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Uri Alon

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Uri Alon
Uri Alon
Born1969 (age 54–55)[3]
Alma materHebrew University of Jerusalem
Weizmann Institute of Science
Known forNetwork motifs
AwardsOverton Prize (2004)
Scientific career
InstitutionsWeizmann Institute of Science
Princeton University
Doctoral advisorDavid Mukamel[1]
Other academic advisors
Doctoral studentsRon Milo
Websitewww.weizmann.ac.il/mcb/UriAlon

Uri Alon (Hebrew: אורי אלון; born 1969) is a Professor and Systems Biologist at the Weizmann Institute of Science.[4] His highly cited[5] research investigates gene expression,[6] network motifs[7][8] and the design principles of biological networks[9] in Escherichia coli and other organisms using both computational biology and traditional experimental wet laboratory techniques.[10]

Education

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Alon earned his bachelor's and master's degrees from the Hebrew University of Jerusalem and his Ph.D. in Theoretical Physics[1][11] from the Weizmann Institute of Science.

Career

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After having his interest in biology sparked, Alon headed to Princeton University for his postdoctoral work in experimental biology. He returned to the Weizmann Institute as a professor.

Alon features in several popular videos on YouTube such as Sunday at the Lab (with Michael Elowitz)[12] and How to Give a Good Talk.[13] As of 2011, he is the author of the most highly bookmarked scientific paper on CiteULike[14] How To Choose a Good Scientific Problem[15] and How to Build a Motivated Research Group.[16]

In 2021 he was appointed visiting professor in the bioengineering department of Stanford University. He is a member of the IBS Biomedical Mathematics Group.[17]

Research

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Uri Alon significantly contributed to our understanding of gene regulatory networks and generalized the term network motif in 2002.[18][19][20]

Together with his team, he reunited different theories of endocrine feedback loops by introducing the closely related concepts of dynamical compensation and autoimmune surveillance of hypersecreting mutants (ASHM).[21][22][23] The theories are able to explain a plethora of phenomena ranging from circannual endocrine rhythms[24] over type 2 diabetes[25] and other common endocrine disorders[26] to alcohol addiction[27] and age-related diseases.[28]

Awards

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In 2004 Alon was awarded the Overton Prize[2] for "outstanding accomplishment by a scientist in the early to mid stage of his or her career" by the International Society for Computational Biology. Alon has also been awarded:

