Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 19:24, 4 November 2007 (UTC)
[edit]Proteins without matches (16)
[edit]Proteins with a High Potential Match (8)
[edit]Redirected Proteins (1)
[edit]Manual Inspection (Page not found) (21)
[edit]
Protein Status Grid - Date: 19:24, 4 November 2007 (UTC)
[edit]Vebose Log - Date: 19:24, 4 November 2007 (UTC)
[edit]- INFO: Beginning work on CCNA2... {November 4, 2007 10:56:50 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCNA2 image.jpg {November 4, 2007 10:57:42 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 10:57:56 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCNA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e9h.
| PDB = {{PDB2|1e9h}}, {{PDB2|1fin}}, {{PDB2|1fvv}}, {{PDB2|1gy3}}, {{PDB2|1h1p}}, {{PDB2|1h1q}}, {{PDB2|1h1r}}, {{PDB2|1h1s}}, {{PDB2|1h24}}, {{PDB2|1h25}}, {{PDB2|1h26}}, {{PDB2|1h27}}, {{PDB2|1h28}}, {{PDB2|1jst}}, {{PDB2|1jsu}}, {{PDB2|1ogu}}, {{PDB2|1oi9}}, {{PDB2|1oiu}}, {{PDB2|1oiy}}, {{PDB2|1okv}}, {{PDB2|1okw}}, {{PDB2|1ol1}}, {{PDB2|1ol2}}, {{PDB2|1p5e}}, {{PDB2|1pkd}}, {{PDB2|1qmz}}, {{PDB2|1urc}}, {{PDB2|1vin}}, {{PDB2|1vyw}}, {{PDB2|2bkz}}, {{PDB2|2bpm}}, {{PDB2|2c4g}}, {{PDB2|2c5n}}, {{PDB2|2c5o}}, {{PDB2|2c5p}}, {{PDB2|2c5v}}, {{PDB2|2c5x}}, {{PDB2|2c6t}}, {{PDB2|2cch}}, {{PDB2|2cci}}, {{PDB2|2cjm}}, {{PDB2|2g9x}}, {{PDB2|2i40}}, {{PDB2|2iw6}}, {{PDB2|2iw8}}, {{PDB2|2iw9}}, {{PDB2|2uue}}
| Name = Cyclin A2
| HGNCid = 1578
| Symbol = CCNA2
| AltSymbols =; CCN1; CCNA
| OMIM = 123835
| ECnumber =
| Homologene = 55562
| MGIid = 108069
| GeneAtlas_image1 = PBB_GE_CCNA2_203418_at_tn.png
| GeneAtlas_image2 = PBB_GE_CCNA2_213226_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0001939 |text = female pronucleus}} {{GNF_GO|id=GO:0001940 |text = male pronucleus}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007095 |text = mitotic cell cycle G2/M transition DNA damage checkpoint}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 890
| Hs_Ensembl = ENSG00000145386
| Hs_RefseqProtein = NP_001228
| Hs_RefseqmRNA = NM_001237
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 122958002
| Hs_GenLoc_end = 122964505
| Hs_Uniprot = P20248
| Mm_EntrezGene = 12428
| Mm_Ensembl = ENSMUSG00000027715
| Mm_RefseqmRNA = NM_009828
| Mm_RefseqProtein = NP_033958
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 36756415
| Mm_GenLoc_end = 36763547
| Mm_Uniprot = Q8BRG1
}}
}}
'''Cyclin A2''', also known as '''CCNA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.<ref>{{cite web | title = Entrez Gene: CCNA2 cyclin A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=890| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCR2... {November 4, 2007 10:59:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 10:59:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) receptor 2
| HGNCid = 1603
| Symbol = CCR2
| AltSymbols =; CC-CKR-2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
| OMIM = 601267
| ECnumber =
| Homologene = 537
| MGIid = 106185
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}} {{GNF_GO|id=GO:0031727 |text = CCR2 chemokine receptor binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1231
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000638
| Hs_RefseqmRNA = NM_000647
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 12772
| Mm_Ensembl = ENSMUSG00000049103
| Mm_RefseqmRNA = NM_009915
| Mm_RefseqProtein = NP_034045
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 123954462
| Mm_GenLoc_end = 123957349
| Mm_Uniprot = Q3TRK1
}}
}}
'''Chemokine (C-C motif) receptor 2''', also known as '''CCR2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.<ref>{{cite web | title = Entrez Gene: CCR2 chemokine (C-C motif) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1231| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sozzani S, Introna M, Bernasconi S, ''et al.'' |title=MCP-1 and CCR2 in HIV infection: regulation of agonist and receptor expression. |journal=J. Leukoc. Biol. |volume=62 |issue= 1 |pages= 30-3 |year= 1997 |pmid= 9225989 |doi= }}
*{{cite journal | author=Cunningham AL, Li S, Juarez J, ''et al.'' |title=The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes. |journal=J. Leukoc. Biol. |volume=68 |issue= 3 |pages= 311-7 |year= 2000 |pmid= 10985245 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD46... {November 4, 2007 11:05:53 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CD46 image.jpg {November 4, 2007 11:07:02 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:07:22 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CD46_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ckl.
