User:Judenicholson

Judenicholson
Names
	IUPAC name (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one Nutlin-3
	Other names Nutlin
Identifiers
CAS Number	675576-98-4 ;
3D model (JSmol)	Interactive image;
PubChem CID	16755649;
UNII	L7C92IOE65 ;
	SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl canonical;
Properties
Chemical formula	C30H30Cl2N4O4
Molar mass	581.4896 [g/mol]
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Nutlins are cis-imidazoline analogs which inhibit the interaction between MDM2 and p53, and were discovered by screening a chemical library by Vassiliev et al. Nutlin-1, Nutlin-2 and Nutlin-3 were all identified in the same screen,^[1] however Nutlin-3 is the compound most commonly used in anti-cancer studies.^[2]

^ Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA (2004). "In vivo activation of the p53 pathway by small-molecule antagonists of MDM2". Science. 6: 844–848. PMID 14704432.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^ Shangary S, Wang S. (2008). "Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy". Annu Rev Pharmacol Toxicol. PMID 18834305.

[Nutlin-1] Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA (2004). "In vivo activation of the p53 pathway by small-molecule antagonists of MDM2". Science. 6: 844–848. PMID 14704432.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[annrev-2] Shangary S, Wang S. (2008). "Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy". Annu Rev Pharmacol Toxicol. PMID 18834305.

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