Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 03:34, 19 November 2007 (UTC)
[edit]Proteins without matches (5)
[edit]Proteins with a High Potential Match (6)
[edit]Redirected Proteins (14)
[edit]Manual Inspection (Page not found) (11)
[edit]Updated with Warning (1)
[edit]
Protein Status Grid - Date: 03:34, 19 November 2007 (UTC)
[edit]Vebose Log - Date: 03:34, 19 November 2007 (UTC)
[edit]- INFO: Beginning work on HNF4A... {November 18, 2007 7:07:40 PM PST}
- SEARCH REDIRECT: Control Box Found: HNF4A {November 18, 2007 7:08:58 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:08:59 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:08:59 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:08:59 PM PST}
- UPDATED: Updated protein page: HNF4A {November 18, 2007 7:09:07 PM PST}
- INFO: Beginning work on HNF4G... {November 18, 2007 7:09:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HNF4G image.jpg {November 18, 2007 7:09:41 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:09:51 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HNF4G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lv2.
| PDB = {{PDB2|1lv2}}
| Name = Hepatocyte nuclear factor 4, gamma
| HGNCid = 5026
| Symbol = HNF4G
| AltSymbols =; NR2A2
| OMIM = 605966
| ECnumber =
| Homologene = 37886
| MGIid = 1353604
| GeneAtlas_image1 = PBB_GE_HNF4G_207456_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3174
| Hs_Ensembl = ENSG00000164749
| Hs_RefseqProtein = NP_004124
| Hs_RefseqmRNA = NM_004133
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 76482826
| Hs_GenLoc_end = 76639117
| Hs_Uniprot = Q14541
| Mm_EntrezGene = 30942
| Mm_Ensembl = ENSMUSG00000017688
| Mm_RefseqmRNA = NM_013920
| Mm_RefseqProtein = NP_038948
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 3493753
| Mm_GenLoc_end = 3643025
| Mm_Uniprot = Q059V1
}}
}}
'''Hepatocyte nuclear factor 4, gamma''', also known as '''HNF4G''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3174| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Drewes T, Senkel S, Holewa B, Ryffel GU |title=Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 925-31 |year= 1996 |pmid= 8622695 |doi= }}
*{{cite journal | author=Plengvidhya N, Antonellis A, Wogan LT, ''et al.'' |title=Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. |journal=Diabetes |volume=48 |issue= 10 |pages= 2099-102 |year= 1999 |pmid= 10512380 |doi= }}
*{{cite journal | author=Wisely GB, Miller AB, Davis RG, ''et al.'' |title=Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. |journal=Structure |volume=10 |issue= 9 |pages= 1225-34 |year= 2003 |pmid= 12220494 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ozeki T, Takahashi Y, Nakayama K, ''et al.'' |title=Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. |journal=Pharmacogenetics |volume=13 |issue= 1 |pages= 49-53 |year= 2003 |pmid= 12544512 |doi= }}
*{{cite journal | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331-5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1D1... {November 18, 2007 7:24:05 PM PST}
- SEARCH REDIRECT: Control Box Found: NR1D1 {November 18, 2007 7:24:48 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:24:50 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:24:50 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:24:50 PM PST}
- UPDATED: Updated protein page: NR1D1 {November 18, 2007 7:24:58 PM PST}
- INFO: Beginning work on NR1D2... {November 18, 2007 7:26:13 PM PST}
- SEARCH REDIRECT: Control Box Found: NR1D2 {November 18, 2007 7:26:45 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:26:46 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:26:46 PM PST}
- SKIP CITATIONS: Skipping Citations, No Errors. {November 18, 2007 7:26:46 PM PST}
- UPDATED: Warning while updating page: Could not find citation box. {November 18, 2007 7:26:53 PM PST}
- UPDATED: Updated protein page (with warnings): NR1D2 {November 18, 2007 7:26:53 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1D2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a6y.
| PDB = {{PDB2|1a6y}}, {{PDB2|1ga5}}, {{PDB2|1hlz}}
| Name = Nuclear receptor subfamily 1, group D, member 2
| HGNCid = 7963
| Symbol = NR1D2
| AltSymbols =; HZF2; BD73; EAR-1r; Hs.37288; RVR
| OMIM = 602304
| ECnumber =
| Homologene = 3763
| MGIid = 2449205
| GeneAtlas_image1 = PBB_GE_NR1D2_209750_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9975
| Hs_Ensembl = ENSG00000174738
| Hs_RefseqProtein = XP_001130839
| Hs_RefseqmRNA = XM_001130839
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 23961810
| Hs_GenLoc_end = 23996240
| Hs_Uniprot = Q14995
| Mm_EntrezGene = 353187
| Mm_Ensembl = ENSMUSG00000021775
| Mm_RefseqmRNA = NM_011584
| Mm_RefseqProtein = NP_035714
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 16997124
| Mm_GenLoc_end = 17032066
| Mm_Uniprot = Q4VAB7
}}
}}
'''Nuclear receptor subfamily 1, group D, member 2''', also known as '''NR1D2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1D2 nuclear receptor subfamily 1, group D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9975| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Retnakaran R, Flock G, Giguère V |title=Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. |journal=Mol. Endocrinol. |volume=8 |issue= 9 |pages= 1234-44 |year= 1995 |pmid= 7838156 |doi= }}
*{{cite journal | author=Dumas B, Harding HP, Choi HS, ''et al.'' |title=A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. |journal=Mol. Endocrinol. |volume=8 |issue= 8 |pages= 996-1005 |year= 1995 |pmid= 7997240 |doi= }}
*{{cite journal | author=Downes M, Burke LJ, Bailey PJ, Muscat GE |title=Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors. |journal=Nucleic Acids Res. |volume=24 |issue= 22 |pages= 4379-86 |year= 1997 |pmid= 8948627 |doi= }}
*{{cite journal | author=Burke LJ, Downes M, Laudet V, Muscat GE |title=Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 248-62 |year= 1998 |pmid= 9482666 |doi= }}
*{{cite journal | author=Koh YS, Moore DD |title=Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication. |journal=Genomics |volume=57 |issue= 2 |pages= 289-92 |year= 1999 |pmid= 10198169 |doi= 10.1006/geno.1998.5683 }}
*{{cite journal | author=Sauvé F, McBroom LD, Gallant J, ''et al.'' |title=CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. |journal=Mol. Cell. Biol. |volume=21 |issue= 1 |pages= 343-53 |year= 2001 |pmid= 11113208 |doi= 10.1128/MCB.21.1.343-353.2001 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1H2... {November 18, 2007 7:21:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:22:26 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1H2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p8d.