| PDB = {{PDB2|1ckl}}, {{PDB2|2o39}}
| Name = CD46 molecule, complement regulatory protein
| HGNCid = 6953
| Symbol = CD46
| AltSymbols =; MCP; MGC26544; MIC10; TLX; TRA2.10
| OMIM = 120920
| ECnumber =
| Homologene = 7832
| MGIid = 1203290
| GeneAtlas_image1 = PBB_GE_CD46_208783_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD46_207549_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CD46_211574_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006958 |text = complement activation, classical pathway}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0045087 |text = innate immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4179
| Hs_Ensembl = ENSG00000117335
| Hs_RefseqProtein = NP_002380
| Hs_RefseqmRNA = NM_002389
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 205992025
| Hs_GenLoc_end = 206035481
| Hs_Uniprot = P15529
| Mm_EntrezGene = 17221
| Mm_Ensembl = ENSMUSG00000016493
| Mm_RefseqmRNA = NM_010778
| Mm_RefseqProtein = NP_034908
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 196763073
| Mm_GenLoc_end = 196792949
| Mm_Uniprot = O88174
}}
}}
'''CD46 molecule, complement regulatory protein''', also known as '''CD46''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: CD46 CD46 molecule, complement regulatory protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4179| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CEBPA... {November 4, 2007 10:57:57 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 10:58:10 AM PST}
- SEARCH REDIRECT: Control Box Found: CEBPB {November 4, 2007 10:58:21 AM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 4, 2007 10:58:22 AM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 4, 2007 10:58:22 AM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 4, 2007 10:58:22 AM PST}
- UPDATED: Updated protein page: CEBPB {November 4, 2007 10:58:27 AM PST}
- INFO: Beginning work on CHUK... {November 4, 2007 10:58:27 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 10:58:57 AM PST}
- CREATED: Created new protein page: CHUK {November 4, 2007 10:59:04 AM PST}
- INFO: Beginning work on CXCR3... {November 4, 2007 11:02:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:04:06 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-X-C motif) receptor 3
| HGNCid = 4540
| Symbol = CXCR3
| AltSymbols =; CD182; CD183; CKR-L2; CMKAR3; GPR9; IP10; IP10-R; Mig-R; MigR
| OMIM = 300574
| ECnumber =
| Homologene = 1153
| MGIid = 1277207
| GeneAtlas_image1 = PBB_GE_CXCR3_207681_at_tn.png
| GeneAtlas_image2 = PBB_GE_CXCR3_217119_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}} {{GNF_GO|id=GO:0016494 |text = C-X-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2833
| Hs_Ensembl = ENSG00000186810
| Hs_RefseqProtein = NP_001495
| Hs_RefseqmRNA = NM_001504
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 70752491
| Hs_GenLoc_end = 70755092
| Hs_Uniprot = P49682
| Mm_EntrezGene = 12766
| Mm_Ensembl = ENSMUSG00000050232
| Mm_RefseqmRNA = NM_009910
| Mm_RefseqProtein = NP_034040
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 97934255
| Mm_GenLoc_end = 97936866
| Mm_Uniprot = O88410
}}
}}
'''Chemokine (C-X-C motif) receptor 3''', also known as '''CXCR3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Historically, CD183 is the third CXC chemokine receptor discovered and, therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. Therefore, CD183 is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases.<ref>{{cite web | title = Entrez Gene: CXCR3 chemokine (C-X-C motif) receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2833| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ENG... {November 4, 2007 10:59:50 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:01:04 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Endoglin (Osler-Rendu-Weber syndrome 1)
| HGNCid = 3349
| Symbol = ENG
| AltSymbols =; CD105; END; FLJ41744; HHT1; ORW; ORW1
| OMIM = 131195
| ECnumber =
| Homologene = 92
| MGIid = 95392
| GeneAtlas_image1 = PBB_GE_ENG_201809_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ENG_201808_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008015 |text = circulation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0017015 |text = regulation of transforming growth factor beta receptor signaling pathway}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2022
| Hs_Ensembl = ENSG00000106991
| Hs_RefseqProtein = NP_000109
| Hs_RefseqmRNA = NM_000118
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 129617112
| Hs_GenLoc_end = 129656856
| Hs_Uniprot = P17813
| Mm_EntrezGene = 13805
| Mm_Ensembl = ENSMUSG00000026814
| Mm_RefseqmRNA = NM_007932
| Mm_RefseqProtein = NP_031958
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 32468604
| Mm_GenLoc_end = 32504127
| Mm_Uniprot = Q3UAM9
}}
}}
'''Endoglin (Osler-Rendu-Weber syndrome 1)''', also known as '''ENG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia.<ref>{{cite web | title = Entrez Gene: ENG endoglin (Osler-Rendu-Weber syndrome 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2022| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Attisano L, Wrana JL |title=Signal transduction by members of the transforming growth factor-beta superfamily. |journal=Cytokine Growth Factor Rev. |volume=7 |issue= 4 |pages= 327-39 |year= 1997 |pmid= 9023056 |doi= }}
*{{cite journal | author=Miyazono K |title=TGF-beta receptors and signal transduction. |journal=Int. J. Hematol. |volume=65 |issue= 2 |pages= 97-104 |year= 1997 |pmid= 9071813 |doi= }}
*{{cite journal | author=Fonsatti E, Altomonte M, Nicotra MR, ''et al.'' |title=Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. |journal=Oncogene |volume=22 |issue= 42 |pages= 6557-63 |year= 2003 |pmid= 14528280 |doi= 10.1038/sj.onc.1206813 }}
*{{cite journal | author=Luft FC |title=Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia molecule. |journal=Nephrol. Dial. Transplant. |volume=21 |issue= 11 |pages= 3052-4 |year= 2007 |pmid= 16870672 |doi= 10.1093/ndt/gfl439 }}
*{{cite journal | author=López-Novoa JM |title=Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia. |journal=Nephrol. Dial. Transplant. |volume=22 |issue= 3 |pages= 712-4 |year= 2007 |pmid= 17210583 |doi= 10.1093/ndt/gfl768 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on F2RL1... {November 4, 2007 11:01:04 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:02:07 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Coagulation factor II (thrombin) receptor-like 1
| HGNCid = 3538
| Symbol = F2RL1
| AltSymbols =; GPR11; PAR2
| OMIM = 600933
| ECnumber =
| Homologene = 21087
| MGIid = 101910
| GeneAtlas_image1 = PBB_GE_F2RL1_206429_at_tn.png
| GeneAtlas_image2 = PBB_GE_F2RL1_213506_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0015057 |text = thrombin receptor activity}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2150
| Hs_Ensembl = ENSG00000164251
| Hs_RefseqProtein = NP_005233
| Hs_RefseqmRNA = NM_005242
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 76150610
| Hs_GenLoc_end = 76166895
| Hs_Uniprot = P55085
| Mm_EntrezGene = 14063
| Mm_Ensembl = ENSMUSG00000021678
| Mm_RefseqmRNA = NM_007974
| Mm_RefseqProtein = NP_032000
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 96612414
| Mm_GenLoc_end = 96625917
| Mm_Uniprot = Q3TU81
}}
}}
'''Coagulation factor II (thrombin) receptor-like 1''', also known as '''F2RL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.<ref>{{cite web | title = Entrez Gene: F2RL1 coagulation factor II (thrombin) receptor-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2150| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kunzelmann K, Schreiber R, König J, Mall M |title=Ion transport induced by proteinase-activated receptors (PAR2) in colon and airways. |journal=Cell Biochem. Biophys. |volume=36 |issue= 2-3 |pages= 209-14 |year= 2003 |pmid= 12139406 |doi= }}
*{{cite journal | author=Kawabata A |title=PAR-2: structure, function and relevance to human diseases of the gastric mucosa. |journal=Expert reviews in molecular medicine |volume=4 |issue= 16 |pages= 1-17 |year= 2004 |pmid= 14585156 |doi= doi:10.1017/S1462399402004799 }}
*{{cite journal | author=Bushell T |title=The emergence of proteinase-activated receptor-2 as a novel target for the treatment of inflammation-related CNS disorders. |journal=J. Physiol. (Lond.) |volume=581 |issue= Pt 1 |pages= 7-16 |year= 2007 |pmid= 17347265 |doi= 10.1113/jphysiol.2007.129577 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on G6PD... {November 4, 2007 11:02:07 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein G6PD image.jpg {November 4, 2007 11:02:38 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:02:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_G6PD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qki.
