5o}}
| Name = Polymerase (DNA directed), eta
| HGNCid = 9181
| Symbol = POLH
| AltSymbols =; FLJ16395; FLJ21978; RAD30A; XP-V; XPV
| OMIM = 603968
| ECnumber =
| Homologene = 38189
| MGIid = 1891457
| GeneAtlas_image1 = PBB_GE_POLH_219380_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0015999 |text = eta DNA polymerase activity}} {{GNF_GO|id=GO:0016451 |text = nu DNA polymerase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006282 |text = regulation of DNA repair}} {{GNF_GO|id=GO:0006290 |text = pyrimidine dimer repair}} {{GNF_GO|id=GO:0006301 |text = postreplication repair}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5429
| Hs_Ensembl = ENSG00000170734
| Hs_RefseqProtein = NP_006493
| Hs_RefseqmRNA = NM_006502
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 43651865
| Hs_GenLoc_end = 43691375
| Hs_Uniprot = Q9Y253
| Mm_EntrezGene = 80905
| Mm_Ensembl = ENSMUSG00000023953
| Mm_RefseqmRNA = XM_001002709
| Mm_RefseqProtein = XP_001002709
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 45634936
| Mm_GenLoc_end = 45666176
| Mm_Uniprot = A1A556
}}
}}
'''Polymerase (DNA directed), eta''', also known as '''POLH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLH polymerase (DNA directed), eta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5429| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Masutani C, Kusumoto R, Yamada A, ''et al.'' |title=The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. |journal=Nature |volume=399 |issue= 6737 |pages= 700-4 |year= 1999 |pmid= 10385124 |doi= 10.1038/21447 }}
*{{cite journal | author=Johnson RE, Kondratick CM, Prakash S, Prakash L |title=hRAD30 mutations in the variant form of xeroderma pigmentosum. |journal=Science |volume=285 |issue= 5425 |pages= 263-5 |year= 1999 |pmid= 10398605 |doi= }}
*{{cite journal | author=Masutani C, Kusumoto R, Iwai S, Hanaoka F |title=Mechanisms of accurate translesion synthesis by human DNA polymerase eta. |journal=EMBO J. |volume=19 |issue= 12 |pages= 3100-9 |year= 2000 |pmid= 10856253 |doi= 10.1093/emboj/19.12.3100 }}
*{{cite journal | author=Yamada A, Masutani C, Iwai S, Hanaoka F |title=Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. |journal=Nucleic Acids Res. |volume=28 |issue= 13 |pages= 2473-80 |year= 2000 |pmid= 10871396 |doi= }}
*{{cite journal | author=Yuasa M, Masutani C, Eki T, Hanaoka F |title=Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. |journal=Oncogene |volume=19 |issue= 41 |pages= 4721-8 |year= 2000 |pmid= 11032022 |doi= 10.1038/sj.onc.1203842 }}
*{{cite journal | author=Itoh T, Linn S, Kamide R, ''et al.'' |title=Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation. |journal=J. Invest. Dermatol. |volume=115 |issue= 6 |pages= 981-5 |year= 2001 |pmid= 11121129 |doi= 10.1046/j.1523-1747.2000.00154.x }}
*{{cite journal | author=Zeng X, Winter DB, Kasmer C, ''et al.'' |title=DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. |journal=Nat. Immunol. |volume=2 |issue= 6 |pages= 537-41 |year= 2001 |pmid= 11376341 |doi= 10.1038/88740 }}
*{{cite journal | author=Matsuda T, Bebenek K, Masutani C, ''et al.'' |title=Error rate and specificity of human and murine DNA polymerase eta. |journal=J. Mol. Biol. |volume=312 |issue= 2 |pages= 335-46 |year= 2001 |pmid= 11554790 |doi= 10.1006/jmbi.2001.4937 }}
*{{cite journal | author=Haracska L, Johnson RE, Unk I, ''et al.'' |title=Physical and functional interactions of human DNA polymerase eta with PCNA. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7199-206 |year= 2001 |pmid= 11585903 |doi= 10.1128/MCB.21.21.7199-7206.2001 }}
*{{cite journal | author=Glick E, Vigna KL, Loeb LA |title=Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions. |journal=EMBO J. |volume=20 |issue= 24 |pages= 7303-12 |year= 2002 |pmid= 11743006 |doi= 10.1093/emboj/20.24.7303 }}
*{{cite journal | author=Limoli CL, Giedzinski E, Bonner WM, Cleaver JE |title=UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 1 |pages= 233-8 |year= 2002 |pmid= 11756691 |doi= 10.1073/pnas.231611798 }}
*{{cite journal | author=Broughton BC, Cordonnier A, Kleijer WJ, ''et al.'' |title=Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 815-20 |year= 2002 |pmid= 11773631 |doi= 10.1073/pnas.022473899 }}
*{{cite journal | author=Chiapperino D, Kroth H, Kramarczuk IH, ''et al.'' |title=Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 11765-71 |year= 2002 |pmid= 11821420 |doi= 10.1074/jbc.M112139200 }}
*{{cite journal | author=Kusumoto R, Masutani C, Iwai S, Hanaoka F |title=Translesion synthesis by human DNA polymerase eta across thymine glycol lesions. |journal=Biochemistry |volume=41 |issue= 19 |pages= 6090-9 |year= 2002 |pmid= 11994004 |doi= }}
*{{cite journal | author=Yavuz S, Yavuz AS, Kraemer KH, Lipsky PE |title=The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant. |journal=J. Immunol. |volume=169 |issue= 7 |pages= 3825-30 |year= 2002 |pmid= 12244178 |doi= }}
*{{cite journal | author=Kannouche P, Fernández de Henestrosa AR, Coull B, ''et al.'' |title=Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. |journal=EMBO J. |volume=21 |issue= 22 |pages= 6246-56 |year= 2003 |pmid= 12426396 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zheng H, Wang X, Warren AJ, ''et al.'' |title=Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. |journal=Mol. Cell. Biol. |volume=23 |issue= 2 |pages= 754-61 |year= 2003 |pmid= 12509472 |doi= }}
*{{cite journal | author=Yang IY, Miller H, Wang Z, ''et al.'' |title=Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13989-94 |year= 2003 |pmid= 12584190 |doi= 10.1074/jbc.M212535200 }}
*{{cite journal | author=Kannouche P, Fernández de Henestrosa AR, Coull B, ''et al.'' |title=Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells. |journal=EMBO J. |volume=22 |issue= 5 |pages= 1223-33 |year= 2003 |pmid= 12606586 |doi= 10.1093/emboj/cdf618 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMB9... {November 17, 2007 10:36:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:36:37 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