| PDB = {{PDB2|1p8d}}, {{PDB2|1pq6}}, {{PDB2|1pq9}}, {{PDB2|1pqc}}, {{PDB2|1upv}}, {{PDB2|1upw}}
| Name = Nuclear receptor subfamily 1, group H, member 2
| HGNCid = 7965
| Symbol = NR1H2
| AltSymbols =; UNR; LXR-b; LXRB; NER; NER-I; RIP15
| OMIM = 600380
| ECnumber =
| Homologene = 21397
| MGIid = 1352463
| GeneAtlas_image1 = PBB_GE_NR1H2_218215_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7376
| Hs_Ensembl = ENSG00000131408
| Hs_RefseqProtein = NP_009052
| Hs_RefseqmRNA = NM_007121
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 55571515
| Hs_GenLoc_end = 55578030
| Hs_Uniprot = P55055
| Mm_EntrezGene = 22260
| Mm_Ensembl = ENSMUSG00000060601
| Mm_RefseqmRNA = XM_001002072
| Mm_RefseqProtein = XP_001002072
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 44417659
| Mm_GenLoc_end = 44421965
| Mm_Uniprot = Q8BP65
}}
}}
'''Nuclear receptor subfamily 1, group H, member 2''', also known as '''NR1H2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: NR1H2 nuclear receptor subfamily 1, group H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7376| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Song C, Hiipakka RA, Kokontis JM, Liao S |title=Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones. |journal=Ann. N. Y. Acad. Sci. |volume=761 |issue= |pages= 38-49 |year= 1995 |pmid= 7625741 |doi= }}
*{{cite journal | author=Seol W, Choi HS, Moore DD |title=Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 72-85 |year= 1995 |pmid= 7760852 |doi= }}
*{{cite journal | author=Le Beau MM, Song C, Davis EM, ''et al.'' |title=Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization. |journal=Genomics |volume=26 |issue= 1 |pages= 166-8 |year= 1995 |pmid= 7782080 |doi= }}
*{{cite journal | author=Shinar DM, Endo N, Rutledge SJ, ''et al.'' |title=NER, a new member of the gene family encoding the human steroid hormone nuclear receptor. |journal=Gene |volume=147 |issue= 2 |pages= 273-6 |year= 1994 |pmid= 7926814 |doi= }}
*{{cite journal | author=Song C, Kokontis JM, Hiipakka RA, Liao S |title=Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 10809-13 |year= 1994 |pmid= 7971966 |doi= }}
*{{cite journal | author=Janowski BA, Grogan MJ, Jones SA, ''et al.'' |title=Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 266-71 |year= 1999 |pmid= 9874807 |doi= }}
*{{cite journal | author=Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA |title=Identification of a novel DNA binding site for nuclear orphan receptor OR1. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10421-9 |year= 1999 |pmid= 10187832 |doi= }}
*{{cite journal | author=Lee SK, Jung SY, Kim YS, ''et al.'' |title=Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2. |journal=Mol. Endocrinol. |volume=15 |issue= 2 |pages= 241-54 |year= 2001 |pmid= 11158331 |doi= }}
*{{cite journal | author=Whitney KD, Watson MA, Goodwin B, ''et al.'' |title=Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43509-15 |year= 2001 |pmid= 11546778 |doi= 10.1074/jbc.M106155200 }}
*{{cite journal | author=Whitney KD, Watson MA, Collins JL, ''et al.'' |title=Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. |journal=Mol. Endocrinol. |volume=16 |issue= 6 |pages= 1378-85 |year= 2003 |pmid= 12040022 |doi= }}
*{{cite journal | author=Brendel C, Schoonjans K, Botrugno OA, ''et al.'' |title=The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. |journal=Mol. Endocrinol. |volume=16 |issue= 9 |pages= 2065-76 |year= 2003 |pmid= 12198243 |doi= }}
*{{cite journal | author=Mo J, Fang SJ, Chen W, Blobe GC |title=Regulation of ALK-1 signaling by the nuclear receptor LXRbeta. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50788-94 |year= 2003 |pmid= 12393874 |doi= 10.1074/jbc.M210376200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Williams S, Bledsoe RK, Collins JL, ''et al.'' |title=X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 27138-43 |year= 2003 |pmid= 12736258 |doi= 10.1074/jbc.M302260200 }}
*{{cite journal | author=Färnegårdh M, Bonn T, Sun S, ''et al.'' |title=The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. |journal=J. Biol. Chem. |volume=278 |issue= 40 |pages= 38821-8 |year= 2003 |pmid= 12819202 |doi= 10.1074/jbc.M304842200 }}
*{{cite journal | author=Fukuchi J, Song C, Ko AL, Liao S |title=Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors. |journal=Steroids |volume=68 |issue= 7-8 |pages= 685-91 |year= 2004 |pmid= 12957674 |doi= }}
*{{cite journal | author=Hoerer S, Schmid A, Heckel A, ''et al.'' |title=Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist. |journal=J. Mol. Biol. |volume=334 |issue= 5 |pages= 853-61 |year= 2004 |pmid= 14643652 |doi= }}
*{{cite journal | author=Walczak R, Joseph SB, Laffitte BA, ''et al.'' |title=Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 9905-11 |year= 2004 |pmid= 14699103 |doi= 10.1074/jbc.M310587200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1H3... {November 18, 2007 7:26:53 PM PST}
- REDIRECT: Protein Redirected to: NR1H3 {November 18, 2007 7:27:12 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:27:14 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:27:14 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:27:14 PM PST}
- UPDATED: Updated protein page: NR1H3 {November 18, 2007 7:27:21 PM PST}
- INFO: Beginning work on NR1H4... {November 18, 2007 7:25:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:26:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1H4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1osh.
| PDB = {{PDB2|1osh}}, {{PDB2|1osv}}, {{PDB2|1ot7}}
| Name = Nuclear receptor subfamily 1, group H, member 4
| HGNCid = 7967
| Symbol = NR1H4
| AltSymbols =; BAR; FXR; HRR-1; HRR1; MGC163445; RIP14
| OMIM = 603826
| ECnumber =
| Homologene = 3760
| MGIid = 1352464
| GeneAtlas_image1 = PBB_GE_NR1H4_206340_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008206 |text = bile acid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9971
| Hs_Ensembl = ENSG00000012504
| Hs_RefseqProtein = NP_005114
| Hs_RefseqmRNA = NM_005123
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 99391810
| Hs_GenLoc_end = 99481772
| Hs_Uniprot = Q96RI1
| Mm_EntrezGene = 20186
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_009108
| Mm_RefseqProtein = NP_033134
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Nuclear receptor subfamily 1, group H, member 4''', also known as '''NR1H4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1H4 nuclear receptor subfamily 1, group H, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9971| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kalaany NY, Mangelsdorf DJ |title=LXRS and FXR: the yin and yang of cholesterol and fat metabolism. |journal=Annu. Rev. Physiol. |volume=68 |issue= |pages= 159-91 |year= 2006 |pmid= 16460270 |doi= 10.1146/annurev.physiol.68.033104.152158 }}
*{{cite journal | author=Kuipers F, Stroeve JH, Caron S, Staels B |title=Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. |journal=Curr. Opin. Lipidol. |volume=18 |issue= 3 |pages= 289-97 |year= 2007 |pmid= 17495603 |doi= 10.1097/MOL.0b013e3281338d08 }}
*{{cite journal | author=Seol W, Choi HS, Moore DD |title=Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. |journal=Mol. Endocrinol. |volume=9 |issue= 1 |pages= 72-85 |year= 1995 |pmid= 7760852 |doi= }}
*{{cite journal | author=Forman BM, Goode E, Chen J, ''et al.'' |title=Identification of a nuclear receptor that is activated by farnesol metabolites. |journal=Cell |volume=81 |issue= 5 |pages= 687-93 |year= 1995 |pmid= 7774010 |doi= }}
*{{cite journal | author=Zavacki AM, Lehmann JM, Seol W, ''et al.'' |title=Activation of the orphan receptor RIP14 by retinoids. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 15 |pages= 7909-14 |year= 1997 |pmid= 9223286 |doi= }}
*{{cite journal | author=Makishima M, Okamoto AY, Repa JJ, ''et al.'' |title=Identification of a nuclear receptor for bile acids. |journal=Science |volume=284 |issue= 5418 |pages= 1362-5 |year= 1999 |pmid= 10334992 |doi= }}
*{{cite journal | author=Parks DJ, Blanchard SG, Bledsoe RK, ''et al.'' |title=Bile acids: natural ligands for an orphan nuclear receptor. |journal=Science |volume=284 |issue= 5418 |pages= 1365-8 |year= 1999 |pmid= 10334993 |doi= }}
*{{cite journal | author=Bramlett KS, Yao S, Burris TP |title=Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids. |journal=Mol. Genet. Metab. |volume=71 |issue= 4 |pages= 609-15 |year= 2001 |pmid= 11136553 |doi= 10.1006/mgme.2000.3106 }}
*{{cite journal | author=Stegh AH, Barnhart BC, Volkland J, ''et al.'' |title=Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 4351-60 |year= 2002 |pmid= 11733517 |doi= 10.1074/jbc.M108947200 }}
*{{cite journal | author=Cui J, Heard TS, Yu J, ''et al.'' |title=The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 25963-9 |year= 2002 |pmid= 12004058 |doi= 10.1074/jbc.M200824200 }}
*{{cite journal | author=Huber RM, Murphy K, Miao B, ''et al.'' |title=Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. |journal=Gene |volume=290 |issue= 1-2 |pages= 35-43 |year= 2002 |pmid= 12062799 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Pineda Torra I, Claudel T, Duval C, ''et al.'' |title=Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. |journal=Mol. Endocrinol. |volume=17 |issue= 2 |pages= 259-72 |year= 2003 |pmid= 12554753 |doi= }}
*{{cite journal | author=Anisfeld AM, Kast-Woelbern HR, Meyer ME, ''et al.'' |title=Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20420-8 |year= 2003 |pmid= 12660231 |doi= 10.1074/jbc.M302505200 }}
*{{cite journal | author=Pircher PC, Kitto JL, Petrowski ML, ''et al.'' |title=Farnesoid X receptor regulates bile acid-amino acid conjugation. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27703-11 |year= 2003 |pmid= 12754200 |doi= 10.1074/jbc.M302128200 }}
*{{cite journal | author=Zhao A, Lew JL, Huang L, ''et al.'' |title=Human kininogen gene is transactivated by the farnesoid X receptor. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28765-70 |year= 2003 |pmid= 12761213 |doi= 10.1074/jbc.M304568200 }}
*{{cite journal | author=Barbier O, Torra IP, Sirvent A, ''et al.'' |title=FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. |journal=Gastroenterology |volume=124 |issue= 7 |pages= 1926-40 |year= 2003 |pmid= 12806625 |doi= }}
*{{cite journal | author=Holt JA, Luo G, Billin AN, ''et al.'' |title=Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. |journal=Genes Dev. |volume=17 |issue= 13 |pages= 1581-91 |year= 2003 |pmid= 12815072 |doi= 10.1101/gad.1083503 }}
*{{cite journal | author=Claudel T, Inoue Y, Barbier O, ''et al.'' |title=Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression. |journal=Gastroenterology |volume=125 |issue= 2 |pages= 544-55 |year= 2003 |pmid= 12891557 |doi= }}
*{{cite journal | author=Hsiao PW, Fryer CJ, Trotter KW, ''et al.'' |title=BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. |journal=Mol. Cell. Biol. |volume=23 |issue= 17 |pages= 6210-20 |year= 2003 |pmid= 12917342 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1I2... {November 18, 2007 7:23:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:24:05 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1I2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ilg.
