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Uracil glycol

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Uracil glycol
Names
IUPAC name
5,6-Dihydroxydihydro-2,4(1H,3H)-pyrimidinedione
Other names
5,6-Dihydroxy-5,6-dihydrouracil
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C4H6N2O4/c7-1-2(8)5-4(10)6-3(1)9/h1-2,7-8H,(H2,5,6,9,10)
    Key: NHOKUDODDWSIAJ-UHFFFAOYSA-N
  • C1(C(NC(=O)NC1=O)O)O
Properties
C4H6N2O4
Molar mass 146.102 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Uracil glycol is a major oxidation product of cytosine in DNA. It can be readily bypassed by E. coli DNA polymerase I (unlike thymine glycol) and be a potent premutagenic lesion.[1]

References

[edit]
  1. ^ "Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine". Jbc.org. Retrieved July 20, 2015.