Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 04:29, 26 November 2007 (UTC)
[edit]Proteins without matches (17)
[edit]Proteins with a High Potential Match (3)
[edit]Redirected Proteins (5)
[edit]Manual Inspection (Page not found) (9)
[edit]
Protein Status Grid - Date: 04:29, 26 November 2007 (UTC)
[edit]Vebose Log - Date: 04:29, 26 November 2007 (UTC)
[edit]- INFO: Beginning work on CXCR4... {November 25, 2007 8:19:21 PM PST}
- SEARCH REDIRECT: Control Box Found: CXCR4 {November 25, 2007 8:20:10 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:20:13 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 25, 2007 8:20:13 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:20:13 PM PST}
- UPDATED: Updated protein page: CXCR4 {November 25, 2007 8:20:19 PM PST}
- INFO: Beginning work on FZD1... {November 25, 2007 8:25:17 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:26:13 PM PST}
- CREATED: Created new protein page: FZD1 {November 25, 2007 8:26:22 PM PST}
- INFO: Beginning work on FZD3... {November 25, 2007 8:22:48 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:23:58 PM PST}
- CREATED: Created new protein page: FZD3 {November 25, 2007 8:24:09 PM PST}
- INFO: Beginning work on FZD4... {November 25, 2007 8:26:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:27:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Frizzled homolog 4 (Drosophila)
| HGNCid = 4042
| Symbol = FZD4
| AltSymbols =; EVR1; FEVR; FZD4S; Fz-4; FzE4; GPCR; MGC34390
| OMIM = 604579
| ECnumber =
| Homologene = 7325
| MGIid = 108520
| GeneAtlas_image1 = PBB_GE_FZD4_218665_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042813 |text = Wnt receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8322
| Hs_Ensembl = ENSG00000174804
| Hs_RefseqProtein = NP_036325
| Hs_RefseqmRNA = NM_012193
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 86334370
| Hs_GenLoc_end = 86344081
| Hs_Uniprot = Q9ULV1
| Mm_EntrezGene = 14366
| Mm_Ensembl = ENSMUSG00000049791
| Mm_RefseqmRNA = NM_008055
| Mm_RefseqProtein = NP_032081
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 89279586
| Mm_GenLoc_end = 89285277
| Mm_Uniprot = Q3V1B2
}}
}}
'''Frizzled homolog 4 (Drosophila)''', also known as '''FZD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8322| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.<ref name="entrez">{{cite web | title = Entrez Gene: FZD4 frizzled homolog 4 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8322| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Li Y, Fuhrmann C, Schwinger E, ''et al.'' |title=The gene for autosomal dominant familial exudative vitreoretinopathy (Criswick-Schepens) on the long arm of chromosome 11. |journal=Am. J. Ophthalmol. |volume=113 |issue= 6 |pages= 712-3 |year= 1992 |pmid= 1598965 |doi= }}
*{{cite journal | author=Tanaka S, Akiyoshi T, Mori M, ''et al.'' |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164-9 |year= 1998 |pmid= 9707618 |doi= }}
*{{cite journal | author=Kirikoshi H, Sagara N, Koike J, ''et al.'' |title=Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 3 |pages= 955-61 |year= 1999 |pmid= 10544037 |doi= 10.1006/bbrc.1999.1612 }}
*{{cite journal | author=Sagara N, Kirikoshi H, Terasaki H, ''et al.'' |title=FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 3 |pages= 750-6 |year= 2001 |pmid= 11401527 |doi= 10.1006/bbrc.2001.4634 }}
*{{cite journal | author=Takeda S, Kadowaki S, Haga T, ''et al.'' |title=Identification of G protein-coupled receptor genes from the human genome sequence. |journal=FEBS Lett. |volume=520 |issue= 1-3 |pages= 97-101 |year= 2002 |pmid= 12044878 |doi= }}
*{{cite journal | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. |journal=FEBS Lett. |volume=521 |issue= 1-3 |pages= 185-9 |year= 2002 |pmid= 12067714 |doi= }}
*{{cite journal | author=Robitaille J, MacDonald ML, Kaykas A, ''et al.'' |title=Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. |journal=Nat. Genet. |volume=32 |issue= 2 |pages= 326-30 |year= 2002 |pmid= 12172548 |doi= 10.1038/ng957 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Chen W, ten Berge D, Brown J, ''et al.'' |title=Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. |journal=Science |volume=301 |issue= 5638 |pages= 1391-4 |year= 2003 |pmid= 12958364 |doi= 10.1126/science.1082808 }}
*{{cite journal | author=Toomes C, Downey LM, Bottomley HM, ''et al.'' |title=Identification of a fourth locus (EVR4) for familial exudative vitreoretinopathy (FEVR). |journal=Mol. Vis. |volume=10 |issue= |pages= 37-42 |year= 2004 |pmid= 14737064 |doi= }}
*{{cite journal | author=Toomes C, Bottomley HM, Jackson RM, ''et al.'' |title=Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. |journal=Am. J. Hum. Genet. |volume=74 |issue= 4 |pages= 721-30 |year= 2004 |pmid= 15024691 |doi= 10.1086/383202 }}
*{{cite journal | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. |journal=Oncogene |volume=23 |issue= 36 |pages= 6023-30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
*{{cite journal | author=Toomes C, Bottomley HM, Scott S, ''et al.'' |title=Spectrum and frequency of FZD4 mutations in familial exudative vitreoretinopathy. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 7 |pages= 2083-90 |year= 2004 |pmid= 15223780 |doi= }}
*{{cite journal | author=Omoto S, Hayashi T, Kitahara K, ''et al.'' |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81-90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
*{{cite journal | author=Yoshida S, Arita R, Yoshida A, ''et al.'' |title=Novel mutation in FZD4 gene in a Japanese pedigree with familial exudative vitreoretinopathy. |journal=Am. J. Ophthalmol. |volume=138 |issue= 4 |pages= 670-1 |year= 2004 |pmid= 15488808 |doi= 10.1016/j.ajo.2004.05.001 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Qin M, Hayashi H, Oshima K, ''et al.'' |title=Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. |journal=Hum. Mutat. |volume=26 |issue= 2 |pages= 104-12 |year= 2006 |pmid= 15981244 |doi= 10.1002/humu.20191 }}
*{{cite journal | author=Nallathambi J, Shukla D, Rajendran A, ''et al.'' |title=Identification of novel FZD4 mutations in Indian patients with familial exudative vitreoretinopathy. |journal=Mol. Vis. |volume=12 |issue= |pages= 1086-92 |year= 2006 |pmid= 17093393 |doi= }}
