Ulf Kahlert
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Ulf Kahlert
[edit]Ulf Dietrich Kahlert (* 1981 in Dresden) is a German cancer researcher and stem cell biologist. He is a professor at the Medical Faculty of the Otto-von-Guericke University Magdeburg (OvGU), where he leads the Department of Molecular and Experimental Surgery at the Clinic for General, Visceral, Vascular, and Transplant Surgery.[1] His extensive research work is documented in more than 95 international publications.[2][3]
Life
[edit]Ulf Kahlert is the son of a physician, Ruth Kahlert, and an engineer, Jürgen Kahlert. He grew up in Dresden and studied biology at the University of Gießen, the University of Sussex in Brighton, UK, and the University of Freiburg, where he completed his diploma in 2008. He earned his PhD under the supervision of Wolfgang Driever in 2012 at the Faculty of Biology, focusing on cancer stem cells. As a fellow of the German Cancer Aid Foundation, he conducted postdoctoral research from 2013 to 2015 at Johns Hopkins Hospital in Baltimore, MD, USA, in the laboratory of Professor Charles G. Eberhart.[4]
Starting in October 2015, he led the Translational Neurotechnologies group at the Clinic for Neurosurgery at the University Hospital Düsseldorf.[5] In November 2020, he habilitated at the Medical Faculty of the University of Düsseldorf on the topic of stem cell technology for precision oncology[6] and received Venia Legendi. In April 2021, he accepted a professorship for Molecular and Experimental Surgery at OvGU. Since 2023, he has been the head of Molecular Research at the AN-Institute for Quality Assurance in Operative Medicine at OvGU.[7] His research group participates in the STIMULATE campus, a public-private partnership[8] focused on the development of modern medical technology. In 2024, he was appointed chairman of the Magdeburg local group of the German Association of University Professors and Lecturers[9] and chairman of the Commission for International Relations of the Faculty of Medicine at OvGU.[10]
Kahlert is married to US American Diana Andrea Duarte and has one son.
Research Fields
[edit]- Cancer Stem Cell Research
- Studies on the plasticity and heterogeneity of malignant solid tumors, particularly glioblastomas, pancreatic adenocarcinomas, and colorectal tumors.[11][12][13]
- Development of new treatment approaches against therapy resistance and metastasis of tumors through personalized therapies focusing on the modulation of cell metabolism.[14][15][16][17][18][19][20]
- Simulation of tumor development using healthy stem cells.[21][22][23][24]
- Ensuring reproducible research results by developing alternative validation techniques.[25][26][27]
- Early Detection of Tumors
- Quality Improvement in Biomedical Research
- Animal-Free Alternative Methods
As part of the COST funding initiative of the European Union, Kahlert's research on the application of stem cells as a testing platform for assessing the specificities and efficiency of innovative nanomedicines against cancer cells was selected as a success story of all European research collaboration networks in 2023.[37]
References
[edit]- ^ "Molekulare und Experimentelle Chirurgie (MEC)" (in German). Otto-von-Guericke-Universität Magdeburg. Retrieved 2024-09-19.
- ^ "Pubmed Datenbank Kahlert, U". Pubmed. Retrieved 2024-09-19.
- ^ "Ulf Kahlert". Google Scholar. Retrieved 2024-09-23.
- ^ "The Brain & Eye Tumor Lab: Alumni". Retrieved 2024-09-19.
- ^ Susanne Dopheide (2021-04-22). "Rapid and low-cost point-of-care diagnostics of fatal diseases of the central nervous system using gene scissors". IDW online. Retrieved 2024-09-19.
- ^ "Abgeschlossene Habilitationsverfahren". Heinrich Heine Universität Düsseldorf (in German). Retrieved 2024-09-19.
- ^ "Experte für Stammzellforschung berufen" (in German). Otto-von-Guericke-Universität Magdeburg. 2021-10-01. Retrieved 2024-09-19.
- ^ "Forschungscampus STIMULATE" (in German). STIMULATE. Retrieved 2024-09-23.
- ^ "Der Landesverband Sachsen-Anhalt". Deutscher Hochschulverband. Retrieved 2024-09-19.
