UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)
| UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.115 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting) (EC 4.2.1.115, FlaA1, UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase, PseB, UDP-N-acetylglucosamine hydro-lyase (inverting, UDP-2-acetamido-2,6-dideoxy-β-L)arabino-hex-4-ulose-forming)) is an enzyme with systematic name UDP-N-acetyl-α-D-glucosamine hydro-lyase (inverting; UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-α-D-glucosamine UDP-2-acetamido-2,6-dideoxy-β-L-arabino-hex-4-ulose + H2O
This enzyme contains NADP+ as a cofactor.
References
[edit]- ^ Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, Lam JS, Berghuis AM (August 2006). "Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity". The Journal of Biological Chemistry. 281 (34): 24489–95. doi:10.1074/jbc.m602393200. PMID 16651261.
- ^ Schirm M, Soo EC, Aubry AJ, Austin J, Thibault P, Logan SM (June 2003). "Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori". Molecular Microbiology. 48 (6): 1579–92. doi:10.1046/j.1365-2958.2003.03527.x. PMID 12791140.
- ^ Schoenhofen IC, McNally DJ, Brisson JR, Logan SM (September 2006). "Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction". Glycobiology. 16 (9): 8C–14C. doi:10.1093/glycob/cwl010. PMID 16751642.
External links
[edit]- UDP-N-acetylglucosamine+4,6-dehydratase+(configuration-inverting) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
