User:Jocelyn Munson/sandbox
Wikipedia's Five Pillars
[edit]Wikipedia is an online encyclopedia
[edit]Wikipedia is an online encyclopedia, and shares the traits of typical encyclopedias and almanacs. It is not meant to be used for any other purpose, including expressing one's own personal opinions.
Wikipedia maintains a neutral point of view
[edit]Wikipedia is an objective source of information. It is not a platform for debate. All articles on Wikipedia should be fair, objective, and balanced. All points of view must be represented equally; one is not better than another.
Anyone can edit Wikipedia
[edit]All articles on Wikipedia can be edited by anyone at anytime. Plagiarism is not allowed.
Respect your fellow Wikipedians
[edit]Be kind to other Wikipedians. The rules of Wikiquette must be applied when interacting with others, especially when disputes occur.
Wikipedia's rules are not strict
[edit]As Wikipedia continues to evolve, rules are often discarded or modified. Mistakes are not huge issues because they are easily correctable.
Summary of characteristics of target article
[edit]Our article should contain enough content so that sections and subsections are necessary, but excessive detailing is kept to a minimum. It should be written at a level that's easy for most readers to understand. The article must be written in a neutral and balanced way. It should contain reliable references and additional content such as tables, pictures, and diagrams. Plagiarism is not allowed.
Practice citations
[edit]p21, a protein that halts the cell cycle, is downregulated by histone deacetylase. Halting the cell cycle prevents the proliferation of tumors.[1] Therefore, p21 has potential in preventing the spread of cancer.[1] [2] Histone deacetylase inhibitors upregulate p21 expression. Histone deacetylase inhibitors have been shown to be possible pancreatic cancer treatments.[2]
Practice references
[edit]- ^ a b Fang, JY (2002 Jun). "Effects of histone acetylation and DNA methylation on p21( WAF1) regulation". World Journal of Gastroenterology : WJG. 8 (3): 400–5. doi:10.3748/wjg.v8.i3.400. PMC 4656409. PMID 12046058.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)CS1 maint: unflagged free DOI (link) - ^ a b Wang, G (2012). "Class I and class II histone deacetylases are potential therapeutic targets for treating pancreatic cancer". PLOS ONE. 7 (12): e52095. doi:10.1371/journal.pone.0052095. PMC 3522644. PMID 23251689.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help)
Possible references for PIAS article
[edit]Articles
[edit]Brief summaries
[edit]hZimp10,[6] a protein similar to PIAS, activates the tumor suppressor p53. This article also cites other studies relating to PIAS.
PIAS1 [7] and PIAS3 [8] inhibit NF-kappaB activity, which may aid in disease prevention.
PIAS1 may prevent adipogenesis via sumoylation, which may have implications in obesity treatment.[9]
This article provides a general overview of PIAS, including its roles in sumoylation. It also describes PIAS's structural domains.[10]
PIAS interacts with the TATA-binding protein [11]
PIAS1 inhibits STAT-1 mediated gene activation in response to interferon. [12]
JAK-STAT signaling pathway and autoimmune disease. There is also a diagram with the PIAS shown.[13]
Images
[edit]
click edit to get infobox template for proteins
| Identifiers | |
|---|---|
| Symbol | ? |
Preliminary outline for PIAS article
[edit]Lead section
[edit]Introduction and summary of PIAS
History/Discovery
[edit]-Seminal papers/ timing for discovery placeholder
Structure
[edit]Known structural motifs:
-RING-finger-like zinc-binding domain (RLD)
-N-terminal SAP (contains LXXLL signature motif - all PIAS proteins have it)
-PINIT
-S/T
-AD/SIM
Mechanisms
[edit]-sumoylation
-recruitment of histone deacetylases
-preventing transcription factors from binding to DNA
-sending transcription factors to co-repressor complexes within the nucleus
Functions
[edit]-repression of NF-kappaB pathway
-inhibition of STAT
Applications in disease treatment
[edit]-obesity
-cancer
-inflammatory/autoimmune disease
Current Research
[edit]-placeholder
Possible references
[edit]- ^ Leaman, DW (1996 Dec). "Regulation of STAT-dependent pathways by growth factors and cytokines". FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 10 (14): 1578–88. doi:10.1096/fasebj.10.14.9002549. PMID 9002549.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help)CS1 maint: unflagged free DOI (link) - ^ Bourgeais, Jérome (1 October 2013). "Oxidative metabolism in cancer: A STAT affair?". JAK-STAT. 2 (4): e25764. doi:10.4161/jkst.25764. PMC 3876433. PMID 24416651.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Timofeeva, OA (2012 Oct 1). "Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation". JAK-STAT. 1 (4): 274–284. doi:10.4161/jkst.22313. PMC 3670285. PMID 24058784.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Shuai, K (2006 Feb). "Regulation of cytokine signaling pathways by PIAS proteins". Cell Research. 16 (2): 196–202. doi:10.1038/sj.cr.7310027. PMID 16474434.
