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Article Evaluation - Monoamine transporter
[edit]First two sentences of the article are uncited. I'm guessing that the facts in them come from the first reference, which is cited in sentence 3, but it's a little unclear. This source's link works, and it's a nature review, so I think we can trust it "Due to their significance in neuronal signaling, MATs are commonly associated with drugsused to treat mental disorders as well as recreational drugs, a line that can become quite blurred in many cases" The claim that the line between mental disorder treatments and recreational drugs can be blurred is seemingly unfounded. It seems a bit more like a judgement call to me than something that is clearly backed up with facts. This article gives a lot of attention to the associated drugs and disorders for MAT's, and not much attention to the mechanism by which they operate (mention of this mechanism is totally absent from the first paragraph) I do see that other editors have added the "citation needed" tag, which indicates that this page has been reviewed by someone other than the original author. I think the structure and mechanism section could use some figures. It talks about the 12 transmemebrane regions with extracellular and extracellular loops, but doesn't have a sample structure indicating these regions. It also notes the location of the termini, without having a good visual representation of them. It would also be helpful in this section to have a representation of how the ion gradients work to take advantage of the Na+ gradient to power the neurotransmitter transport. In the "Research History" section, it would be very helpful to have citations to the actual primary literature articles that they are referencing. The citations are for that same nature review that has been heavily cited throughout the article. These citations should be changed to the primary literature sources. There have been several editors over the course of the five years or so that the page has been live, and there is a lot of positive feedback in the talk section. There isn't much "discussion" beyond some minor suggestions in the talk page. I think the biggest issue with this article is the lack of information and figures about how the proteins actually function. It seems like the authors are more concerned with the clinical relevance of the MAT's than the biochemical function of them.
Emily Fortey
[edit]Add more about her educational and research history
Compile a list of publications
http://pubs.rsc.org/en/Content/ArticleLanding/1896/CT/CT8966901352#!divAbstract
http://pubs.rsc.org/EN/content/articlelanding/1896/ct/ct8966901349#!divAbstract
http://pubs.rsc.org/en/content/articlelanding/ct/1902/ct9028100752#!divAbstract
Ladies in the laboratory publication list
Fortey, Emily C. Hexamethylene from American and Galician petroleum. Chem. Soc. J., 73 (Pt.2)(1898) 932-49
Fortey, Emily C. Hexanaphthene and its derivatives. Preliminary note. [1897] Chem. Soc. Proc., 13 (1898) 161-2
Fortey, Emily C. Action of light and oxygen on dibenzyl ketone. Chem. Soc. J., 75 (Pt. 2) (1899) 871-3
Richardson, Arthur; Fortey, Emily C. Action of light on amyl alcohol. Chem. Soc. J., 69 (1896) 1349-52
Richardson, Arthur; Fortey, Emily C. Note on teh action of light on ether. Chem. Soc. J., 69 (1896) 1352-5
Richardson, Arthur; Fortey, Emily C. Action of light on amyl alcohol. Chem. Soc. Proc., 12 (1897) 164-5
Richardson, Arthur; Fortey, Emily C. Note on the action of light on ether. Chem. Soc. Proc., 12 (1897) 165-6
Young Sydney; Fortey, Emily C. The vapour pressures, specific volumes, and critical constants of hexamethylene,. Chem. Soc. J., 75 (Pt.2) (1899) 873-83
Young Sydney; Fortey, Emily C. Note on the refraction and magnetic rotation of hexamethylene, chlorohexamethylene, and dichlorohexamethylene. Chem. Soc. J., 77 (Pt.1) (1900) 372-4
Young Sydney; Fortey, Emily C. Vapour pressures, specific volumes, and critical constants of diisopropyl and diisobutyl. Chem. Soc. J., 77 (Pt.1) (1900) 1126-44.
Emily Comber Fortey (1866 – 10 September 1946) was a British chemist and politician. She gained her B.Sc. in 1886 before working with Vladimir Markovnikov and Sydney young on fractional distillation. [1] In 1904, she was one of nineteen signatories on a petition to allow the admission of women to the Chemical Society.