| PDB = {{PDB2|1qki}}, {{PDB2|2bh9}}, {{PDB2|2bhl}}
| Name = Glucose-6-phosphate dehydrogenase
| HGNCid = 4057
| Symbol = G6PD
| AltSymbols =; G6PD1
| OMIM = 305900
| ECnumber =
| Homologene = 37906
| MGIid = 105979
| GeneAtlas_image1 = PBB_GE_G6PD_202275_at_tn.png
| Function = {{GNF_GO|id=GO:0004345 |text = glucose-6-phosphate dehydrogenase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006006 |text = glucose metabolic process}} {{GNF_GO|id=GO:0006010 |text = glucose 6-phosphate utilization}} {{GNF_GO|id=GO:0006098 |text = pentose-phosphate shunt}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2539
| Hs_Ensembl = ENSG00000160211
| Hs_RefseqProtein = NP_000393
| Hs_RefseqmRNA = NM_000402
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 153412800
| Hs_GenLoc_end = 153428981
| Hs_Uniprot = P11413
| Mm_EntrezGene = 14381
| Mm_Ensembl = ENSMUSG00000031400
| Mm_RefseqmRNA = NM_008062
| Mm_RefseqProtein = NP_032088
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 70662206
| Mm_GenLoc_end = 70681881
| Mm_Uniprot = Q3TNL1
}}
}}
'''Glucose-6-phosphate dehydrogenase''', also known as '''G6PD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: G6PD glucose-6-phosphate dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2539| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Vulliamy T, Beutler E, Luzzatto L |title=Variants of glucose-6-phosphate dehydrogenase are due to missense mutations spread throughout the coding region of the gene. |journal=Hum. Mutat. |volume=2 |issue= 3 |pages= 159-67 |year= 1993 |pmid= 8364584 |doi= 10.1002/humu.1380020302 }}
*{{cite journal | author=Mason PJ |title=New insights into G6PD deficiency. |journal=Br. J. Haematol. |volume=94 |issue= 4 |pages= 585-91 |year= 1996 |pmid= 8826878 |doi= }}
*{{cite journal | author=Wajcman H, Galactéros F |title=[Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents] |journal=C. R. Biol. |volume=327 |issue= 8 |pages= 711-20 |year= 2004 |pmid= 15506519 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HDAC3... {November 4, 2007 11:21:57 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 11:22:33 AM PST}
- CREATED: Created new protein page: HDAC3 {November 4, 2007 11:22:44 AM PST}
- INFO: Beginning work on ITGA6... {November 4, 2007 11:04:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:05:08 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, alpha 6
| HGNCid = 6142
| Symbol = ITGA6
| AltSymbols =; CD49f; ITGA6B; VLA-6
| OMIM = 147556
| ECnumber =
| Homologene = 20091
| MGIid = 96605
| GeneAtlas_image1 = PBB_GE_ITGA6_201656_at_tn.png
| GeneAtlas_image2 = PBB_GE_ITGA6_215177_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0007044 |text = cell-substrate junction assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0046847 |text = filopodium formation}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3655
| Hs_Ensembl = ENSG00000091409
| Hs_RefseqProtein = NP_000201
| Hs_RefseqmRNA = NM_000210
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 173000616
| Hs_GenLoc_end = 173079256
| Hs_Uniprot = P23229
| Mm_EntrezGene = 16403
| Mm_Ensembl = ENSMUSG00000027111
| Mm_RefseqmRNA = NM_008397
| Mm_RefseqProtein = NP_032423
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 71587779
| Mm_GenLoc_end = 71657597
| Mm_Uniprot = Q3TWK2
}}
}}
'''Integrin, alpha 6''', also known as '''ITGA6''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ITGA6 integrin, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lipscomb EA, Mercurio AM |title=Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. |journal=Cancer Metastasis Rev. |volume=24 |issue= 3 |pages= 413-23 |year= 2006 |pmid= 16258729 |doi= 10.1007/s10555-005-5133-4 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LGALS1... {November 4, 2007 11:05:08 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LGALS1 image.jpg {November 4, 2007 11:05:39 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:05:53 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LGALS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gzw.
| PDB = {{PDB2|1gzw}}, {{PDB2|1w6m}}, {{PDB2|1w6n}}, {{PDB2|1w6o}}, {{PDB2|1w6p}}, {{PDB2|1w6q}}
| Name = Lectin, galactoside-binding, soluble, 1 (galectin 1)
| HGNCid = 6561
| Symbol = LGALS1
| AltSymbols =; GBP; DKFZp686E23103
| OMIM = 150570
| ECnumber =
| Homologene = 7399
| MGIid = 96777
| GeneAtlas_image1 = PBB_GE_LGALS1_201105_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0045445 |text = myoblast differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3956
| Hs_Ensembl = ENSG00000100097
| Hs_RefseqProtein = NP_002296
| Hs_RefseqmRNA = NM_002305
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 36401559
| Hs_GenLoc_end = 36405736
| Hs_Uniprot = P09382
| Mm_EntrezGene = 16852
| Mm_Ensembl = ENSMUSG00000068220
| Mm_RefseqmRNA = NM_008495
| Mm_RefseqProtein = NP_032521
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 78753980
| Mm_GenLoc_end = 78757722
| Mm_Uniprot = P16045
}}
}}
'''Lectin, galactoside-binding, soluble, 1 (galectin 1)''', also known as '''LGALS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS1 may act as an autocrine negative growth factor that regulates cell proliferation.<ref>{{cite web | title = Entrez Gene: LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3956| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Barondes SH, Cooper DN, Gitt MA, Leffler H |title=Galectins. Structure and function of a large family of animal lectins. |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 20807-10 |year= 1994 |pmid= 8063692 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MEN1... {November 4, 2007 11:07:22 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:07:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Multiple endocrine neoplasia I
| HGNCid = 7010
| Symbol = MEN1
| AltSymbols =; MEAI; SCG2
| OMIM = 131100
| ECnumber =
| Homologene = 7418
| MGIid = 1316736
| GeneAtlas_image1 = PBB_GE_MEN1_202645_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0032154 |text = cleavage furrow}} {{GNF_GO|id=GO:0035097 |text = histone methyltransferase complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016571 |text = histone methylation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4221
| Hs_Ensembl = ENSG00000133895
| Hs_RefseqProtein = NP_000235
| Hs_RefseqmRNA = NM_000244
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 64327564
| Hs_GenLoc_end = 64335342
| Hs_Uniprot = O00255
| Mm_EntrezGene = 17283
| Mm_Ensembl = ENSMUSG00000024947
| Mm_RefseqmRNA = NM_008583
| Mm_RefseqProtein = NP_032609