| HGNCid = 9546
| Symbol = PSMB9
| AltSymbols =; LMP2; MGC70470; RING12
| OMIM = 177045
| ECnumber =
| Homologene = 2094
| MGIid = 1346526
| GeneAtlas_image1 = PBB_GE_PSMB9_204279_at_tn.png
| Function = {{GNF_GO|id=GO:0004298 |text = threonine endopeptidase activity}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005839 |text = proteasome core complex (sensu Eukaryota)}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5698
| Hs_Ensembl = ENSG00000204261
| Hs_RefseqProtein = NP_002791
| Hs_RefseqmRNA = NM_002800
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 32929916
| Hs_GenLoc_end = 32935606
| Hs_Uniprot = P28065
| Mm_EntrezGene = 16912
| Mm_Ensembl = ENSMUSG00000024337
| Mm_RefseqmRNA = NM_013585
| Mm_RefseqProtein = NP_038613
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 33792336
| Mm_GenLoc_end = 33797608
| Mm_Uniprot = Q3TAR7
}}
}}
'''Proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)''', also known as '''PSMB9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5698| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified; both isoforms are processed to yield the same mature subunit.<ref name="entrez">{{cite web | title = Entrez Gene: PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5698| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
*{{cite journal | author=Früh K, Yang Y, Arnold D, ''et al.'' |title=Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits. |journal=J. Biol. Chem. |volume=267 |issue= 31 |pages= 22131-40 |year= 1992 |pmid= 1429565 |doi= }}
*{{cite journal | author=Beck S, Kelly A, Radley E, ''et al.'' |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433-41 |year= 1992 |pmid= 1453454 |doi= }}
*{{cite journal | author=Bodmer JG, Marsh SG, Albert ED, ''et al.'' |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161-73 |year= 1992 |pmid= 1529427 |doi= }}
*{{cite journal | author=Martinez CK, Monaco JJ |title=Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene. |journal=Nature |volume=353 |issue= 6345 |pages= 664-7 |year= 1991 |pmid= 1681432 |doi= 10.1038/353664a0 }}
*{{cite journal | author=Kelly A, Powis SH, Glynne R, ''et al.'' |title=Second proteasome-related gene in the human MHC class II region. |journal=Nature |volume=353 |issue= 6345 |pages= 667-8 |year= 1991 |pmid= 1922385 |doi= 10.1038/353667a0 }}
*{{cite journal | author=Kristensen P, Johnsen AH, Uerkvitz W, ''et al.'' |title=Human proteasome subunits from 2-dimensional gels identified by partial sequencing. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1785-9 |year= 1995 |pmid= 7811265 |doi= }}
*{{cite journal | author=Singal DP, Ye M, Quadri SA |title=Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA. |journal=J. Biol. Chem. |volume=270 |issue= 4 |pages= 1966-70 |year= 1995 |pmid= 7829535 |doi= }}
*{{cite journal | author=Beck S, Abdulla S, Alderton RP, ''et al.'' |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1-13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001 }}
*{{cite journal | author=Hisamatsu H, Shimbara N, Saito Y, ''et al.'' |title=Newly identified pair of proteasomal subunits regulated reciprocally by interferon gamma. |journal=J. Exp. Med. |volume=183 |issue= 4 |pages= 1807-16 |year= 1996 |pmid= 8666937 |doi= }}
*{{cite journal | author=Schmidtke G, Kraft R, Kostka S, ''et al.'' |title=Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis. |journal=EMBO J. |volume=15 |issue= 24 |pages= 6887-98 |year= 1997 |pmid= 9003765 |doi= }}
*{{cite journal | author=Seeger M, Ferrell K, Frank R, Dubiel W |title=HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8145-8 |year= 1997 |pmid= 9079628 |doi= }}
*{{cite journal | author=Cruz M, Elenich LA, Smolarek TA, ''et al.'' |title=DNA sequence, chromosomal localization, and tissue expression of the mouse proteasome subunit lmp10 (Psmb10) gene. |journal=Genomics |volume=45 |issue= 3 |pages= 618-22 |year= 1998 |pmid= 9367687 |doi= 10.1006/geno.1997.4977 }}
*{{cite journal | author=Madani N, Kabat D |title=An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. |journal=J. Virol. |volume=72 |issue= 12 |pages= 10251-5 |year= 1998 |pmid= 9811770 |doi= }}
*{{cite journal | author=Simon JH, Gaddis NC, Fouchier RA, Malim MH |title=Evidence for a newly discovered cellular anti-HIV-1 phenotype. |journal=Nat. Med. |volume=4 |issue= 12 |pages= 1397-400 |year= 1998 |pmid= 9846577 |doi= 10.1038/3987 }}
*{{cite journal | author=Schmidt M, Zantopf D, Kraft R, ''et al.'' |title=Sequence information within proteasomal prosequences mediates efficient integration of beta-subunits into the 20 S proteasome complex. |journal=J. Mol. Biol. |volume=288 |issue= 1 |pages= 117-28 |year= 1999 |pmid= 10329130 |doi= 10.1006/jmbi.1999.2660 }}
*{{cite journal | author=Elenich LA, Nandi D, Kent AE, ''et al.'' |title=The complete primary structure of mouse 20S proteasomes. |journal=Immunogenetics |volume=49 |issue= 10 |pages= 835-42 |year= 1999 |pmid= 10436176 |doi= }}
*{{cite journal | author=Mulder LC, Muesing MA |title=Degradation of HIV-1 integrase by the N-end rule pathway. |journal=J. Biol. Chem. |volume=275 |issue= 38 |pages= 29749-53 |year= 2000 |pmid= 10893419 |doi= 10.1074/jbc.M004670200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RAD9A... {November 17, 2007 10:36:38 AM PST}
- SEARCH REDIRECT: Control Box Found: RAD9A {November 17, 2007 10:37:06 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 17, 2007 10:37:10 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 17, 2007 10:37:10 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 17, 2007 10:37:10 AM PST}
- UPDATED: Updated protein page: RAD9A {November 17, 2007 10:37:23 AM PST}
- INFO: Beginning work on SET... {November 17, 2007 10:37:23 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:37:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SET_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e50.