| PDB = {{PDB2|1ilg}}, {{PDB2|1ilh}}, {{PDB2|1m13}}, {{PDB2|1nrl}}, {{PDB2|1skx}}, {{PDB2|2o9i}}
| Name = Nuclear receptor subfamily 1, group I, member 2
| HGNCid = 7968
| Symbol = NR1I2
| AltSymbols =; SAR; PAR1; PAR2; PRR; BXR; ONR1; PAR; PARq; PXR; SXR
| OMIM = 603065
| ECnumber =
| Homologene = 40757
| MGIid = 1337040
| GeneAtlas_image1 = PBB_GE_NR1I2_207202_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR1I2_207203_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8856
| Hs_Ensembl = ENSG00000144852
| Hs_RefseqProtein = NP_003880
| Hs_RefseqmRNA = NM_003889
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 120984236
| Hs_GenLoc_end = 121020021
| Hs_Uniprot = O75469
| Mm_EntrezGene = 18171
| Mm_Ensembl = ENSMUSG00000022809
| Mm_RefseqmRNA = NM_010936
| Mm_RefseqProtein = NP_035066
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 16
| Mm_GenLoc_start = 38167590
| Mm_GenLoc_end = 38214062
| Mm_Uniprot = Q0P525
}}
}}
'''Nuclear receptor subfamily 1, group I, member 2''', also known as '''NR1I2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1I2 nuclear receptor subfamily 1, group I, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8856| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.<ref name="entrez">{{cite web | title = Entrez Gene: NR1I2 nuclear receptor subfamily 1, group I, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8856| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Watkins RE, Noble SM, Redinbo MR |title=Structural insights into the promiscuity and function of the human pregnane X receptor. |journal=Current opinion in drug discovery & development |volume=5 |issue= 1 |pages= 150-8 |year= 2002 |pmid= 11865669 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Kliewer SA, Moore JT, Wade L, ''et al.'' |title=An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. |journal=Cell |volume=92 |issue= 1 |pages= 73-82 |year= 1998 |pmid= 9489701 |doi= }}
*{{cite journal | author=Lehmann JM, McKee DD, Watson MA, ''et al.'' |title=The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. |journal=J. Clin. Invest. |volume=102 |issue= 5 |pages= 1016-23 |year= 1998 |pmid= 9727070 |doi= }}
*{{cite journal | author=Bertilsson G, Heidrich J, Svensson K, ''et al.'' |title=Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12208-13 |year= 1998 |pmid= 9770465 |doi= }}
*{{cite journal | author=Blumberg B, Sabbagh W, Juguilon H, ''et al.'' |title=SXR, a novel steroid and xenobiotic-sensing nuclear receptor. |journal=Genes Dev. |volume=12 |issue= 20 |pages= 3195-205 |year= 1998 |pmid= 9784494 |doi= }}
*{{cite journal | author=Dotzlaw H, Leygue E, Watson P, Murphy LC |title=The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue. |journal=Clin. Cancer Res. |volume=5 |issue= 8 |pages= 2103-7 |year= 1999 |pmid= 10473093 |doi= }}
*{{cite journal | author=Geick A, Eichelbaum M, Burk O |title=Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14581-7 |year= 2001 |pmid= 11297522 |doi= 10.1074/jbc.M010173200 }}
*{{cite journal | author=Watkins RE, Wisely GB, Moore LB, ''et al.'' |title=The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. |journal=Science |volume=292 |issue= 5525 |pages= 2329-33 |year= 2001 |pmid= 11408620 |doi= 10.1126/science.1060762 }}
*{{cite journal | author=Zhang J, Kuehl P, Green ED, ''et al.'' |title=The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants. |journal=Pharmacogenetics |volume=11 |issue= 7 |pages= 555-72 |year= 2001 |pmid= 11668216 |doi= }}
*{{cite journal | author=Gonzalez MM, Carlberg C |title=Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18501-9 |year= 2002 |pmid= 11891224 |doi= 10.1074/jbc.M200205200 }}
*{{cite journal | author=Takeshita A, Taguchi M, Koibuchi N, Ozawa Y |title=Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32453-8 |year= 2002 |pmid= 12072427 |doi= 10.1074/jbc.M111245200 }}
*{{cite journal | author=Frungieri MB, Weidinger S, Meineke V, ''et al.'' |title=Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 15072-7 |year= 2003 |pmid= 12397176 |doi= 10.1073/pnas.232422999 }}
*{{cite journal | author=Fukuen S, Fukuda T, Matsuda H, ''et al.'' |title=Identification of the novel splicing variants for the hPXR in human livers. |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 3 |pages= 433-8 |year= 2002 |pmid= 12413960 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Chang TK, Bandiera SM, Chen J |title=Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. |journal=Drug Metab. Dispos. |volume=31 |issue= 1 |pages= 7-10 |year= 2003 |pmid= 12485946 |doi= }}
*{{cite journal | author=Dussault I, Yoo HD, Lin M, ''et al.'' |title=Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 833-8 |year= 2003 |pmid= 12569201 |doi= 10.1073/pnas.0336235100 }}
*{{cite journal | author=Kawana K, Ikuta T, Kobayashi Y, ''et al.'' |title=Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR. |journal=Mol. Pharmacol. |volume=63 |issue= 3 |pages= 524-31 |year= 2003 |pmid= 12606758 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR1I3... {November 18, 2007 7:24:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:25:32 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NR1I3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1xv9.
| PDB = {{PDB2|1xv9}}, {{PDB2|1xvp}}
| Name = Nuclear receptor subfamily 1, group I, member 3
| HGNCid = 7969
| Symbol = NR1I3
| AltSymbols =; CAR; CAR1; MB67; MGC150433; MGC97144; MGC97209
| OMIM = 603881
| ECnumber =
| Homologene = 3759
| MGIid = 1346307
| GeneAtlas_image1 = PBB_GE_NR1I3_207007_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0004882 |text = androgen receptor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9970
| Hs_Ensembl = ENSG00000143257
| Hs_RefseqProtein = NP_001070937
| Hs_RefseqmRNA = NM_001077469
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 159466079
| Hs_GenLoc_end = 159474590
| Hs_Uniprot = Q14994
| Mm_EntrezGene = 12355
| Mm_Ensembl = ENSMUSG00000005677
| Mm_RefseqmRNA = NM_009803
| Mm_RefseqProtein = NP_033933
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 173050645
| Mm_GenLoc_end = 173055519
| Mm_Uniprot = Q3UEP1
}}
}}
'''Nuclear receptor subfamily 1, group I, member 3''', also known as '''NR1I3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR1I3 nuclear receptor subfamily 1, group I, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9970| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NR1I3 nuclear receptor subfamily 1, group I, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9970| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Masuno M, Shimozawa N, Suzuki Y, ''et al.'' |title=Assignment of the human peroxisome assembly factor-1 gene (PXMP3) responsible for Zellweger syndrome to chromosome 8q21.1 by fluorescence in situ hybridization. |journal=Genomics |volume=20 |issue= 1 |pages= 141-2 |year= 1994 |pmid= 8020947 |doi= 10.1006/geno.1994.1144 }}
*{{cite journal | author=Baes M, Gulick T, Choi HS, ''et al.'' |title=A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. |journal=Mol. Cell. Biol. |volume=14 |issue= 3 |pages= 1544-52 |year= 1994 |pmid= 8114692 |doi= }}
*{{cite journal | author=Choi HS, Seol W, Moore DD |title=A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. |journal=J. Steroid Biochem. Mol. Biol. |volume=56 |issue= 1-6 Spec No |pages= 23-30 |year= 1996 |pmid= 8603043 |doi= }}
*{{cite journal | author=Seol W, Choi HS, Moore DD |title=An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. |journal=Science |volume=272 |issue= 5266 |pages= 1336-9 |year= 1996 |pmid= 8650544 |doi= }}
*{{cite journal | author=Choi HS, Chung M, Tzameli I, ''et al.'' |title=Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23565-71 |year= 1997 |pmid= 9295294 |doi= }}
*{{cite journal | author=Seol W, Hanstein B, Brown M, Moore DD |title=Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). |journal=Mol. Endocrinol. |volume=12 |issue= 10 |pages= 1551-7 |year= 1998 |pmid= 9773978 |doi= }}
*{{cite journal | author=Forman BM, Tzameli I, Choi HS, ''et al.'' |title=Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta. |journal=Nature |volume=395 |issue= 6702 |pages= 612-5 |year= 1998 |pmid= 9783588 |doi= 10.1038/26996 }}
*{{cite journal | author=Gonzalez MM, Carlberg C |title=Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18501-9 |year= 2002 |pmid= 11891224 |doi= 10.1074/jbc.M200205200 }}
*{{cite journal | author=Min G, Kim H, Bae Y, ''et al.'' |title=Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34626-33 |year= 2002 |pmid= 12114525 |doi= 10.1074/jbc.M205239200 }}
*{{cite journal | author=Goodwin B, Hodgson E, D'Costa DJ, ''et al.'' |title=Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 359-65 |year= 2002 |pmid= 12130689 |doi= }}
*{{cite journal | author=Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA |title=Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site. |journal=Mol. Pharmacol. |volume=62 |issue= 3 |pages= 737-46 |year= 2002 |pmid= 12181452 |doi= }}
*{{cite journal | author=Zhang J, Huang W, Chua SS, ''et al.'' |title=Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. |journal=Science |volume=298 |issue= 5592 |pages= 422-4 |year= 2002 |pmid= 12376703 |doi= 10.1126/science.1073502 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Chang TK, Bandiera SM, Chen J |title=Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels. |journal=Drug Metab. Dispos. |volume=31 |issue= 1 |pages= 7-10 |year= 2003 |pmid= 12485946 |doi= }}
*{{cite journal | author=Pascussi JM, Busson-Le Coniat M, Maurel P, Vilarem MJ |title=Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element. |journal=Mol. Endocrinol. |volume=17 |issue= 1 |pages= 42-55 |year= 2003 |pmid= 12511605 |doi= }}
*{{cite journal | author=Shiraki T, Sakai N, Kanaya E, Jingami H |title=Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11344-50 |year= 2003 |pmid= 12551939 |doi= 10.1074/jbc.M212859200 }}
*{{cite journal | author=Maglich JM, Parks DJ, Moore LB, ''et al.'' |title=Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17277-83 |year= 2003 |pmid= 12611900 |doi= 10.1074/jbc.M300138200 }}
*{{cite journal | author=Xie W, Yeuh MF, Radominska-Pandya A, ''et al.'' |title=Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4150-5 |year= 2003 |pmid= 12644700 |doi= 10.1073/pnas.0438010100 }}
*{{cite journal | author=Huang W, Zhang J, Chua SS, ''et al.'' |title=Induction of bilirubin clearance by the constitutive androstane receptor (CAR). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4156-61 |year= 2003 |pmid= 12644704 |doi= 10.1073/pnas.0630614100 }}
*{{cite journal | author=Auerbach SS, Ramsden R, Stoner MA, ''et al.'' |title=Alternatively spliced isoforms of the human constitutive androstane receptor. |journal=Nucleic Acids Res. |volume=31 |issue= 12 |pages= 3194-207 |year= 2003 |pmid= 12799447 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NR2C1... {November 18, 2007 7:20:07 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:21:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor subfamily 2, group C, member 1
| HGNCid = 7971
| Symbol = NR2C1
| AltSymbols =; TR2; TR2-11
| OMIM = 601529
| ECnumber =
| Homologene = 55731
| MGIid = 1352465
| GeneAtlas_image1 = PBB_GE_NR2C1_210530_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NR2C1_210531_at_tn.png
| GeneAtlas_image3 = PBB_GE_NR2C1_204791_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7181
| Hs_Ensembl = ENSG00000120798
| Hs_RefseqProtein = NP_001027458
| Hs_RefseqmRNA = NM_001032287
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 93939802
| Hs_GenLoc_end = 93991444
| Hs_Uniprot = P13056
| Mm_EntrezGene = 22025
| Mm_Ensembl = ENSMUSG00000005897
| Mm_RefseqmRNA = NM_011629
| Mm_RefseqProtein = NP_035759
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 93577812
| Mm_GenLoc_end = 93625483
| Mm_Uniprot = Q0VGP8
}}
}}
'''Nuclear receptor subfamily 2, group C, member 1''', also known as '''NR2C1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Chang C, Kokontis J, Acakpo-Satchivi L, ''et al.'' |title=Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains. |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 2 |pages= 735-41 |year= 1990 |pmid= 2597158 |doi= }}
*{{cite journal | author=Chang C, Kokontis J |title=Identification of a new member of the steroid receptor super-family by cloning and sequence analysis. |journal=Biochem. Biophys. Res. Commun. |volume=155 |issue= 2 |pages= 971-7 |year= 1988 |pmid= 3421977 |doi= }}
*{{cite journal | author=Lin DL, Wu SQ, Chang C |title=The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily. |journal=Endocrine |volume=8 |issue= 2 |pages= 123-34 |year= 1998 |pmid= 9704569 |doi= }}
*{{cite journal | author=Lee CH, Chinpaisal C, Wei LN |title=A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25209-15 |year= 1998 |pmid= 9737983 |doi= }}
*{{cite journal | author=Lee CH, Chinpaisal C, Wei LN |title=Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6745-55 |year= 1998 |pmid= 9774688 |doi= }}
*{{cite journal | author=Yu Z, Lee CH, Chinpaisal C, Wei LN |title=A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2. |journal=J. Endocrinol. |volume=159 |issue= 1 |pages= 53-60 |year= 1999 |pmid= 9795341 |doi= }}
*{{cite journal | author=Franco PJ, Farooqui M, Seto E, Wei LN |title=The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases. |journal=Mol. Endocrinol. |volume=15 |issue= 8 |pages= 1318-28 |year= 2001 |pmid= 11463856 |doi= }}
*{{cite journal | author=Tanabe O, Katsuoka F, Campbell AD, ''et al.'' |title=An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3434-42 |year= 2002 |pmid= 12093744 |doi= 10.1093/emboj/cdf340 }}
*{{cite journal | author=Hu YC, Shyr CR, Che W, ''et al.'' |title=Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 33571-9 |year= 2002 |pmid= 12093804 |doi= 10.1074/jbc.M203531200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Inui S, Lee YF, Chang E, ''et al.'' |title=Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. |journal=J. Dermatol. Sci. |volume=31 |issue= 1 |pages= 65-71 |year= 2003 |pmid= 12615366 |doi= }}
*{{cite journal | author=Franco PJ, Li G, Wei LN |title=Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. |journal=Mol. Cell. Endocrinol. |volume=206 |issue= 1-2 |pages= 1-12 |year= 2004 |pmid= 12943985 |doi= }}
*{{cite journal | author=Mu X, Chang C |title=TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3. |journal=Prostate |volume=57 |issue= 2 |pages= 129-33 |year= 2003 |pmid= 12949936 |doi= 10.1002/pros.10282 }}
*{{cite journal | author=Li G, Franco PJ, Wei LN |title=Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 2 |pages= 384-90 |year= 2003 |pmid= 14521922 |doi= }}
*{{cite journal | author=Lin YL, Wang YH, Lee HJ |title=Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 2 |pages= 430-6 |year= 2006 |pmid= 17010934 |doi= 10.1016/j.bbrc.2006.09.061 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PPARA... {November 18, 2007 7:09:51 PM PST}
- SEARCH REDIRECT: Control Box Found: PPARA {November 18, 2007 7:11:03 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:11:04 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 18, 2007 7:11:04 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:11:04 PM PST}
- UPDATED: Updated protein page: PPARA {November 18, 2007 7:11:12 PM PST}
- INFO: Beginning work on PPARD... {November 18, 2007 7:11:12 PM PST}
- SEARCH REDIRECT: Control Box Found: PPARD {November 18, 2007 7:12:01 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:12:03 PM PST}
- SKIP SUMMARY: SKIPPING Summary, No Errors. {November 18, 2007 7:12:03 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:12:03 PM PST}
- UPDATED: Updated protein page: PPARD {November 18, 2007 7:12:10 PM PST}
- INFO: Beginning work on PPARG... {November 18, 2007 7:12:10 PM PST}
- REDIRECT: Protein Redirected to: PPARG {November 18, 2007 7:12:36 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:12:37 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:12:37 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:12:37 PM PST}
- UPDATED: Updated protein page: PPARG {November 18, 2007 7:12:44 PM PST}
- INFO: Beginning work on RARA... {November 18, 2007 7:12:44 PM PST}
- SEARCH REDIRECT: Control Box Found: RARA {November 18, 2007 7:13:18 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:13:20 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:13:20 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:13:20 PM PST}
- UPDATED: Updated protein page: RARA {November 18, 2007 7:13:27 PM PST}
- INFO: Beginning work on RARB... {November 18, 2007 7:13:27 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:13:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RARB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dsz.
