My Sandbox page

Hey there again. I started this page based on the instructional video. It was pretty straight forward.

~~I'm going to start writing here...~~

The 5 Pillars of Wikipedia

It's an encyclopedia!

Wikipedia is not a promotional platform, or a news source, it is a reference.

It's fair and balanced!

Major points of view, if multiple exist, are presented without bias. All material must be referenced.

It's free!

Content is not owned by the writer or editor and can be freely distributed or edited.

Be nice to each other!

Those working on the same article should be respectful of each other and avoid creating unnecessary conflict.

It's more of a guideline than a rule...

Wikipedia is an evolving ecosystem, and interpretation of the rules may change if it means improving Wikipedia.

Summary of characteristics of target article

To take an article from stub class to B or Good Article status, we must be complete in information scope about the subject article and diligent with our sources. The facts must be well sourced and noted inline. There should be, if possible, supplemental pictures or charts to enhance the text.

Ultimately, the article will provide a very comprehensive study on the subject, with limited details missing. Along with final details, styling may still require attention to reach A or Featured Article status.

Common Substructure and drug design

Therapeutic drug design often involves the identification of common substructures, or scaffolds, amongst compounds active against a specific target. Knowing what structures are present in a collection can tell you if there is diversity, or if the collection is targeted, with many compounds structurally based around few scaffolds.^[1] Visualization of the resultant information can be a challenge, with many collections containing millions of compounds.^[2]Several different techniques exist for identifying the major structural components of scaffolds. Two very widely used methods are Murcko frameworks and scaffold trees.^[1]

Notes

^ ^a ^b Langdon SR, Brown N, Blagg J (September 2011). "Scaffold diversity of exemplified medicinal chemistry space". J Chem Inf Model. 51 (9): 2174–85. doi:10.1021/ci2001428. PMC 3180201. PMID 21877753.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)
^ Ertl P, Rohde B (2012). "The Molecule Cloud - compact visualization of large collections of molecules". J Cheminform. 4 (1): 12. doi:10.1186/1758-2946-4-12. PMC 3403880. PMID 22769057.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[Langdon-1] Langdon SR, Brown N, Blagg J (September 2011). "Scaffold diversity of exemplified medicinal chemistry space". J Chem Inf Model. 51 (9): 2174–85. doi:10.1021/ci2001428. PMC 3180201. PMID 21877753.{{cite journal}}: CS1 maint: date and year (link) CS1 maint: multiple names: authors list (link)

[2] Ertl P, Rohde B (2012). "The Molecule Cloud - compact visualization of large collections of molecules". J Cheminform. 4 (1): 12. doi:10.1186/1758-2946-4-12. PMC 3403880. PMID 22769057.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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