User:Naomie MM
Antimicrobial[1]
There are few studies regarding the antimicrobial activity of nimbin. Although microbial activity of nimbin is found for only a few fungal phytopathogenic species. Several researches have shown that neem has antimicrobial activity. The antimicrobial effects of neem can be studied by HCL characterization. An agar diffusion test allows to realize this activity against bacteria like Bacillus cereus, or Escherichia coli.These bacteria present in the soil, have the property to induce in many cultivated plants a systemic resistance against various phytopathogenic agents. This is why neem is chosen to fight against these bacteria. The nutrient agar is then covered by cultures of these bacteria in petri dishes. We can then see zones of inhibition on certain parts of the agar, characterizing the antimicrobial side of the nimbin. There are few studies regarding the antimicrobial activity of nimbin. Although microbial activity of nimbin is found for only a few fungal phytopathogenic species. The concentration of azadirachtin is much higher than nimbin and salannin in nimbin extracts and could therefore be the metabolite of neem that acts more than the others on bacteria.
Antifungal
Nimbin, which is extracted from the bark of neem has antifungal activity like other neem compounds such as azadirachtin and salaninne. This can be observed when neem is mixed with ethanol[2] to make it a liquid or by taking the oil from the seeds of Azadirachta Indica. This oil is then used against phytopathogenic fungi if the oil is cold extracted at 1000 ppm[3]. A fungus is then chosen and allowed to grow alone as a control to observe its fungicidal properties and then neem prepared in water is added to another fungus. This reduces the growth of the fungus, but it will not be completely inhibited even when the concentration of azadirachtin is increased[4]. The crude oil of neem is very active against fungi but also bacteria.[5]
Health
The neem tree has useful properties for health and is often used in medicine as an anti-inflammatory, anti-cancer or antioxidant.[6] Its toxicity to mammals is very low and negligible and not targeted to other living beings. The nimbin can be used in people with diabetes because it has an anti-diabetic effect. Especially when it is modified and transformed into semi-natural molecules such as N2 (semisynthetic nimbin analogs N2) or N3 (deacetylnimbin (N3)). Making molecules This effectiveness is not verified for the N2 molecule, however its hypoglycemic effect on ß cells has been evaluated with insulin. Abnormal ß cells in people with diabetes are one of the causes of the dysfunction of the insulin system. A study on zebrafish embryos has made it possible to evaluate the cytotoxic effects of Nimbin molecules on the larvae of these fish. N2 then serves as an antioxidant protection against ß cells and anti-hyperglycemic activity. The insulin system is then restored. This study showed that N2 had no toxic impact on the health of these individuals and their development. [7]But a high concentration could be dangerous if used excessively.
- ^ Coventry, E.; Allan, E. J. (2001-10). "Microbiological and Chemical Analysis of Neem (Azadirachta indica) Extracts: New Data on Antimicrobial Activity". Phytoparasitica. 29 (5): 441–450. doi:10.1007/BF02981863. ISSN 0334-2123.
{{cite journal}}: Check date values in:|date=(help) - ^ S., Mondall, N. K. Mojumdar, A. Chatterje, S. K. Banerjee, A. Datta, J.K. Gupta, (2009-07-01). Antifungal activities and chemical characterization of Neem leaf extracts on the growth of some selected fungal species in vitro culture medium. World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt. OCLC 732418414.
{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link) - ^ Govindachari, T. R.; Suresh, G.; Gopalakrishnan, Geetha; Banumathy, Balaganesan; Masilamani, S. (1998-06). "Identification of antifungal compounds from the seed oil ofAzadirachta Indica". Phytoparasitica. 26 (2): 109–116. doi:10.1007/BF02980677. ISSN 0334-2123.
{{cite journal}}: Check date values in:|date=(help) - ^ Mahmoud, D. A.; Hassanein, N. M.; Youssef, K. A.; Abou Zeid, M. A. (2011-09). "Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens". Brazilian Journal of Microbiology. 42: 1007–1016. doi:10.1590/S1517-83822011000300021. ISSN 1517-8382.
{{cite journal}}: Check date values in:|date=(help) - ^ S., Mondall, N. K. Mojumdar, A. Chatterje, S. K. Banerjee, A. Datta, J.K. Gupta, (2009-07-01). Antifungal activities and chemical characterization of Neem leaf extracts on the growth of some selected fungal species in vitro culture medium. World Bank assisted National Agricultural Research Project (NARP) - University of Port Harcourt. OCLC 732418414.
{{cite book}}: CS1 maint: extra punctuation (link) CS1 maint: multiple names: authors list (link) - ^ Harborne, J.B. (1972-05). "Pharmacognosy and Phytochemistry". Phytochemistry. 11 (5): 1869–1870. doi:10.1016/0031-9422(72)85069-6. ISSN 0031-9422.
{{cite journal}}: Check date values in:|date=(help) - ^ Sudhakaran, Gokul; Rajesh, Ravi; Guru, Ajay; Haridevamuthu, B.; Murugan, Raghul; Bhuvanesh, Nattamai; Wadaan, Mohammad Ahmad; Mahboob, Shalid; Juliet, Annie; Gopinath, Pushparathinam; Arockiaraj, Jesu (2022-11). "Deacetylated nimbin analog N2 fortifies alloxan-induced pancreatic β-cell damage in insulin-resistant zebrafish larvae by upregulating phosphoenolpyruvate carboxykinase (PEPCK) and insulin levels". Toxicology and Applied Pharmacology. 454: 116229. doi:10.1016/j.taap.2022.116229.
{{cite journal}}: Check date values in:|date=(help)