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Teratocarcinoma-derived growth factor 1

From Wikipedia, the free encyclopedia
TDGF1
Identifiers
AliasesTDGF1, CR, CRGF, CRIPTO, teratocarcinoma-derived growth factor 1, CR-1
External IDsMGI: 98658; HomoloGene: 2416; GeneCards: TDGF1; OMA:TDGF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003212
NM_001174136

NM_011562

RefSeq (protein)

NP_001167607
NP_003203

n/a

Location (UCSC)Chr 3: 46.57 – 46.58 MbChr 9: 110.77 – 110.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the TDGF1 gene.[5][6] The protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241186Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032494Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dono R, Montuori N, Rocchi M, De Ponti-Zilli L, Ciccodicola A, Persico MG (Oct 1991). "Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence". Am J Hum Genet. 49 (3): 555–65. PMC 1683146. PMID 1882841.
  6. ^ Scognamiglio B, Baldassarre G, Cassano C, Tucci M, Montuori N, Dono R, Lembo G, Barra A, Lago CT, Viglietto G, Rocchi M, Persico MG (Jul 1999). "Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1". Cytogenet Cell Genet. 84 (3–4): 220–4. doi:10.1159/000015263. PMID 10393436. S2CID 539075.
  7. ^ "Entrez Gene: TDGF1 teratocarcinoma-derived growth factor 1".

Further reading

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See also

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Cripto