| PDB = {{PDB2|2e50}}
| Name = SET translocation (myeloid leukemia-associated)
| HGNCid = 10760
| Symbol = SET
| AltSymbols =; 2PP2A; I2PP2A; IGAAD; PHAPII; TAF-IBETA
| OMIM = 600960
| ECnumber =
| Homologene = 55707
| MGIid = 1860267
| Function = {{GNF_GO|id=GO:0004864 |text = protein phosphatase inhibitor activity}} {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}} {{GNF_GO|id=GO:0042393 |text = histone binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006337 |text = nucleosome disassembly}} {{GNF_GO|id=GO:0006913 |text = nucleocytoplasmic transport}} {{GNF_GO|id=GO:0035067 |text = negative regulation of histone acetylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6418
| Hs_Ensembl =
| Hs_RefseqProtein = NP_003002
| Hs_RefseqmRNA = NM_003011
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 56086
| Mm_Ensembl =
| Mm_RefseqmRNA = XM_978154
| Mm_RefseqProtein = XP_983248
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''SET translocation (myeloid leukemia-associated)''', also known as '''SET''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SET SET translocation (myeloid leukemia-associated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6418| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=von Lindern M, van Baal S, Wiegant J, ''et al.'' |title=Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. |journal=Mol. Cell. Biol. |volume=12 |issue= 8 |pages= 3346-55 |year= 1992 |pmid= 1630450 |doi= }}
*{{cite journal | author=Nagata K, Kawase H, Handa H, ''et al.'' |title=Replication factor encoded by a putative oncogene, set, associated with myeloid leukemogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 10 |pages= 4279-83 |year= 1995 |pmid= 7753797 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Adachi Y, Pavlakis GN, Copeland TD |title=Identification of in vivo phosphorylation sites of SET, a nuclear phosphoprotein encoded by the translocation breakpoint in acute undifferentiated leukemia. |journal=FEBS Lett. |volume=340 |issue= 3 |pages= 231-5 |year= 1994 |pmid= 8131851 |doi= }}
*{{cite journal | author=Vaesen M, Barnikol-Watanabe S, Götz H, ''et al.'' |title=Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. |journal=Biol. Chem. Hoppe-Seyler |volume=375 |issue= 2 |pages= 113-26 |year= 1994 |pmid= 8192856 |doi= }}
*{{cite journal | author=Adachi Y, Pavlakis GN, Copeland TD |title=Identification and characterization of SET, a nuclear phosphoprotein encoded by the translocation break point in acute undifferentiated leukemia. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2258-62 |year= 1994 |pmid= 8294483 |doi= }}
*{{cite journal | author=Li M, Makkinje A, Damuni Z |title=The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11059-62 |year= 1996 |pmid= 8626647 |doi= }}
*{{cite journal | author=Adler HT, Nallaseth FS, Walter G, Tkachuk DC |title=HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28407-14 |year= 1997 |pmid= 9353299 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Carlson SG, Eng E, Kim EG, ''et al.'' |title=Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor. |journal=J. Am. Soc. Nephrol. |volume=9 |issue= 10 |pages= 1873-80 |year= 1999 |pmid= 9773788 |doi= }}
*{{cite journal | author=Brennan CM, Gallouzi IE, Steitz JA |title=Protein ligands to HuR modulate its interaction with target mRNAs in vivo. |journal=J. Cell Biol. |volume=151 |issue= 1 |pages= 1-14 |year= 2000 |pmid= 11018049 |doi= }}
*{{cite journal | author=Shikama N, Chan HM, Krstic-Demonacos M, ''et al.'' |title=Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8933-43 |year= 2000 |pmid= 11073993 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Seo SB, McNamara P, Heo S, ''et al.'' |title=Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. |journal=Cell |volume=104 |issue= 1 |pages= 119-30 |year= 2001 |pmid= 11163245 |doi= }}
*{{cite journal | author=Minakuchi M, Kakazu N, Gorrin-Rivas MJ, ''et al.'' |title=Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET. |journal=Eur. J. Biochem. |volume=268 |issue= 5 |pages= 1340-51 |year= 2001 |pmid= 11231286 |doi= }}
*{{cite journal | author=Beresford PJ, Zhang D, Oh DY, ''et al.'' |title=Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43285-93 |year= 2001 |pmid= 11555662 |doi= 10.1074/jbc.M108137200 }}
*{{cite journal | author=Gallouzi IE, Brennan CM, Steitz JA |title=Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. |journal=RNA |volume=7 |issue= 9 |pages= 1348-61 |year= 2001 |pmid= 11565755 |doi= }}
*{{cite journal | author=Qu D, Li Q, Lim HY, ''et al.'' |title=The protein SET binds the neuronal Cdk5 activator p35nck5a and modulates Cdk5/p35nck5a activity. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7324-32 |year= 2002 |pmid= 11741927 |doi= 10.1074/jbc.M107270200 }}
*{{cite journal | author=Fan Z, Beresford PJ, Zhang D, Lieberman J |title=HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2810-20 |year= 2002 |pmid= 11909973 |doi= }}
*{{cite journal | author=Cervoni N, Detich N, Seo SB, ''et al.'' |title=The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25026-31 |year= 2002 |pmid= 11978794 |doi= 10.1074/jbc.M202256200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC11A1... {November 17, 2007 10:38:25 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:39:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
| HGNCid = 10907
| Symbol = SLC11A1
| AltSymbols =; LSH; NRAMP; NRAMP1
| OMIM = 600266
| ECnumber =
| Homologene = 73884
| MGIid = 1345275
| GeneAtlas_image1 = PBB_GE_SLC11A1_210423_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC11A1_210422_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC11A1_217473_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0009617 |text = response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6556
| Hs_Ensembl = ENSG00000018280
| Hs_RefseqProtein = NP_000569
| Hs_RefseqmRNA = NM_000578
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 218955203
| Hs_GenLoc_end = 218968994
| Hs_Uniprot = P49279
| Mm_EntrezGene = 18173
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_013612
| Mm_RefseqProtein = NP_038640
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1''', also known as '''SLC11A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6556| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6556| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Blackwell JM, Searle S, Mohamed H, White JK |title=Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story. |journal=Immunol. Lett. |volume=85 |issue= 2 |pages= 197-203 |year= 2003 |pmid= 12527228 |doi= }}