*{{cite journal | author=Planutis K, Planutiene M, Moyer MP, ''et al.'' |title=Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells. |journal=BMC Cell Biol. |volume=8 |issue= |pages= 12 |year= 2007 |pmid= 17386109 |doi= 10.1186/1471-2121-8-12 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FZD5... {November 25, 2007 8:20:19 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:21:03 PM PST}
- CREATED: Created new protein page: FZD5 {November 25, 2007 8:21:12 PM PST}
- INFO: Beginning work on FZD6... {November 25, 2007 8:27:24 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:28:05 PM PST}
- CREATED: Created new protein page: FZD6 {November 25, 2007 8:28:16 PM PST}
- INFO: Beginning work on GPR68... {November 25, 2007 8:24:09 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:25:08 PM PST}
- CREATED: Created new protein page: GPR68 {November 25, 2007 8:25:17 PM PST}
- INFO: Beginning work on OR2H2... {November 25, 2007 8:21:12 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:22:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 2, subfamily H, member 2
| HGNCid = 8253
| Symbol = OR2H2
| AltSymbols =; FAT11; MGC126732; MGC138381; OLFR 42B; OLFR2; OR2H3; dJ271M21.2; hs6M1-12
| OMIM = 600578
| ECnumber =
| Homologene = 68546
| MGIid = 2177473
| GeneAtlas_image1 = PBB_GE_OR2H2_208573_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR2H2_217081_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0007618 |text = mating}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7932
| Hs_Ensembl = ENSG00000204657
| Hs_RefseqProtein = NP_009091
| Hs_RefseqmRNA = NM_007160
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 29663211
| Hs_GenLoc_end = 29664794
| Hs_Uniprot = O95918
| Mm_EntrezGene = 258469
| Mm_Ensembl = ENSMUSG00000056600
| Mm_RefseqmRNA = NM_146477
| Mm_RefseqProtein = NP_666688
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 36693284
| Mm_GenLoc_end = 36694216
| Mm_Uniprot =
}}
}}
'''Olfactory receptor, family 2, subfamily H, member 2''', also known as '''OR2H2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Fan W, Liu YC, Parimoo S, Weissman SM |title=Olfactory receptor-like genes are located in the human major histocompatibility complex. |journal=Genomics |volume=27 |issue= 1 |pages= 119-23 |year= 1995 |pmid= 7665158 |doi= 10.1006/geno.1995.1013 }}
*{{cite journal | author=Fan W, Cai W, Parimoo S, ''et al.'' |title=Identification of seven new human MHC class I region genes around the HLA-F locus. |journal=Immunogenetics |volume=44 |issue= 2 |pages= 97-103 |year= 1996 |pmid= 8662070 |doi= }}
*{{cite journal | author=Eklund AC, Belchak MM, Lapidos K, ''et al.'' |title=Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. |journal=Hum. Immunol. |volume=61 |issue= 7 |pages= 711-7 |year= 2000 |pmid= 10880742 |doi= }}
*{{cite journal | author=Younger RM, Amadou C, Bethel G, ''et al.'' |title=Characterization of clustered MHC-linked olfactory receptor genes in human and mouse. |journal=Genome Res. |volume=11 |issue= 4 |pages= 519-30 |year= 2001 |pmid= 11282967 |doi= 10.1101/gr.160301 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Volz A, Ehlers A, Younger R, ''et al.'' |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691-701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RGR... {November 25, 2007 8:06:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:07:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinal G protein coupled receptor
| HGNCid = 9990
| Symbol = RGR
| AltSymbols =;
| OMIM = 600342
| ECnumber =
| Homologene = 37709
| MGIid = 1929473
| GeneAtlas_image1 = PBB_GE_RGR_207070_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007602 |text = phototransduction}} {{GNF_GO|id=GO:0018298 |text = protein-chromophore linkage}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5995
| Hs_Ensembl = ENSG00000148604
| Hs_RefseqProtein = NP_001012738
| Hs_RefseqmRNA = NM_001012720
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 85994789
| Hs_GenLoc_end = 86009696
| Hs_Uniprot = P47804
| Mm_EntrezGene = 57811
| Mm_Ensembl = ENSMUSG00000021804
| Mm_RefseqmRNA = NM_021340
| Mm_RefseqProtein = NP_067315
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 35948731
| Mm_GenLoc_end = 35960205
| Mm_Uniprot = Q3UEX9
}}
}}
'''Retinal G protein coupled receptor''', also known as '''RGR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: RGR retinal G protein coupled receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5995| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jiang M, Shen D, Tao L, ''et al.'' |title=Alternative splicing in human retinal mRNA transcripts of an opsin-related protein. |journal=Exp. Eye Res. |volume=60 |issue= 4 |pages= 401-6 |year= 1995 |pmid= 7789419 |doi= }}
*{{cite journal | author=Shen D, Jiang M, Hao W, ''et al.'' |title=A human opsin-related gene that encodes a retinaldehyde-binding protein. |journal=Biochemistry |volume=33 |issue= 44 |pages= 13117-25 |year= 1994 |pmid= 7947717 |doi= }}
*{{cite journal | author=Chen XN, Korenberg JR, Jiang M, ''et al.'' |title=Localization of the human RGR opsin gene to chromosome 10q23. |journal=Hum. Genet. |volume=97 |issue= 6 |pages= 720-2 |year= 1996 |pmid= 8641686 |doi= }}
*{{cite journal | author=Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP |title=Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 393-4 |year= 1999 |pmid= 10581022 |doi= 10.1038/70496 }}
*{{cite journal | author=Chen P, Lee TD, Fong HK |title=Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21098-104 |year= 2001 |pmid= 11274198 |doi= 10.1074/jbc.M010441200 }}
*{{cite journal | author=Yang M, Fong HK |title=Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3318-24 |year= 2002 |pmid= 11723126 |doi= 10.1074/jbc.M108946200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bellingham J, Wells DJ, Foster RG |title=In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 3 |year= 2003 |pmid= 12542842 |doi= }}
*{{cite journal | author=Tarttelin EE, Bellingham J, Bibb LC, ''et al.'' |title=Expression of opsin genes early in ocular development of humans and mice. |journal=Exp. Eye Res. |volume=76 |issue= 3 |pages= 393-6 |year= 2003 |pmid= 12573668 |doi= }}
*{{cite journal | author=Bernal S, Calaf M, Garcia-Hoyos M, ''et al.'' |title=Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= e89 |year= 2003 |pmid= 12843338 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Zhu L, Imanishi Y, Filipek S, ''et al.'' |title=Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22289-98 |year= 2006 |pmid= 16737970 |doi= 10.1074/jbc.M602664200 }}