After leaving chemical research in 1904, she moved to Leicester in 1909 to pursue a political career. She was in charge of a shelter for girls during World War One and became the first female to be elected as a Labour Councillor in Leicester.[2]
Education
[edit]Fortey attended Clifton High School, before studying University College Bristol from 1892 to 1893.[1][3] Three years later, she was awarded a chemical scholarship and graduated with a London B.Sc. in 1896, earning honors in experimental physics and chemistry.[1] [4] In 1896 after earning her degree, she was granted an Associateship of University College, Bristol and Exhibition Science Research Scholarship, enabling her to work as a researcher.[4]
Research
[edit]Upon transitioning to a researcher at Bristol, Fortey first researched in photochemistry. This work was published in 1896.[4] She then began working with Sydney Young on fractional distillation. This collaboration produced seven co-authored papers from 1899 to 1903. Much of this research was integral in Young's book, Fractional Distillation.[1][4] While her work to contribute to this project was significant, her name was not included in the acknowledgements of the text.[5] Another notable project of Fortey's was her research with Russian Vladimir Markownikoff, where she demonstrated that the cyclohexane fractions of crude oil from three geographical areas (American, Galician, and Caucasian) were not only the same, but also matched synthetic cyclohexane.[1][4] Fortey was the sole author of the paper on this work, published in 1898.[1] There is also evidence that Fortey collaborated with William A. Tilden in 1902 on alcohol-water mixtures. The data generated by Fortey and Tilden contributed to the conclusion that no alcohol hydrates can be formed above 0 °C.[6]
Publication List
[edit]Below is a partial list of Fortey's publications, which include 14 articles and multiple shorter notes.[1][5]
Fortey, Emily C. Hexamethylene from American and Galician petroleum. Chem. Soc. J., 73 (Pt.2)(1898) 932-49
Fortey, Emily C. Hexanaphthene and its derivatives. Preliminary note. [1897] Chem. Soc. Proc., 13 (1898) 161-2
Fortey, Emily C. Action of light and oxygen on dibenzyl ketone. Chem. Soc. J., 75 (Pt. 2) (1899) 871-3
Richardson, Arthur; Fortey, Emily C. Action of light on amyl alcohol. Chem. Soc. J., 69 (1896) 1349-52
Richardson, Arthur; Fortey, Emily C. Note on teh action of light on ether. Chem. Soc. J., 69 (1896) 1352-5
Richardson, Arthur; Fortey, Emily C. Action of light on amyl alcohol. Chem. Soc. Proc., 12 (1897) 164-5
Richardson, Arthur; Fortey, Emily C. Note on the action of light on ether. Chem. Soc. Proc., 12 (1897) 165-6
Young Sydney; Fortey, Emily C. The vapour pressures, specific volumes, and critical constants of hexamethylene,. Chem. Soc. J., 75 (Pt.2) (1899) 873-83
Young Sydney; Fortey, Emily C. Note on the refraction and magnetic rotation of hexamethylene, chlorohexamethylene, and dichlorohexamethylene. Chem. Soc. J., 77 (Pt.1) (1900) 372-4
Young Sydney; Fortey, Emily C. Vapour pressures, specific volumes, and critical constants of diisopropyl and diisobutyl. Chem. Soc. J., 77 (Pt.1) (1900) 1126-44.
Catholic Faith
[edit]Fortey wrote to Fr. John Henry Newman at age 16, asking for insight into whether she should convert to Catholicism. At the time, she was an Anglican, but felt a draw to the Catholic Church, despite her parent's disapproval. Newman responded, advising her to seek direction from a priest nearby.[7] Fortey's father consented to allowing her to enter the Church after a two year waiting period. After her conversion, she remained in correspondence with Fr. Newman and met him in person in August of 1887.[3] Her Catholic faith remained influential in her life. When she was serving as labor councillor in Leicester, she campaigned to end the sale of contraceptives in the city, in accordance with the Catholic community.[8]
Early Life
[edit]Fortey was the daughter of Henry Fortey. Her father worked in India, leaving him largely absent from her adolescence.[3] Around age 12, she began thinking of converting from Anglicanism to Catholicism. Fortey wrote to Fr. John Henry Newman at age 16, asking for insight into whether she should convert to Catholicism Newman responded, advising her to seek direction from a priest nearby.[7] Though he initially strongly objected to his daughter's conversion, Henry Fortey consented to allowing her to enter the Church after a two year waiting period. After her conversion, she remained in correspondence with Fr. Newman and met him in person in August of 1887.[3]
- ^ a b c d e f g Creese, Mary R. S. (2000-01-01). Ladies in the Laboratory? American and British Women in Science, 1800-1900: A Survey of their Contributions to Research. Scarecrow Press. ISBN 9780585276847.
- ^ Doyle, Barry M. (2009-10-02). Urban Politics and Space in the Nineteenth and Twentieth Centuries: Regional Perspectives. Cambridge Scholars Publishing. ISBN 9781443815918.
- ^ a b c d Sugg, Joyce (1996). Ever Yours Affly: John Henry Newman and His Female Circle. Gracewing Publishing. ISBN 9780852443156.
- ^ a b c d e Creese, Mary R. S. (1991). "British Women of the Nineteenth and Early Twentieth Centuries Who Contributed to Research in the Chemical Sciences". The British Journal for the History of Science. 24 (3): 275–305.
- ^ a b Rayner-Canham, Marelene F.; Rayner-Canham, Geoffrey (2008). Chemistry Was Their Life: Pioneering British Women Chemists, 1880-1949. Imperial College Press. ISBN 9781860949876.
- ^ Tilden, William. Note 111. pp. 80–1.
- ^ a b Strange, Roderick (2015-10-29). John Henry Newman: A Portrait in Letters. Oxford University Press. ISBN 9780191066351.
- ^ Welshman, John (1997). "Eugenics and public health in Britain, 1900–40: scenes from provincial life". Urban History. 24 (1): 56–75. doi:10.1017/s0963926800012177. ISSN 1469-8706.