Trametenolic acid

Trametenolic acid
Names
	IUPAC name 3β-Hydroxylanosta-8,24-dien-21-oic acid
	Systematic IUPAC name (2R)-2-[(1R,3aR,5aR,7S,9aS,11aR)-7-Hydroxy-3a,6,6,9a,11a-pentamethyl-2,3,3a,4,5,5a,6,7,8,9,9a,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-enoic acid
Identifiers
CAS Number	24160-36-9 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL387689;
ChemSpider	10193870;
PubChem CID	12309443;
UNII	8PF73ZP92L ;
CompTox Dashboard (EPA)	DTXSID50946989 ;
	InChI InChI=1S/C30H48O3/c1-19(2)9-8-10-20(26(32)33)21-13-17-30(7)23-11-12-24-27(3,4)25(31)15-16-28(24,5)22(23)14-18-29(21,30)6/h9,20-21,24-25,31H,8,10-18H2,1-7H3,(H,32,33)/t20-,21-,24+,25+,28-,29-,30+/m1/s1 Key: NBSBUIQBEPROBM-GIICLEHTSA-N;
	SMILES CC(=CCC[C@H]([C@H]1CC[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)C)C)C(=O)O)C;
Properties
Chemical formula	C30H48O3
Molar mass	456.711 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Trametenolic acid is an anti-inflammatory sterol isolated from Inonotus obliquus.^[1] Duan et al reported that Trametenolic Acid had exhibited protective effect on the kidneys and ameliorated the progression of Diabetic Nephropathy in db/db Mice (The db/db mice are perfect animal models of type 2 diabetes.) via Nrf2/HO-1 and NF-κB-Mediated Pathways ^[2] Trametenolic Acid Mitigated Oxidative Stress in animal studies

References

^ Ma, L; Chen, H; Dong, P; Lu, X (2013). "Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus". Food Chemistry. 139 (1–4): 503–8. doi:10.1016/j.foodchem.2013.01.030. PMID 23561137.
^ Duan Q, Tian L, Feng J, Ping X, Li L, Yaigoub H, Li R, Li Y. Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways. J Immunol Res. 2022 Aug 30;2022:6151847. doi:10.1155/2022/6151847. PMID: 36081452; PMCID: PMC9448586

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[1] Ma, L; Chen, H; Dong, P; Lu, X (2013). "Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus". Food Chemistry. 139 (1–4): 503–8. doi:10.1016/j.foodchem.2013.01.030. PMID 23561137.

[2] Duan Q, Tian L, Feng J, Ping X, Li L, Yaigoub H, Li R, Li Y. Trametenolic Acid Ameliorates the Progression of Diabetic Nephropathy in db/db Mice via Nrf2/HO-1 and NF-κB-Mediated Pathways. J Immunol Res. 2022 Aug 30;2022:6151847. doi:10.1155/2022/6151847. PMID: 36081452; PMCID: PMC9448586

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