*{{cite journal | author=Lin MY, Kochounian H, Moore RE, ''et al.'' |title=Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane. |journal=Mol. Vis. |volume=13 |issue= |pages= 1203-14 |year= 2007 |pmid= 17679941 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RHO... {November 25, 2007 8:07:09 PM PST}
- SEARCH REDIRECT: Control Box Found: Rhodopsin {November 25, 2007 8:07:43 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:07:44 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 25, 2007 8:07:44 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:07:44 PM PST}
- UPDATED: Updated protein page: Rhodopsin {November 25, 2007 8:07:52 PM PST}
- INFO: Beginning work on SCTR... {November 25, 2007 8:07:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:08:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secretin receptor
| HGNCid = 10608
| Symbol = SCTR
| AltSymbols =; SR
| OMIM = 182098
| ECnumber =
| Homologene = 68290
| MGIid =
| GeneAtlas_image1 = PBB_GE_SCTR_210382_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004999 |text = vasoactive intestinal polypeptide receptor activity}} {{GNF_GO|id=GO:0015055 |text = secretin receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0007588 |text = excretion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6344
| Hs_Ensembl = ENSG00000080293
| Hs_RefseqProtein = NP_002971
| Hs_RefseqmRNA = NM_002980
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 119913891
| Hs_GenLoc_end = 119998537
| Hs_Uniprot = P47872
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Secretin receptor''', also known as '''SCTR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCTR secretin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6344| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism.<ref name="entrez">{{cite web | title = Entrez Gene: SCTR secretin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6344| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ulrich CD, Holtmann M, Miller LJ |title=Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors. |journal=Gastroenterology |volume=114 |issue= 2 |pages= 382-97 |year= 1998 |pmid= 9453500 |doi= }}
*{{cite journal | author=Felley CP, Qian JM, Mantey S, ''et al.'' |title=Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release. |journal=Am. J. Physiol. |volume=263 |issue= 6 Pt 1 |pages= G901-7 |year= 1993 |pmid= 1335692 |doi= }}
*{{cite journal | author=Ishihara T, Nakamura S, Kaziro Y, ''et al.'' |title=Molecular cloning and expression of a cDNA encoding the secretin receptor. |journal=EMBO J. |volume=10 |issue= 7 |pages= 1635-41 |year= 1991 |pmid= 1646711 |doi= }}
*{{cite journal | author=Robberecht P, De Neef P, Waelbroeck M, ''et al.'' |title=Secretin receptors in human pancreatic membranes. |journal=Pancreas |volume=3 |issue= 5 |pages= 529-35 |year= 1988 |pmid= 3186683 |doi= }}
*{{cite journal | author=Chow BK |title=Molecular cloning and functional characterization of a human secretin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=212 |issue= 1 |pages= 204-11 |year= 1995 |pmid= 7612008 |doi= 10.1006/bbrc.1995.1957 }}
*{{cite journal | author=Patel DR, Kong Y, Sreedharan SP |title=Molecular cloning and expression of a human secretin receptor. |journal=Mol. Pharmacol. |volume=47 |issue= 3 |pages= 467-73 |year= 1995 |pmid= 7700244 |doi= }}
*{{cite journal | author=Holtmann MH, Hadac EM, Miller LJ |title=Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14394-8 |year= 1995 |pmid= 7782300 |doi= }}
*{{cite journal | author=Jiang S, Ulrich C |title=Molecular cloning and functional expression of a human pancreatic secretin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=207 |issue= 3 |pages= 883-90 |year= 1995 |pmid= 7864894 |doi= }}
*{{cite journal | author=Sreedharan SP, Patel DR, Huang JX, Goetzl EJ |title=Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 2 |pages= 546-53 |year= 1993 |pmid= 8390245 |doi= 10.1006/bbrc.1993.1658 }}
*{{cite journal | author=Mark HF, Chow BK |title=Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry. |journal=Genomics |volume=29 |issue= 3 |pages= 817-8 |year= 1996 |pmid= 8575789 |doi= 10.1006/geno.1995.9922 }}
*{{cite journal | author=Vilardaga JP, di Paolo E, de Neef P, ''et al.'' |title=Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 3 |pages= 842-6 |year= 1996 |pmid= 8579602 |doi= 10.1006/bbrc.1996.0150 }}
*{{cite journal | author=Chow BK |title=Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor. |journal=Receptors & signal transduction |volume=7 |issue= 3 |pages= 143-50 |year= 1998 |pmid= 9440501 |doi= }}
*{{cite journal | author=Shetzline MA, Premont RT, Walker JK, ''et al.'' |title=A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6756-62 |year= 1998 |pmid= 9506976 |doi= }}
*{{cite journal | author=Ho PK, Fong RS, Kai HS, ''et al.'' |title=The human secretin receptor gene: genomic organization and promoter characterization. |journal=FEBS Lett. |volume=455 |issue= 3 |pages= 209-14 |year= 1999 |pmid= 10437774 |doi= }}
*{{cite journal | author=Pang RT, Ng SS, Cheng CH, ''et al.'' |title=Role of N-linked glycosylation on the function and expression of the human secretin receptor. |journal=Endocrinology |volume=140 |issue= 11 |pages= 5102-11 |year= 1999 |pmid= 10537138 |doi= }}
*{{cite journal | author=Chan KY, Pang RT, Chow BK |title=Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor. |journal=Endocrinology |volume=142 |issue= 9 |pages= 3926-34 |year= 2001 |pmid= 11517171 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Pang RT, Lee LT, Ng SS, ''et al.'' |title=CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene. |journal=Mol. Endocrinol. |volume=18 |issue= 2 |pages= 471-83 |year= 2004 |pmid= 14645499 |doi= 10.1210/me.2003-0245 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMO... {November 25, 2007 8:08:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:09:10 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Smoothened homolog (Drosophila)
| HGNCid = 11119
| Symbol = SMO
| AltSymbols =; Gx; SMOH
| OMIM = 601500
| ECnumber =
| Homologene = 4115
| MGIid = 108075
| GeneAtlas_image1 = PBB_GE_SMO_218629_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004926 |text = non-G-protein coupled 7TM receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005929 |text = cilium}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0001649 |text = osteoblast differentiation}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007224 |text = smoothened signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0009953 |text = dorsal/ventral pattern formation}} {{GNF_GO|id=GO:0043392 |text = negative regulation of DNA binding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6608
