Thiadiazine
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3D model (JSmol)
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PubChem CID
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Properties | |
C3H4N2S | |
Molar mass | 100.14 g·mol−1 |
Related compounds | |
Related compounds
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Thiadiazole |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Thiadiazine is a heterocyclic compound containing a six-membered ring composed of three carbon atoms, one sulfur atom, and two nitrogen atoms.[1] It exists in several isomeric forms, each characterized by the different arrangement of the sulfur and nitrogen atoms in the ring structure.[2] Common isomers include 1,2,4-thiadiazine, 1,2,6-thiadiazine, and 1,3,4-thiadiazine.[1] Thiadiazines have gained significant interest in organic and medicinal chemistry research due to their diverse potential biological activities, including antimicrobial, anti-inflammatory, and muscle relaxant properties. They have been explored their potential applications in treating conditions such as Huntington's disease, rheumatoid arthritis, and type 2 diabetes.[2][1]
References
[edit]- ^ a b c Rodríguez H, Suárez M, Albericio F (June 2012). "Thiadiazines, N,N-heterocycles of biological relevance". Molecules (Basel, Switzerland). 17 (7): 7612–28. doi:10.3390/molecules17077612. PMC 6268759. PMID 22732878.
- ^ a b Terrab L, Rosenker CJ, Johnstone L, Ngo LK, Zhang L, Ware NF, Miller B, Topacio AZ, Sannino S, Brodsky JL, Wipf P (May 2020). "Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease". ACS Medicinal Chemistry Letters. 11 (5): 984–990. doi:10.1021/acsmedchemlett.0c00018. PMC 7236266. PMID 32435415.