Uracil glycol
Appearance
Names | |
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IUPAC name
5,6-Dihydroxydihydro-2,4(1H,3H)-pyrimidinedione
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Other names
5,6-Dihydroxy-5,6-dihydrouracil
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C4H6N2O4 | |
Molar mass | 146.102 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Uracil glycol is a major oxidation product of cytosine in DNA. It can be readily bypassed by E. coli DNA polymerase I (unlike thymine glycol) and be a potent premutagenic lesion.[1]
References
[edit]- ^ "Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA Cytosine". Jbc.org. Retrieved July 20, 2015.