USP39

USP39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3JCR
Identifiers
Aliases	USP39, 65K, HSPC332, SAD1, SNRNP65, CGI-21, ubiquitin specific peptidase 39
External IDs	OMIM: 611594; MGI: 107622; HomoloGene: 13183; GeneCards: USP39; OMA:USP39 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,649,283 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,322,167 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gastrocnemius muscle; ; granulocyte; ; muscle of thigh; ; monocyte; ; stromal cell of endometrium; ; muscle layer of sigmoid colon; ; upper lobe of left lung; ; right lung;
	Top expressed in
	epiblast; ; ventricular zone; ; tail of embryo; ; spermatocyte; ; placenta; ; yolk sac; ; granulocyte; ; ganglionic eminence; ; genital tubercle; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiol-dependent deubiquitinase; zinc ion binding; metal ion binding; protein binding;
Cellular component	spliceosomal complex; nucleus; nucleoplasm; U4/U6 x U5 tri-snRNP complex;
Biological process	protein deubiquitination; mRNA splicing, via spliceosome; cell cycle; mRNA processing; RNA splicing; cell division; spliceosomal complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	10713
	28035
	ENSG00000168883
	ENSMUSG00000056305
	Q53GS9
	Q3TIX9
	NM_001256725; NM_001256726; NM_001256727; NM_001256728; NM_006590
	NM_138592
	NP_001243654; NP_001243655; NP_001243656; NP_001243657; NP_006581
	NP_613058
	Wikidata
View/Edit Human	View/Edit Mouse

U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168883 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056305 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ "Entrez Gene: USP39 ubiquitin specific peptidase 39".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lygerou Z, Christophides G, Séraphin B (1999). "A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing". Mol. Cell. Biol. 19 (3): 2008–20. doi:10.1128/mcb.19.3.2008. PMC 83994. PMID 10022888.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–713. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Makarova OV, Makarov EM, Lührmann R (2001). "The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes". EMBO J. 20 (10): 2553–2563. doi:10.1093/emboj/20.10.2553. PMC 125249. PMID 11350945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168883 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056305 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP39 ubiquitin specific peptidase 39".

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[5]

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References

Further reading