User:Nerdseeksblonde/GeneralNotes

General thoughts on confirmation bias SNDRI page etc

Hi, I was skimming recent changes and ran across this,

http://en.wikipedia.org/wiki/Serotonin-catecholamine_reuptake_inhibitor

. This could really use references in many sections. Also, note that some of these terms don't appear very often on pubmed ( "triple reuptake inhitor" IIRC only had the one hit from DOVP and SNDRI only had two hits ). Keep in mind that not every acronym from a drug company is a widely used scientific term. These classifications, as you point out in one place, are not precise and in the case of SSRI anti-depressants it isn't even undisputed that the SSRI property is the primary cause of clinical effect- for example, clinical time course doesn't correlate real well with 5HT levels. You also did a bit of "crystal ball" text. Small molecule CNS drugs are not terribly predictable but in any case wiki is not supposed to express opinions without sources or even take sides. You may also want to mention peripheral effects- I happen to catch fenfluaramine at one point, certainly valve damage warrants a mention thought to be linked to SERT+5ht2b and possibly platelet 5ht release. I've followed a number of biotech companies and drug candidates and it is important to remain critical and scientifically sceptical and actively find and state counter-evidence where it exists. Nerdseeksblonde (talk) 23:59, 6 August 2009 (UTC)