- ^ "Kommission für Internationale Beziehungen". Otto-von-Guericke-Universität Magdeburg. Retrieved 2024-09-23.
- ^ U. D. Kahlert, G. Nikkhah, J. Maciaczyk (2013-05-01), "Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas", Cancer Letters, vol. 331, no. 2, pp. 131–138, doi:10.1016/j.canlet.2012.12.010, ISSN 0304-3835, PMID 23268331, retrieved 2024-09-22
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ D. Maciaczyk, D. Picard, L. Zhao, K. Koch, D. Herrera-Rios, G. Li, V. Marquardt, D. Pauck, T. Hoerbelt, W. Zhang, D. M. Ouwens, M. Remke, T. Jiang, H. J. Steiger, J. Maciaczyk, U. D. Kahlert (2017-06-27), "CBF1 is clinically prognostic and serves as a target to block cellular invasion and chemoresistance of EMT-like glioblastoma cells", British Journal of Cancer, vol. 117, no. 1, pp. 102–112, doi:10.1038/bjc.2017.157, ISSN 1532-1827, PMC 5520214, PMID 28571041
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Ulf Dietrich Kahlert, Donata Maciaczyk, Fangping Dai, Rainer Claus, Elke Firat, Soroush Doostkam, Tomasz Bogiel, Maria Stella Carro, Mate Döbrössy, Christel Herold-Mende, Gabriele Niedermann, Marco Prinz, Guido Nikkhah, Jaroslaw Maciaczyk (2012), "Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro", Journal of Neuropathology and Experimental Neurology, vol. 71, no. 12, pp. 1086–1099, doi:10.1097/NEN.0b013e3182772d83, ISSN 1554-6578, PMID 23147506, retrieved 2024-09-23
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ "27. Chirurgische Forschungstage "Strukturierte Forschung für den klinischen Erfolg" 26. – 28. September 2024 in Tübingen" (PDF). bg-kliniken (in de en). Retrieved 2024-09-22.
{{cite web}}: CS1 maint: unrecognized language (link) - ^ "Magdeburger Forscher finden Biomarker zur Früherkennung von Bauchspeicheldrüsenkrebs" (in German). 2023-11-17. Retrieved 2024-09-22.
- ^ U. D. Kahlert, S. M. Mooney, M. Natsumeda, H.-J. Steiger, J. Maciaczyk (2017-01-01), "Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways", International Journal of Cancer, vol. 140, no. 1, pp. 10–22, doi:10.1002/ijc.30259, ISSN 1097-0215, PMID 27389307, retrieved 2024-09-23
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Dymphna Margriet Ouwens, Michael Hewera, Guanzhang Li, Wang Di, Sajjad Muhammad, Daniel Hänggi, Hans-Jakob Steiger, Claudia A. Dumitru, Erol Sandalcioglu, Roland S. Croner, Wei Zhang, Or Kakhlon, Ulf D. Kahlert (2022-01-18), "Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells", Frontiers in Bioscience (Landmark Edition), vol. 27, no. 1, p. 35, doi:10.31083/j.fbl2701035, ISSN 2768-6698, PMID 35090340, retrieved 2024-09-23
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Katharina Koch, Rudolf Hartmann, Julia Tsiampali, Constanze Uhlmann, Ann-Christin Nickel, Xiaoling He, Marcel A. Kamp, Michael Sabel, Roger A. Barker, Hans-Jakob Steiger, Daniel Hänggi, Dieter Willbold, Jaroslaw Maciaczyk, Ulf D. Kahlert (2020), "A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity", Cell Death Discovery, vol. 6, p. 20, doi:10.1038/s41420-020-0258-3, ISSN 2058-7716, PMC 7162917, PMID 32337072
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Ulf D. Kahlert, Menglin Cheng, Katharina Koch, Luigi Marchionni, Xing Fan, Eric H. Raabe, Jarek Maciaczyk, Kristine Glunde, Charles G. Eberhart (2016-03-01), "Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells", International Journal of Cancer, vol. 138, no. 5, pp. 1246–1255, doi:10.1002/ijc.29873, ISSN 1097-0215, PMC 4772139, PMID 26422827
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ "Wie könnte die Entwicklung von Krebsmedikamenten verbessert werden?" (in German). idw-online. 2022-07-05. Retrieved 2024-09-22.