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 6335038
| Mm_GenLoc_end = 6340895
| Mm_Uniprot = Q3U491
}}
}}
'''Multiple endocrine neoplasia I''', also known as '''MEN1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the CDS. Five variants where alternative splicing takes place in the 5' UTR have also been identified.<ref>{{cite web | title = Entrez Gene: MEN1 multiple endocrine neoplasia I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4221| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tsukada T, Yamaguchi K, Kameya T |title=The MEN1 gene and associated diseases: an update. |journal=Endocr. Pathol. |volume=12 |issue= 3 |pages= 259-73 |year= 2002 |pmid= 11740047 |doi= }}
*{{cite journal | author=Kong C, Ellard S, Johnston C, Farid NR |title=Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 mutation. |journal=J. Endocrinol. Invest. |volume=24 |issue= 10 |pages= 806-10 |year= 2002 |pmid= 11765051 |doi= }}
*{{cite journal | author=Thakker RV |title=Multiple endocrine neoplasia. |journal=Horm. Res. |volume=56 Suppl 1 |issue= |pages= 67-72 |year= 2002 |pmid= 11786689 |doi= }}
*{{cite journal | author=Stowasser M, Gunasekera TG, Gordon RD |title=Familial varieties of primary aldosteronism. |journal=Clin. Exp. Pharmacol. Physiol. |volume=28 |issue= 12 |pages= 1087-90 |year= 2002 |pmid= 11903322 |doi= }}
*{{cite journal | author=Kameya T, Tsukada T, Yamaguchi K |title=Recent advances in MEN1 gene study for pituitary tumor pathogenesis. |journal=Frontiers of hormone research |volume=32 |issue= |pages= 265-91 |year= 2004 |pmid= 15281352 |doi= }}
*{{cite journal | author=Balogh K, Rácz K, Patócs A, Hunyady L |title=Menin and its interacting proteins: elucidation of menin function. |journal=Trends Endocrinol. Metab. |volume=17 |issue= 9 |pages= 357-64 |year= 2007 |pmid= 16997566 |doi= 10.1016/j.tem.2006.09.004 }}
*{{cite journal | author=Lytras A, Tolis G |title=Growth hormone-secreting tumors: genetic aspects and data from animal models. |journal=Neuroendocrinology |volume=83 |issue= 3-4 |pages= 166-78 |year= 2006 |pmid= 17047380 |doi= 10.1159/000095525 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MKI67... {November 4, 2007 11:07:57 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein MKI67 image.jpg {November 4, 2007 11:08:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:08:22 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MKI67_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r21.
| PDB = {{PDB2|1r21}}, {{PDB2|2aff}}
| Name = Antigen identified by monoclonal antibody Ki-67
| HGNCid = 7107
| Symbol = MKI67
| AltSymbols =; KIA; Ki-67
| OMIM = 176741
| ECnumber =
| Homologene = 1814
| MGIid = 106035
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4288
| Hs_Ensembl =
| Hs_RefseqProtein = NP_002408
| Hs_RefseqmRNA = NM_002417
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 17345
| Mm_Ensembl = ENSMUSG00000031004
| Mm_RefseqmRNA = XM_001000692
| Mm_RefseqProtein = XP_001000692
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 135528432
| Mm_GenLoc_end = 135554639
| Mm_Uniprot =
}}
}}
'''Antigen identified by monoclonal antibody Ki-67''', also known as '''MKI67''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on MYH7... {November 4, 2007 11:08:22 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 11:09:11 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:09:34 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_MYH7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fxm.
| PDB = {{PDB2|2fxm}}, {{PDB2|2fxo}}
| Name = Myosin, heavy chain 7, cardiac muscle, beta
| HGNCid = 7577
| Symbol = MYH7
| AltSymbols =; CMD1S; CMH1; MGC138376; MGC138378; MPD1; MYHCB
| OMIM = 160760
| ECnumber =
| Homologene = 68044
| MGIid = 2155600
| GeneAtlas_image1 = PBB_GE_MYH7_204737_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYH7_216265_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000146 |text = microfilament motor activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008307 |text = structural constituent of muscle}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0030898 |text = actin-dependent ATPase activity}}
| Component = {{GNF_GO|id=GO:0005859 |text = muscle myosin complex}} {{GNF_GO|id=GO:0005863 |text = striated muscle thick filament}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0002027 |text = cardiac chronotropy}} {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0007512 |text = adult heart development}} {{GNF_GO|id=GO:0030049 |text = muscle filament sliding}} {{GNF_GO|id=GO:0055010 |text = ventricular cardiac muscle morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4625
| Hs_Ensembl = ENSG00000092054
| Hs_RefseqProtein = NP_000248
| Hs_RefseqmRNA = NM_000257
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 22951789
| Hs_GenLoc_end = 22974690
| Hs_Uniprot = P12883
| Mm_EntrezGene = 140781
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_080728
| Mm_RefseqProtein = NP_542766
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Myosin, heavy chain 7, cardiac muscle, beta''', also known as '''MYH7''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = MYH7 encodes the cardiac muscle beta (or slow) isoform of myosin. Changes in the relative abundance of MYH7 and MYH6 (the alpha, or fast, isoform of cardiac myosin heavy chain) correlate with the contractile velocity of cardiac muscle. Mutations in MYH7 are associated with familial hypertrophic cardiomyopathy.<ref>{{cite web | title = Entrez Gene: MYH7 myosin, heavy chain 7, cardiac muscle, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4625| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jääskeläinen P, Miettinen R, Kärkkäinen P, ''et al.'' |title=Genetics of hypertrophic cardiomyopathy in eastern Finland: few founder mutations with benign or intermediary phenotypes. |journal=Ann. Med. |volume=36 |issue= 1 |pages= 23-32 |year= 2004 |pmid= 15000344 |doi= }}
*{{cite journal | author=Kamisago M, Schmitt JP, McNamara D, ''et al.'' |title=Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure. |journal=Novartis Found. Symp. |volume=274 |issue= |pages= 176-89; discussion 189-95, 272-6 |year= 2007 |pmid= 17019812 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PDGFB... {November 4, 2007 11:09:35 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PDGFB image.jpg {November 4, 2007 11:10:47 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:11:07 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDGFB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pdg.
