Template:Side effects of combined androgen blockade with flutamide
| Side effect | Flutamide 750 mg/daya + GnRH agonist (n = 294) (%)b,c |
Placebo + GnRH agonist (n = 285) (%)b,c |
|---|---|---|
| Hot flashes | 61 | 57 |
| Decreased libido | 36 | 31 |
| Erectile dysfunction | 33 | 29 |
| Diarrhea | 12 | 4 |
| Severe | 4 | <1 |
| Nausea/vomiting | 11 | 10 |
| Gynecomastia | 9 | 11 |
| Others | 7 | 9 |
| Other gastrointestinal disorders | 6 | 4 |
| Anemia | 6 | ND |
| Footnotes: a = 250 mg three times per day at 8-hour intervals. b = Phase III studies of combined androgen blockade (flutamide + GnRH agonist) in men with advanced prostate cancer. c = Incidence ≥5% regardless of causality. Sources: [1][2] | ||
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