| Hs_Ensembl = ENSG00000128602
| Hs_RefseqProtein = NP_005622
| Hs_RefseqmRNA = NM_005631
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 128615949
| Hs_GenLoc_end = 128640617
| Hs_Uniprot = Q99835
| Mm_EntrezGene = 319757
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_176996
| Mm_RefseqProtein = NP_795970
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Smoothened homolog (Drosophila)''', also known as '''SMO''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMO smoothened homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6608| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chen Y, Struhl G |title=Dual roles for patched in sequestering and transducing Hedgehog. |journal=Cell |volume=87 |issue= 3 |pages= 553-63 |year= 1996 |pmid= 8898207 |doi= }}
*{{cite journal | author=Stone DM, Hynes M, Armanini M, ''et al.'' |title=The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. |journal=Nature |volume=384 |issue= 6605 |pages= 129-34 |year= 1996 |pmid= 8906787 |doi= 10.1038/384129a0 }}
*{{cite journal | author=Xie J, Murone M, Luoh SM, ''et al.'' |title=Activating Smoothened mutations in sporadic basal-cell carcinoma. |journal=Nature |volume=391 |issue= 6662 |pages= 90-2 |year= 1998 |pmid= 9422511 |doi= 10.1038/34201 }}
*{{cite journal | author=Reifenberger J, Wolter M, Weber RG, ''et al.'' |title=Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1798-803 |year= 1998 |pmid= 9581815 |doi= }}
*{{cite journal | author=Sublett JE, Entrekin RE, Look AT, Reardon DA |title=Chromosomal localization of the human smoothened gene (SMOH) to 7q32. 3 by fluorescence in situ hybridization and radiation hybrid mapping. |journal=Genomics |volume=50 |issue= 1 |pages= 112-4 |year= 1999 |pmid= 9628830 |doi= 10.1006/geno.1998.5227 }}
*{{cite journal | author=McGarvey TW, Maruta Y, Tomaszewski JE, ''et al.'' |title=PTCH gene mutations in invasive transitional cell carcinoma of the bladder. |journal=Oncogene |volume=17 |issue= 9 |pages= 1167-72 |year= 1998 |pmid= 9764827 |doi= 10.1038/sj.onc.1202045 }}
*{{cite journal | author=Chidambaram A, Gerrard B, Hanson M, Dean M |title=Chromosomal localization of the human and murine orthologues of the Drosophila smoothened gene. |journal=Genomics |volume=53 |issue= 3 |pages= 416-7 |year= 1998 |pmid= 9799615 |doi= 10.1006/geno.1998.5531 }}
*{{cite journal | author=Carpenter D, Stone DM, Brush J, ''et al.'' |title=Characterization of two patched receptors for the vertebrate hedgehog protein family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 23 |pages= 13630-4 |year= 1998 |pmid= 9811851 |doi= }}
*{{cite journal | author=Detmer K, Walker AN, Jenkins TM, ''et al.'' |title=Erythroid differentiation in vitro is blocked by cyclopamine, an inhibitor of hedgehog signaling. |journal=Blood Cells Mol. Dis. |volume=26 |issue= 4 |pages= 360-72 |year= 2000 |pmid= 11042037 |doi= 10.1006/bcmd.2000.0318 }}
*{{cite journal | author=Long F, Zhang XM, Karp S, ''et al.'' |title=Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. |journal=Development |volume=128 |issue= 24 |pages= 5099-108 |year= 2002 |pmid= 11748145 |doi= }}
*{{cite journal | author=Incardona JP, Gruenberg J, Roelink H |title=Sonic hedgehog induces the segregation of patched and smoothened in endosomes. |journal=Curr. Biol. |volume=12 |issue= 12 |pages= 983-95 |year= 2002 |pmid= 12123571 |doi= }}
*{{cite journal | author=Lowrey JA, Stewart GA, Lindey S, ''et al.'' |title=Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1869-75 |year= 2002 |pmid= 12165511 |doi= }}
*{{cite journal | author=Taipale J, Cooper MK, Maiti T, Beachy PA |title=Patched acts catalytically to suppress the activity of Smoothened. |journal=Nature |volume=418 |issue= 6900 |pages= 892-7 |year= 2002 |pmid= 12192414 |doi= 10.1038/nature00989 }}
*{{cite journal | author=Katayam M, Yoshida K, Ishimori H, ''et al.'' |title=Patched and smoothened mRNA expression in human astrocytic tumors inversely correlates with histological malignancy. |journal=J. Neurooncol. |volume=59 |issue= 2 |pages= 107-15 |year= 2003 |pmid= 12241103 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Couvé-Privat S, Bouadjar B, Avril MF, ''et al.'' |title=Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. |journal=Cancer Res. |volume=62 |issue= 24 |pages= 7186-9 |year= 2003 |pmid= 12499255 |doi= }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Grachtchouk V, Grachtchouk M, Lowe L, ''et al.'' |title=The magnitude of hedgehog signaling activity defines skin tumor phenotype. |journal=EMBO J. |volume=22 |issue= 11 |pages= 2741-51 |year= 2003 |pmid= 12773389 |doi= 10.1093/emboj/cdg271 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Chen W, Ren XR, Nelson CD, ''et al.'' |title=Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. |journal=Science |volume=306 |issue= 5705 |pages= 2257-60 |year= 2005 |pmid= 15618519 |doi= 10.1126/science.1104135 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SSTR1... {November 25, 2007 8:09:10 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:09:50 PM PST}
- CREATED: Created new protein page: SSTR1 {November 25, 2007 8:09:59 PM PST}
- INFO: Beginning work on SSTR2... {November 25, 2007 8:09:59 PM PST}
- REDIRECT: Protein Redirected to: SSTR2 {November 25, 2007 8:10:21 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:10:24 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 8:10:24 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:10:24 PM PST}
- UPDATED: Updated protein page: SSTR2 {November 25, 2007 8:10:30 PM PST}
- INFO: Beginning work on SSTR3... {November 25, 2007 8:10:30 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:11:06 PM PST}
- CREATED: Created new protein page: SSTR3 {November 25, 2007 8:11:14 PM PST}
- INFO: Beginning work on SSTR4... {November 25, 2007 8:11:15 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:11:56 PM PST}
- CREATED: Created new protein page: SSTR4 {November 25, 2007 8:12:04 PM PST}
- INFO: Beginning work on SSTR5... {November 25, 2007 8:12:04 PM PST}
