Transcriptional adaptation

Transcriptional adaptation is a recently described type of genetic compensation by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes or modifiers.^[1]^[2]

References

^ Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, Stainier DY (August 2015). "Genetic compensation induced by deleterious mutations but not gene knockdowns". Nature. 524 (7564): 230–3. Bibcode:2015Natur.524..230R. doi:10.1038/nature14580. PMID 26168398. S2CID 4462277.
^ El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, et al. (April 2019). "Genetic compensation triggered by mutant mRNA degradation". Nature. 568 (7751): 193–197. Bibcode:2019Natur.568..193E. doi:10.1038/s41586-019-1064-z. PMC 6707827. PMID 30944477.

[1] Rossi A, Kontarakis Z, Gerri C, Nolte H, Hölper S, Krüger M, Stainier DY (August 2015). "Genetic compensation induced by deleterious mutations but not gene knockdowns". Nature. 524 (7564): 230–3. Bibcode:2015Natur.524..230R. doi:10.1038/nature14580. PMID 26168398. S2CID 4462277.

[2] El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, et al. (April 2019). "Genetic compensation triggered by mutant mRNA degradation". Nature. 568 (7751): 193–197. Bibcode:2019Natur.568..193E. doi:10.1038/s41586-019-1064-z. PMC 6707827. PMID 30944477.

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