- ^ Constanze Uhlmann, Ann-Christin Nickel, Daniel Picard, Andrea Rossi, Guanzhang Li, Barbara Hildebrandt, Gabriele Brockerhoff, Farina Bendt, Ulrike Hübenthal, Michael Hewera, Hans-Jakob Steiger, Dagmar Wieczorek, Aristoteles Perrakis, Wei Zhang, Marc Remke, Katharina Koch, Julia Tigges, Roland S. Croner, Ellen Fritsche, Ulf D. Kahlert (2022), "Progenitor cells derived from gene-engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology", Biotechnology Journal, vol. 17, no. 6, pp. e2100693, doi:10.1002/biot.202100693, ISSN 1860-7314, PMID 35334498, retrieved 2024-09-22
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ N. Z. Mehjardi, J. Kessler, A. Y. Sanin, D. Picard, P. Westhoff, Ann-Christin Nickel, C. Uhlmann, W. Shi, H. J. Steiger, M. Remke, I. Fischer, D. Vordermark, R. S. Croner, U. D. Kahlert (2023-12-12), "The development of a hiPSC-based platform to identify tissue-dependencies of IDH1 R132H", Cell Death Discovery, vol. 9, no. 1, p. 452, doi:10.1038/s41420-023-01747-w, ISSN 2058-7716, PMC 10716401, PMID 38086797
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Allison R. Hanaford, Tenley C. Archer, Antoinette Price, Ulf D. Kahlert, Jarek Maciaczyk, Guido Nikkhah, Jong Wook Kim, Tobias Ehrenberger, Paul A. Clemons, Vlado Dančík, Brinton Seashore-Ludlow, Vasanthi Viswanathan, Michelle L. Stewart, Matthew G. Rees, Alykhan Shamji, Stuart Schreiber, Ernest Fraenkel, Scott L. Pomeroy, Jill P. Mesirov, Pablo Tamayo, Charles G. Eberhart, Eric H. Raabe (2016-08-01), "DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets", Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol. 22, no. 15, pp. 3903–3914, doi:10.1158/1078-0432.CCR-15-3011, ISSN 1557-3265, PMC 5055054, PMID 27012813
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Eric H. Raabe, Kah Suan Lim, Julia M. Kim, Alan Meeker, Xing-Gang Mao, Guido Nikkhah, Jarek Maciaczyk, Ulf Kahlert, Deepali Jain, Eli Bar, Kenneth J. Cohen, Charles G. Eberhart (2011-06-01), "BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model", Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol. 17, no. 11, pp. 3590–3599, doi:10.1158/1078-0432.CCR-10-3349, ISSN 1557-3265, PMC 4086658, PMID 21636552
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Dilaware Khan, Ann-Christin Nickel, Sebastian Jeising, Constanze Uhlmann, Sajjad Muhammad, Daniel Hänggi, Igor Fischer, Ulf Dietrich Kahlert (2021-09-11), "Testing the Stability of Drug Resistance on Cryopreserved, Gene-Engineered Human Induced Pluripotent Stem Cells", Pharmaceuticals (Basel, Switzerland), vol. 14, no. 9, p. 919, doi:10.3390/ph14090919, ISSN 1424-8247, PMC 8466661, PMID 34577619
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ "Validierungsprojekte: DisCoVer". BmBF: Validierungsförderung VIP+ (in German). Bundesministerium für Bildung und Forschung. Retrieved 2024-09-22.
- ^ a b "Krebsforschung: Der Weg zu mehr Qualität" (in German). DocCheck. Retrieved 2024-09-22.
- ^ Wenjie Shi, Thomas Wartmann, Sara Accuffi, Sara Al-Madhi, Aristotelis Perrakis, Christoph Kahlert, Alexander Link, Marino Venerito, Verena Keitel-Anselmino, Christiane Bruns, Roland S. Croner, Yue Zhao, Ulf D. Kahlert (2024), "Integrating a microRNA signature as a liquid biopsy-based tool for the early diagnosis and prediction of potential therapeutic targets in pancreatic cancer", British Journal of Cancer, vol. 130, no. 1, pp. 125–134, doi:10.1038/s41416-023-02488-4, ISSN 1532-1827, PMC 10781694, PMID 37950093
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Lennard M. Wurm, Björn Fischer, Volker Neuschmelting, David Reinecke, Igor Fischer, Roland S. Croner, Roland Goldbrunner, Michael C. Hacker, Jakub Dybaś, Ulf D. Kahlert (2023-11-20), "Rapid, label-free classification of glioblastoma differentiation status combining confocal Raman spectroscopy and machine learning", The Analyst, vol. 148, no. 23, pp. 6109–6119, Bibcode:2023Ana...148.6109W, doi:10.1039/d3an01303k, ISSN 1364-5528, PMID 37927114, retrieved 2024-09-23
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ "CRISPR/Cas-Technologie ermöglicht schnelle und minimal-invasive Diagnostik". Heinrich Heine Universität Düsseldorf (in German). 2021-04-23. Retrieved 2024-09-23.
- ^ Timo Sander, Joly Ghanawi, Emma Wilson, Sajjad Muhammad, Malcolm Macleod, Ulf Dietrich Kahlert (2022), "Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research", BMJ Open Science, vol. 6, no. 1, pp. e100272, doi:10.1136/bmjos-2021-100272, ISSN 2398-8703, PMC 9171230, PMID 35721833
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Michael Hewera, Daniel Hänggi, Björn Gerlach, Ulf Dietrich Kahlert (2021), "eLabFTW as an Open Science tool to improve the quality and translation of preclinical research", F1000Research, vol. 10, p. 292, doi:10.12688/f1000research.52157.3, ISSN 2046-1402, PMC 8323070, PMID 34381592
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Michael Hewera, Ann-Christin Nickel, Nina Knipprath, Sajjad Muhammad, Xiaolong Fan, Hans-Jakob Steiger, Daniel Hänggi, Ulf Dietrich Kahlert (2020), "An inexpensive and easy-to-implement approach to a Quality Management System for an academic research lab", F1000Research, vol. 9, p. 660, doi:10.12688/f1000research.24494.2, ISSN 2046-1402, PMC 7385541, PMID 32765843
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Dilaware Khan, Ann-Christin Nickel, Sebastian Jeising, Constanze Uhlmann, Sajjad Muhammad, Daniel Hänggi, Igor Fischer, Ulf Dietrich Kahlert (2021-09-11), "Testing the Stability of Drug Resistance on Cryopreserved, Gene-Engineered Human Induced Pluripotent Stem Cells", Pharmaceuticals (Basel, Switzerland), vol. 14, no. 9, p. 919, doi:10.3390/ph14090919, ISSN 1424-8247, PMC 8466661, PMID 34577619
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ Constanze Uhlmann, Ann-Christin Nickel, Daniel Picard, Andrea Rossi, Guanzhang Li, Barbara Hildebrandt, Gabriele Brockerhoff, Farina Bendt, Ulrike Hübenthal, Michael Hewera, Hans-Jakob Steiger, Dagmar Wieczorek, Aristoteles Perrakis, Wei Zhang, Marc Remke, Katharina Koch, Julia Tigges, Roland S. Croner, Ellen Fritsche, Ulf D. Kahlert (2022), "Progenitor cells derived from gene-engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology", Biotechnology Journal, vol. 17, no. 6, pp. e2100693, doi:10.1002/biot.202100693, ISSN 1860-7314, PMID 35334498, retrieved 2024-09-23
{{citation}}: CS1 maint: multiple names: authors list (link) - ^ "CA21139 - 3Rs concepts to improve the quality of biomedical science (IMPROVE)". COST-EU. 2022-05-27. Retrieved 2024-09-25.
- ^ "COST: a career booster!". cost.eu. 2024-07-22. Retrieved 2024-09-22.