| PDB = {{PDB2|1dsz}}, {{PDB2|1hra}}, {{PDB2|1xap}}, {{PDB2|1xdk}}
| Name = Retinoic acid receptor, beta
| HGNCid = 9865
| Symbol = RARB
| AltSymbols =; HAP; NR1B2; RRB2
| OMIM = 180220
| ECnumber =
| Homologene = 68100
| MGIid = 97857
| GeneAtlas_image1 = PBB_GE_RARB_205080_at_tn.png
| GeneAtlas_image2 = PBB_GE_RARB_208530_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_RARB_208412_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003708 |text = retinoic acid receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5915
| Hs_Ensembl = ENSG00000077092
| Hs_RefseqProtein = NP_000956
| Hs_RefseqmRNA = NM_000965
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 25190893
| Hs_GenLoc_end = 25614424
| Hs_Uniprot = P10826
| Mm_EntrezGene = 218772
| Mm_Ensembl = ENSMUSG00000017491
| Mm_RefseqmRNA = NM_011243
| Mm_RefseqProtein = NP_035373
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 15224106
| Mm_GenLoc_end = 15612134
| Mm_Uniprot = Q8K1P6
}}
}}
'''Retinoic acid receptor, beta''', also known as '''RARB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RARB retinoic acid receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5915| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: RARB retinoic acid receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5915| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Dejean A, de Thé H |title=Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma. |journal=Mol. Biol. Med. |volume=7 |issue= 3 |pages= 213-22 |year= 1990 |pmid= 2170809 |doi= }}
*{{cite journal | author=Sun SY |title=Retinoic acid receptor beta and colon cancer. |journal=Cancer Biol. Ther. |volume=3 |issue= 1 |pages= 87-8 |year= 2004 |pmid= 14726690 |doi= }}
*{{cite journal | author=Saba N, Jain S, Khuri F |title=Chemoprevention in lung cancer. |journal=Current problems in cancer |volume=28 |issue= 5 |pages= 287-306 |year= 2004 |pmid= 15375805 |doi= }}
*{{cite journal | author=Klein O, Grignon Y, Civit T, ''et al.'' |title=[Methylation status of RARbeta gene promoter in low and high grade cerebral glioma. Comparison with normal tissue. Immuno-histochemical study of nuclear RARbeta expression in low and high grade cerebral glioma cells. Comparison with normal cells. 48 tumors] |journal=Neuro-Chirurgie |volume=51 |issue= 3-4 Pt 1 |pages= 147-54 |year= 2006 |pmid= 16389900 |doi= }}
*{{cite journal | author=Katahira M, Knegtel RM, Boelens R, ''et al.'' |title=Homo- and heteronuclear NMR studies of the human retinoic acid receptor beta DNA-binding domain: sequential assignments and identification of secondary structure elements. |journal=Biochemistry |volume=31 |issue= 28 |pages= 6474-80 |year= 1992 |pmid= 1321662 |doi= }}
*{{cite journal | author=Berrodin TJ, Marks MS, Ozato K, ''et al.'' |title=Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. |journal=Mol. Endocrinol. |volume=6 |issue= 9 |pages= 1468-78 |year= 1992 |pmid= 1331778 |doi= }}
*{{cite journal | author=van der Leede BJ, Folkers GE, Kruyt FA, van der Saag PT |title=Genomic organization of the human retinoic acid receptor beta 2. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 2 |pages= 695-702 |year= 1992 |pmid= 1332705 |doi= }}
*{{cite journal | author=Prentice A, Matthews CJ, Thomas EJ, Redfern CP |title=The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid. |journal=Hum. Reprod. |volume=7 |issue= 5 |pages= 692-700 |year= 1992 |pmid= 1379266 |doi= }}
*{{cite journal | author=Shen S, Kruyt FA, den Hertog J, ''et al.'' |title=Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness. |journal=DNA Seq. |volume=2 |issue= 2 |pages= 111-9 |year= 1992 |pmid= 1663808 |doi= }}
*{{cite journal | author=de Thé H, Vivanco-Ruiz MM, Tiollais P, ''et al.'' |title=Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene. |journal=Nature |volume=343 |issue= 6254 |pages= 177-80 |year= 1990 |pmid= 2153268 |doi= 10.1038/343177a0 }}
*{{cite journal | author=Hoffmann B, Lehmann JM, Zhang XK, ''et al.'' |title=A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter. |journal=Mol. Endocrinol. |volume=4 |issue= 11 |pages= 1727-36 |year= 1991 |pmid= 2177841 |doi= }}
*{{cite journal | author=de Thé H, Marchio A, Tiollais P, Dejean A |title=A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. |journal=Nature |volume=330 |issue= 6149 |pages= 667-70 |year= 1988 |pmid= 2825037 |doi= 10.1038/330667a0 }}
*{{cite journal | author=Brand N, Petkovich M, Krust A, ''et al.'' |title=Identification of a second human retinoic acid receptor. |journal=Nature |volume=332 |issue= 6167 |pages= 850-3 |year= 1988 |pmid= 2833708 |doi= 10.1038/332850a0 }}
*{{cite journal | author=Benbrook D, Lernhardt E, Pfahl M |title=A new retinoic acid receptor identified from a hepatocellular carcinoma. |journal=Nature |volume=333 |issue= 6174 |pages= 669-72 |year= 1988 |pmid= 2836738 |doi= 10.1038/333669a0 }}
*{{cite journal | author=Mattei MG, de Thé H, Mattei JF, ''et al.'' |title=Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3. |journal=Hum. Genet. |volume=80 |issue= 2 |pages= 189-90 |year= 1988 |pmid= 2844650 |doi= }}
*{{cite journal | author=Dejean A, Bougueleret L, Grzeschik KH, Tiollais P |title=Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma. |journal=Nature |volume=322 |issue= 6074 |pages= 70-2 |year= 1986 |pmid= 3014347 |doi= 10.1038/322070a0 }}
*{{cite journal | author=Si SP, Tsou HC, Lee X, Peacocke M |title=Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding proteins in skin fibroblasts. |journal=Exp. Cell Res. |volume=219 |issue= 1 |pages= 243-8 |year= 1995 |pmid= 7628539 |doi= 10.1006/excr.1995.1224 }}
*{{cite journal | author=Houle B, Pelletier M, Wu J, ''et al.'' |title=Fetal isoform of human retinoic acid receptor beta expressed in small cell lung cancer lines. |journal=Cancer Res. |volume=54 |issue= 2 |pages= 365-9 |year= 1994 |pmid= 8275470 |doi= }}
*{{cite journal | author=Knegtel RM, Katahira M, Schilthuis JG, ''et al.'' |title=The solution structure of the human retinoic acid receptor-beta DNA-binding domain. |journal=J. Biomol. NMR |volume=3 |issue= 1 |pages= 1-17 |year= 1993 |pmid= 8383553 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RARG... {November 18, 2007 7:13:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:14:27 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RARG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dsz.