| PDB = {{PDB2|1pdg}}
| Name = Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
| HGNCid = 8800
| Symbol = PDGFB
| AltSymbols =; FLJ12858; PDGF2; SIS; SSV; c-sis
| OMIM = 190040
| ECnumber =
| Homologene = 74303
| MGIid = 97528
| GeneAtlas_image1 = PBB_GE_PDGFB_204200_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PDGFB_216061_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PDGFB_217112_at_tn.png
| Function = {{GNF_GO|id=GO:0005161 |text = platelet-derived growth factor receptor binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006929 |text = substrate-bound cell migration}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0030031 |text = cell projection biogenesis}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5155
| Hs_Ensembl = ENSG00000100311
| Hs_RefseqProtein = NP_002599
| Hs_RefseqmRNA = NM_002608
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 22
| Hs_GenLoc_start = 37949310
| Hs_GenLoc_end = 37971006
| Hs_Uniprot = P01127
| Mm_EntrezGene = 18591
| Mm_Ensembl = ENSMUSG00000000489
| Mm_RefseqmRNA = XM_985718
| Mm_RefseqProtein = XP_990812
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 79823129
| Mm_GenLoc_end = 79842063
| Mm_Uniprot = Q549C6
}}
}}
'''Platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)''', also known as '''PDGFB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5155| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kurup S, Abramsson A, Li JP, ''et al.'' |title=Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment. |journal=Biochem. Soc. Trans. |volume=34 |issue= Pt 3 |pages= 454-5 |year= 2006 |pmid= 16709185 |doi= 10.1042/BST0340454 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PKD1... {November 4, 2007 11:11:07 AM PST}
- UPLOAD: Added new Image to wiki:
{November 4, 2007 11:12:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:12:41 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PKD1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b4r.
| PDB = {{PDB2|1b4r}}
| Name = Polycystic kidney disease 1 (autosomal dominant)
| HGNCid = 9008
| Symbol = PKD1
| AltSymbols =; PBP
| OMIM = 601313
| ECnumber =
| Homologene = 250
| MGIid = 97603
| GeneAtlas_image1 = PBB_GE_PKD1_202328_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PKD1_202327_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PKD1_216949_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007161 |text = calcium-independent cell-matrix adhesion}} {{GNF_GO|id=GO:0007218 |text = neuropeptide signaling pathway}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5310
| Hs_Ensembl = ENSG00000008710
| Hs_RefseqProtein = NP_000287
| Hs_RefseqmRNA = NM_000296
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 2078712
| Hs_GenLoc_end = 2125900
| Hs_Uniprot = P98161
| Mm_EntrezGene = 18763
| Mm_Ensembl = ENSMUSG00000032855
| Mm_RefseqmRNA = NM_013630
| Mm_RefseqProtein = NP_038658
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 24277550
| Mm_GenLoc_end = 24324083
| Mm_Uniprot =
}}
}}
'''Polycystic kidney disease 1 (autosomal dominant)''', also known as '''PKD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It may function as an integral membrane protein involved in cell-cell/matrix interactions, and may modulate intracellular calcium homoeostasis and other signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene have been associated with autosomal dominant polycystic kidney disease. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.<ref>{{cite web | title = Entrez Gene: PKD1 polycystic kidney disease 1 (autosomal dominant)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5310| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834-45 |year= 2001 |pmid= 11274246 |doi= }}
*{{cite journal | author=Boletta A, Germino GG |title=Role of polycystins in renal tubulogenesis. |journal=Trends Cell Biol. |volume=13 |issue= 9 |pages= 484-92 |year= 2004 |pmid= 12946628 |doi= }}
*{{cite journal | author=Everson GT, Taylor MR, Doctor RB |title=Polycystic disease of the liver. |journal=Hepatology |volume=40 |issue= 4 |pages= 774-82 |year= 2004 |pmid= 15382167 |doi= 10.1002/hep.20431 }}
*{{cite journal | author=Weimbs T |title=Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair? |journal=Cell Cycle |volume=5 |issue= 21 |pages= 2425-9 |year= 2007 |pmid= 17102641 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PMP22... {November 4, 2007 11:12:41 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:13:31 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Peripheral myelin protein 22
| HGNCid = 9118
| Symbol = PMP22
| AltSymbols =; DSS; CMT1A; CMT1E; GAS-3; HMSNIA; HNPP; MGC20769; Sp110
| OMIM = 601097
| ECnumber =
| Homologene = 7482
| MGIid = 97631
| GeneAtlas_image1 = PBB_GE_PMP22_210139_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0007638 |text = mechanosensory behavior}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5376
| Hs_Ensembl = ENSG00000109099
| Hs_RefseqProtein = NP_000295
| Hs_RefseqmRNA = NM_000304
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 15073822
| Hs_GenLoc_end = 15109369
| Hs_Uniprot = Q01453
| Mm_EntrezGene = 18858
| Mm_Ensembl = ENSMUSG00000018217
| Mm_RefseqmRNA = NM_008885
| Mm_RefseqProtein = NP_032911
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 62947705
| Mm_GenLoc_end = 62975741
| Mm_Uniprot = Q5SXS3
}}
}}
'''Peripheral myelin protein 22''', also known as '''PMP22''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing of this gene results in three transcript variants that encode the same protein.<ref>{{cite web | title = Entrez Gene: PMP22 peripheral myelin protein 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5376| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Patel PI, Lupski JR |title=Charcot-Marie-Tooth disease: a new paradigm for the mechanism of inherited disease. |journal=Trends Genet. |volume=10 |issue= 4 |pages= 128-33 |year= 1994 |pmid= 7518101 |doi= }}
*{{cite journal | author=Roa BB, Lupski JR |title=Molecular genetics of Charcot-Marie-Tooth neuropathy. |journal=Adv. Hum. Genet. |volume=22 |issue= |pages= 117-52 |year= 1995 |pmid= 7762451 |doi= }}
*{{cite journal | author=Nelis E, Haites N, Van Broeckhoven C |title=Mutations in the peripheral myelin genes and associated genes in inherited peripheral neuropathies. |journal=Hum. Mutat. |volume=13 |issue= 1 |pages= 11-28 |year= 1999 |pmid= 9888385 |doi= 10.1002/(SICI)1098-1004(1999)13:1<11::AID-HUMU2>3.0.CO;2-A }}
*{{cite journal | author=Jetten AM, Suter U |title=The peripheral myelin protein 22 and epithelial membrane protein family. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=64 |issue= |pages= 97-129 |year= 2000 |pmid= 10697408 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKCG... {November 4, 2007 11:13:31 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRKCG image.jpg {November 4, 2007 11:14:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:14:27 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKCG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tbn.