- REDIRECT: Protein Redirected to: SSTR5 {November 25, 2007 8:12:21 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:12:23 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 25, 2007 8:12:23 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:12:23 PM PST}
- UPDATED: Updated protein page: SSTR5 {November 25, 2007 8:12:29 PM PST}
- INFO: Beginning work on TACR1... {November 25, 2007 8:13:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:13:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Tachykinin receptor 1
| HGNCid = 11526
| Symbol = TACR1
| AltSymbols =; SPR; NK1R; NKIR; TAC1R
| OMIM = 162323
| ECnumber =
| Homologene = 20288
| MGIid = 98475
| GeneAtlas_image1 = PBB_GE_TACR1_208049_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TACR1_210637_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004995 |text = tachykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007217 |text = tachykinin signaling pathway}} {{GNF_GO|id=GO:0007638 |text = mechanosensory behavior}} {{GNF_GO|id=GO:0009582 |text = detection of abiotic stimulus}} {{GNF_GO|id=GO:0048265 |text = response to pain}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6869
| Hs_Ensembl = ENSG00000115353
| Hs_RefseqProtein = NP_001049
| Hs_RefseqmRNA = NM_001058
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 75129738
| Hs_GenLoc_end = 75279781
| Hs_Uniprot = P25103
| Mm_EntrezGene = 21336
| Mm_Ensembl = ENSMUSG00000030043
| Mm_RefseqmRNA = NM_009313
| Mm_RefseqProtein = NP_033339
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 82368133
| Mm_GenLoc_end = 82525757
| Mm_Uniprot = Q3V353
}}
}}
'''Tachykinin receptor 1''', also known as '''TACR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TACR1 tachykinin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6869| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. This receptor is also involved in the mediation of phosphatidylinositol metabolism of substance P.<ref name="entrez">{{cite web | title = Entrez Gene: TACR1 tachykinin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6869| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Burcher E |title=The study of tachykinin receptors. |journal=Clin. Exp. Pharmacol. Physiol. |volume=16 |issue= 6 |pages= 539-43 |year= 1989 |pmid= 2548782 |doi= }}
*{{cite journal | author=Kowall NW, Quigley BJ, Krause JE, ''et al.'' |title=Substance P and substance P receptor histochemistry in human neurodegenerative diseases. |journal=Regul. Pept. |volume=46 |issue= 1-2 |pages= 174-85 |year= 1993 |pmid= 7692486 |doi= }}
*{{cite journal | author=Patacchini R, Maggi CA |title=Peripheral tachykinin receptors as targets for new drugs. |journal=Eur. J. Pharmacol. |volume=429 |issue= 1-3 |pages= 13-21 |year= 2002 |pmid= 11698023 |doi= }}
*{{cite journal | author=Saito R, Takano Y, Kamiya HO |title=Roles of substance P and NK(1) receptor in the brainstem in the development of emesis. |journal=J. Pharmacol. Sci. |volume=91 |issue= 2 |pages= 87-94 |year= 2003 |pmid= 12686752 |doi= }}
*{{cite journal | author=Fong TM, Yu H, Huang RR, Strader CD |title=The extracellular domain of the neurokinin-1 receptor is required for high-affinity binding of peptides. |journal=Biochemistry |volume=31 |issue= 47 |pages= 11806-11 |year= 1992 |pmid= 1280161 |doi= }}
*{{cite journal | author=Fong TM, Huang RR, Strader CD |title=Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor. |journal=J. Biol. Chem. |volume=267 |issue= 36 |pages= 25664-7 |year= 1993 |pmid= 1281469 |doi= }}
*{{cite journal | author=Fong TM, Anderson SA, Yu H, ''et al.'' |title=Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor. |journal=Mol. Pharmacol. |volume=41 |issue= 1 |pages= 24-30 |year= 1992 |pmid= 1310144 |doi= }}
*{{cite journal | author=Takahashi K, Tanaka A, Hara M, Nakanishi S |title=The primary structure and gene organization of human substance P and neuromedin K receptors. |journal=Eur. J. Biochem. |volume=204 |issue= 3 |pages= 1025-33 |year= 1992 |pmid= 1312928 |doi= }}
*{{cite journal | author=Walsh DA, Mapp PI, Wharton J, ''et al.'' |title=Localisation and characterisation of substance P binding to human synovial tissue in rheumatoid arthritis. |journal=Ann. Rheum. Dis. |volume=51 |issue= 3 |pages= 313-7 |year= 1992 |pmid= 1374227 |doi= }}
*{{cite journal | author=Gerard NP, Garraway LA, Eddy RL, ''et al.'' |title=Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones. |journal=Biochemistry |volume=30 |issue= 44 |pages= 10640-6 |year= 1991 |pmid= 1657150 |doi= }}
*{{cite journal | author=Hopkins B, Powell SJ, Danks P, ''et al.'' |title=Isolation and characterisation of the human lung NK-1 receptor cDNA. |journal=Biochem. Biophys. Res. Commun. |volume=180 |issue= 2 |pages= 1110-7 |year= 1991 |pmid= 1659396 |doi= }}
*{{cite journal | author=Takeda Y, Chou KB, Takeda J, ''et al.'' |title=Molecular cloning, structural characterization and functional expression of the human substance P receptor. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 3 |pages= 1232-40 |year= 1991 |pmid= 1718267 |doi= }}
*{{cite journal | author=Giuliani S, Barbanti G, Turini D, ''et al.'' |title=NK2 tachykinin receptors and contraction of circular muscle of the human colon: characterization of the NK2 receptor subtype. |journal=Eur. J. Pharmacol. |volume=203 |issue= 3 |pages= 365-70 |year= 1992 |pmid= 1723045 |doi= }}
*{{cite journal | author=Ichinose H, Katoh S, Sueoka T, ''et al.'' |title=Cloning and sequencing of cDNA encoding human sepiapterin reductase--an enzyme involved in tetrahydrobiopterin biosynthesis. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 1 |pages= 183-9 |year= 1991 |pmid= 1883349 |doi= }}
*{{cite journal | author=Thöny B, Heizmann CW, Mattei MG |title=Human GTP-cyclohydrolase I gene and sepiapterin reductase gene map to region 14q21-q22 and 2p14-p12, respectively, by in situ hybridization. |journal=Genomics |volume=26 |issue= 1 |pages= 168-70 |year= 1995 |pmid= 7782081 |doi= }}
*{{cite journal | author=Fong TM, Cascieri MA, Yu H, ''et al.'' |title=Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345. |journal=Nature |volume=362 |issue= 6418 |pages= 350-3 |year= 1993 |pmid= 8384323 |doi= 10.1038/362350a0 }}
*{{cite journal | author=Derocq JM, Ségui M, Blazy C, ''et al.'' |title=Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists. |journal=FEBS Lett. |volume=399 |issue= 3 |pages= 321-5 |year= 1997 |pmid= 8985172 |doi= }}
