User:MiltonRex
KIAA0895 is a human gene that codes for a protein known as KIAA0895 protein or hypothetical protein LOC23366.[1] Other known aliases are OTTHUMP00000206979 and OTTHUMP00000206980.[2]
Gene
[edit]The KIAA0895 gene is located at p14.2 on chromosome 7.
It can be transcribed into 15 different transcript variants, which in turn can produce 13 different isoforms of the protein.[3]
The genomic DNA is 65,976 [base pair]s long [1], while the longest mRNA that it produces is 4463 bases long.
Gene Neighborhood
[edit]KIAA0895 is surrounded by the following genes on chromosome 7 [1]:
Protein
[edit]The longest protein isoform that is produced by the KIAA0895 gene is termed LOC23366 isoform 1 and is 520 amino acids long[4].
Regions
[edit]| Domain of unknown function 1704 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | DUF1704 | ||||||||
| Pfam | PF08014 | ||||||||
| InterPro | IPR012548 | ||||||||
| |||||||||
LOC23366 contains a domain of unknown function called DUF 1704 [5].
It also contains a region of low complexity from position 120 to position 150 in the protein[6], and an arginine-rich area from position 12 to position 51[7].
Post-translational Modification
[edit]The KIAA0895 protein is predicted to undergo phosphorylation at several serines, threonines, and tyrosines throughout it's structure, particularly in the first half of the protein[8] The predicted phosphorylation sites are shown on the accompanying graph. There are also predicted to be three N-linked glycosylation sites[9].
Expression
[edit]KIAA0895 is shown to be expressed at low levels in various tissues throughout the body. It is expressed most highly in the adrenal gland, the bone marrow, and the testis.[10]. It is also found in cancerous tissues, most highly in cervical tumors and bladder carcinoma.
Conservation
[edit]KIAA0895 has one paralog in humans known as KIAA0895L [11]. Orthologs have been found in all mammals, and eukaryotes through T. thermophila[12]. The full list of organisms in which orthologs have been found is given below.
- Pan troglodytes
- Pongo abelii
- Macaca mulatta
- Callithrix jacchus
- Sus scrofa
- Canis familiaris
- Ailuropoda melanoleuca
- Equus caballus
- Oryctolagus cuniculus
- Mus musculus
- Rattus norvegicus
- Monodelphis domestica
- Ornithorhynchus anatinus
- Taeniopygia guttata
- Meleagris gallopavo
- Gallus gallus
- Xenopus (Silurana) tropicalis
- Danio rerio
- Ciona intestinalis
- Strongylocentrotus purpuratus
- Branchiostoma floridae
- Tetrahymena thermophila
References
[edit]- ^ a b c "Entrez Gene: KIAA0895". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "GeneCards: KIAA0895 Gene". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI AceView: KIAA0895". Retrieved 4-24-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI Protein: LOC23366 isoform 1". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Wellcome Trust Sanger Institute, Pfam". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "MyHits Dotlet". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Uniprot". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "DTU Center for Biological Sciences, NetPhos". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "DTU Center for Biological Sciences, NetNGlyc". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI Unigene EST Profile: KIAA0895". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "KEGG: KIAA0895". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "NCBI BLAST". Retrieved 5-9-2011.
{{cite web}}: Check date values in:|accessdate=(help)