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S cells are cells which release secretin, found in the jejunum and duodenum. They are stimulated by a drop in pH to 4 or below in the small intestine's lumen. The released secretin will increase the secretion of bicarbonate (HCO3−) into the lumen, via thepancreas. This is primarily accomplished by an increase in cyclic AMP that activates CFTR to release chloride anions into the lumen. The luminal Cl− is then involved in a bicarbonate transporter protein exchange, in which the chloride is reabsorbed by the cell and HCO3− is secreted into the lumen. S cells are also one of the main producers of cyclosamatin.
- Secretin, a chemical released by S cells.
- Duodenum, the first part of the small intestine in humans
- Jejunum, second part of the small intestine in humans
References
[edit]- ^ al., Koo J , et. "Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25.
{{cite web}}: no-break space character in|title=at position 71 (help)CS1 maint: multiple names: authors list (link) - ^ al., Delanoue R , et. "Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25.
{{cite web}}: CS1 maint: multiple names: authors list (link) - ^ al., Boraschi P , et. "Secretin-stimulated MR cholangiopancreatography: spectrum of findings in pancreatic diseases. - PubMed - NCBI". www-ncbi-nlm-nih-gov.proxy.wexler.hunter.cuny.edu. Retrieved 2016-10-25.
{{cite web}}: CS1 maint: multiple names: authors list (link)