User:Chandler.c.ho/sandbox

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PubMed Assignment

Hemoglobin is composed of two alpha globin and two beta globin chains. Deletions in alpha globin gene or point mutations in beta globin gene can contribute thalassemia. Seven common deletions in alpha thalassemia can be detected in a multiplex polymerase chain reaction.^[1]

Unlike alpha thalassemia, beta thalassemia is predominantly caused by point mutations.^[2]

/Terminator (genetics)

Prokaryotes

1. transcription arrest by Rna pol and endonuclease Uvr(A) triggered by damage dna

2. rho dependent terminator description of rut site atp dependent^[3] 3 purposed mechanism rho act on polymerase by pushing rho act on rna by pulling rho induces a conformational change in polymerase

3.rho-independent terminator requires no other factor show sequence element^[4]

Eurkaryotes

1.Torpedo model

2.alloseteric model

to be continue

Notes

^ Tan, A. S.; Quah, T. C.; Low, P. S.; Chong, S. S. (07/01/2001). "A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for alpha-thalassemia". Blood. 98 (1): 250–251. doi:10.1182/blood.v98.1.250. PMID 11439976. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
^ Maritsi, D. N.; Kosmidis, H. V.; Douna, V.; Traeger-Synodinos, J.; Tsolia, M. N.; Kossiva, L. (10/05/2013). "Detection of acquried hemoglobinopathy in children with hematological malignancies at disease onset: results form a national referral centre". Int J Hemtol. 98 (5): 563–568. doi:10.1007/s12185-013-1451-4. PMID 24096989. S2CID 154878. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |month= ignored (help)CS1 maint: date and year (link)
^ Richardson, J.P. (2003). "Loading Rho to terminate transcription". Cell. 114 (2): 157–159. doi:10.1016/S0092-8674(03)00554-3. PMID 12887917. S2CID 14837961.
^ Rosonina, E. (2006). "Terminating the transcript: Breaking up is hard to do". Genes Dev. 20 (9): 1050–1056. doi:10.1101/gad.1431606. PMID 16651651. S2CID 44809012. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

[1] Tan, A. S.; Quah, T. C.; Low, P. S.; Chong, S. S. (07/01/2001). "A rapid and reliable 7-deletion multiplex polymerase chain reaction assay for alpha-thalassemia". Blood. 98 (1): 250–251. doi:10.1182/blood.v98.1.250. PMID 11439976. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |month= ignored (help)CS1 maint: date and year (link)

[2] Maritsi, D. N.; Kosmidis, H. V.; Douna, V.; Traeger-Synodinos, J.; Tsolia, M. N.; Kossiva, L. (10/05/2013). "Detection of acquried hemoglobinopathy in children with hematological malignancies at disease onset: results form a national referral centre". Int J Hemtol. 98 (5): 563–568. doi:10.1007/s12185-013-1451-4. PMID 24096989. S2CID 154878. {{cite journal}}: Check date values in: |date= (help); Unknown parameter |month= ignored (help)CS1 maint: date and year (link)

[3] Richardson, J.P. (2003). "Loading Rho to terminate transcription". Cell. 114 (2): 157–159. doi:10.1016/S0092-8674(03)00554-3. PMID 12887917. S2CID 14837961.

[4] Rosonina, E. (2006). "Terminating the transcript: Breaking up is hard to do". Genes Dev. 20 (9): 1050–1056. doi:10.1101/gad.1431606. PMID 16651651. S2CID 44809012. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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