UFD1L

UFD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YUJ, 5C1B
Identifiers
Aliases	UFD1, UFD1L, ubiquitin fusion degradation 1 like (yeast), ubiquitin recognition factor in ER associated degradation 1
External IDs	OMIM: 601754; MGI: 109353; HomoloGene: 39090; GeneCards: UFD1; OMA:UFD1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	19,479,202 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	18,654,011 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; islet of Langerhans; ; corpus epididymis; ; gastrocnemius muscle; ; stromal cell of endometrium; ; palpebral conjunctiva; ; skin of thigh; ; oral cavity; ; placenta; ; glutes;
	Top expressed in
	dorsomedial hypothalamic nucleus; ; median eminence; ; seminiferous tubule; ; habenula; ; ventral tegmental area; ; dentate gyrus of hippocampal formation granule cell; ; superior cervical ganglion; ; neural layer of retina; ; cerebellar cortex; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; ATPase binding; K48-linked polyubiquitin modification-dependent protein binding; signaling receptor binding; protein binding; thiol-dependent deubiquitinase;
Cellular component	cytoplasm; cytosol; nucleus; UFD1-NPL4 complex; nucleoplasm; endoplasmic reticulum; VCP-NPL4-UFD1 AAA ATPase complex;
Biological process	error-free translesion synthesis; skeletal system development; retrograde protein transport, ER to cytosol; ER-associated misfolded protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process; protein deubiquitination; negative regulation of type I interferon production; negative regulation of RIG-I signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7353
	22230
	ENSG00000070010
	ENSMUSG00000005262
	Q92890
	P70362
	NM_001035247; NM_005659; NM_001362910
	NM_011672
	NP_001030324; NP_005650; NP_001349839
	NP_035802
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.^[5]^[6]

Function

The protein encoded by this gene forms a complex with two other proteins, NPL4 and VCP, that is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

Interactions

UFD1L has been shown to interact with NPLOC4.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070010 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pizzuti A, Novelli G, Ratti A, Amati F, Mari A, Calabrese G, Nicolis S, Silani V, Marino B, Scarlato G, Ottolenghi S, Dallapiccola B (August 1997). "UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome". Hum. Mol. Genet. 6 (2): 259–65. doi:10.1093/hmg/6.2.259. PMID 9063746.
^ ^a ^b "Entrez Gene: UFD1L ubiquitin fusion degradation 1 like (yeast)".
^ Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (September 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
^ Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (August 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Novelli G, Mari A, Amati F, Colosimo A, Sangiuolo F, Bengala M, Conti E, Ratti A, Bordoni R, Pizzuti A, Baldini A, Crinelli R, Pandolfi F, Magnani M, Dallapiccola B (1998). "Structure and expression of the human ubiquitin fusion-degradation gene (UFD1L)". Biochim. Biophys. Acta. 1396 (2): 158–62. doi:10.1016/s0167-4781(97)00211-x. PMID 9540831.
Yamagishi H, Garg V, Matsuoka R, Thomas T, Srivastava D (1999). "A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects". Science. 283 (5405): 1158–61. Bibcode:1999Sci...283.1158Y. doi:10.1126/science.283.5405.1158. PMID 10024240.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.
Amati F, Conti E, Botta A, Amicucci P, Dallapiccola B, Novelli G (2002). "Functional characterization of the 5' flanking region of human ubiquitin fusion degradation 1 like gene (UFD1L)". Cell Biochem. Funct. 20 (2): 163–70. doi:10.1002/cbf.966. PMID 11979512. S2CID 13377004.
Amati F, Condò I, Conti E, Sangiuolo F, Dallapiccola B, Testi R, Novelli G (2003). "Analysis of intracellular distribution and apoptosis involvement of the Ufd1l gene product by over-expression studies". Cell Biochem. Funct. 21 (3): 263–7. doi:10.1002/cbf.1021. PMID 12910480. S2CID 37752313.
Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA (2004). "A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol". Nature. 429 (6994): 841–7. Bibcode:2004Natur.429..841Y. doi:10.1038/nature02656. PMID 15215856. S2CID 4317750.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2005). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
McConnell E, Lass A, Wójcik C (2007). "Ufd1-Npl4 is a negative regulator of cholera toxin retrotranslocation". Biochem. Biophys. Res. Commun. 355 (4): 1087–90. doi:10.1016/j.bbrc.2007.02.077. PMID 17331469.
Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL (2007). "Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase". Cell Metab. 6 (2): 115–28. doi:10.1016/j.cmet.2007.07.002. PMID 17681147.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070010 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005262 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9063746-5] Pizzuti A, Novelli G, Ratti A, Amati F, Mari A, Calabrese G, Nicolis S, Silani V, Marino B, Scarlato G, Ottolenghi S, Dallapiccola B (August 1997). "UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome". Hum. Mol. Genet. 6 (2): 259–65. doi:10.1093/hmg/6.2.259. PMID 9063746.

[entrez-6] "Entrez Gene: UFD1L ubiquitin fusion degradation 1 like (yeast)".

[pmid11574150-7] Botta A, Tandoi C, Fini G, Calabrese G, Dallapiccola B, Novelli G (September 2001). "Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L)". Gene. 275 (1): 39–46. doi:10.1016/S0378-1119(01)00649-7. PMID 11574150.

[pmid18586029-8] Lass A, McConnell E, Fleck K, Palamarchuk A, Wójcik C (August 2008). "Analysis of Npl4 deletion mutants in mammalian cells unravels new Ufd1-interacting motifs and suggests a regulatory role of Npl4 in ERAD". Exp. Cell Res. 314 (14): 2715–23. doi:10.1016/j.yexcr.2008.06.008. PMID 18586029.

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Function

Interactions

References

Further reading