| PDB = {{PDB2|1dsz}}, {{PDB2|1exa}}, {{PDB2|1exx}}, {{PDB2|1fcx}}, {{PDB2|1fcy}}, {{PDB2|1fcz}}, {{PDB2|1fd0}}, {{PDB2|1hra}}, {{PDB2|2lbd}}, {{PDB2|3lbd}}, {{PDB2|4lbd}}
| Name = Retinoic acid receptor, gamma
| HGNCid = 9866
| Symbol = RARG
| AltSymbols =; NR1B3; RARC
| OMIM = 180190
| ECnumber =
| Homologene = 20263
| MGIid = 97858
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003708 |text = retinoic acid receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0048048 |text = embryonic eye morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5916
| Hs_Ensembl =
| Hs_RefseqProtein = XP_945931
| Hs_RefseqmRNA = XM_940838
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19411
| Mm_Ensembl = ENSMUSG00000001288
| Mm_RefseqmRNA = NM_001042727
| Mm_RefseqProtein = NP_001036192
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 102062974
| Mm_GenLoc_end = 102085313
| Mm_Uniprot = Q3UG86
}}
}}
'''Retinoic acid receptor, gamma''', also known as '''RARG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RARG retinoic acid receptor, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5916| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Leid M, Kastner P, Lyons R, ''et al.'' |title=Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. |journal=Cell |volume=68 |issue= 2 |pages= 377-95 |year= 1992 |pmid= 1310259 |doi= }}
*{{cite journal | author=Vollberg TM, Nervi C, George MD, ''et al.'' |title=Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. |journal=Mol. Endocrinol. |volume=6 |issue= 5 |pages= 667-76 |year= 1992 |pmid= 1318502 |doi= }}
*{{cite journal | author=Lehmann JM, Zhang XK, Pfahl M |title=RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites. |journal=Mol. Cell. Biol. |volume=12 |issue= 7 |pages= 2976-85 |year= 1992 |pmid= 1320193 |doi= }}
*{{cite journal | author=Mattei MG, Rivière M, Krust A, ''et al.'' |title=Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes. |journal=Genomics |volume=10 |issue= 4 |pages= 1061-9 |year= 1991 |pmid= 1655630 |doi= }}
*{{cite journal | author=Lehmann JM, Hoffmann B, Pfahl M |title=Genomic organization of the retinoic acid receptor gamma gene. |journal=Nucleic Acids Res. |volume=19 |issue= 3 |pages= 573-8 |year= 1991 |pmid= 1849262 |doi= }}
*{{cite journal | author=Kastner P, Krust A, Mendelsohn C, ''et al.'' |title=Murine isoforms of retinoic acid receptor gamma with specific patterns of expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2700-4 |year= 1990 |pmid= 2157210 |doi= }}
*{{cite journal | author=Giguère V, Shago M, Zirngibl R, ''et al.'' |title=Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo. |journal=Mol. Cell. Biol. |volume=10 |issue= 5 |pages= 2335-40 |year= 1990 |pmid= 2157970 |doi= }}
*{{cite journal | author=Ishikawa T, Umesono K, Mangelsdorf DJ, ''et al.'' |title=A functional retinoic acid receptor encoded by the gene on human chromosome 12. |journal=Mol. Endocrinol. |volume=4 |issue= 6 |pages= 837-44 |year= 1990 |pmid= 2172793 |doi= }}
*{{cite journal | author=Krust A, Kastner P, Petkovich M, ''et al.'' |title=A third human retinoic acid receptor, hRAR-gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 14 |pages= 5310-4 |year= 1989 |pmid= 2546152 |doi= }}
*{{cite journal | author=Renaud JP, Rochel N, Ruff M, ''et al.'' |title=Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. |journal=Nature |volume=378 |issue= 6558 |pages= 681-9 |year= 1996 |pmid= 7501014 |doi= 10.1038/378681a0 }}
*{{cite journal | author=Zhou L, Pang J, Munroe DG, Lau C |title=A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7. |journal=Nucleic Acids Res. |volume=21 |issue= 10 |pages= 2520 |year= 1993 |pmid= 7685085 |doi= }}
*{{cite journal | author=Zitnik RJ, Kotloff RM, Latifpour J, ''et al.'' |title=Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts. |journal=J. Immunol. |volume=152 |issue= 3 |pages= 1419-27 |year= 1994 |pmid= 8301142 |doi= }}
*{{cite journal | author=Botling J, Castro DS, Oberg F, ''et al.'' |title=Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9443-9 |year= 1997 |pmid= 9083083 |doi= }}
*{{cite journal | author=Lømo J, Smeland EB, Ulven S, ''et al.'' |title=RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes. |journal=J. Cell. Physiol. |volume=175 |issue= 1 |pages= 68-77 |year= 1998 |pmid= 9491782 |doi= 10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A }}
*{{cite journal | author=Klaholz BP, Renaud JP, Mitschler A, ''et al.'' |title=Conformational adaptation of agonists to the human nuclear receptor RAR gamma. |journal=Nat. Struct. Biol. |volume=5 |issue= 3 |pages= 199-202 |year= 1998 |pmid= 9501913 |doi= }}
*{{cite journal | author=Zhang ZP, Gambone CJ, Gabriel JL, ''et al.'' |title=Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34016-21 |year= 1999 |pmid= 9852056 |doi= }}
*{{cite journal | author=Yang C, Zhou D, Chen S |title=Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor. |journal=Cancer Res. |volume=58 |issue= 24 |pages= 5695-700 |year= 1999 |pmid= 9865725 |doi= }}
*{{cite journal | author=Nagpal S, Ghosn C, DiSepio D, ''et al.'' |title=Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22563-8 |year= 1999 |pmid= 10428834 |doi= }}
*{{cite journal | author=Egea PF, Mitschler A, Rochel N, ''et al.'' |title=Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2592-601 |year= 2000 |pmid= 10835357 |doi= 10.1093/emboj/19.11.2592 }}
*{{cite journal | author=Boudjelal M, Voorhees JJ, Fisher GJ |title=Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells. |journal=Exp. Cell Res. |volume=274 |issue= 1 |pages= 130-7 |year= 2002 |pmid= 11855864 |doi= 10.1006/excr.2001.5450 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RORA... {November 18, 2007 7:14:27 PM PST}
- SEARCH REDIRECT: Control Box Found: RORA {November 18, 2007 7:15:10 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:15:11 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:15:11 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:15:11 PM PST}
- UPDATED: Updated protein page: RORA {November 18, 2007 7:15:18 PM PST}
- INFO: Beginning work on RORB... {November 18, 2007 7:15:18 PM PST}
- SEARCH REDIRECT: Control Box Found: RORB {November 18, 2007 7:15:51 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:15:52 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:15:52 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:15:52 PM PST}
- UPDATED: Updated protein page: RORB {November 18, 2007 7:15:59 PM PST}
- INFO: Beginning work on RORC... {November 18, 2007 7:15:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:16:31 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RAR-related orphan receptor C
| HGNCid = 10260
| Symbol = RORC
| AltSymbols =; MGC129539; NR1F3; RORG; RZRG; TOR
| OMIM = 602943
| ECnumber =
| Homologene = 21051
| MGIid = 104856
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6097
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001001523
| Hs_RefseqmRNA = NM_001001523
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 19885
| Mm_Ensembl = ENSMUSG00000028150
| Mm_RefseqmRNA = NM_011281
| Mm_RefseqProtein = NP_035411
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 94458190
| Mm_GenLoc_end = 94483992
| Mm_Uniprot = Q3TVH3
}}
}}
'''RAR-related orphan receptor C''', also known as '''RORC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RORC RAR-related orphan receptor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6097| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RORC RAR-related orphan receptor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6097| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Winoto A, Littman DR |title=Nuclear hormone receptors in T lymphocytes. |journal=Cell |volume=109 Suppl |issue= |pages= S57-66 |year= 2002 |pmid= 11983153 |doi= }}
*{{cite journal | author=Huang Z, Xie H, Wang R, Sun Z |title=Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 6 |pages= 737-43 |year= 2007 |pmid= 17504012 |doi= 10.1517/14728222.11.6.737 }}
*{{cite journal | author=Hirose T, Smith RJ, Jetten AM |title=ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1976-83 |year= 1995 |pmid= 7811290 |doi= 10.1006/bbrc.1994.2902 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Medvedev A, Chistokhina A, Hirose T, Jetten AM |title=Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. |journal=Genomics |volume=46 |issue= 1 |pages= 93-102 |year= 1998 |pmid= 9403063 |doi= 10.1006/geno.1997.4980 }}
*{{cite journal | author=Villey I, de Chasseval R, de Villartay JP |title=RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. |journal=Eur. J. Immunol. |volume=29 |issue= 12 |pages= 4072-80 |year= 2000 |pmid= 10602018 |doi= }}
*{{cite journal | author=Sun Z, Unutmaz D, Zou YR, ''et al.'' |title=Requirement for RORgamma in thymocyte survival and lymphoid organ development. |journal=Science |volume=288 |issue= 5475 |pages= 2369-73 |year= 2000 |pmid= 10875923 |doi= }}
*{{cite journal | author=Kurebayashi S, Ueda E, Sakaue M, ''et al.'' |title=Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 18 |pages= 10132-7 |year= 2000 |pmid= 10963675 |doi= }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Wang H, Chu W, Das SK, ''et al.'' |title=Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. |journal=Mol. Genet. Metab. |volume=79 |issue= 3 |pages= 176-82 |year= 2004 |pmid= 12855222 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Weaver CT, Murphy KM |title=T-cell subsets: the more the merrier. |journal=Curr. Biol. |volume=17 |issue= 2 |pages= R61-3 |year= 2007 |pmid= 17240331 |doi= 10.1016/j.cub.2006.12.015 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RXRA... {November 18, 2007 7:16:31 PM PST}
- SEARCH REDIRECT: Control Box Found: Retinoid X receptor, alpha {November 18, 2007 7:17:04 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:17:05 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:17:05 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:17:05 PM PST}
- UPDATED: Updated protein page: Retinoid X receptor, alpha {November 18, 2007 7:17:12 PM PST}
- INFO: Beginning work on RXRB... {November 18, 2007 7:17:12 PM PST}
- REDIRECT: Protein Redirected to: RXRB {November 18, 2007 7:17:37 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:17:39 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:17:39 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:17:39 PM PST}
- UPDATED: Updated protein page: RXRB {November 18, 2007 7:17:45 PM PST}
- INFO: Beginning work on RXRG... {November 18, 2007 7:17:45 PM PST}
- SEARCH REDIRECT: Control Box Found: RXRG {November 18, 2007 7:18:13 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:18:15 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:18:15 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:18:15 PM PST}
- UPDATED: Updated protein page: RXRG {November 18, 2007 7:18:24 PM PST}
- INFO: Beginning work on THRA... {November 18, 2007 7:18:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:19:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THRA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nav.
