User:Ebuddha5/4-Dehydroepiandrosterone

Ebuddha5/4-Dehydroepiandrosterone
Clinical data
Other names	(3β)-3-Hydroxyandrost-4-en-17-one
Routes of; administration	Oral
Legal status
Legal status	Commercially available; (US);
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	12 hours
Excretion	Urinary:?%
Chemical and physical data
Formula	C19H28O2
Molar mass	288.424 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3[C@]2(CC[C@@H]1[C@@]4(C(=C/C[C@H]1[C@@H]2CC3)\C[C@@H](O)CC4)C)C;
	(verify)

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4-Dehydroepiandrosterone is an adrenal steroid that is an isomer to 5-DHEA. The endogenous formation of androstenedione has been well documented in healthy human and animal tissues. Under DSHEA, 4-DHEA is a natural metabolite of androstenedione and DHEA that is proven to occur in rabbits, sheep and rats.(1,2) It is a pro-hormone to 4-androstenedione and 4-Androstenediol via 3bHSD and 17bHSD respectively.

Synonyms and brand names

Synonyms for 4-dehydroepiandrosterone are:

3-beta-Hydroxy-4-androsten-17-one, 3.beta.-Hydroxyandrost-4-en-17-one, 3beta-hydroxy-4-androsten-17-one, 3beta-hydroxy-androst-4-en-17-one, 3beta-Hydroxy-D4-androsten-17-one, 3beta-Hydroxyandrost-4-en-17-one, 3beta-Hydroxyandrost-4-ene-17-one, 3-beta-hydroxy-etioallocholan-4-ene-17-one , 4-Androsten-3beta-ol-17-one,

References

1. BREUER H, DAHM K, NORYMBERSKI JK. ENZYMIC FORMATION OF 3-BETA-HYDROXYANDROST-4-EN-17-ONE. J Endocrinol. 1963 Nov;27:357-8.

2. THOMAS PZ, DORFMAN RI. METABOLISM OF ANDROST-4-ENE-3,17-DIONE-4-14C BY RABBIT SKELETAL MUSCLE SUPERNATANT FRACTION. ISOLATION OF 3BETA-HYDROXYANDROST-4-EN-17-ONE-14C AND TESTOSTERONE-14C. J Biol Chem. 1964 Mar;239:766-72.