Ubiquitin-fold modifier conjugating enzyme 1

UFC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2K07, 2Z6O, 2Z6P, 3EVX
Identifiers
Aliases	UFC1, HSPC155, ubiquitin-fold modifier conjugating enzyme 1, NEDSG
External IDs	OMIM: 610554; MGI: 1913405; HomoloGene: 9500; GeneCards: UFC1; OMA:UFC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,158,856 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,295,024 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; olfactory zone of nasal mucosa; ; epithelium of nasopharynx; ; body of pancreas; ; caudate nucleus; ; islet of Langerhans; ; nucleus accumbens; ; body of stomach; ; left ovary;
	Top expressed in
	parotid gland; ; facial motor nucleus; ; islet of Langerhans; ; lacrimal gland; ; seminal vesicula; ; calvaria; ; Paneth cell; ; medial ganglionic eminence; ; lens; ; Epithelium of choroid plexus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; UFM1 transferase activity;
Cellular component	extracellular exosome; cytoplasm;
Biological process	protein K69-linked ufmylation; response to endoplasmic reticulum stress; protein ufmylation; brain development;
	Sources:Amigo / QuickGO
Orthologs
	51506
	66155
	ENSG00000143222
	ENSMUSG00000062963
	Q9Y3C8
	Q9CR09
	NM_016406
	NM_025388
	NP_057490
	NP_079664; NP_001347860; NP_001347861; NP_001347862
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene. ^[5]

Function

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143222 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062963 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1". Retrieved 2020-04-15.

Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325. PMID 15071506.
Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T (April 2009). "NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway". J. Struct. Funct. Genomics. 10 (2): 127–36. doi:10.1007/s10969-008-9054-7. PMC 2850604. PMID 19101823.
Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S (June 2014). "Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1)". Exp. Cell Res. 324 (2): 192–9. doi:10.1016/j.yexcr.2014.04.003. PMID 24726913.
Xie S (August 2014). "Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex". Acta Crystallogr F. 70 (Pt 8): 1093–7. doi:10.1107/S2053230X14014502. PMC 4118812. PMID 25084390.
Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT (February 2015). "Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections". HIV Med. 16 (2): 114–21. doi:10.1111/hiv.12194. PMID 25213431.
Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L (February 2015). "The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells". Gastroenterology. 148 (2): 415–26.e18. doi:10.1053/j.gastro.2014.10.012. PMID 25449213.
Zhang G, Wu Y, Xu D, Yan X (November 2016). "Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a". DNA Cell Biol. 35 (11): 691–695. doi:10.1089/dna.2016.3397. PMID 27529373.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143222 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062963 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ubiquitin-fold modifier conjugating enzyme 1". Retrieved 2020-04-15.

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading