User:IcyEd/Alphathesin

Alfaxolone/alfadolone
	Alfaxolone/alfadolone in a 3:1 ratio
Clinical data
Trade names	Saffan
Routes of; administration	Intravenous
Identifiers
	IUPAC name (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3, 4,5,6,7,8,9,12,14,15,16, 17-tetradecahydrocyclopenta[a]phenanthren-11-one; [2-[(3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3, 4,5,6,7,8,9,12,14,15,16, 17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate;
PubChem CID	24732;
Chemical and physical data
Formula	C44H66O8
Molar mass	722.99004 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H] (C4)O)C)C.CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CC[C@@H]4 [C@@]3(CC[C@H](C4)O)C)C;

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Alphathesin is a general anaesthetic made from a 3:1 mixture of alfaxalone with alfadolone acetate.^[1]

Mechanism

Alphathesin is short-duration, intravenous anaesthetic made from a combination of two steroidial compounds, alfaxalone and alfadolone of which the former is the primary anasethetic agent. Alfadolone acts to increase the solubility of the mixture which is dissolved in an polyethylated caster oil adjuvant. ^[1]

Clinical Use

Alphathesin is short-acting, rapid onset anaesthetic which has been used for out-patient surgery. It does not have significant analgesic properties and anaesthesia has often been maintained with inhalational anaesthetics such as halothane. These have also been accompanied by neuromuscular blockers. Procedures carried out under Alphathesin are greatly varied and have included orthopaedic, gynaecological, dental and urological surgery. Notable effects include a drop in arterial and venous pressure in a quarter of patients; this is accompanied by a compensatory mild tachycardia in around 35% of those observed in a population of skewed towards geriatrics. ^[1]

References

^ ^a ^b ^c Dechêne, JP (1976 Mar). "Alphathesin, a new steroid anaesthetic agent". Canadian Anaesthetists' Society Journal. 23 (2): 163–9. doi:10.1007/BF03005687. PMID 943212. S2CID 46395582. {{cite journal}}: Check date values in: |date= (help)

External links

Pubchem - Alphathesin

Category: General Anaesthetics

[Alphathesin,_a_new_steroid_anaesthetic_agent.-1] Dechêne, JP (1976 Mar). "Alphathesin, a new steroid anaesthetic agent". Canadian Anaesthetists' Society Journal. 23 (2): 163–9. doi:10.1007/BF03005687. PMID 943212. S2CID 46395582. {{cite journal}}: Check date values in: |date= (help)

[1]