| PDB = {{PDB2|1tbn}}, {{PDB2|1tbo}}, {{PDB2|2uzp}}
| Name = Protein kinase C, gamma
| HGNCid = 9402
| Symbol = PRKCG
| AltSymbols =; MGC57564; PKC-gamma; PKCC; PKCG; SCA14
| OMIM = 176980
| ECnumber =
| Homologene = 20602
| MGIid =
| GeneAtlas_image1 = PBB_GE_PRKCG_206270_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004697 |text = protein kinase C activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0031397 |text = negative regulation of protein ubiquitination}} {{GNF_GO|id=GO:0032425 |text = positive regulation of mismatch repair}} {{GNF_GO|id=GO:0042177 |text = negative regulation of protein catabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5582
| Hs_Ensembl = ENSG00000126583
| Hs_RefseqProtein = NP_002730
| Hs_RefseqmRNA = NM_002739
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 59077279
| Hs_GenLoc_end = 59102713
| Hs_Uniprot = P05129
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Protein kinase C, gamma''', also known as '''PRKCG''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).<ref>{{cite web | title = Entrez Gene: PRKCG protein kinase C, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5582| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527-40 |year= 2002 |pmid= 11749387 |doi= }}
*{{cite journal | author=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1-2 |pages= 75-91 |year= 2003 |pmid= 12093536 |doi= }}
*{{cite journal | author=Saito N, Shirai Y |title=Protein kinase C gamma (PKC gamma): function of neuron specific isotype. |journal=J. Biochem. |volume=132 |issue= 5 |pages= 683-7 |year= 2003 |pmid= 12417016 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SELP... {November 4, 2007 11:14:27 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SELP image.jpg {November 4, 2007 11:15:06 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:15:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SELP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fsb.
| PDB = {{PDB2|1fsb}}, {{PDB2|1g1q}}, {{PDB2|1g1r}}, {{PDB2|1g1s}}
| Name = Selectin P (granule membrane protein 140kDa, antigen CD62)
| HGNCid = 10721
| Symbol = SELP
| AltSymbols =; CD62; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PSEL
| OMIM = 173610
| ECnumber =
| Homologene = 2260
| MGIid = 98280
| GeneAtlas_image1 = PBB_GE_SELP_206049_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031092 |text = platelet alpha granule membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6403
| Hs_Ensembl = ENSG00000174175
| Hs_RefseqProtein = NP_002996
| Hs_RefseqmRNA = NM_003005
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 167824661
| Hs_GenLoc_end = 167866023
| Hs_Uniprot = P16109
| Mm_EntrezGene = 20344
| Mm_Ensembl = ENSMUSG00000026580
| Mm_RefseqmRNA = XM_982736
| Mm_RefseqProtein = XP_987830
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 165960377
| Mm_GenLoc_end = 165985205
| Mm_Uniprot = Q32MF1
}}
}}
'''Selectin P (granule membrane protein 140kDa, antigen CD62)''', also known as '''SELP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = SELP is a platelet alpha-granule membrane protein of molecular weight 140,000 that redistributes to the plasma membrane during platelet activation and degranulation. It is a member of a family of adhesion/homing receptors. Alternative splice variants may occur but are not well documented<ref>{{cite web | title = Entrez Gene: SELP selectin P (granule membrane protein 140kDa, antigen CD62)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6403| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33-7 |year= 1992 |pmid= 1375831 |doi= }}
*{{cite journal | author=Bajorath J, Stenkamp R, Aruffo A |title=Knowledge-based model building of proteins: concepts and examples. |journal=Protein Sci. |volume=2 |issue= 11 |pages= 1798-810 |year= 1994 |pmid= 7505680 |doi= }}
*{{cite journal | author=Varki NM, Varki A |title=Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans. |journal=Semin. Thromb. Hemost. |volume=28 |issue= 1 |pages= 53-66 |year= 2002 |pmid= 11885026 |doi= 10.1055/s-2002-20564 }}
*{{cite journal | author=Furie B, Furie BC |title=Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. |journal=Trends in molecular medicine |volume=10 |issue= 4 |pages= 171-8 |year= 2004 |pmid= 15059608 |doi= 10.1016/j.molmed.2004.02.008 }}
*{{cite journal | author=Cambien B, Wagner DD |title=A new role in hemostasis for the adhesion receptor P-selectin. |journal=Trends in molecular medicine |volume=10 |issue= 4 |pages= 179-86 |year= 2004 |pmid= 15059609 |doi= 10.1016/j.molmed.2004.02.007 }}
*{{cite journal | author=Chen M, Geng JG |title=P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=54 |issue= 2 |pages= 75-84 |year= 2006 |pmid= 16648968 |doi= 10.1007/s00005-006-0010-6 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SHH... {November 4, 2007 11:15:29 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SHH image.jpg {November 4, 2007 11:16:03 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:16:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SHH_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vhh.
