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The interferon-induced protein 44-like gene (i.e., IFI44L gene) is a type I interferon-stimulated gene.[1] In humans, the type I interferons are cytokines that consist of 13 different type I interferon-α proteins, i.e., type I interferon-α1, -α2, - α4, -α5, -α6, -α7, -α8, - α10, -α13, - α14, -α16, -α17, and -α21, and four other type I interferon proteins, i.e., type I interferon -beta, -epsilon, -kappa, and -omega.[2] The type I interferons bind to the heterodimeric IFNAR1/IFNAR2 receptor termed the interferon-alpha/beta receptor. This receptor located on the surface of a wide range of cells many of which are involved in regulating inflammatory responses and susceptibility to infections. The type 1 interferons stimulate cells to activate the IFI44L gene to from the IFI44L protein.[3] The approximately 47 kDa protein, and located on chromosome 1 at area p31 IFI44L, one of the type I Type I interferon-stimulated gene, Clinically, the expression level of IFI44L significantly reduced in HCC tumor tissues. hepatic cancer stem-like cells in culture overexpression of IFI44L decreased chemoresistance towards doxorubicin and knockdown of IFI44L restored chemoresistance as well as promoted sphere formation. Furthermore, we found that depletion of IFI44L enhanced migration, invasion, and pulmonary metastasis through activating Met/Src signaling pathway.Low expression of IFI44L levels also correlated with larger tumor size, disease relapse, advanced stages, and poor clinical survival in HCC patients Clinically, the expression level of IFI44L significantly reduced in HCC tumor tissues. Low expression of IFI44L levels also correlated with larger tumor size, disease relapse, advanced stages, and poor clinical survival in HCC patients sup FI44L is a novel tumor suppressor to affect cancer stemness, metastasis, and drug resistance via regulating Met/Src signaling pathway in human hepatocellular carcinoma [1]
The type I IFN family is a multi-gene that encodes 13 partially homologous IFNα subtypes in humans (14 in mice), a single IFNβ and several poorly defined single gene products (IFNɛ, IFNτ, IFNκ, IFNω, IFNδ and IFNζ)1. The type II IFN family consists of a single gene product, IFNγ, that is predominantly produced by T cells and natural killer (NK) cells, and can act on a broad range of cell types that express the IFNγ receptor (IFNγR)2.
- ^ a b Huang WC, Tung SL, Chen YL, Chen PM, Chu PY (May 2018). "IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway". BMC Cancer. 18 (1): 609. doi:10.1186/s12885-018-4529-9. PMC 5977745. PMID 29848298.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Uzé G, Schreiber G, Piehler J, Pellegrini S (2007). "The receptor of the type I interferon family". Current Topics in Microbiology and Immunology. 316: 71–95. doi:10.1007/978-3-540-71329-6_5. PMID 17969444.
- ^ Schoggins JW (September 2019). "Interferon-Stimulated Genes: What Do They All Do?". Annual Review of Virology. 6 (1): 567–584. doi:10.1146/annurev-virology-092818-015756. PMID 31283436.