User:Biohisham/Crc protein

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Crc
Crc
	Crystal structure of Crc in Pseudomonas aeruginosa.
Identifiers
Symbol	Crc
Pfam	PF03372
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

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The Catabolite repression control (Crc) protein participates in suppressing expression of several genes involved in utilization of carbon sources in Pseudomonas bacteria. Presence of organic acids triggers activation of Crc and in conjunction with the Hfq protein genes that metabolize a given carbon source are downregulated until another more favorable carbon source is depleted ^[2]. Crc-mediated regulation impact processes such as biofilm formation ^[3], virulence ^[4] and antibiotic susceptibility ^[5].

Interactions

A consensus sequence targeted by Crc mediated regulation

Hfq and Crc bind to A-rich sequences in the ribosome binding sites of genes that code for carbon utilization enzymes and consequently suppress their translation.

References

^ Wei, Y; Zhang, H; Gao, Z.-Q.; Xu, J.-H; Liu, Q.-S; Dong, Y.-H (2013 Jan). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life. 65 (1): 50–57. doi:10.1002/iub.1103. {{cite journal}}: Check date values in: |date= (help)
^ Sonnleitner, E; Bläsi, U (2014 June). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression". PLOS Genetics. 10 (6). doi:10.1371/journal.pgen.1004440. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)
^ O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000 Jan). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa". J Bacteriol. 182: 425–431. doi:10.1128/jb.182.2.425-431.2000. {{cite journal}}: Check date values in: |date= (help)
^ Zhang, L; Chiang, WC; Gao, Q; Givskov, M; Tolker-Nielsen, T; et al. (2012 Jan). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology. 158: 3014–3019. doi:10.1099/mic.0.061192-0. {{cite journal}}: Check date values in: |date= (help); Explicit use of et al. in: |first5= (help)CS1 maint: unflagged free DOI (link)
^ Yeung, AT; Bains, M; Hancock, RE (2011 Dec). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". J Bacteriol. 193: 918–931. doi:10.1128/jb.00911-10. {{cite journal}}: Check date values in: |date= (help)

Category:Protein domains Category:Protein complexes

[1] Wei, Y; Zhang, H; Gao, Z.-Q.; Xu, J.-H; Liu, Q.-S; Dong, Y.-H (2013 Jan). "Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa". IUBMB Life. 65 (1): 50–57. doi:10.1002/iub.1103. {{cite journal}}: Check date values in: |date= (help)

[2] Sonnleitner, E; Bläsi, U (2014 June). "Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression". PLOS Genetics. 10 (6). doi:10.1371/journal.pgen.1004440. {{cite journal}}: Check date values in: |date= (help)CS1 maint: unflagged free DOI (link)

[3] O'Toole, GA; Gibbs, KA; Hager, PW; Phibbs, PV jr; Kolter, R (2000 Jan). "The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa". J Bacteriol. 182: 425–431. doi:10.1128/jb.182.2.425-431.2000. {{cite journal}}: Check date values in: |date= (help)

[4] Zhang, L; Chiang, WC; Gao, Q; Givskov, M; Tolker-Nielsen, T; et al. (2012 Jan). "The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms". Microbiology. 158: 3014–3019. doi:10.1099/mic.0.061192-0. {{cite journal}}: Check date values in: |date= (help); Explicit use of et al. in: |first5= (help)CS1 maint: unflagged free DOI (link)

[5] Yeung, AT; Bains, M; Hancock, RE (2011 Dec). "The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa". J Bacteriol. 193: 918–931. doi:10.1128/jb.00911-10. {{cite journal}}: Check date values in: |date= (help)

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