| PDB = {{PDB2|1nav}}, {{PDB2|2h77}}, {{PDB2|2h79}}
| Name = Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
| HGNCid = 11796
| Symbol = THRA
| AltSymbols =; AR7; EAR7; ERB-T-1; ERBA; ERBA1; MGC000261; MGC43240; NR1A1; THRA1; THRA2; c-ERBA-1
| OMIM = 190120
| ECnumber =
| Homologene = 37747
| MGIid = 98742
| GeneAtlas_image1 = PBB_GE_THRA_35846_at_tn.png
| GeneAtlas_image2 = PBB_GE_THRA_204100_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001502 |text = cartilage condensation}} {{GNF_GO|id=GO:0001503 |text = ossification}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7067
| Hs_Ensembl = ENSG00000126351
| Hs_RefseqProtein = NP_003241
| Hs_RefseqmRNA = NM_003250
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 35472686
| Hs_GenLoc_end = 35503644
| Hs_Uniprot = P10827
| Mm_EntrezGene = 21833
| Mm_Ensembl = ENSMUSG00000058756
| Mm_RefseqmRNA = XM_994382
| Mm_RefseqProtein = XP_999476
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98557963
| Mm_GenLoc_end = 98585094
| Mm_Uniprot = Q80Y90
}}
}}
'''Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)''', also known as '''THRA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7067| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: THRA thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7067| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Forrest D, Reh TA, Rüsch A |title=Neurodevelopmental control by thyroid hormone receptors. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 1 |pages= 49-56 |year= 2002 |pmid= 11861164 |doi= }}
*{{cite journal | author=Sakurai A, Bell GI, DeGroot LJ |title=Dinucleotide repeat polymorphism in the human thyroid hormone receptor alpha gene (THRA1) on chromosome 17. |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 553 |year= 1993 |pmid= 1307263 |doi= }}
*{{cite journal | author=Berrodin TJ, Marks MS, Ozato K, ''et al.'' |title=Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. |journal=Mol. Endocrinol. |volume=6 |issue= 9 |pages= 1468-78 |year= 1992 |pmid= 1331778 |doi= }}
*{{cite journal | author=Schmidt ED, Schmidt ED, van der Gaag R, ''et al.'' |title=Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles. |journal=J. Endocrinol. |volume=133 |issue= 1 |pages= 67-74 |year= 1992 |pmid= 1517709 |doi= }}
*{{cite journal | author=Yen PM, Sunday ME, Darling DS, Chin WW |title=Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. |journal=Endocrinology |volume=130 |issue= 3 |pages= 1539-46 |year= 1992 |pmid= 1537303 |doi= }}
*{{cite journal | author=Laudet V, Begue A, Henry-Duthoit C, ''et al.'' |title=Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene. |journal=Nucleic Acids Res. |volume=19 |issue= 5 |pages= 1105-12 |year= 1991 |pmid= 1850510 |doi= }}
*{{cite journal | author=Nakai A, Sakurai A, Bell GI, DeGroot LJ |title=Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. |journal=Mol. Endocrinol. |volume=2 |issue= 11 |pages= 1087-92 |year= 1989 |pmid= 2464749 |doi= }}
*{{cite journal | author=Miyajima N, Horiuchi R, Shibuya Y, ''et al.'' |title=Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. |journal=Cell |volume=57 |issue= 1 |pages= 31-9 |year= 1989 |pmid= 2539258 |doi= }}
*{{cite journal | author=Sakurai A, Nakai A, DeGroot LJ |title=Expression of three forms of thyroid hormone receptor in human tissues. |journal=Mol. Endocrinol. |volume=3 |issue= 2 |pages= 392-9 |year= 1989 |pmid= 2710139 |doi= }}
*{{cite journal | author=Sap J, Muñoz A, Damm K, ''et al.'' |title=The c-erb-A protein is a high-affinity receptor for thyroid hormone. |journal=Nature |volume=324 |issue= 6098 |pages= 635-40 |year= 1987 |pmid= 2879242 |doi= 10.1038/324635a0 }}
*{{cite journal | author=Nakai A, Seino S, Sakurai A, ''et al.'' |title=Characterization of a thyroid hormone receptor expressed in human kidney and other tissues. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 8 |pages= 2781-5 |year= 1988 |pmid= 3357890 |doi= }}
*{{cite journal | author=Mitelman F, Manolov G, Manolova Y, ''et al.'' |title=High resolution chromosome analysis of constitutional and acquired t(15;17) maps c-erbA to subband 17q11.2. |journal=Cancer Genet. Cytogenet. |volume=22 |issue= 2 |pages= 95-8 |year= 1986 |pmid= 3458521 |doi= }}
*{{cite journal | author=Benbrook D, Pfahl M |title=A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. |journal=Science |volume=238 |issue= 4828 |pages= 788-91 |year= 1987 |pmid= 3672126 |doi= }}
*{{cite journal | author=Pfahl M, Benbrook D |title=Nucleotide sequence of cDNA encoding a novel human thyroid hormone receptor. |journal=Nucleic Acids Res. |volume=15 |issue= 22 |pages= 9613 |year= 1988 |pmid= 3684612 |doi= }}
*{{cite journal | author=Spurr NK, Solomon E, Jansson M, ''et al.'' |title=Chromosomal localisation of the human homologues to the oncogenes erbA and B. |journal=EMBO J. |volume=3 |issue= 1 |pages= 159-63 |year= 1984 |pmid= 6323162 |doi= }}
*{{cite journal | author=Dayton AI, Selden JR, Laws G, ''et al.'' |title=A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 14 |pages= 4495-9 |year= 1984 |pmid= 6589608 |doi= }}
*{{cite journal | author=Chen JD, Evans RM |title=A transcriptional co-repressor that interacts with nuclear hormone receptors. |journal=Nature |volume=377 |issue= 6548 |pages= 454-7 |year= 1995 |pmid= 7566127 |doi= 10.1038/377454a0 }}
*{{cite journal | author=Desai-Yajnik V, Hadzic E, Modlinger P, ''et al.'' |title=Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator. |journal=J. Virol. |volume=69 |issue= 8 |pages= 5103-12 |year= 1995 |pmid= 7609079 |doi= }}
*{{cite journal | author=Lee JW, Choi HS, Gyuris J, ''et al.'' |title=Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. |journal=Mol. Endocrinol. |volume=9 |issue= 2 |pages= 243-54 |year= 1995 |pmid= 7776974 |doi= }}
*{{cite journal | author=Desai-Yajnik V, Samuels HH |title=Regulation of the human immunodeficiency virus type 1 long terminal repeat: interactions of thyroid hormone receptor with retinoid-X receptor, nuclear factor kappa B, Sp1, and Tat. |journal=Trans. Assoc. Am. Physicians |volume=106 |issue= |pages= 13-32 |year= 1994 |pmid= 8036737 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on THRB... {November 18, 2007 7:19:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 18, 2007 7:20:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_THRB_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bsx.
