User:Ian Kates/VLDL Receptor Project
Introduction
[edit]This is the project proposal for the creation of the Wikipedia page for the VLDL receptor (Very Low Density Lipoprotein Receptor). This project for BI481 Introduction to Neuroscience to help expand the field of neuroscience for the Society for Neuroscience.
Members working on this project: Ian Kates, Katie Czepiel, and Jennifer Goldberg.
The project page can be found here.
Proposal
[edit]Topics to Cover
[edit]- Function
- Role in the nervous system
- Systems it affects, or is present in
- Structure
- Protein structure
- Genetic basis of structure
- Protein Biosythesis
- subcellular localization
- Genetic variants and mutations
- Mechanism and Interactions
- Transport mechanism
- Result of ligand binding
- Inhibitors
- Positive and negative feedback control
- Associated Conditions and Diseases
- Bipolar disorder, schizophrenia, Parkinson's
- Genetic mutation of VLDL receptor gene
- Clinical Research
- References
Division of Work
[edit]This is the planned division of work. This will be subject to change depending on the amount of work that is needed to complete each topic and the amount of information available.
Ian Kates: Protein structure, genetic basis of structure, Inhibitors, Positive and Negative feedback control, Clinical Research
Katie Czepiel: Tranport mechanism, Result of ligand binding, Associated Diseases(Parkinson's)
Jennifer Goldberg: Role in nervous system, Systems it affects or is present in, Genetic mutation of VLDL-R gene, Associated Diseases (Schizophrenia and Biopolar disorder)
Current Articles and Information
[edit]VLDL receptor structure. [1]
LDL protein mediated neurite growth in CNS. [2]
Physiological role of LDL receptor family. [3]
VLDLR role in corticol neuron migration. [4]
VLDLR role in neuronal migration mechanisms in development and disease. [5]
Lissencephaly with cerebellar hypoplasia (LCH). [6]
Neuronal Migration. [7]
VLDLR Types. [8]
Type I lissencephaly. [9]
Structure 1. [10]
Structure 2. [11]
VLDLR Expression. [12]
Discovery in 1992. [13]
Cerebellar Hypoplasia. [14]
References
[edit]- ^ "The VLDL receptor: an LDL receptor relative with eight ligand binding repeats, LR8", Atherosclerosis, 1 December 1998
- ^ "Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line", Proceedings of the National Academy of Sciences of the United States of America, 10 October 1995
- ^ "Diverse roles for the LDL receptor family", Trends in Endocrinology and Metabolism, 1 March 2002
- ^ "Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons", Development, 1 November 2007
- ^ "Neuronal migration mechanisms in development and disease", Current Opinion in Neurobiology, 5 January 2012
- ^ "New trends in neuronal migration disorders", European Journal of Paediatric Neurology, 30 January 2009
- ^ "Cortical Neuronal Migration Mutants suggest separate but Intersecting Pathways", Annual Review of Cell and Developmental Biology, 28 June 2004
- ^ "Similarities and differences in structure, expression, and functions of VLDLR and ApoER2", Molecular Neurodegeneration, 2011
- ^ "Neuronal migration disorders: clinical, neuroradiologic and genetics aspects.", Acta Paediatr, 12 November 2008
- ^ "The Very Low-density Lipoprotein (VLDL) Receptor: Characterization and Functions as a Peripheral Lipoprotein Receptor.", Journal of Atherosclerosis and Thrombosis, 23 March 2004
- ^ "Reelin and brain development.", Nature Reviews Neuroscience, June 2003
- ^ "Low-density Lipoprotein receptor (LDLR) Family orchestrates cholesterol Homeostasis.", Yale Journal of Biology and Medicine, 2012
- ^ "From cholesterol transport to signal transduction: low density lipoprotein receptor, very low density lipoprotein receptor, and apolipoprotein E receptor-2.", Molecular and Cell Biology of Lipids, 15 December 2000
- ^ "VLDLR-Associated Cerebellar Hypoplasia", Molecular and Cell Biology of Lipids, 26 August 2008