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User:Kendalse/GAB2

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Project Proposal

By: Ashley Tran, Bryan Tan and Seth Kendall

Summary

Discovery

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In this section we will give a basic overview of the history of the gene including its discovery and advances in our understanding of its function.

Importance

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Description of the importance to cellular function of the protein.

Location

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Description of the physical location of the GAB2 gene on the genome and any importance related to this.

Structure

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Description of the structure of the GAB2 protein.

Function

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More detailed description of the function of the protein in the cell.

Interactions

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Descriptions of the various interactions of the GAB2 protein. Including interactions with Grb2, PTPN11, PLCG2, RICS, PIK3R1, CRKL, AKT1 and SHC1.

Association with Alzheimer’s Disease

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Brief overview of the body of knowledge linking GAB2 to Alzheimer's Disease.