References

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  1. ^ a b Alon, U.; Evans, M.; Hinrichsen, H.; Mukamel, D. (1996). "Roughening Transition in a One-Dimensional Growth Process". Physical Review Letters. 76 (15): 2746–2749. arXiv:cond-mat/9512069. Bibcode:1996PhRvL..76.2746A. doi:10.1103/PhysRevLett.76.2746. PMID 10060778. S2CID 26730428.
  2. ^ a b "ISCB Newsletter 7-3". iscb.org.
  3. ^ "Wis-Find: Author Search Results". weizmann.ac.il.
  4. ^ "Homepage - Uri Alon". weizmann.ac.il.
  5. ^ Uri Alon publications indexed by Google Scholar
  6. ^ Alon, U.; Barkai, N.; Notterman, D. A.; Gish, K.; Ybarra, S.; Mack, D.; Levine, A. J. (1999). "Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays". Proceedings of the National Academy of Sciences. 96 (12): 6745–6750. Bibcode:1999PNAS...96.6745A. doi:10.1073/pnas.96.12.6745. PMC 21986. PMID 10359783.
  7. ^ Milo, R.; Shen-Orr, S.; Itzkovitz, S.; Kashtan, N.; Chklovskii, D.; Alon, U. (2002). "Network Motifs: Simple Building Blocks of Complex Networks". Science. 298 (5594): 824–827. Bibcode:2002Sci...298..824M. CiteSeerX 10.1.1.225.8750. doi:10.1126/science.298.5594.824. PMID 12399590. S2CID 9884096.
  8. ^ Shen-Orr, S. S.; Milo, R.; Mangan, S.; Alon, U. (2002). "Network motifs in the transcriptional regulation network of Escherichia coli". Nature Genetics. 31 (1): 64–68. doi:10.1038/ng881. PMID 11967538. S2CID 2180121.
  9. ^ Uri Alon (2007). An introduction to systems biology: design principles of biological circuits. Boca Raton: Chapman & Hall/CRC. ISBN 978-1-58488-642-6.
  10. ^ Uri Alon publications indexed by Microsoft Academic
  11. ^ "arXiv.org Search". arxiv.org.
  12. ^ "Uri Alon's Song - Sunday at the Lab co-written with Elowitz" on YouTube
  13. ^ "How to Give a Good Talk by Uri Alon" on YouTube
  14. ^ "CiteULike CiteGeist: Popular Papers". Retrieved 2011-06-09.
  15. ^ Alon, U. (2009). "How to Choose a Good Scientific Problem" (PDF). Molecular Cell. 35 (6): 726–728. doi:10.1016/j.molcel.2009.09.013. PMID 19782018. Retrieved 2020-09-16.
  16. ^ Alon, U. (2010). "How to Build a Motivated Research Group" (PDF). Molecular Cell. 37 (2): 151–152. doi:10.1016/j.molcel.2010.01.011. PMID 20122395. Retrieved 2020-09-16.
  17. ^ "Uri Alon". Biomedical Mathematics Group. Retrieved 2024-05-26.
  18. ^ R. Milo, S. Shen-Orr, S. Itzkovitz, N. Kashtan, D. Chklovskii, U. Alon: Network motifs: simple building blocks of complex networks, Science 298, 2002, S. 824–827
  19. ^ S. Shen-Orr, R. Milo, S. Mangan, U. Alon: Network motifs in the transcriptional regulation network of Escherichia coli, Nature Genetics 31, 2002,: 64–68
  20. ^ Alon, Uri (June 2007). "Network motifs: theory and experimental approaches". Nature Reviews Genetics. 8 (6): 450–461. doi:10.1038/nrg2102. PMID 17510665. S2CID 7169406.
  21. ^ Karin, O; Swisa, A; Glaser, B; Dor, Y; Alon, U (8 November 2016). "Dynamical compensation in physiological circuits". Molecular Systems Biology. 12 (11): 886. doi:10.15252/msb.20167216. PMC 5147051. PMID 27875241.
  22. ^ Maimon, L; Milo, T; Moyal, RS; Mayo, A; Danon, T; Bren, A; Alon, U (26 August 2020). "Timescales of Human Hair Cortisol Dynamics". iScience. 23 (9): 101501. Bibcode:2020iSci...23j1501M. doi:10.1016/j.isci.2020.101501. PMC 7490542. PMID 32911331.
  23. ^ Korem Kohanim, Y; Tendler, A; Mayo, A; Friedman, N; Alon, U (19 May 2020). "Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants". Immunity. 52 (5): 872–884.e5. doi:10.1016/j.immuni.2020.04.022. PMC 7237888. PMID 32433950.
  24. ^ Tendler, A; Bar, A; Mendelsohn-Cohen, N; Karin, O; Korem Kohanim, Y; Maimon, L; Milo, T; Raz, M; Mayo, A; Tanay, A; Alon, U (16 February 2021). "Hormone seasonality in medical records suggests circannual endocrine circuits". Proceedings of the National Academy of Sciences of the United States of America. 118 (7): e2003926118. Bibcode:2021PNAS..11803926T. doi:10.1073/pnas.2003926118. PMC 7896322. PMID 33531344.
  25. ^ Karin, O; Alon, U (26 June 2017). "Biphasic response as a mechanism against mutant takeover in tissue homeostasis circuits". Molecular Systems Biology. 13 (6): 933. doi:10.15252/msb.20177599. PMC 5488663. PMID 28652282.
  26. ^ Karin, O; Raz, M; Tendler, A; Bar, A; Korem Kohanim, Y; Milo, T; Alon, U (July 2020). "A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks". Molecular Systems Biology. 16 (7): e9510. doi:10.15252/msb.20209510. PMC 7364861. PMID 32672906.
  27. ^ Karin, O; Raz, M; Alon, U (19 March 2021). "An opponent process for alcohol addiction based on changes in endocrine gland mass". iScience. 24 (3): 102127. Bibcode:2021iSci...24j2127K. doi:10.1016/j.isci.2021.102127. PMC 7903339. PMID 33665551.
  28. ^ Katzir, I; Adler, M; Karin, O; Mendelsohn-Cohen, N; Mayo, A; Alon, U (March 2021). "Senescent cells and the incidence of age-related diseases". Aging Cell. 20 (3): e13314. doi:10.1111/acel.13314. PMC 7963340. PMID 33559235.
  29. ^ "Uri Alon". f1000.com.
  30. ^ Radcliffe Fellows
  31. ^ "2014 HFSP Nakasone Award goes to Uri Alon". hfsp.org.
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