User:JenniferconnellyII

André Hoelz

André Hoelz is a German chemist and biochemist. He is currently the Mary and Charles Ferkel Professor of Chemistry and Biochemistry at the California Institute of Technology California Institute of Technology (Caltech) and an Investigator of the Howard Hughes Medical Institute (HHMI). Formerly, he was an Investigator of the Heritage Medical Research Institute and a Faculty Scholar of the Howard Hughes Medical Institute (HHMI). He is best known for his research on the structure and function of the nuclear pore complex (NPC) and its role in nucleocytoplasmic transport.

Early life and education

Andre Hoelz obtained a Vordiplom (B.Sc.) in Chemistry and Diploma (M.Sc.) in Chemistry and Biochemistry from the Albert Ludwig University of Freiburg in Freiburg, Germany. Subsequently, he obtained his Ph.D. in Biochemistry and Structural Biology at The Rockefeller University in New York, NY.

Research

Hoelz’s research focuses on the structural biology of nucleocytoplasmic transport, particularly the nuclear pore complex (NPC). His laboratory has made major contributions to the understanding of the NPC's structural architecture and its role in regulating the transport of molecules between the nucleus and the cytoplasm.

He has employed techniques such as X-ray crystallography and cryo-electron microscopy to reveal the molecular details of the NPC. His work has significant implications for understanding diseases related to defects in nuclear transport, including cancer and neurodegenerative disorders.

His lab is also known for its work on mRNA export, exploring how messenger RNA is transported from the nucleus to the cytoplasm, a key step in gene expression.

Grants and Funding

Andre Hoelz’s research has been supported by several major grants, including funding from the Howard Hughes Medical Institute (HHMI) and the National Institutes of Health (NIH).

Selected Publications

Hoelz has authored numerous high-impact research papers in leading scientific journals. His publications cover a range of topics related to cell biology and structural biology, particularly nucleocytoplasmic transport.^[1]^[2]^[3]

References

^ Petrovic, Stefan; Samanta, Dipanjan; Perriches, Thibaud; Bley, Christopher J.; Thierbach, Karsten; Brown, Bonnie; Nie, Si; Mobbs, George W.; Stevens, Taylor A.; Liu, Xiaoyu; Tomaleri, Giovani Pinton; Schaus, Lucas; Hoelz, André (2022-06-10). "Architecture of the linker-scaffold in the nuclear pore". Science (New York, N.Y.). 376 (6598): eabm9798. doi:10.1126/science.abm9798. ISSN 1095-9203. PMC 9867570. PMID 35679425.
^ Bley, Christopher J.; Nie, Si; Mobbs, George W.; Petrovic, Stefan; Gres, Anna T.; Liu, Xiaoyu; Mukherjee, Somnath; Harvey, Sho; Huber, Ferdinand M.; Lin, Daniel H.; Brown, Bonnie; Tang, Aaron W.; Rundlet, Emily J.; Correia, Ana R.; Chen, Shane (2022-06-10). "Architecture of the cytoplasmic face of the nuclear pore". Science (New York, N.Y.). 376 (6598): eabm9129. doi:10.1126/science.abm9129. ISSN 1095-9203. PMC 9348906. PMID 35679405.
^ Lin, Daniel H.; Stuwe, Tobias; Schilbach, Sandra; Rundlet, Emily J.; Perriches, Thibaud; Mobbs, George; Fan, Yanbin; Thierbach, Karsten; Huber, Ferdinand M.; Collins, Leslie N.; Davenport, Andrew M.; Jeon, Young E.; Hoelz, André (2016-04-15). "Architecture of the symmetric core of the nuclear pore". Science (New York, N.Y.). 352 (6283): aaf1015. doi:10.1126/science.aaf1015. ISSN 1095-9203. PMC 5207208. PMID 27081075.

External Links

[1] Petrovic, Stefan; Samanta, Dipanjan; Perriches, Thibaud; Bley, Christopher J.; Thierbach, Karsten; Brown, Bonnie; Nie, Si; Mobbs, George W.; Stevens, Taylor A.; Liu, Xiaoyu; Tomaleri, Giovani Pinton; Schaus, Lucas; Hoelz, André (2022-06-10). "Architecture of the linker-scaffold in the nuclear pore". Science (New York, N.Y.). 376 (6598): eabm9798. doi:10.1126/science.abm9798. ISSN 1095-9203. PMC 9867570. PMID 35679425.

[2] Bley, Christopher J.; Nie, Si; Mobbs, George W.; Petrovic, Stefan; Gres, Anna T.; Liu, Xiaoyu; Mukherjee, Somnath; Harvey, Sho; Huber, Ferdinand M.; Lin, Daniel H.; Brown, Bonnie; Tang, Aaron W.; Rundlet, Emily J.; Correia, Ana R.; Chen, Shane (2022-06-10). "Architecture of the cytoplasmic face of the nuclear pore". Science (New York, N.Y.). 376 (6598): eabm9129. doi:10.1126/science.abm9129. ISSN 1095-9203. PMC 9348906. PMID 35679405.

[3] Lin, Daniel H.; Stuwe, Tobias; Schilbach, Sandra; Rundlet, Emily J.; Perriches, Thibaud; Mobbs, George; Fan, Yanbin; Thierbach, Karsten; Huber, Ferdinand M.; Collins, Leslie N.; Davenport, Andrew M.; Jeon, Young E.; Hoelz, André (2016-04-15). "Architecture of the symmetric core of the nuclear pore". Science (New York, N.Y.). 352 (6283): aaf1015. doi:10.1126/science.aaf1015. ISSN 1095-9203. PMC 5207208. PMID 27081075.

[1]

[2]

[3]