*{{cite journal | author=De Felipe C, Herrero JF, O'Brien JA, ''et al.'' |title=Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. |journal=Nature |volume=392 |issue= 6674 |pages= 394-7 |year= 1998 |pmid= 9537323 |doi= 10.1038/32904 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TACR2... {November 25, 2007 8:12:29 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:13:14 PM PST}
- CREATED: Created new protein page: TACR2 {November 25, 2007 8:13:24 PM PST}
- INFO: Beginning work on TACR3... {November 25, 2007 8:13:52 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:14:37 PM PST}
- CREATED: Created new protein page: TACR3 {November 25, 2007 8:14:45 PM PST}
- INFO: Beginning work on TBXA2R... {November 25, 2007 8:14:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:15:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thromboxane A2 receptor
| HGNCid = 11608
| Symbol = TBXA2R
| AltSymbols =; TXA2-R
| OMIM = 188070
| ECnumber =
| Homologene = 825
| MGIid = 98496
| GeneAtlas_image1 = PBB_GE_TBXA2R_336_at_tn.png
| GeneAtlas_image2 = PBB_GE_TBXA2R_207554_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_TBXA2R_211590_x_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004960 |text = thromboxane receptor activity}} {{GNF_GO|id=GO:0004961 |text = thromboxane A2 receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6915
| Hs_Ensembl = ENSG00000006638
| Hs_RefseqProtein = NP_001051
| Hs_RefseqmRNA = NM_001060
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 3545778
| Hs_GenLoc_end = 3557658
| Hs_Uniprot = P21731
| Mm_EntrezGene = 21390
| Mm_Ensembl = ENSMUSG00000034881
| Mm_RefseqmRNA = NM_009325
| Mm_RefseqProtein = NP_033351
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 80731957
| Mm_GenLoc_end = 80738300
| Mm_Uniprot = Q5FW61
}}
}}
'''Thromboxane A2 receptor''', also known as '''TBXA2R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBXA2R thromboxane A2 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6915| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Namba T, Narumiya S |title=[Thromboxane A2 receptor; structure, function and tissue distribution] |journal=Nippon Rinsho |volume=51 |issue= 1 |pages= 233-40 |year= 1993 |pmid= 8433523 |doi= }}
*{{cite journal | author=Murugappan S, Shankar H, Kunapuli SP |title=Platelet receptors for adenine nucleotides and thromboxane A2. |journal=Semin. Thromb. Hemost. |volume=30 |issue= 4 |pages= 411-8 |year= 2005 |pmid= 15354262 |doi= 10.1055/s-2004-833476 }}
*{{cite journal | author=Hirata M, Hayashi Y, Ushikubi F, ''et al.'' |title=Cloning and expression of cDNA for a human thromboxane A2 receptor. |journal=Nature |volume=349 |issue= 6310 |pages= 617-20 |year= 1991 |pmid= 1825698 |doi= 10.1038/349617a0 }}
*{{cite journal | author=Raychowdhury MK, Yukawa M, Collins LJ, ''et al.'' |title=Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 12 |pages= 7011 |year= 1995 |pmid= 7896853 |doi= }}
*{{cite journal | author=Hirata T, Kakizuka A, Ushikubi F, ''et al.'' |title=Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. |journal=J. Clin. Invest. |volume=94 |issue= 4 |pages= 1662-7 |year= 1994 |pmid= 7929844 |doi= }}
*{{cite journal | author=D'Angelo DD, Davis MG, Ali S, Dorn GW |title=Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. |journal=J. Pharmacol. Exp. Ther. |volume=271 |issue= 2 |pages= 1034-41 |year= 1994 |pmid= 7965765 |doi= }}
*{{cite journal | author=Raychowdhury MK, Yukawa M, Collins LJ, ''et al.'' |title=Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 30 |pages= 19256-61 |year= 1994 |pmid= 8034687 |doi= }}
*{{cite journal | author=Borg C, Lim CT, Yeomans DC, ''et al.'' |title=Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 6109-16 |year= 1994 |pmid= 8119956 |doi= }}
*{{cite journal | author=Nüsing RM, Hirata M, Kakizuka A, ''et al.'' |title=Characterization and chromosomal mapping of the human thromboxane A2 receptor gene. |journal=J. Biol. Chem. |volume=268 |issue= 33 |pages= 25253-9 |year= 1993 |pmid= 8227091 |doi= }}
*{{cite journal | author=Funk CD, Furci L, Moran N, Fitzgerald GA |title=Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites. |journal=Mol. Pharmacol. |volume=44 |issue= 5 |pages= 934-9 |year= 1994 |pmid= 8246916 |doi= }}
*{{cite journal | author=Schwengel DA, Nouri N, Meyers DA, Levitt RC |title=Linkage mapping of the human thromboxane A2 receptor (TBXA2R) to chromosome 19p13.3 using transcribed 3' untranslated DNA sequence polymorphisms. |journal=Genomics |volume=18 |issue= 2 |pages= 212-5 |year= 1994 |pmid= 8288221 |doi= 10.1006/geno.1993.1457 }}
*{{cite journal | author=Offermanns S, Laugwitz KL, Spicher K, Schultz G |title=G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 2 |pages= 504-8 |year= 1994 |pmid= 8290554 |doi= }}
*{{cite journal | author=Hirata T, Ushikubi F, Kakizuka A, ''et al.'' |title=Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. |journal=J. Clin. Invest. |volume=97 |issue= 4 |pages= 949-56 |year= 1996 |pmid= 8613548 |doi= }}
*{{cite journal | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957-64 |year= 1997 |pmid= 9152406 |doi= }}
*{{cite journal | author=Becker KP, Garnovskaya M, Gettys T, Halushka PV |title=Coupling of thromboxane A2 receptor isoforms to Galpha13: effects on ligand binding and signalling. |journal=Biochim. Biophys. Acta |volume=1450 |issue= 3 |pages= 288-96 |year= 1999 |pmid= 10395940 |doi= }}
*{{cite journal | author=Barr CL, Wigg KG, Pakstis AJ, ''et al.'' |title=Genome scan for linkage to Gilles de la Tourette syndrome. |journal=Am. J. Med. Genet. |volume=88 |issue= 4 |pages= 437-45 |year= 1999 |pmid= 10402514 |doi= }}
*{{cite journal | author=Zhou H, Yan F, Tai HH |title=Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases. |journal=J. Pharmacol. Exp. Ther. |volume=298 |issue= 3 |pages= 1243-51 |year= 2001 |pmid= 11504827 |doi= }}
*{{cite journal | author=Vezza R, Mezzasoma AM, Venditti G, Gresele P |title=Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. |journal=Thromb. Haemost. |volume=87 |issue= 1 |pages= 114-21 |year= 2002 |pmid= 11848439 |doi= }}
*{{cite journal | author=Turek JW, Halmos T, Sullivan NL, ''et al.'' |title=Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16791-7 |year= 2002 |pmid= 11877412 |doi= 10.1074/jbc.M105872200 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TRHR... {November 25, 2007 8:15:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:15:49 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thyrotropin-releasing hormone receptor
| HGNCid = 12299
| Symbol = TRHR
