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SHINE Technologies
Company typeL.L.C.
IndustryRadiopharmaceutical
FoundedJune 2010
FounderGregory Piefer
Headquarters
Janesville, Wisconsin
Websitehttp://SHINEfusion.com

SHINE Technologies, is a private corporation based in Janesville, Wisconsin US which is building a facility to produce radioactive isotopes for medical applications.[1] SHINE is an acronym for Subcritical Hybrid Intense Neutron Emitter.[2]

Company Description

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SHINE is a next-generation nuclear technology company, deploying state-of-the-art fusion technology to create a scalable path toward fusion energy. SHINE deploys its safe, cost-effective and environmentally-friendly technology in a step-wise approach, beginning with our systems used for industrial imaging of components used in aerospace, defense, transportation, energy and other sectors. SHINE’s proprietary isotope production process creates Molybdenum 99 and non-carrier-added Lutetium 177 used in tens of thousands of daily procedures to diagnose and treat heart disease and late stage cancer.

Business model

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In 2009, the supply of molybdenum-99 (Mo-99), a precursor to technetium-99m used in more than 30 medical imaging procedures, fell short of demand due to maintenance idling of a pair of research reactors, one located in the Netherlands, forcing doctors to use more dangerous isotopes.[3][4] By 2016, the largest global supplier of the isotope, a Canadian research reactor, was scheduled to go idle.[3][4] In 2010, the National Nuclear Security Administration (NNSA), a part of the United States Department of Energy, began funding a number of method development ventures aimed at ensuring that shortages in the United States could be avoided[4] as well as reducing the use of highly enriched uranium and with it lowering the risk of nuclear proliferation.[5]

SHINE was among a handful of early recipients of funds from the NNSA program and received US$13,900,000 through it as of 2014.[4] SHINE has also relied on venture capital funding, having secured up to US$125,000,000 from Deerfield Management beginning in October 2014.[4][6]

The 2014 market for medical isotopes was estimated to be about US$600,000,000 per year.[4] Several companies in addition to SHINE are vying for part of this market, and the need for redundancy in production will support a number suppliers beyond the minimum needed to meet current demand.[4]

The company plans to start production scale generation of isotope in 2018, having pushed the proposed start date back several times,[7] it has secured a number of supply agreements predicated on this start date.[4][8]

In addition to supplying Mo-99, SHINE has secured a US$150,000 National Science Foundation grant to develop production methods for Iodine-131, used in the treatment of Graves' disease and certain cancers.[9]

Facilities and technology

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Original technology for production of Mo-99 was reactor-based and unavoidably produced significant nuclear waste.[3] SHINE plans to use particle accelerator technology developed at the University of Wisconsin–Madison by company founder Gregory Piefer.[4][9] The method, referred to as "neutron generator technology", uses helium and free neutrons, produced by colliding a beam of deuterium particles with tritium gas, to bombard low-level enriched uranium targets leading to the production of "useful isotopes with minimal waste."[4] In addition to the diagnostically useful Mo-99, the process can also produce Iodine-131, used in medical treatments.[1]

In 2013, SHINE constructed a full-scale prototype particle accelerator at their Monona, Wisconsin facility to be used to demonstrate the technology. Eight accelerators would be used at the Janesville facility.[10]

On June 15, 2015, Argonne National Laboratory demonstrated that SHINE's production, separation and purification process could produce Mo-99 which meets purity specifications of the British Pharmacopoeia.[5]

The NRC approved SHINE's construction permit for a facility in Janesville, Wisconsin in late February 2016. If constructed, the facility would still require NRC licensing to operate.[11] In 2014 the facility was originally slated for opening in 2016, was then delayed to 2017.[12] As of February 2016, construction was planned for 2017 with production potentially beginning in 2019.[11]

References

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  1. ^ a b Gallagher, Kathleen (June 30, 2015). "Shine Medical Technologies receives $150,000 National Science Foundation grant". The Milwaukee Journal Sentinel. Retrieved 2015-07-24.
  2. ^ Chemerisov, S. (April 14, 2014). "Development of the mini-SHINE/MIPS experiments" (PDF). Argonne National Laboratory. doi:10.2172/1132249. Retrieved July 17, 2015.
  3. ^ a b c Noorden, Richard Van (December 11, 2013). "Radioisotopes: The medical testing crisis". Nature. 504 (7479): 202–204. doi:10.1038/504202a. ISSN 0028-0836. PMID 24336269. Retrieved 14 July 2015.
  4. ^ a b c d e f g h i j LaMonica, Martin (December 18, 2014). "Startups Race to Solve Looming Medical Radioisotope Crisis". Xconomy. Retrieved July 23, 2015. The company has supply agreements in place and plans to build a production plant in Janesville, WI.
  5. ^ a b Cunningham, Greg (June 15, 2015). "Argonne confirms new commercial method for producing medical isotope". Argonne National Lab. Retrieved July 17, 2015.
  6. ^ Engel, Jeff (October 9, 2014). "Deerfield Pouring $125M Into WI Startup Shine Medical Technologies". Xconomy. Retrieved July 23, 2015.
  7. ^ Newman, Judy. "Environmental report supports SHINE Medical's plan to build radioisotope plant in Janesville". Wisconsin State Journal. Retrieved July 23, 2015.
  8. ^ Gallagher, Kathleen (April 3, 2014). "Shine Medical Technologies signs supply contract with GE Healthcare". Milwaukee Journal Sentinel. Retrieved July 23, 2015.
  9. ^ a b Gallagher, Kathleen (September 3, 2014). "Shine Medical Technologies raises $2.4 million". Milwaukee Journal Sentinel. Retrieved July 23, 2015.
  10. ^ Leute, Jim (February 17, 2013). "Testing 1, 2, 3: SHINE makes progress at demonstration facility". Janesville Gazette. Retrieved July 17, 2015.
  11. ^ a b Newman, Judy (February 25, 2016). "SHINE Medical wins NRC's OK to build medical isotope plant". Wisconsin State Journal. Retrieved February 25, 2016.
  12. ^ "Financing deal for $125 million brings SHINE Janesville plant closer to reality". The Janesville Gazette. October 10, 2014. Retrieved July 23, 2015.(subscription required)
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