*{{cite journal | author=Awomoyi AA |title=The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer? |journal=FEMS Immunol. Med. Microbiol. |volume=49 |issue= 3 |pages= 324-9 |year= 2007 |pmid= 17378896 |doi= 10.1111/j.1574-695X.2007.00231.x }}
*{{cite journal | author=Liu J, Fujiwara TM, Buu NT, ''et al.'' |title=Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. |journal=Am. J. Hum. Genet. |volume=56 |issue= 4 |pages= 845-53 |year= 1995 |pmid= 7717395 |doi= }}
*{{cite journal | author=Cellier M, Govoni G, Vidal S, ''et al.'' |title=Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. |journal=J. Exp. Med. |volume=180 |issue= 5 |pages= 1741-52 |year= 1994 |pmid= 7964458 |doi= }}
*{{cite journal | author=Kishi F |title=Isolation and characterization of human Nramp cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=204 |issue= 3 |pages= 1074-80 |year= 1994 |pmid= 7980580 |doi= 10.1006/bbrc.1994.2572 }}
*{{cite journal | author=Vidal SM, Malo D, Vogan K, ''et al.'' |title=Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. |journal=Cell |volume=73 |issue= 3 |pages= 469-85 |year= 1993 |pmid= 8490962 |doi= }}
*{{cite journal | author=Blackwell JM, Barton CH, White JK, ''et al.'' |title=Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. |journal=Mol. Med. |volume=1 |issue= 2 |pages= 194-205 |year= 1996 |pmid= 8529098 |doi= }}
*{{cite journal | author=Kishi F, Nobumoto M |title=Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes. |journal=Immunol. Lett. |volume=47 |issue= 1-2 |pages= 93-6 |year= 1996 |pmid= 8537108 |doi= }}
*{{cite journal | author=Gruenheid S, Pinner E, Desjardins M, Gros P |title=Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. |journal=J. Exp. Med. |volume=185 |issue= 4 |pages= 717-30 |year= 1997 |pmid= 9034150 |doi= }}
*{{cite journal | author=Atkinson PG, Blackwell JM, Barton CH |title=Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages. |journal=Biochem. J. |volume=325 ( Pt 3) |issue= |pages= 779-86 |year= 1997 |pmid= 9271100 |doi= }}
*{{cite journal | author=Gruenheid S, Canonne-Hergaux F, Gauthier S, ''et al.'' |title=The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. |journal=J. Exp. Med. |volume=189 |issue= 5 |pages= 831-41 |year= 1999 |pmid= 10049947 |doi= }}
*{{cite journal | author=Searle S, Blackwell JM |title=Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. |journal=J. Med. Genet. |volume=36 |issue= 4 |pages= 295-9 |year= 1999 |pmid= 10227396 |doi= }}
*{{cite journal | author=Marquet S, Lepage P, Hudson TJ, ''et al.'' |title=Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. |journal=Mamm. Genome |volume=11 |issue= 9 |pages= 755-62 |year= 2000 |pmid= 10967134 |doi= }}
*{{cite journal | author=Canonne-Hergaux F, Calafat J, Richer E, ''et al.'' |title=Expression and subcellular localization of NRAMP1 in human neutrophil granules. |journal=Blood |volume=100 |issue= 1 |pages= 268-75 |year= 2002 |pmid= 12070036 |doi= }}
*{{cite journal | author=Rodríguez MR, González-Escribano MF, Aguilar F, ''et al.'' |title=Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis. |journal=Tissue Antigens |volume=59 |issue= 4 |pages= 311-5 |year= 2003 |pmid= 12135431 |doi= }}
*{{cite journal | author=Bassuny WM, Ihara K, Matsuura N, ''et al.'' |title=Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes. |journal=Immunogenetics |volume=54 |issue= 4 |pages= 282-5 |year= 2002 |pmid= 12136340 |doi= 10.1007/s00251-002-0459-3 }}
*{{cite journal | author=Søborg C, Andersen AB, Madsen HO, ''et al.'' |title=Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis. |journal=J. Infect. Dis. |volume=186 |issue= 4 |pages= 517-21 |year= 2002 |pmid= 12195379 |doi= }}
*{{cite journal | author=Puzyrev VP, Freĭdin MB, Rudko AA, ''et al.'' |title=[Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study] |journal=Mol. Biol. (Mosk.) |volume=36 |issue= 5 |pages= 788-91 |year= 2002 |pmid= 12391841 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC6A2... {November 17, 2007 10:37:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:38:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
| HGNCid = 11048
| Symbol = SLC6A2
| AltSymbols =; NAT1; NET; NET1; SLC6A5
| OMIM = 163970
| ECnumber =
| Homologene = 816
| MGIid = 1270850
| GeneAtlas_image1 = PBB_GE_SLC6A2_210353_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC6A2_216611_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC6A2_217621_at_tn.png
| Function = {{GNF_GO|id=GO:0005328 |text = neurotransmitter:sodium symporter activity}} {{GNF_GO|id=GO:0005334 |text = norephinephrine:sodium symporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008504 |text = monoamine transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006836 |text = neurotransmitter transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0015844 |text = monoamine transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6530
| Hs_Ensembl = ENSG00000103546
| Hs_RefseqProtein = NP_001034
| Hs_RefseqmRNA = NM_001043
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 54248057
| Hs_GenLoc_end = 54296685
| Hs_Uniprot = P23975
| Mm_EntrezGene = 20538
| Mm_Ensembl = ENSMUSG00000055368
| Mm_RefseqmRNA = NM_009209
| Mm_RefseqProtein = NP_033235
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 95850358
| Mm_GenLoc_end = 95890795
| Mm_Uniprot = Q6NZB4
}}
}}
'''Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2''', also known as '''SLC6A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6530| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Eisenhofer G |title=The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. |journal=Pharmacol. Ther. |volume=91 |issue= 1 |pages= 35-62 |year= 2001 |pmid= 11707293 |doi= }}
*{{cite journal | author=Pacholczyk T, Blakely RD, Amara SG |title=Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. |journal=Nature |volume=350 |issue= 6316 |pages= 350-4 |year= 1991 |pmid= 2008212 |doi= 10.1038/350350a0 }}
*{{cite journal | author=Pörzgen P, Bönisch H, Brüss M |title=Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. |journal=Biochem. Biophys. Res. Commun. |volume=215 |issue= 3 |pages= 1145-50 |year= 1995 |pmid= 7488042 |doi= 10.1006/bbrc.1995.2582 }}