| AltSymbols =; MGC141920
| OMIM = 188545
| ECnumber =
| Homologene = 20707
| MGIid = 98824
| GeneAtlas_image1 = PBB_GE_TRHR_211438_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004997 |text = thyrotropin-releasing hormone receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7201
| Hs_Ensembl = ENSG00000174417
| Hs_RefseqProtein = NP_003292
| Hs_RefseqmRNA = NM_003301
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 110168900
| Hs_GenLoc_end = 110200989
| Hs_Uniprot = P34981
| Mm_EntrezGene = 22045
| Mm_Ensembl = ENSMUSG00000038760
| Mm_RefseqmRNA = NM_013696
| Mm_RefseqProtein = NP_038724
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 44027160
| Mm_GenLoc_end = 44059621
| Mm_Uniprot = Q32MS1
}}
}}
'''Thyrotropin-releasing hormone receptor''', also known as '''TRHR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRHR thyrotropin-releasing hormone receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7201| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Short RE, James LF, Panter KE, ''et al.'' |title=Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep. |journal=J. Anim. Sci. |volume=70 |issue= 11 |pages= 3498-504 |year= 1993 |pmid= 1459912 |doi= }}
*{{cite journal | author=Yamada M, Iwasaki T, Satoh T, ''et al.'' |title=Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. |journal=Neurosci. Lett. |volume=196 |issue= 1-2 |pages= 109-12 |year= 1996 |pmid= 7501234 |doi= }}
*{{cite journal | author=Hinuma S, Hosoya M, Ogi K, ''et al.'' |title=Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 251-9 |year= 1994 |pmid= 7918619 |doi= }}
*{{cite journal | author=Morrison N, Duthie SM, Boyd E, ''et al.'' |title=Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=93 |issue= 6 |pages= 716-8 |year= 1994 |pmid= 8005602 |doi= }}
*{{cite journal | author=Yamada M, Monden T, Konaka S, Mori M |title=Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. |journal=Somat. Cell Mol. Genet. |volume=19 |issue= 6 |pages= 577-80 |year= 1994 |pmid= 8128317 |doi= }}
*{{cite journal | author=Duthie SM, Taylor PL, Anderson L, ''et al.'' |title=Cloning and functional characterisation of the human TRH receptor. |journal=Mol. Cell. Endocrinol. |volume=95 |issue= 1-2 |pages= R11-5 |year= 1994 |pmid= 8243797 |doi= }}
*{{cite journal | author=Matre V, Karlsen HE, Wright MS, ''et al.'' |title=Molecular cloning of a functional human thyrotropin-releasing hormone receptor. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 179-85 |year= 1993 |pmid= 8395824 |doi= 10.1006/bbrc.1993.2027 }}
*{{cite journal | author=Yamada M, Monden T, Satoh T, ''et al.'' |title=Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 737-45 |year= 1993 |pmid= 8396925 |doi= 10.1006/bbrc.1993.2107 }}
*{{cite journal | author=Iwasaki T, Yamada M, Satoh T, ''et al.'' |title=Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22183-8 |year= 1996 |pmid= 8703031 |doi= }}
*{{cite journal | author=Cook JV, McGregor A, Lee T, ''et al.'' |title=A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. |journal=Endocrinology |volume=137 |issue= 7 |pages= 2851-8 |year= 1996 |pmid= 8770906 |doi= }}
*{{cite journal | author=Collu R, Tang J, Castagné J, ''et al.'' |title=A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 5 |pages= 1561-5 |year= 1997 |pmid= 9141550 |doi= }}
*{{cite journal | author=Petrou C, Tashjian AH |title=The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles. |journal=Cell. Signal. |volume=10 |issue= 8 |pages= 553-9 |year= 1999 |pmid= 9794253 |doi= }}
*{{cite journal | author=Matre V, Høvring PI, Orstavik S, ''et al.'' |title=Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 40-50 |year= 1999 |pmid= 9886052 |doi= }}
*{{cite journal | author=Kroeger KM, Hanyaloglu AC, Seeber RM, ''et al.'' |title=Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12736-43 |year= 2001 |pmid= 11278883 |doi= 10.1074/jbc.M011311200 }}
*{{cite journal | author=Zhu CC, Cook LB, Hinkle PM |title=Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28228-37 |year= 2002 |pmid= 12023974 |doi= 10.1074/jbc.M204221200 }}
*{{cite journal | author=Hanyaloglu AC, Seeber RM, Kohout TA, ''et al.'' |title=Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50422-30 |year= 2003 |pmid= 12393857 |doi= 10.1074/jbc.M209340200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Cook LB, Zhu CC, Hinkle PM |title=Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation. |journal=Mol. Endocrinol. |volume=17 |issue= 9 |pages= 1777-91 |year= 2004 |pmid= 12805411 |doi= 10.1210/me.2003-0073 }}
*{{cite journal | author=Igarashi-Migitaka J, Yamada S, Hara M, ''et al.'' |title=Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas. |journal=Endocr. J. |volume=50 |issue= 4 |pages= 459-67 |year= 2004 |pmid= 14599121 |doi= }}
*{{cite journal | author=Cook LB, Hinkle PM |title=Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein. |journal=Endocrinology |volume=145 |issue= 7 |pages= 3095-100 |year= 2004 |pmid= 15117874 |doi= 10.1210/en.2004-0304 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TSHR... {November 25, 2007 8:15:49 PM PST}
- SEARCH REDIRECT: Control Box Found: Thyrotropin receptor {November 25, 2007 8:16:24 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 25, 2007 8:16:27 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 25, 2007 8:16:27 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 25, 2007 8:16:27 PM PST}
- UPDATED: Updated protein page: Thyrotropin receptor {November 25, 2007 8:16:34 PM PST}
- INFO: Beginning work on VIPR1... {November 25, 2007 8:16:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 25, 2007 8:17:22 PM PST}
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Vasoactive intestinal peptide receptor 1
| HGNCid = 12694
| Symbol = VIPR1
| AltSymbols =; II; FLJ41949; HVR1; PACAP-R-2; RDC1; VAPC1; VIPR; VIRG; VPAC1
| OMIM = 192321
| ECnumber =
| Homologene = 3399
| MGIid = 109272
| GeneAtlas_image1 = PBB_GE_VIPR1_205019_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004999 |text = vasoactive intestinal polypeptide receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007187 |text = G-protein signaling, coupled to cyclic nucleotide second messenger}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7433
| Hs_Ensembl = ENSG00000114812
| Hs_RefseqProtein = NP_004615
| Hs_RefseqmRNA = NM_004624
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 42519121
| Hs_GenLoc_end = 42554064
| Hs_Uniprot = P32241
