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The World Professional Association for Transgender Health (WPATH) and the Endocrine Society formulated guidelines that created a foundation for health care providers to care for transgender patients.[1] UCSF guidelines are also used.[2] There is no generally agreed-upon set of guidelines, however.[citation needed][3]


Masculinizing hormone therapy is typically used by transgender men, who desire the development of masculine secondary sex characteristics. Masculinizing hormone therapy usually includes testosterone to produce masculinization and suppress the production of estrogen.[4] Treatment options include oral, parenteral, subcutaneous implant, and transdermal (patches, gels). Dosing is patient-specific and is discussed with the physician.[5] The most commonly prescribed methods are intramuscular and subcutaneous injections. This dosing can be weekly or biweekly depending on the individual patient.[6]


Some transgender people choose to self-administer hormone replacement medications, often because doctors have too little experience in this area, or because no doctor is available. Others self-administer because their doctor will not prescribe hormones without a letter from a psychotherapist stating that the patient meets the diagnostic criteria and is making an informed decision to transition. Many therapists require at least three months of continuous psychotherapy and/or real-life experience before they will write such a letter. Because many individuals must pay for evaluation and care out-of-pocket, costs can be prohibitive.[citation needed][7]


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  1. ^ Unger CA (December 2016). "Hormone therapy for transgender patients". Translational Andrology and Urology. 5 (6): 877–884. doi:10.21037/tau.2016.09.04. PMC 5182227. PMID 28078219.
  2. ^ Deutsch MB, ed. (June 2016). Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People (2nd ed.). San Francisco, CA: UCSF Transgender Care, Department of Family and Community Medicine, University of California San Francisco.
  3. ^ Houssayni, Sarah (28 Feb 2018). "Transgender Competent Provider: Identifying Transgender Health Needs, Health Disparities, and Health Coverage". National Library of Medicine. Retrieved 10/15/2023. {{cite web}}: Check date values in: |access-date= (help)CS1 maint: url-status (link)
  4. ^ "Masculinizing hormone therapy - Mayo Clinic". www.mayoclinic.org. Retrieved 2019-08-02.
  5. ^ "Information on Testosterone Hormone Therapy". Transgender Care. transcare.ucsf.edu. Retrieved 2019-08-07.
  6. ^ Warner, Leah (April 4, 2017). "SFDPH Transgender Health Services" (PDF). HormoneTxAllinOne. [file:///C:/Users/Cityw/Downloads/HormoneTxAllinOne.pdf Archived] (PDF) from the original on 10/15/2023. Retrieved 10/15/2023. {{cite web}}: Check |archive-url= value (help); Check date values in: |access-date= and |archive-date= (help)
  7. ^ White Hugto, Jacquelyn; Reisner, Sari; Pachankis, John (18 November, 2015). "sciencedirect.com". Transgender stigma and health: A critical review of stigma determinants, mechanisms, and interventions. Retrieved 10/15/2023. {{cite web}}: Check date values in: |access-date= and |date= (help)CS1 maint: url-status (link)