*{{cite journal | author=Gelernter J, Kruger S, Pakstis AJ, ''et al.'' |title=Assignment of the norepinephrine transporter protein (NET1) locus to chromosome 16. |journal=Genomics |volume=18 |issue= 3 |pages= 690-2 |year= 1994 |pmid= 7905857 |doi= }}
*{{cite journal | author=Brüss M, Kunz J, Lingen B, Bönisch H |title=Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 278-80 |year= 1993 |pmid= 8478011 |doi= }}
*{{cite journal | author=Pörzgen P, Bönisch H, Hammermann R, Brüss M |title=The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. |journal=Biochim. Biophys. Acta |volume=1398 |issue= 3 |pages= 365-70 |year= 1998 |pmid= 9655936 |doi= }}
*{{cite journal | author=Apparsundaram S, Schroeter S, Giovanetti E, Blakely RD |title=Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. |journal=J. Pharmacol. Exp. Ther. |volume=287 |issue= 2 |pages= 744-51 |year= 1998 |pmid= 9808705 |doi= }}
*{{cite journal | author=Kim CH, Kim HS, Cubells JF, Kim KS |title=A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6507-18 |year= 1999 |pmid= 10037744 |doi= }}
*{{cite journal | author=Shannon JR, Flattem NL, Jordan J, ''et al.'' |title=Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. |journal=N. Engl. J. Med. |volume=342 |issue= 8 |pages= 541-9 |year= 2000 |pmid= 10684912 |doi= }}
*{{cite journal | author=Torres GE, Yao WD, Mohn AR, ''et al.'' |title=Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. |journal=Neuron |volume=30 |issue= 1 |pages= 121-34 |year= 2001 |pmid= 11343649 |doi= }}
*{{cite journal | author=Gu HH, Wu X, Giros B, ''et al.'' |title=The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells. |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3797-807 |year= 2002 |pmid= 11739781 |doi= }}
*{{cite journal | author=Paczkowski FA, Bryan-Lluka LJ |title=Tyrosine residue 271 of the norepinephrine transporter is an important determinant of its pharmacology. |journal=Brain Res. Mol. Brain Res. |volume=97 |issue= 1 |pages= 32-42 |year= 2002 |pmid= 11744160 |doi= }}
*{{cite journal | author=Paczkowski FA, Bönisch H, Bryan-Lluka LJ |title=Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter. |journal=Pharmacogenetics |volume=12 |issue= 2 |pages= 165-73 |year= 2002 |pmid= 11875370 |doi= }}
*{{cite journal | author=Barr CL, Kroft J, Feng Y, ''et al.'' |title=The norepinephrine transporter gene and attention-deficit hyperactivity disorder. |journal=Am. J. Med. Genet. |volume=114 |issue= 3 |pages= 255-9 |year= 2002 |pmid= 11920844 |doi= }}
*{{cite journal | author=Zill P, Engel R, Baghai TC, ''et al.'' |title=Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. |journal=Neuropsychopharmacology |volume=26 |issue= 4 |pages= 489-93 |year= 2002 |pmid= 11927173 |doi= 10.1016/S0893-133X(01)00386-4 }}
*{{cite journal | author=Leszczyńska-Rodziewicz A, Czerski PM, Kapelski P, ''et al.'' |title=A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. |journal=Neuropsychobiology |volume=45 |issue= 4 |pages= 182-5 |year= 2002 |pmid= 12097806 |doi= }}
*{{cite journal | author=Bauman PA, Blakely RD |title=Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity. |journal=Arch. Biochem. Biophys. |volume=404 |issue= 1 |pages= 80-91 |year= 2002 |pmid= 12127072 |doi= }}
*{{cite journal | author=Urwin RE, Bennetts B, Wilcken B, ''et al.'' |title=Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region. |journal=Mol. Psychiatry |volume=7 |issue= 6 |pages= 652-7 |year= 2003 |pmid= 12140790 |doi= 10.1038/sj.mp.4001080 }}
*{{cite journal | author=McEvoy B, Hawi Z, Fitzgerald M, Gill M |title=No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population. |journal=Am. J. Med. Genet. |volume=114 |issue= 6 |pages= 665-6 |year= 2003 |pmid= 12210284 |doi= 10.1002/ajmg.10416 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TAL1... {November 17, 2007 10:39:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:40:05 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T-cell acute lymphocytic leukemia 1
| HGNCid = 11556
| Symbol = TAL1
| AltSymbols =; SCL; TCL5; tal-1
| OMIM = 187040
| ECnumber =
| Homologene = 2400
| MGIid = 98480
| GeneAtlas_image1 = PBB_GE_TAL1_206283_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAL1_216925_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6886
| Hs_Ensembl = ENSG00000162367
| Hs_RefseqProtein = NP_003180
| Hs_RefseqmRNA = NM_003189
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 47454550
| Hs_GenLoc_end = 47469974
| Hs_Uniprot = P17542
| Mm_EntrezGene = 21349
| Mm_Ensembl = ENSMUSG00000028717
| Mm_RefseqmRNA = NM_011527
| Mm_RefseqProtein = NP_035657
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 114554358
| Mm_GenLoc_end = 114569687
| Mm_Uniprot = Q3TZH7
}}
}}
'''T-cell acute lymphocytic leukemia 1''', also known as '''TAL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6886| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Green AR, Begley CG |title=SCL and related hemopoietic helix-loop-helix transcription factors. |journal=Int. J. Cell Cloning |volume=10 |issue= 5 |pages= 269-76 |year= 1993 |pmid= 1453013 |doi= }}
*{{cite journal | author=Aplan PD, Lombardi DP, Reaman GH, ''et al.'' |title=Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia. |journal=Blood |volume=79 |issue= 5 |pages= 1327-33 |year= 1992 |pmid= 1311214 |doi= }}
*{{cite journal | author=Aplan PD, Nakahara K, Orkin SH, Kirsch IR |title=The SCL gene product: a positive regulator of erythroid differentiation. |journal=EMBO J. |volume=11 |issue= 11 |pages= 4073-81 |year= 1992 |pmid= 1396592 |doi= }}
*{{cite journal | author=Goldfarb AN, Goueli S, Mickelson D, Greenberg JM |title=T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein. |journal=Blood |volume=80 |issue= 11 |pages= 2858-66 |year= 1992 |pmid= 1450410 |doi= }}
*{{cite journal | author=Bernard O, Lecointe N, Jonveaux P, ''et al.'' |title=Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene. |journal=Oncogene |volume=6 |issue= 8 |pages= 1477-88 |year= 1991 |pmid= 1886719 |doi= }}
*{{cite journal | author=Bernard O, Guglielmi P, Jonveaux P, ''et al.'' |title=Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias. |journal=Genes Chromosomes Cancer |volume=1 |issue= 3 |pages= 194-208 |year= 1991 |pmid= 1964581 |doi= }}
*{{cite journal | author=Chen Q, Yang CY, Tsan JT, ''et al.'' |title=Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. |journal=J. Exp. Med. |volume=172 |issue= 5 |pages= 1403-8 |year= 1990 |pmid= 2230650 |doi= }}
