Toxoplasma lactate dehydrogenase 1 regulatory UTR

LDH1 5′UTR
LDH1 5′UTR
	Predicted secondary structure and sequence conservation of LDH1 5′UTR
Identifiers
Rfam	RF02697
Other data
Domain(s)	Bacteria
GO	GO:0045182
SO	SO:0005836,SO:0000204
PDB structures	PDBe

In Toxoplasma gondii the translational repression of lactate dehydrogenase 1 (LDH1) was discovered to be mediated through its 5′UTR. A small nucleotide regulatory RNA hairpin was shown to be essential for the repression. It is possible that this hairpin may act as the nucleation site for the binding of a trans-acting factor(s) that allow for the translational repression.^[1]

References

^ Holmes M, Itaas V, Ananvoranich S (November 2014). "Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin". The FEBS Journal. 281 (22): 5077–5091. doi:10.1111/febs.13048. PMID 25223457. S2CID 45643970.

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[1] Holmes M, Itaas V, Ananvoranich S (November 2014). "Sustained translational repression of lactate dehydrogenase 1 in Toxoplasma gondii bradyzoites is conferred by a small regulatory RNA hairpin". The FEBS Journal. 281 (22): 5077–5091. doi:10.1111/febs.13048. PMID 25223457. S2CID 45643970.

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