Testis expressed 15

TEX15
Identifiers
Aliases	TEX15, CT42, testis expressed 15, testis expressed 15, meiosis and synapsis associated, SPGF25
External IDs	OMIM: 605795; MGI: 1934816; HomoloGene: 12837; GeneCards: TEX15; OMA:TEX15 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	30,913,008 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	34,075,610 bp
RNA expression pattern
	Top expressed in
	testicle; ; sperm; ; secondary oocyte; ; gonad; ; right testis; ; left testis; ; body of uterus; ; smooth muscle tissue; ; ventricular zone; ; ganglionic eminence;
	Top expressed in
	spermatid; ; lacrimal gland; ; parotid gland; ; cumulus cell; ; Gonadal ridge; ; seminiferous tubule; ; zygote; ; olfactory epithelium; ; secondary oocyte; ; primary oocyte;
	More reference expression data
	n/a
Orthologs
	56154
	104271
	ENSG00000133863
	ENSMUSG00000009628
	Q9BXT5
	F8VPN2
	NM_001350162
	NM_031374
	NP_001337091
	NP_113551
	Wikidata
View/Edit Human	View/Edit Mouse

Testis expressed 15 is a protein that in humans is encoded by the TEX15 gene.^[5]

The TEX15 gene displays testis-specific expression, maps to chromosome 8, contains four exons and encodes a 2789-amino acid protein.^[6] The TEX15 gene encodes a DNA damage response factor important in meiosis.

Animal studies

In mice, disruption of an ortholog of the TEX15 gene caused a drastic reduction in testis size and meiotic arrest in males.^[7] TEX15, in mice, is required for chromosome synapsis, meiotic recombination and DNA double-strand break repair.^[7] Furthermore, TEX15 regulates the loading of recombination proteins (RAD51 and DMC1) onto sites of DNA double-strand breaks, and its absence causes a failure of meiotic recombination.

Clinical significance

A mutation in the TEX15 gene was found to be associated with male infertility and meiotic maturation arrest.^[6]

Truncation variants of TEX15 are also potential breast cancer risk factors.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133863 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Testis expressed 15".
^ ^a ^b Okutman O, Muller J, Baert Y, Serdarogullari M, Gultomruk M, Piton A, Rombaut C, Benkhalifa M, Teletin M, Skory V, Bakircioglu E, Goossens E, Bahceci M, Viville S (October 2015). "Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family". Human Molecular Genetics. 24 (19): 5581–8. doi:10.1093/hmg/ddv290. PMID 26199321.
^ ^a ^b Yang F, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ (February 2008). "Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis". The Journal of Cell Biology. 180 (4): 673–9. doi:10.1083/jcb.200709057. PMC 2265566. PMID 18283110.
^ Mantere T, Tervasmäki A, Nurmi A, Rapakko K, Kauppila S, Tang J, Schleutker J, Kallioniemi A, Hartikainen JM, Mannermaa A, Nieminen P, Hanhisalo R, Lehto S, Suvanto M, Grip M, Jukkola-Vuorinen A, Tengström M, Auvinen P, Kvist A, Borg Å, Blomqvist C, Aittomäki K, Greenberg RA, Winqvist R, Nevanlinna H, Pylkäs K (April 2017). "Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility". Scientific Reports. 7 (1): 681. Bibcode:2017NatSR...7..681M. doi:10.1038/s41598-017-00766-9. PMC 5429682. PMID 28386063.

Animal studies

Clinical significance

References

Further reading