*{{cite journal | author=Aplan PD, Begley CG, Bertness V, ''et al.'' |title=The SCL gene is formed from a transcriptionally complex locus. |journal=Mol. Cell. Biol. |volume=10 |issue= 12 |pages= 6426-35 |year= 1991 |pmid= 2247063 |doi= }}
*{{cite journal | author=Chen Q, Cheng JT, Tasi LH, ''et al.'' |title=The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. |journal=EMBO J. |volume=9 |issue= 2 |pages= 415-24 |year= 1990 |pmid= 2303035 |doi= }}
*{{cite journal | author=Begley CG, Aplan PD, Denning SM, ''et al.'' |title=The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 10128-32 |year= 1990 |pmid= 2602361 |doi= }}
*{{cite journal | author=Finger LR, Kagan J, Christopher G, ''et al.'' |title=Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 13 |pages= 5039-43 |year= 1989 |pmid= 2740341 |doi= }}
*{{cite journal | author=Osada H, Grutz G, Axelson H, ''et al.'' |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585-9 |year= 1995 |pmid= 7568177 |doi= }}
*{{cite journal | author=Pulford K, Lecointe N, Leroy-Viard K, ''et al.'' |title=Expression of TAL-1 proteins in human tissues. |journal=Blood |volume=85 |issue= 3 |pages= 675-84 |year= 1995 |pmid= 7833471 |doi= }}
*{{cite journal | author=Wadman I, Li J, Bash RO, ''et al.'' |title=Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. |journal=EMBO J. |volume=13 |issue= 20 |pages= 4831-9 |year= 1994 |pmid= 7957052 |doi= }}
*{{cite journal | author=Valge-Archer VE, Osada H, Warren AJ, ''et al.'' |title=The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 18 |pages= 8617-21 |year= 1994 |pmid= 8078932 |doi= }}
*{{cite journal | author=Cross MA, Heyworth CM, Murrell AM, ''et al.'' |title=Expression of lineage restricted transcription factors precedes lineage specific differentiation in a multipotent haemopoietic progenitor cell line. |journal=Oncogene |volume=9 |issue= 10 |pages= 3013-6 |year= 1994 |pmid= 8084606 |doi= }}
*{{cite journal | author=Hsu HL, Wadman I, Baer R |title=Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3181-5 |year= 1994 |pmid= 8159721 |doi= }}
*{{cite journal | author=Hwang LY, Siegelman M, Davis L, ''et al.'' |title=Expression of the TAL1 proto-oncogene in cultured endothelial cells and blood vessels of the spleen. |journal=Oncogene |volume=8 |issue= 11 |pages= 3043-6 |year= 1993 |pmid= 8414504 |doi= }}
*{{cite journal | author=Cheng JT, Cobb MH, Baer R |title=Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. |journal=Mol. Cell. Biol. |volume=13 |issue= 2 |pages= 801-8 |year= 1993 |pmid= 8423803 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFRSF11A... {November 17, 2007 10:41:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:41:44 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tumor necrosis factor receptor superfamily, member 11a, NFKB activator
| HGNCid = 11908
| Symbol = TNFRSF11A
| AltSymbols =; CD265; ODFR; OFE; RANK; TRANCER
| OMIM = 603499
| ECnumber =
| Homologene = 2848
| MGIid = 1314891
| GeneAtlas_image1 = PBB_GE_TNFRSF11A_207037_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0048535 |text = lymph node development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8792
| Hs_Ensembl = ENSG00000141655
| Hs_RefseqProtein = NP_003830
| Hs_RefseqmRNA = NM_003839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 58143500
| Hs_GenLoc_end = 58205872
| Hs_Uniprot = Q9Y6Q6
| Mm_EntrezGene = 21934
| Mm_Ensembl = ENSMUSG00000026321
| Mm_RefseqmRNA = NM_009399
| Mm_RefseqProtein = NP_033425
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 107608270
| Mm_GenLoc_end = 107672751
| Mm_Uniprot = O35305
}}
}}
'''Tumor necrosis factor receptor superfamily, member 11a, NFKB activator''', also known as '''TNFRSF11A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8792| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Studies of the mouse counterpart suggest that this receptor directly mediates the osteoprotegerin ligand (OPGL)-induced osteoclastogenesis in osteoclast precursor cells.<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8792| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Romas E, Gillespie MT, Martin TJ |title=Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. |journal=Bone |volume=30 |issue= 2 |pages= 340-6 |year= 2002 |pmid= 11856640 |doi= }}
*{{cite journal | author=Collin-Osdoby P |title=Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. |journal=Circ. Res. |volume=95 |issue= 11 |pages= 1046-57 |year= 2005 |pmid= 15564564 |doi= 10.1161/01.RES.0000149165.99974.12 }}
*{{cite journal | author=Clohisy DR, Mantyh PW |title=Bone cancer pain and the role of RANKL/OPG. |journal=Journal of musculoskeletal & neuronal interactions |volume=4 |issue= 3 |pages= 293-300 |year= 2005 |pmid= 15615497 |doi= }}
*{{cite journal | author=Anandarajah AP, Schwarz EM |title=Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 226-32 |year= 2006 |pmid= 16240334 |doi= 10.1002/jcb.20674 }}
*{{cite journal | author=Baud'huin M, Duplomb L, Ruiz Velasco C, ''et al.'' |title=Key roles of the OPG-RANK-RANKL system in bone oncology. |journal=Expert Rev Anticancer Ther |volume=7 |issue= 2 |pages= 221-32 |year= 2007 |pmid= 17288531 |doi= 10.1586/14737140.7.2.221 }}
*{{cite journal | author=Boyce BF, Xing L |title=Biology of RANK, RANKL, and osteoprotegerin. |journal=Arthritis Res. Ther. |volume=9 Suppl 1 |issue= |pages= S1 |year= 2007 |pmid= 17634140 |doi= 10.1186/ar2165 }}
*{{cite journal | author=Hughes AE, Shearman AM, Weber JL, ''et al.'' |title=Genetic linkage of familial expansile osteolysis to chromosome 18q. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 359-61 |year= 1994 |pmid= 7911698 |doi= }}
*{{cite journal | author=Cody JD, Singer FR, Roodman GD, ''et al.'' |title=Genetic linkage of Paget disease of the bone to chromosome 18q. |journal=Am. J. Hum. Genet. |volume=61 |issue= 5 |pages= 1117-22 |year= 1997 |pmid= 9345096 |doi= }}
*{{cite journal | author=Anderson DM, Maraskovsky E, Billingsley WL, ''et al.'' |title=A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. |journal=Nature |volume=390 |issue= 6656 |pages= 175-9 |year= 1997 |pmid= 9367155 |doi= 10.1038/36593 }}
*{{cite journal | author=Haslam SI, Van Hul W, Morales-Piga A, ''et al.'' |title=Paget's disease of bone: evidence for a susceptibility locus on chromosome 18q and for genetic heterogeneity. |journal=J. Bone Miner. Res. |volume=13 |issue= 6 |pages= 911-7 |year= 1998 |pmid= 9626621 |doi= }}
