UNC93A

UNC93A
Identifiers
Aliases	UNC93A, Unc-93A, dJ366N23.1, dJ366N23.2, UNC93A (gene), unc-93 homolog A (C. elegans), unc-93 homolog A
External IDs	OMIM: 607995; MGI: 1933250; HomoloGene: 10356; GeneCards: UNC93A; OMA:UNC93A - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	167,316,014 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	13,350,697 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; secondary oocyte; ; skin of abdomen; ; right lobe of liver; ; buccal mucosa cell; ; duodenum; ; rectum; ; gallbladder; ; human kidney; ; metanephros;
	Top expressed in
	jejunum; ; spermatid; ; esophagus; ; duodenum; ; placenta; ; white adipose tissue; ; colon; ; ileum; ; blastocyst; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	54346
	381058
	ENSG00000112494
	ENSMUSG00000067049
	Q86WB7
	Q710D3
	NM_001143947; NM_018974
	NM_199252
	NP_001137419; NP_061847
	NP_954860
	Wikidata
View/Edit Human	View/Edit Mouse

Unc-93 homolog A (C. elegans) is a protein that in humans is encoded by the UNC93A gene.^[5]

Unc93A is a major facilitator superfamily (MFS), and a putative solute carrier in humans.^[6]^[7] It belongs to the atypical SLCs that was recently listed.^[6] It is therefore presumed that UNC93A is a transporter protein.

UNC93A is closely related to UNC93B1 and MFSD11.^[8]^[9]

UNC93A is affected by amino acid deprivation in cell cortex cultures^[7]^[8] and starvation in in vivo samples.^[8]

It is expressed in neurons, with staining close to the plasma membrane.^[8]

Read also ^[10]^[11] for functional studies in C.elegans.

For you who are interested to read more about Unc93A in different species, see: ^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112494 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067049 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Unc-93 homolog A (C. elegans)".
^ ^a ^b Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
^ ^a ^b Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
^ ^a ^b ^c ^d Ceder MM, Lekholm E, Hellsten SV, Perland E, Fredriksson R (2017). "The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice". Frontiers in Molecular Neuroscience. 10: 351. doi:10.3389/fnmol.2017.00351. PMC 5671512. PMID 29163028.
^ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6): e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
^ Levin JZ, Horvitz HR (April 1992). "The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction". The Journal of Cell Biology. 117 (1): 143–55. doi:10.1083/jcb.117.1.143. PMC 2289394. PMID 1313436.
^ de la Cruz IP, Levin JZ, Cummins C, Anderson P, Horvitz HR (October 2003). "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans". The Journal of Neuroscience. 23 (27): 9133–45. doi:10.1523/JNEUROSCI.23-27-09133.2003. PMC 6740817. PMID 14534247.
^ Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert (2020). "CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A". Frontiers in Cell and Developmental Biology. 8: 580291. doi:10.3389/fcell.2020.580291. ISSN 2296-634X. PMC 7591606. PMID 33163493.

References

Further reading