User:HawwaMD/sandbox
Geographic Atrophy
[edit]Original: Geographic atrophy (also called atrophic AMD) is an advanced form of AMD in which progressive and irreversible loss of retinal cells leads to a loss of visual function.
Geographic atrophy, a late complication of dry AMD is defined by scattered or merged areas of degenerated retinal pigment epithelium (RPE) and the overlying light-sensing retinal photoreceptors which are dependent on RPE for trophic support [1]. This leads to irreversible vision loss.
Stages:
Replace the way current staging (early, intermediate, late, dry, wet) criteria is presented in a more palatable manner. I would replace these five categories with No-,Early-, Intermediate, and Advanced-AMD[2]. I would also include specific drusen levels that define each category. Late AMD in this classification would include both wet and dry geographic atrophy forms. (Grouping both of the end-stage presentations (Geographic atrophy and Wet AMD) together gives a more accurate depiction of the realistic endpoints of the disease)
- ^ Ambati, Jayakrishna; Fowler, Benjamin J. (2012). "Mechanisms of Age-Related Macular Degeneration". Neuron. 75 (1): 26–39. doi:10.1016/j.neuron.2012.06.018. ISSN 0896-6273. PMC 3404137. PMID 22794258.
{{cite journal}}: no-break space character in|first2=at position 9 (help)CS1 maint: PMC format (link) - ^ Ferris, Frederick L.; Wilkinson, C.P.; Bird, Alan; Chakravarthy, Usha; Chew, Emily; Csaky, Karl; Sadda, Srinivas R. (2013). "Clinical Classification of Age-related Macular Degeneration". Ophthalmology. 120 (4): 844–851. doi:10.1016/j.ophtha.2012.10.036. ISSN 0161-6420.
Comments
[edit]Thanks for adding your suggestions here. I have a few notes:
- Can you add any more wikilinks? retinal pigment epithelium, photoreceptors, etc If not already linked earlier in the article.
- Can you please give us a little more info about your "stages" suggestions? You can write in your exact proposed changes and then we can help with formatting, etc.
- Citations go immediately after the punctuation (no spaces).
Great work so far! JenOttawa (talk) 17:23, 6 November 2018 (UTC)