*{{cite journal | author=Darnay BG, Haridas V, Ni J, ''et al.'' |title=Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=273 |issue= 32 |pages= 20551-5 |year= 1998 |pmid= 9685412 |doi= }}
*{{cite journal | author=Wong BR, Josien R, Lee SY, ''et al.'' |title=The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28355-9 |year= 1998 |pmid= 9774460 |doi= }}
*{{cite journal | author=Galibert L, Tometsko ME, Anderson DM, ''et al.'' |title=The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34120-7 |year= 1999 |pmid= 9852070 |doi= }}
*{{cite journal | author=Nakagawa N, Kinosaki M, Yamaguchi K, ''et al.'' |title=RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 395-400 |year= 1999 |pmid= 9878548 |doi= 10.1006/bbrc.1998.9788 }}
*{{cite journal | author=Kim HH, Lee DE, Shin JN, ''et al.'' |title=Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase. |journal=FEBS Lett. |volume=443 |issue= 3 |pages= 297-302 |year= 1999 |pmid= 10025951 |doi= }}
*{{cite journal | author=Darnay BG, Ni J, Moore PA, Aggarwal BB |title=Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7724-31 |year= 1999 |pmid= 10075662 |doi= }}
*{{cite journal | author=Hsu H, Lacey DL, Dunstan CR, ''et al.'' |title=Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3540-5 |year= 1999 |pmid= 10097072 |doi= }}
*{{cite journal | author=Dougall WC, Glaccum M, Charrier K, ''et al.'' |title=RANK is essential for osteoclast and lymph node development. |journal=Genes Dev. |volume=13 |issue= 18 |pages= 2412-24 |year= 1999 |pmid= 10500098 |doi= }}
*{{cite journal | author=Hughes AE, Ralston SH, Marken J, ''et al.'' |title=Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. |journal=Nat. Genet. |volume=24 |issue= 1 |pages= 45-8 |year= 2000 |pmid= 10615125 |doi= 10.1038/71667 }}
*{{cite journal | author=Wong BR, Besser D, Kim N, ''et al.'' |title=TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. |journal=Mol. Cell |volume=4 |issue= 6 |pages= 1041-9 |year= 2000 |pmid= 10635328 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TYK2... {November 17, 2007 10:40:05 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:40:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tyrosine kinase 2
| HGNCid = 12440
| Symbol = TYK2
| AltSymbols =; JTK1
| OMIM = 176941
| ECnumber =
| Homologene = 20712
| MGIid = 1929470
| GeneAtlas_image1 = PBB_GE_TYK2_205546_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004715 |text = non-membrane spanning protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004718 |text = Janus kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7297
| Hs_Ensembl = ENSG00000105397
| Hs_RefseqProtein = NP_003322
| Hs_RefseqmRNA = NM_003331
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 10322205
| Hs_GenLoc_end = 10350114
| Hs_Uniprot = P29597
| Mm_EntrezGene = 54721
| Mm_Ensembl = ENSMUSG00000032175
| Mm_RefseqmRNA = NM_018793
| Mm_RefseqProtein = NP_061263
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 20854476
| Mm_GenLoc_end = 20881612
| Mm_Uniprot = Q2M4G5
}}
}}
'''Tyrosine kinase 2''', also known as '''TYK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TYK2 tyrosine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7297| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Velazquez L, Fellous M, Stark GR, Pellegrini S |title=A protein tyrosine kinase in the interferon alpha/beta signaling pathway. |journal=Cell |volume=70 |issue= 2 |pages= 313-22 |year= 1992 |pmid= 1386289 |doi= }}
*{{cite journal | author=Krolewski JJ, Lee R, Eddy R, ''et al.'' |title=Identification and chromosomal mapping of new human tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 3 |pages= 277-82 |year= 1990 |pmid= 2156206 |doi= }}
*{{cite journal | author=Firmbach-Kraft I, Byers M, Shows T, ''et al.'' |title=tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. |journal=Oncogene |volume=5 |issue= 9 |pages= 1329-36 |year= 1990 |pmid= 2216457 |doi= }}
*{{cite journal | author=Partanen J, Mäkelä TP, Alitalo R, ''et al.'' |title=Putative tyrosine kinases expressed in K-562 human leukemia cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 22 |pages= 8913-7 |year= 1991 |pmid= 2247464 |doi= }}
*{{cite journal | author=Colamonici O, Yan H, Domanski P, ''et al.'' |title=Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8133-42 |year= 1994 |pmid= 7526154 |doi= }}
*{{cite journal | author=Novak U, Harpur AG, Paradiso L, ''et al.'' |title=Colony-stimulating factor 1-induced STAT1 and STAT3 activation is accompanied by phosphorylation of Tyk2 in macrophages and Tyk2 and JAK1 in fibroblasts. |journal=Blood |volume=86 |issue= 8 |pages= 2948-56 |year= 1995 |pmid= 7579387 |doi= }}
*{{cite journal | author=Domanski P, Yan H, Witte MM, ''et al.'' |title=Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase. |journal=FEBS Lett. |volume=374 |issue= 3 |pages= 317-22 |year= 1995 |pmid= 7589562 |doi= }}
*{{cite journal | author=Yetter A, Uddin S, Krolewski JJ, ''et al.'' |title=Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic cell phosphatase. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18179-82 |year= 1995 |pmid= 7629131 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Trask B, Fertitta A, Christensen M, ''et al.'' |title=Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers. |journal=Genomics |volume=15 |issue= 1 |pages= 133-45 |year= 1993 |pmid= 8432525 |doi= }}
*{{cite journal | author=Platanias LC, Uddin S, Yetter A, ''et al.'' |title=The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 278-82 |year= 1996 |pmid= 8550573 |doi= }}
*{{cite journal | author=Gauzzi MC, Velazquez L, McKendry R, ''et al.'' |title=Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20494-500 |year= 1996 |pmid= 8702790 |doi= }}
*{{cite journal | author=Uddin S, Gardziola C, Dangat A, ''et al.'' |title=Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 833-8 |year= 1996 |pmid= 8780698 |doi= 10.1006/bbrc.1996.1259 }}
*{{cite journal | author=Zou J, Presky DH, Wu CY, Gubler U |title=Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 6073-7 |year= 1997 |pmid= 9038232 |doi= }}
*{{cite journal | author=Miyakawa Y, Oda A, Druker BJ, ''et al.'' |title=Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. |journal=Blood |volume=89 |issue= 8 |pages= 2789-98 |year= 1997 |pmid= 9108397 |doi= }}
*{{cite journal | author=Uddin S, Sher DA, Alsayed Y, ''et al.'' |title=Interaction of p59fyn with interferon-activated Jak kinases. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 83-8 |year= 1997 |pmid= 9196040 |doi= 10.1006/bbrc.1997.6741 }}