| PDB = {{PDB2|1vhh}}
| Name = Sonic hedgehog homolog (Drosophila)
| HGNCid = 10848
| Symbol = SHH
| AltSymbols =; HHG1; HLP3; HPE3; SMMCI
| OMIM = 600725
| ECnumber =
| Homologene = 30961
| MGIid = 98297
| GeneAtlas_image1 = PBB_GE_SHH_207586_at_tn.png
| Function = {{GNF_GO|id=GO:0005113 |text = patched binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0043237 |text = laminin-1 binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0045121 |text = lipid raft}}
| Process = {{GNF_GO|id=GO:0001569 |text = patterning of blood vessels}} {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0001656 |text = metanephros development}} {{GNF_GO|id=GO:0001658 |text = ureteric bud branching}} {{GNF_GO|id=GO:0001708 |text = cell fate specification}} {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007224 |text = smoothened signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007389 |text = pattern specification process}} {{GNF_GO|id=GO:0007405 |text = neuroblast proliferation}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007418 |text = ventral midline development}} {{GNF_GO|id=GO:0007435 |text = salivary gland morphogenesis}} {{GNF_GO|id=GO:0007500 |text = mesodermal cell fate determination}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0008209 |text = androgen metabolic process}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0014003 |text = oligodendrocyte development}} {{GNF_GO|id=GO:0016539 |text = intein-mediated protein splicing}} {{GNF_GO|id=GO:0030162 |text = regulation of proteolysis}} {{GNF_GO|id=GO:0030324 |text = lung development}} {{GNF_GO|id=GO:0030336 |text = negative regulation of cell migration}} {{GNF_GO|id=GO:0030539 |text = male genitalia development}} {{GNF_GO|id=GO:0030850 |text = prostate gland development}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0030901 |text = midbrain development}} {{GNF_GO|id=GO:0030902 |text = hindbrain development}} {{GNF_GO|id=GO:0042733 |text = embryonic digit morphogenesis}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0048468 |text = cell development}} {{GNF_GO|id=GO:0048598 |text = embryonic morphogenesis}} {{GNF_GO|id=GO:0048663 |text = neuron fate commitment}} {{GNF_GO|id=GO:0051146 |text = striated muscle cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6469
| Hs_Ensembl = ENSG00000164690
| Hs_RefseqProtein = NP_000184
| Hs_RefseqmRNA = NM_000193
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 155288319
| Hs_GenLoc_end = 155297728
| Hs_Uniprot = Q15465
| Mm_EntrezGene = 20423
| Mm_Ensembl = ENSMUSG00000002633
| Mm_RefseqmRNA = NM_009170
| Mm_RefseqProtein = NP_033196
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 28787602
| Mm_GenLoc_end = 28797888
| Mm_Uniprot = Q8C765
}}
}}
'''Sonic hedgehog homolog (Drosophila)''', also known as '''SHH''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.<ref>{{cite web | title = Entrez Gene: SHH sonic hedgehog homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6469| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kim J, Kim P, Hui CC |title=The VACTERL association: lessons from the Sonic hedgehog pathway. |journal=Clin. Genet. |volume=59 |issue= 5 |pages= 306-15 |year= 2001 |pmid= 11359461 |doi= }}
*{{cite journal | author=Nanni L, Ming JE, Du Y, ''et al.'' |title=SHH mutation is associated with solitary median maxillary central incisor: a study of 13 patients and review of the literature. |journal=Am. J. Med. Genet. |volume=102 |issue= 1 |pages= 1-10 |year= 2001 |pmid= 11471164 |doi= }}
*{{cite journal | author=Mullor JL, Sánchez P, Altaba AR |title=Pathways and consequences: Hedgehog signaling in human disease. |journal=Trends Cell Biol. |volume=12 |issue= 12 |pages= 562-9 |year= 2003 |pmid= 12495844 |doi= }}
*{{cite journal | author=Williams JA |title=Hedgehog and spinal cord injury. |journal=Expert Opin. Ther. Targets |volume=9 |issue= 6 |pages= 1137-45 |year= 2006 |pmid= 16300466 |doi= 10.1517/14728222.9.6.1137 }}
*{{cite journal | author=Morton JP, Lewis BC |title=Shh signaling and pancreatic cancer: implications for therapy? |journal=Cell Cycle |volume=6 |issue= 13 |pages= 1553-7 |year= 2007 |pmid= 17611415 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNFSF11... {November 4, 2007 11:20:25 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNFSF11 image.jpg {November 4, 2007 11:21:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:21:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNFSF11_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s55.
| PDB = {{PDB2|1s55}}
| Name = Tumor necrosis factor (ligand) superfamily, member 11
| HGNCid = 11926
| Symbol = TNFSF11
| AltSymbols =; ODF; CD254; OPGL; RANKL; TRANCE; hRANKL2; sOdf
| OMIM = 602642
| ECnumber =
| Homologene = 2744
| MGIid = 1100089
| GeneAtlas_image1 = PBB_GE_TNFSF11_210643_at_tn.png
| GeneAtlas_image2 = PBB_GE_TNFSF11_211153_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005125 |text = cytokine activity}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045453 |text = bone resorption}} {{GNF_GO|id=GO:0045672 |text = positive regulation of osteoclast differentiation}} {{GNF_GO|id=GO:0051260 |text = protein homooligomerization}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8600
| Hs_Ensembl = ENSG00000120659
| Hs_RefseqProtein = NP_003692
| Hs_RefseqmRNA = NM_003701
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 42034872
| Hs_GenLoc_end = 42079308
| Hs_Uniprot = O14788
| Mm_EntrezGene = 21943
| Mm_Ensembl = ENSMUSG00000022015
| Mm_RefseqmRNA = NM_011613
| Mm_RefseqProtein = NP_035743
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 77011609
| Mm_GenLoc_end = 77042189
| Mm_Uniprot = Q059M3
}}
}}
'''Tumor necrosis factor (ligand) superfamily, member 11''', also known as '''TNFSF11''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.<ref>{{cite web | title = Entrez Gene: TNFSF11 tumor necrosis factor (ligand) superfamily, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8600| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Buckley KA, Fraser WD |title=Receptor activator for nuclear factor kappaB ligand and osteoprotegerin: regulators of bone physiology and immune responses/potential therapeutic agents and biochemical markers. |journal=Ann. Clin. Biochem. |volume=39 |issue= Pt 6 |pages= 551-6 |year= 2003 |pmid= 12564836 |doi= }}
*{{cite journal | author=Jeffcoate W |title=Vascular calcification and osteolysis in diabetic neuropathy-is RANK-L the missing link? |journal=Diabetologia |volume=47 |issue= 9 |pages= 1488-92 |year= 2005 |pmid= 15322748 |doi= 10.1007/s00125-004-1477-5 }}
*{{cite journal | author=Collin-Osdoby P |title=Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. |journal=Circ. Res. |volume=95 |issue= 11 |pages= 1046-57 |year= 2005 |pmid= 15564564 |doi= 10.1161/01.RES.0000149165.99974.12 }}
*{{cite journal | author=Whyte MP, Mumm S |title=Heritable disorders of the RANKL/OPG/RANK signaling pathway. |journal=Journal of musculoskeletal & neuronal interactions |volume=4 |issue= 3 |pages= 254-67 |year= 2005 |pmid= 15615493 |doi= }}
*{{cite journal | author=Clohisy DR, Mantyh PW |title=Bone cancer pain and the role of RANKL/OPG. |journal=Journal of musculoskeletal & neuronal interactions |volume=4 |issue= 3 |pages= 293-300 |year= 2005 |pmid= 15615497 |doi= }}
*{{cite journal | author=Anandarajah AP, Schwarz EM |title=Anti-RANKL therapy for inflammatory bone disorders: Mechanisms and potential clinical applications. |journal=J. Cell. Biochem. |volume=97 |issue= 2 |pages= 226-32 |year= 2006 |pmid= 16240334 |doi= 10.1002/jcb.20674 }}
*{{cite journal | author=Baud'huin M, Duplomb L, Ruiz Velasco C, ''et al.'' |title=Key roles of the OPG-RANK-RANKL system in bone oncology. |journal=Expert Rev Anticancer Ther |volume=7 |issue= 2 |pages= 221-32 |year= 2007 |pmid= 17288531 |doi= 10.1586/14737140.7.2.221 }}
*{{cite journal | author=Yogo K, Ishida-Kitagawa N, Takeya T |title=Negative autoregulation of RANKL and c-Src signaling in osteoclasts. |journal=J. Bone Miner. Metab. |volume=25 |issue= 4 |pages= 205-10 |year= 2007 |pmid= 17593489 |doi= 10.1007/s00774-007-0751-2 }}
*{{cite journal | author=Boyce BF, Xing L |title=Biology of RANK, RANKL, and osteoprotegerin. |journal=Arthritis Res. Ther. |volume=9 Suppl 1 |issue= |pages= S1 |year= 2007 |pmid= 17634140 |doi= 10.1186/ar2165 }}
*{{cite journal | author=McClung M |title=Role of RANKL inhibition in osteoporosis. |journal=Arthritis Res. Ther. |volume=9 Suppl 1 |issue= |pages= S3 |year= 2007 |pmid= 17634142 |doi= 10.1186/ar2167 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TYMS... {November 4, 2007 11:16:21 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TYMS image.jpg {November 4, 2007 11:16:57 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:17:16 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TYMS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hvy.
