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User:Benjah-bmm27/degree/3/GCLJ2

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Synthetic uses of transition metals, GCLJ

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Textbooks

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  • Clayden, Chapter 48 (Organometallic chemistry), pp. 1311–1343

Introduction

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Pd-catalyzed coupling reactions

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Stille

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Suzuki

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Negishi

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Kumada

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Sonogashira

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Use of Sonogashira coupling in enediyne synthesis

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Hartwig-Buchwald coupling

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  • "Amination", R-X → R-NH-R′
  • RX + R′NH2 → RNHR′ + HX
  • Catalysed by 0PdL2
  • [R′H2N+PdL2R][X] deprotonated

sp³ hybridised carbon in the oxidative addition process

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Heck reaction

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Mechanism

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Other interactions of alkenes with Pd(II)

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Cyclopropanation using electrophilic carbene complexes

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Cilastatin synthesis

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  • Example of a Cu-catalysed asymmetric cyclopropanation: synthesis of cilastatin

Ring-closing metathesis

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