*{{cite journal | author=Burfoot MS, Rogers NC, Watling D, ''et al.'' |title=Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24183-90 |year= 1997 |pmid= 9305869 |doi= }}
*{{cite journal | author=Gauzzi MC, Barbieri G, Richter MF, ''et al.'' |title=The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 22 |pages= 11839-44 |year= 1997 |pmid= 9342324 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Ahmad S, Alsayed YM, Druker BJ, Platanias LC |title=The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 29991-4 |year= 1997 |pmid= 9374471 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VAMP2... {November 17, 2007 10:39:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 17, 2007 10:39:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_VAMP2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}, {{PDB2|1n7s}}, {{PDB2|1sfc}}
| Name = Vesicle-associated membrane protein 2 (synaptobrevin 2)
| HGNCid = 12643
| Symbol = VAMP2
| AltSymbols =; FLJ11460; SYB2; VAMP-2
| OMIM = 185881
| ECnumber =
| Homologene = 7591
| MGIid = 1313277
| GeneAtlas_image1 = PBB_GE_VAMP2_201556_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VAMP2_201557_at_tn.png
| GeneAtlas_image3 = PBB_GE_VAMP2_214792_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000149 |text = SNARE binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0030141 |text = secretory granule}} {{GNF_GO|id=GO:0030672 |text = synaptic vesicle membrane}} {{GNF_GO|id=GO:0042589 |text = zymogen granule membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0016079 |text = synaptic vesicle exocytosis}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0017156 |text = calcium ion-dependent exocytosis}} {{GNF_GO|id=GO:0017157 |text = regulation of exocytosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6844
| Hs_Ensembl = ENSG00000179036
| Hs_RefseqProtein = NP_055047
| Hs_RefseqmRNA = NM_014232
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 8003189
| Hs_GenLoc_end = 8007017
| Hs_Uniprot = P63027
| Mm_EntrezGene = 22318
| Mm_Ensembl = ENSMUSG00000020894
| Mm_RefseqmRNA = NM_009497
| Mm_RefseqProtein = NP_033523
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 68904705
| Mm_GenLoc_end = 68908573
| Mm_Uniprot = O35619
}}
}}
'''Vesicle-associated membrane protein 2 (synaptobrevin 2)''', also known as '''VAMP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6844| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6844| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Archer BT, Ozçelik T, Jahn R, ''et al.'' |title=Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. |journal=J. Biol. Chem. |volume=265 |issue= 28 |pages= 17267-73 |year= 1990 |pmid= 1976629 |doi= }}
*{{cite journal | author=Brumell JH, Volchuk A, Sengelov H, ''et al.'' |title=Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments. |journal=J. Immunol. |volume=155 |issue= 12 |pages= 5750-9 |year= 1996 |pmid= 7499863 |doi= }}
*{{cite journal | author=Kutay U, Ahnert-Hilger G, Hartmann E, ''et al.'' |title=Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. |journal=EMBO J. |volume=14 |issue= 2 |pages= 217-23 |year= 1995 |pmid= 7835332 |doi= }}
*{{cite journal | author=Chapman ER, An S, Barton N, Jahn R |title=SNAP-25, a t-SNARE which binds to both syntaxin and synaptobrevin via domains that may form coiled coils. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27427-32 |year= 1994 |pmid= 7961655 |doi= }}
*{{cite journal | author=Hunt JM, Bommert K, Charlton MP, ''et al.'' |title=A post-docking role for synaptobrevin in synaptic vesicle fusion. |journal=Neuron |volume=12 |issue= 6 |pages= 1269-79 |year= 1994 |pmid= 8011337 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Jagadish MN, Fernandez CS, Hewish DR, ''et al.'' |title=Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. |journal=Biochem. J. |volume=317 ( Pt 3) |issue= |pages= 945-54 |year= 1996 |pmid= 8760387 |doi= }}
*{{cite journal | author=Mandon B, Chou CL, Nielsen S, Knepper MA |title=Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking. |journal=J. Clin. Invest. |volume=98 |issue= 4 |pages= 906-13 |year= 1996 |pmid= 8770861 |doi= }}
*{{cite journal | author=Timmers KI, Clark AE, Omatsu-Kanbe M, ''et al.'' |title=Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. |journal=Biochem. J. |volume=320 ( Pt 2) |issue= |pages= 429-36 |year= 1997 |pmid= 8973549 |doi= }}
*{{cite journal | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520-6 |year= 1997 |pmid= 8999968 |doi= }}
*{{cite journal | author=Hao JC, Salem N, Peng XR, ''et al.'' |title=Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes. |journal=J. Neurosci. |volume=17 |issue= 5 |pages= 1596-603 |year= 1997 |pmid= 9030619 |doi= }}
*{{cite journal | author=Martincic I, Peralta ME, Ngsee JK |title=Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 26991-8 |year= 1997 |pmid= 9341137 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Weir ML, Klip A, Trimble WS |title=Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. |journal=Biochem. J. |volume=333 ( Pt 2) |issue= |pages= 247-51 |year= 1998 |pmid= 9657962 |doi= }}
*{{cite journal | author=Isenmann S, Khew-Goodall Y, Gamble J, ''et al.'' |title=A splice-isoform of vesicle-associated membrane protein-1 (VAMP-1) contains a mitochondrial targeting signal. |journal=Mol. Biol. Cell |volume=9 |issue= 7 |pages= 1649-60 |year= 1999 |pmid= 9658161 |doi= }}
*{{cite journal | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957-71 |year= 1998 |pmid= 9817754 |doi= }}
*{{cite journal | author=Nishimura Y, Hayashi M, Inada H, Tanaka T |title=Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 1 |pages= 21-6 |year= 1999 |pmid= 9920726 |doi= 10.1006/bbrc.1998.9876 }}
*{{cite journal | author=Valdez AC, Cabaniols JP, Brown MJ, Roche PA |title=Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. |journal=J. Cell. Sci. |volume=112 ( Pt 6) |issue= |pages= 845-54 |year= 1999 |pmid= 10036234 |doi= }}
*{{cite journal | author=Margittai M, Otto H, Jahn R |title=A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains. |journal=FEBS Lett. |volume=446 |issue= 1 |pages= 40-4 |year= 1999 |pmid= 10100611 |doi= }}
*{{cite journal | author=Fasshauer D, Antonin W, Margittai M, ''et al.'' |title=Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15440-6 |year= 1999 |pmid= 10336434 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