{{cite journal}}: Check date values in:|date=(help) - ^ Shuai, Ke; Liu, Bin (August 2005). "Regulation of gene-activation pathways by PIAS proteins in the immune system". Nature Reviews Immunology. 5 (8): 593–605. doi:10.1038/nri1667. PMID 16056253.
- ^ a b Lee, Jane; Beliakoff, Jason; Sun, Zijie (18 June 2007). "The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor". Nucleic Acids Research. 35 (13): 4523–4534. doi:10.1093/nar/gkm476. PMC 1935018. PMID 17584785.
- ^ a b Liu, B.; Yang, R.; Wong, K. A.; Getman, C.; Stein, N.; Teitell, M. A.; Cheng, G.; Wu, H.; Shuai, K. (2005 Feb). "Negative regulation of NF-kappaB signaling by PIAS1". Molecular and Cellular Biology. 25 (3): 1113–23. doi:10.1128/MCB.25.3.1113-1123.2005. PMC 544018. PMID 15657437.
{{cite journal}}: Check date values in:|date=(help) - ^ a b Jang, H. D.; Yoon, K.; Shin, Y. J.; Kim, J.; Lee, S. Y. (2004 Jun 4). "PIAS3 suppresses NF-kappaB-mediated transcription by interacting with the p65/RelA subunit". The Journal of Biological Chemistry. 279 (23): 24873–80. doi:10.1074/jbc.M313018200. PMID 15140884.
{{cite journal}}: Check date values in:|date=(help) - ^ a b Liu, Y. (23 September 2013). "Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer-Binding Protein (C/EBP ) during Adipogenesis". Molecular and Cellular Biology. 33 (22): 4606–4617. doi:10.1128/MCB.00723-13. PMID 24061474.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Palvimo, J.J. (1 December 2007). "PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription". Biochemical Society Transactions. 35 (6): 1405–1408. doi:10.1042/BST0351405. PMID 18031232.
- ^ a b Prigge, JR (2006 May 5). "Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP". The Journal of Biological Chemistry. 281 (18): 12260–9. doi:10.1074/jbc.M510835200. PMC 2030495. PMID 16522640.
{{cite journal}}: Check date values in:|date=(help); Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ a b Liu, B.; Liao, J.; Rao, X.; Kushner, S. A.; Chung, C. D.; Chang, D. D.; Shuai, K. (1998 Sep 1). "Inhibition of Stat1-mediated gene activation by PIAS1". Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10626–31. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
{{cite journal}}: Check date values in:|date=(help) - ^ Ortmann, Robert A.; Cheng, Tammy; Visconti, Roberta; Frucht, David M.; O'Shea, John J. (2000). "Janus kinases and signal transducers and activators of transcription: Their roles in cytokine signaling, development and immunoregulation". Arthritis Research. 2 (1): 16–32. doi:10.1186/ar66. PMC 129988. PMID 11094415.
{{cite journal}}: CS1 maint: unflagged free DOI (link)