| Mm_EntrezGene = 22354
| Mm_Ensembl = ENSMUSG00000032528
| Mm_RefseqmRNA = NM_011703
| Mm_RefseqProtein = NP_035833
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 121491414
| Mm_GenLoc_end = 121519332
| Mm_Uniprot = P97751
}}
}}
'''Vasoactive intestinal peptide receptor 1''', also known as '''VIPR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7433| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase.<ref name="entrez">{{cite web | title = Entrez Gene: VIPR1 vasoactive intestinal peptide receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7433| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author= |title=[Quaternary structure of rabbit skeletal muscle glycogen synthetase] |journal=Dokl. Akad. Nauk SSSR |volume=222 |issue= 4 |pages= 997-1000 |year= 1975 |pmid= 807467 |doi= }}
*{{cite journal | author=Sreedharan SP, Huang JX, Cheung MC, Goetzl EJ |title=Structure, expression, and chromosomal localization of the type I human vasoactive intestinal peptide receptor gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 7 |pages= 2939-43 |year= 1995 |pmid= 7708752 |doi= }}
*{{cite journal | author=Couvineau A, Gaudin P, Maoret JJ, ''et al.'' |title=Highly conserved aspartate 68, tryptophane 73 and glycine 109 in the N-terminal extracellular domain of the human VIP receptor are essential for its ability to bind VIP. |journal=Biochem. Biophys. Res. Commun. |volume=206 |issue= 1 |pages= 246-52 |year= 1995 |pmid= 7818527 |doi= }}
*{{cite journal | author=Gagnon AW, Aiyar N, Elshourbagy NA |title=Molecular cloning and functional characterization of a human liver vasoactive intestinal peptide receptor. |journal=Cell. Signal. |volume=6 |issue= 3 |pages= 321-33 |year= 1994 |pmid= 7917790 |doi= }}
*{{cite journal | author=Sreedharan SP, Patel DR, Xia M, ''et al.'' |title=Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 1 |pages= 141-8 |year= 1994 |pmid= 8074647 |doi= }}
*{{cite journal | author=Couvineau A, Rouyer-Fessard C, Darmoul D, ''et al.'' |title=Human intestinal VIP receptor: cloning and functional expression of two cDNA encoding proteins with different N-terminal domains. |journal=Biochem. Biophys. Res. Commun. |volume=200 |issue= 2 |pages= 769-76 |year= 1994 |pmid= 8179610 |doi= }}
*{{cite journal | author=Moody TW, Zia F, Draoui M, ''et al.'' |title=A vasoactive intestinal peptide antagonist inhibits non-small cell lung cancer growth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4345-9 |year= 1993 |pmid= 8389448 |doi= }}
*{{cite journal | author=Sreedharan SP, Patel DR, Huang JX, Goetzl EJ |title=Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor. |journal=Biochem. Biophys. Res. Commun. |volume=193 |issue= 2 |pages= 546-53 |year= 1993 |pmid= 8390245 |doi= 10.1006/bbrc.1993.1658 }}
*{{cite journal | author=Couvineau A, Fabre C, Gaudin P, ''et al.'' |title=Mutagenesis of N-glycosylation sites in the human vasoactive intestinal peptide 1 receptor. Evidence that asparagine 58 or 69 is crucial for correct delivery of the receptor to plasma membrane. |journal=Biochemistry |volume=35 |issue= 6 |pages= 1745-52 |year= 1996 |pmid= 8639654 |doi= 10.1021/bi952022h }}
*{{cite journal | author=Pozo D, Guerrero JM, Segura JJ, Calvo JR |title=Thymosin alpha 1 interacts with the VIP receptor-effector system in rat and mouse immunocompetent cells. |journal=Immunopharmacology |volume=34 |issue= 2-3 |pages= 113-23 |year= 1997 |pmid= 8886855 |doi= }}
*{{cite journal | author=Couvineau A, Maoret JJ, Rouyer-Fessard C, ''et al.'' |title=Cloning and functional characterization of the human VIP1/PACAP receptor promoter. |journal=Ann. N. Y. Acad. Sci. |volume=865 |issue= |pages= 59-63 |year= 1999 |pmid= 9927997 |doi= }}
*{{cite journal | author=Knudsen SM, Tams JW, Wulff BS, Fahrenkrug J |title=Importance of conserved cysteines in the extracellular loops of human PACAP/VIP1 receptor for ligand binding and stimulation of cAMP production. |journal=Ann. N. Y. Acad. Sci. |volume=865 |issue= |pages= 259-65 |year= 1999 |pmid= 9928020 |doi= }}
*{{cite journal | author=Marie J, Wakkach A, Coudray A, ''et al.'' |title=Functional expression of receptors for calcitonin gene-related peptide, calcitonin, and vasoactive intestinal peptide in the human thymus and thymomas from myasthenia gravis patients. |journal=J. Immunol. |volume=162 |issue= 4 |pages= 2103-12 |year= 1999 |pmid= 9973484 |doi= }}
*{{cite journal | author=Mimuro H, Suzuki T, Suetsugu S, ''et al.'' |title=Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28893-901 |year= 2000 |pmid= 10867004 |doi= 10.1074/jbc.M003882200 }}
*{{cite journal | author=Nicole P, Maoret JJ, Couvineau A, ''et al.'' |title=Tryptophan 67 in the human VPAC(1) receptor: crucial role for VIP binding. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 2 |pages= 654-9 |year= 2000 |pmid= 11027527 |doi= 10.1006/bbrc.2000.3375 }}
*{{cite journal | author=Bajo AM, Juarranz MG, Valenzuela P, ''et al.'' |title=Expression of vasoactive intestinal peptide (VIP) receptors in human uterus. |journal=Peptides |volume=21 |issue= 9 |pages= 1383-8 |year= 2001 |pmid= 11072126 |doi= }}
*{{cite journal | author=Lara-Marquez M, O'Dorisio M, O'Dorisio T, ''et al.'' |title=Selective gene expression and activation-dependent regulation of vasoactive intestinal peptide receptor type 1 and type 2 in human T cells. |journal=J. Immunol. |volume=166 |issue= 4 |pages= 2522-30 |year= 2001 |pmid= 11160313 |doi= }}
*{{cite journal | author=Martin Shreeve S |title=Identification of G-proteins coupling to the vasoactive intestinal peptide receptor VPAC(1) using immunoaffinity chromatography: evidence for precoupling. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 4 |pages= 1300-7 |year= 2002 |pmid= 11812005 |doi= 10.1006/bbrc.2002.6342 }}
*{{cite journal | author=Dorsam G, Goetzl EJ |title=Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13488-93 |year= 2002 |pmid= 11812772 |doi= 10.1074/jbc.M107922200 }}
*{{cite journal | author=Branch DR, Valenta LJ, Yousefi S, ''et al.'' |title=VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection. |journal=AIDS |volume=16 |issue= 3 |pages= 309-19 |year= 2002 |pmid= 11834941 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VIPR2... {November 25, 2007 8:17:22 PM PST}
- CREATE: Found no pages, creating new page. {November 25, 2007 8:19:12 PM PST}
- CREATED: Created new protein page: VIPR2 {November 25, 2007 8:19:21 PM PST}
end log.