| PDB = {{PDB2|1bsx}}, {{PDB2|1n46}}, {{PDB2|1nax}}, {{PDB2|1nq0}}, {{PDB2|1nq1}}, {{PDB2|1nq2}}, {{PDB2|1nuo}}, {{PDB2|1q4x}}, {{PDB2|1r6g}}, {{PDB2|1xzx}}, {{PDB2|1y0x}}, {{PDB2|2h6w}}, {{PDB2|2nll}}
| Name = Thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)
| HGNCid = 11799
| Symbol = THRB
| AltSymbols =; ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; THR1; THRB1; THRB2
| OMIM = 190160
| ECnumber =
| Homologene = 36025
| MGIid = 98743
| GeneAtlas_image1 = PBB_GE_THRB_207044_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004887 |text = thyroid hormone receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7068
| Hs_Ensembl = ENSG00000151090
| Hs_RefseqProtein = NP_000452
| Hs_RefseqmRNA = NM_000461
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 24134709
| Hs_GenLoc_end = 24511317
| Hs_Uniprot = P10828
| Mm_EntrezGene = 21834
| Mm_Ensembl = ENSMUSG00000021779
| Mm_RefseqmRNA = NM_009380
| Mm_RefseqProtein = NP_033406
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 16756327
| Mm_GenLoc_end = 16827040
| Mm_Uniprot = Q0VDR8
}}
}}
'''Thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)''', also known as '''THRB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7068| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.<ref name="entrez">{{cite web | title = Entrez Gene: THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7068| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Lazar MA, Chin WW |title=Nuclear thyroid hormone receptors. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 1777-82 |year= 1991 |pmid= 2254444 |doi= }}
*{{cite journal | author=Forrest D, Reh TA, Rüsch A |title=Neurodevelopmental control by thyroid hormone receptors. |journal=Curr. Opin. Neurobiol. |volume=12 |issue= 1 |pages= 49-56 |year= 2002 |pmid= 11861164 |doi= }}
*{{cite journal | author=González-Sancho JM, García V, Bonilla F, Muñoz A |title=Thyroid hormone receptors/THR genes in human cancer. |journal=Cancer Lett. |volume=192 |issue= 2 |pages= 121-32 |year= 2003 |pmid= 12668276 |doi= }}
*{{cite journal | author=Cugini CD, Leidy JW, Chertow BS, ''et al.'' |title=An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity. |journal=J. Clin. Endocrinol. Metab. |volume=74 |issue= 5 |pages= 1164-70 |year= 1992 |pmid= 1314846 |doi= }}
*{{cite journal | author=Behr M, Loos U |title=A point mutation (Ala229 to Thr) in the hinge domain of the c-erbA beta thyroid hormone receptor gene in a family with generalized thyroid hormone resistance. |journal=Mol. Endocrinol. |volume=6 |issue= 7 |pages= 1119-26 |year= 1992 |pmid= 1324420 |doi= }}
*{{cite journal | author=Falcone M, Miyamoto T, Fierro-Renoy F, ''et al.'' |title=Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform. |journal=Endocrinology |volume=131 |issue= 5 |pages= 2419-29 |year= 1992 |pmid= 1425440 |doi= }}
*{{cite journal | author=Schmidt ED, Schmidt ED, van der Gaag R, ''et al.'' |title=Distribution of the nuclear thyroid-hormone receptor in extraocular and skeletal muscles. |journal=J. Endocrinol. |volume=133 |issue= 1 |pages= 67-74 |year= 1992 |pmid= 1517709 |doi= }}
*{{cite journal | author=Adams M, Nagaya T, Tone Y, ''et al.'' |title=Functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome. |journal=Clin. Endocrinol. (Oxf) |volume=36 |issue= 3 |pages= 281-9 |year= 1992 |pmid= 1563081 |doi= }}
*{{cite journal | author=Sasaki S, Nakamura H, Tagami T, ''et al.'' |title=A point mutation of the T3 receptor beta 1 gene in a kindred of generalized resistance to thyroid hormone. |journal=Mol. Cell. Endocrinol. |volume=84 |issue= 3 |pages= 159-66 |year= 1992 |pmid= 1587388 |doi= }}
*{{cite journal | author=Nagaya T, Madison LD, Jameson JL |title=Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 13014-9 |year= 1992 |pmid= 1618799 |doi= }}
*{{cite journal | author=Shuto Y, Wakabayashi I, Amuro N, ''et al.'' |title=A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-beta associated with a family with generalized resistance to thyroid hormone. |journal=J. Clin. Endocrinol. Metab. |volume=75 |issue= 1 |pages= 213-7 |year= 1992 |pmid= 1619012 |doi= }}
*{{cite journal | author=Näär AM, Boutin JM, Lipkin SM, ''et al.'' |title=The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. |journal=Cell |volume=65 |issue= 7 |pages= 1267-79 |year= 1991 |pmid= 1648451 |doi= }}
*{{cite journal | author=Usala SJ, Menke JB, Watson TL, ''et al.'' |title=A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor. |journal=Mol. Endocrinol. |volume=5 |issue= 3 |pages= 327-35 |year= 1991 |pmid= 1653889 |doi= }}
*{{cite journal | author=Bodenner DL, Mroczynski MA, Weintraub BD, ''et al.'' |title=A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene. |journal=J. Biol. Chem. |volume=266 |issue= 32 |pages= 21666-73 |year= 1991 |pmid= 1657975 |doi= }}
*{{cite journal | author=Parrilla R, Mixson AJ, McPherson JA, ''et al.'' |title=Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain. |journal=J. Clin. Invest. |volume=88 |issue= 6 |pages= 2123-30 |year= 1992 |pmid= 1661299 |doi= }}
*{{cite journal | author=Usala SJ, Menke JB, Watson TL, ''et al.'' |title=A new point mutation in the 3,5,3'-triiodothyronine-binding domain of the c-erbA beta thyroid hormone receptor is tightly linked to generalized thyroid hormone resistance. |journal=J. Clin. Endocrinol. Metab. |volume=72 |issue= 1 |pages= 32-8 |year= 1991 |pmid= 1846005 |doi= }}
*{{cite journal | author=Sakurai A, Nakai A, DeGroot LJ |title=Structural analysis of human thyroid hormone receptor beta gene. |journal=Mol. Cell. Endocrinol. |volume=71 |issue= 2 |pages= 83-91 |year= 1990 |pmid= 1973914 |doi= }}
*{{cite journal | author=Usala SJ, Tennyson GE, Bale AE, ''et al.'' |title=A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds. |journal=J. Clin. Invest. |volume=85 |issue= 1 |pages= 93-100 |year= 1990 |pmid= 2153155 |doi= }}
*{{cite journal | author=Sakurai A, Takeda K, Ain K, ''et al.'' |title=Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8977-81 |year= 1989 |pmid= 2510172 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on VDR... {November 18, 2007 7:22:26 PM PST}
- SEARCH REDIRECT: Control Box Found: Calcitriol receptor {November 18, 2007 7:22:59 PM PST}
- UPDATE PROTEIN BOX: Updating Protein Box, No errors. {November 18, 2007 7:23:00 PM PST}
- UPDATE SUMMARY: Updating Summary, No Errors. {November 18, 2007 7:23:00 PM PST}
- UPDATE CITATIONS: Updating Citations, No Errors. {November 18, 2007 7:23:00 PM PST}
- UPDATED: Updated protein page: Calcitriol receptor {November 18, 2007 7:23:07 PM PST}
end log.
