User:Matteo.battaglini91/sandbox
Uses
[edit]Barium titanate nanoparticles (BTNPs) have also been investigated for their ability to generate electrical potential under physical stimuli: one of the main way to achieve this stimulation is through the use of ultrasound waves, that are able to generate extremely precise and penetrating physical stimuli[1] . This ability has been studied also for biomedical application: In one example the electrical stimuli generated by BTNPs has been used to remotely stimulate neuronal cells[2]. Other applications include the tratment of breast cancer[3] and glioblastoma multiforme[4], where the remote electrical stimulation of cancer cell is able to induce the distruption of ions homeostasis, block cell proliferation and induce death. BTNPs have also been used to develop active substrate able to stimulate the differentiation of human bones cells[5].
- ^ Tufail, Yusuf; Matyushov, Alexei; Baldwin, Nathan; Tauchmann, Monica L.; Georges, Joseph; Yoshihiro, Anna; Tillery, Stephen I. Helms; Tyler, William J. (2010). "Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits". Neuron. 66 (5): 681–694. doi:10.1016/j.neuron.2010.05.008. ISSN 0896-6273.
- ^ Marino, Attilio; Arai, Satoshi; Hou, Yanyan; Sinibaldi, Edoardo; Pellegrino, Mario; Chang, Young-Tae; Mazzolai, Barbara; Mattoli, Virgilio; Suzuki, Madoka; Ciofani, Gianni (2015). "Piezoelectric Nanoparticle-Assisted Wireless Neuronal Stimulation". ACS Nano. 9 (7): 7678–7689. doi:10.1021/acsnano.5b03162. ISSN 1936-0851.
- ^ Marino, Attilio; Battaglini, Matteo; De Pasquale, Daniele; Degl’Innocenti, Andrea; Ciofani, Gianni (2018). "Ultrasound-Activated Piezoelectric Nanoparticles Inhibit Proliferation of Breast Cancer Cells". Scientific Reports. 8 (1). doi:10.1038/s41598-018-24697-1. ISSN 2045-2322.
- ^ Marino, Attilio; Almici, Enrico; Migliorin, Simone; Tapeinos, Christos; Battaglini, Matteo; Cappello, Valentina; Marchetti, Marco; de Vito, Giuseppe; Cicchi, Riccardo; Pavone, Francesco Saverio; Ciofani, Gianni (2019). "Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme". Journal of Colloid and Interface Science. 538: 449–461. doi:10.1016/j.jcis.2018.12.014. ISSN 0021-9797.
- ^ Marino, Attilio; Barsotti, Jonathan; de Vito, Giuseppe; Filippeschi, Carlo; Mazzolai, Barbara; Piazza, Vincenzo; Labardi, Massimiliano; Mattoli, Virgilio; Ciofani, Gianni (2015). "Two-Photon Lithography of 3D Nanocomposite Piezoelectric Scaffolds for Cell Stimulation". ACS Applied Materials & Interfaces. 7 (46): 25574–25579. doi:10.1021/acsami.5b08764. ISSN 1944-8244.