User:Benjah-bmm27/degree/2/CLW

Retronecine, a pyrrolizidine alkaloid studied by CLW

Introduction

"Organic Synthesis", Professor Chris Willis

Retrosynthetic analysis

• Retrosynthetic analysis
• Synthon
• Umpolung

Application to organic synthesis

• Encyclopedia of Reagents for Organic Synthesis
• Baeyer-Villiger oxidation
• Osmylation
• Ozonolysis - ozone is a pair of molecular scissors
• Vicinal diols:
  • Osmium tetroxide gives syn diols
  • Epoxidation followed by hydrolysis gives anti diols
  • Woodward cis-hydroxylation gives syn diols
  • Prévost reaction gives anti diols
• Pyrrolizidine alkaloids

Textbooks

• Chris Willis and Martin Wills, Organic Synthesis (Oxford Chemistry Primer) (1995) (on Amazon.co.uk)
• Stuart Warren and Paul Wyatt, Organic Synthesis: The Disconnection Approach (2008) (on Amazon.co.uk)
• Stuart Warren, Organic Synthesis: The Disconnection Approach (1983) (on Amazon.co.uk)