| PDB = {{PDB2|1hvy}}, {{PDB2|1hw3}}, {{PDB2|1hw4}}, {{PDB2|1hzw}}, {{PDB2|1i00}}, {{PDB2|1ju6}}, {{PDB2|1juj}}, {{PDB2|1ypv}}, {{PDB2|2onb}}
| Name = Thymidylate synthetase
| HGNCid = 12441
| Symbol = TYMS
| AltSymbols =; TS; HsT422; MGC88736; TMS; TSase
| OMIM = 188350
| ECnumber =
| Homologene = 834
| MGIid = 98878
| GeneAtlas_image1 = PBB_GE_TYMS_202589_at_tn.png
| Function = {{GNF_GO|id=GO:0004799 |text = thymidylate synthase activity}} {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006231 |text = dTMP biosynthetic process}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0009157 |text = deoxyribonucleoside monophosphate biosynthetic process}} {{GNF_GO|id=GO:0009165 |text = nucleotide biosynthetic process}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7298
| Hs_Ensembl = ENSG00000176890
| Hs_RefseqProtein = NP_001062
| Hs_RefseqmRNA = NM_001071
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 647619
| Hs_GenLoc_end = 663492
| Hs_Uniprot = P04818
| Mm_EntrezGene = 22171
| Mm_Ensembl = ENSMUSG00000025747
| Mm_RefseqmRNA = NM_021288
| Mm_RefseqProtein = NP_067263
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 30389614
| Mm_GenLoc_end = 30404368
| Mm_Uniprot = Q544L2
}}
}}
'''Thymidylate synthetase''', also known as '''TYMS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Thymidylate synthase (TYMS, or TS; EC 2.1.1.45) uses the 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor to maintain the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: TYMS thymidylate synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7298| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Banerjee D, Mayer-Kuckuk P, Capiaux G, ''et al.'' |title=Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 164-73 |year= 2002 |pmid= 12084458 |doi= }}
*{{cite journal | author=Liu J, Schmitz JC, Lin X, ''et al.'' |title=Thymidylate synthase as a translational regulator of cellular gene expression. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 174-82 |year= 2002 |pmid= 12084459 |doi= }}
*{{cite journal | author=Chu J, Dolnick BJ |title=Natural antisense (rTSalpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 183-93 |year= 2002 |pmid= 12084460 |doi= }}
*{{cite journal | author=Peters GJ, Backus HH, Freemantle S, ''et al.'' |title=Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 194-205 |year= 2002 |pmid= 12084461 |doi= }}
*{{cite journal | author=Costi MP, Tondi D, Rinaldi M, ''et al.'' |title=Structure-based studies on species-specific inhibition of thymidylate synthase. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 206-14 |year= 2002 |pmid= 12084462 |doi= }}
*{{cite journal | author=Lin D, Li H, Tan W, ''et al.'' |title=Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development. |journal=Forum of nutrition |volume=60 |issue= |pages= 140-5 |year= 2007 |pmid= 17684410 |doi= 10.1159/0000107090 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on XRCC5... {November 4, 2007 11:17:16 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein XRCC5 image.jpg {November 4, 2007 11:18:24 AM PST}
- CREATE: Found no pages, creating new page. {November 4, 2007 11:18:47 AM PST}
- CREATED: Created new protein page: XRCC5 {November 4, 2007 11:18:54 AM PST}
- INFO: Beginning work on YWHAB... {November 4, 2007 11:18:54 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein YWHAB image.jpg {November 4, 2007 11:20:09 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 4, 2007 11:20:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_YWHAB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bq0.
| PDB = {{PDB2|2bq0}}, {{PDB2|2c23}}
| Name = Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
| HGNCid = 12849
| Symbol = YWHAB
| AltSymbols =; HS1; GW128; KCIP-1
| OMIM = 601289
| ECnumber =
| Homologene = 20724
| MGIid = 1891917
| GeneAtlas_image1 = PBB_GE_YWHAB_208743_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_YWHAB_217717_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_YWHAB_217718_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0019904 |text = protein domain specific binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006605 |text = protein targeting}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7529
| Hs_Ensembl = ENSG00000166913
| Hs_RefseqProtein = NP_003395
| Hs_RefseqmRNA = NM_003404
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 42947731
| Hs_GenLoc_end = 42970587
| Hs_Uniprot = P31946
| Mm_EntrezGene = 54401
| Mm_Ensembl = ENSMUSG00000018326
| Mm_RefseqmRNA = NM_018753
| Mm_RefseqProtein = NP_061223
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 163686638
| Mm_GenLoc_end = 163710028
| Mm_Uniprot = Q9CQV8
}}
}}
'''Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide''', also known as '''YWHAB''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.<ref>{{cite web | title = Entrez Gene: YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7529| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kino T, Pavlakis GN |title=Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 193-205 |year= 2004 |pmid= 15142377 |doi= 10.1089/104454904773819789 }}
*{{cite journal | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue= |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal | author=Calinisan V, Gravem D, Chen RP, ''et al.'' |title=New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. |journal=Front. Biosci. |volume=11 |issue= |pages= 1646-66 |year= 2006 |pmid= 16368544 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
