User:Fvasconcellos/Oxazolidinone antibiotic
The oxazolidinones (/ˈɒksəzɵˌlɪdɨnoʊn/[1]) are a class of synthetic antibiotics used in the treatment of severe bacterial infections.
Linezolid sources
[edit]- PMID 20455685 (STR)
- PMID 20528004 (review)
- PMID 19766891 (safety review)
- PMID 20639754 (vs. glycopeptides in nosocomial pneumonia)
- PMID 19900794
- PMID 20429820 (cSSTIs)
- Notably, the concentration of linezolid in the epithelial lining fluid of the lower respiratory tract is at least equal to, and often higher than, that achieved in serum (some authors have reported bronchial fluid concentrations up to four times higher than serum concentrations). This may account for its efficacy in treating pneumonia, but the actual clinical significance (if any) is still unknown.[2]
- PMID 19766889 (economic considerations)
- ^ "oxazolidinone" at Dorland's Medical Dictionary
- ^ Stein GE, Wells EM (2010). "The importance of tissue penetration in achieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid". Curr Med Res Opin. 26 (3): 571–88. doi:10.1185/03007990903512057. PMID 20055750.
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