User:Gabbyyy123/sandbox/Escherichia coli NC101
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Article name is...Escherichia coli NC101
| Escherichia coli NC101 O2:H6/41 | |
|---|---|
Scientific classification
| |
| Domain: | Bacteria |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Enterobacterales |
| Family: | Enterobacteriaceae |
| Genus: | Escherichia |
| Species: | E. coli |
| Serotype: | E. c. 'NC101 O2:H6/41' |
| Trionomial name | |
| Escherichia coli 'NC101 O2:H6/41' | |
Escherichia coli (AIEC) NC101 is a mouse isolate, serotype O2:H6/41, that is pro-carcinogenic, adherent-invasive (AEIC), probiotic strain of Escherichia coli, a species of bacteria that thrives in the intestines of mammals[1][2]. NC101 has also been identified as a nicotinic acid (NA) auxotroph, a pathobiont, organisms that are harmful under certain circumstances[3], and is an important, relevant model organism that demonstrates how susceptible individuals may produce inappropriate immune responses to seemingly benign intestinal E. coli.[4]
History
[edit]NC101 was first isolated and found from a specific pathogen-free wild-type mouse at the North Carolina State University between 2004 and 2005.[5] Sequencing of NC101 showed it has a missense mutation in nadA, a gene that encodes for quinolinate synthase A, which is necessary for de novo nicotinamide adenine dinucleotide (NAD) biosynthesis. [6]
Effects
[edit]E. coli NC101 has been found to promote carcinoma specifically, mucinous adenocarcinoma, in while performing experiments in azoxymethane treated mice. The findings of the study found "...tumorigenesis by altering microbial composition and inducing the expansion of microorganisms with genotoxic capabilities."[7] The frequency of specific E. coli strains like NC101 in laboratory mouse colonies is currently unknown.
See also
[edit]References
[edit]- ^ Sadecki, Patric W.; Balboa, Samantha J.; Lopez, Lacey R.; Kedziora, Katarzyna M.; Arthur, Janelle C.; Hicks, Leslie M. (2021-07-16). "Evolution of Polymyxin Resistance Regulates Colibactin Production in Escherichia coli". ACS Chemical Biology. 16 (7): 1243–1254. doi:10.1021/acschembio.1c00322. ISSN 1554-8929. PMC 8601121. PMID 34232632.
- ^ García, Alexis; Mannion, Anthony; Feng, Yan; Madden, Carolyn M.; Bakthavatchalu, Vasudevan; Shen, Zeli; Ge, Zhongming; Fox, James G. (December 2016). "Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice". Microbes and Infection. 18 (12): 777–786. doi:10.1016/j.micinf.2016.07.005. hdl:1721.1/117656. ISSN 1286-4579. PMC 5182106. PMID 27480057.
- ^ Jochum, Lara; Stecher, Bärbel (2020-10-01). "Label or Concept – What Is a Pathobiont?". Trends in Microbiology. 28 (10): 789–792. doi:10.1016/j.tim.2020.04.011. ISSN 0966-842X. PMID 32376073. S2CID 218532205.
- ^ Lopez, Lacey R.; Barlogio, Cassandra J.; Broberg, Christopher A.; Wang, Jeremy; Arthur, Janelle C. (2021). "A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101". Frontiers in Microbiology. 12: 1081. doi:10.3389/fmicb.2021.670005. ISSN 1664-302X. PMC 8207962. PMID 34149655.
- ^ Carey, Hannah (2005-04-19). "Faculty Opinions recommendation of Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria". Gastroenterology. 128 (4). doi:10.3410/f.1015543.298863.
- ^ Lopez, Lacey R.; Barlogio, Cassandra J.; Broberg, Christopher A.; Wang, Jeremy; Arthur, Janelle C. (2021). "A nadA Mutation Confers Nicotinic Acid Auxotrophy in Pro-carcinogenic Intestinal Escherichia coli NC101". Frontiers in Microbiology. 12: 1081. doi:10.3389/fmicb.2021.670005. ISSN 1664-302X. PMC 8207962. PMID 34149655.
- ^ Arthur, Janelle C.; Perez-Chanona, Ernesto; Mühlbauer, Marcus; Tomkovich, Sarah; Uronis, Joshua M.; Fan, Ting-Jia; Campbell, Barry J.; Abujamel, Turki; Dogan, Belgin; Rogers, Arlin B.; Rhodes, Jonathan M. (2012-10-05). "Intestinal inflammation targets cancer-inducing activity of the microbiota". Science (New York, N.Y.). 338 (6103): 120–123. Bibcode:2012Sci...338..120A. doi:10.1126/science.1224820. ISSN 0036-8075. PMC 3645302. PMID 22903521.